[Molecular targets of bacterial effectors and toxins that underlie vulnerability to diseases].

Takeshi Shimizu, Yukako Fujinaga, Akiko Takaya, Hiroshi Ashida, Toshio Kodama, Masanori Hatakeyama
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引用次数: 0

Abstract

Pathogenic bacteria produce a variety of effectors and/or toxins, which subvert target cell/tissue functions in the infected hosts. Some of those effectors/toxins also perturb host defense mechanism, thereby making up more complicated pathophysiological conditions. Such bacterial effectors/toxins may have been positively selected during evolution because they directly strike vulnerable points in the host system. In turn, this indicates that systemic exploration of molecules and signaling pathways targeted by bacterial effectors/toxins provides a powerful tool in digging up an unexpected Achilles' heel(s), malfunctioning of which gives rise to disorders not restricted to infectious diseases. Based on this viewpoint, this review shows molecular basis underlying host susceptibility and vulnerability to diseases through the studies of host molecules targeted by bacterial effectors and toxins.

[导致疾病易感性的细菌效应物和毒素的分子目标]。
致病菌产生多种效应物和/或毒素,破坏受感染宿主的靶细胞/组织功能。其中一些效应器/毒素还会扰乱宿主的防御机制,从而构成更复杂的病理生理条件。这些细菌效应物/毒素可能在进化过程中被积极选择,因为它们直接攻击宿主系统的脆弱点。反过来,这表明对细菌效应物/毒素靶向的分子和信号通路的系统探索为挖掘意想不到的阿喀琉斯之踵提供了一个强大的工具,其故障会导致不限于传染病的疾病。基于这一观点,本文通过对细菌效应物和毒素靶向宿主分子的研究,揭示宿主易感性和易感染性疾病的分子基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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