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Recalcitrant Optic Nerve and Retinal Infiltration in a Relapse of Acute Lymphoblastic Leukaemia 顽固性视神经和视网膜浸润在急性淋巴细胞白血病复发中的作用
IF 0.8
Neuro-Ophthalmology Pub Date : 2021-06-11 DOI: 10.1080/01658107.2021.1933079
Corrina P. Azarcon, G. V. Mercado, R. N. Alfonso
{"title":"Recalcitrant Optic Nerve and Retinal Infiltration in a Relapse of Acute Lymphoblastic Leukaemia","authors":"Corrina P. Azarcon, G. V. Mercado, R. N. Alfonso","doi":"10.1080/01658107.2021.1933079","DOIUrl":"https://doi.org/10.1080/01658107.2021.1933079","url":null,"abstract":"ABSTRACT Isolated ocular relapse of leukaemia is rare. We present the case of a 20-year-old male with T-cell acute lymphoblastic leukaemia (ALL) who reported sudden blurring of vision in both eyes 6 months after documentation of ALL remission. Ocular examination showed bilateral infiltrative optic neuropathies and serous retinal detachments. Cerebrospinal fluid and bone marrow samples were negative for blast cells. Systemic work-up did not reveal any other sites of involvement. The ocular infiltration partially responded to reinduction chemotherapy, intraconal steroids, and radiotherapy. This report demonstrates a challenging case of isolated ocular ALL relapse presenting as bilateral optic nerve and retinal infiltration.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"180 1","pages":"126 - 130"},"PeriodicalIF":0.8,"publicationDate":"2021-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80181741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scrub Typhus Presenting as Unilateral Abducens Nerve Palsy 恙虫病表现为单侧外展神经麻痹
IF 0.8
Neuro-Ophthalmology Pub Date : 2021-06-04 DOI: 10.1080/01658107.2021.1909073
R. Ghosh, S. Biswas, A. Mandal, Kaustav De, Srijit Bandyopadhyay, Sona Singh Sardar, A. Mandal, J. Benito‐León
{"title":"Scrub Typhus Presenting as Unilateral Abducens Nerve Palsy","authors":"R. Ghosh, S. Biswas, A. Mandal, Kaustav De, Srijit Bandyopadhyay, Sona Singh Sardar, A. Mandal, J. Benito‐León","doi":"10.1080/01658107.2021.1909073","DOIUrl":"https://doi.org/10.1080/01658107.2021.1909073","url":null,"abstract":"ABSTRACT Scrub typhus, an acute febrile infectious disease prevalent in the “Tsutsugamushi Triangle”, is a mite-born rickettsial zoonosis, caused by Orientia tsutsugamushi. Although the clinical presentation is protean, it rarely causes abducens nerve palsy. We report a 14-year-old previously healthy Indian girl who presented with a recent onset right abducens nerve palsy and headache, but without fever and without the classic dermatological manifestation (“eschar”) of the disease. After exclusion of common infectious, autoimmune, and neoplastic causes, she was finally diagnosed with scrub typhus associated with an abducens nerve palsy, which responded to doxycycline therapy.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"2 1","pages":"99 - 103"},"PeriodicalIF":0.8,"publicationDate":"2021-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87646675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Systemic Lupus Erythematosus and Third Nerve Palsy: Unusual Presentation and Review of the Literature 系统性红斑狼疮和第三神经麻痹:不寻常的表现和文献综述
IF 0.8
Neuro-Ophthalmology Pub Date : 2021-05-24 DOI: 10.1080/01658107.2021.1912113
Divya Natarajan, Mohan Kannam, M. V. V. Reddy, V. Sachdeva
{"title":"Systemic Lupus Erythematosus and Third Nerve Palsy: Unusual Presentation and Review of the Literature","authors":"Divya Natarajan, Mohan Kannam, M. V. V. Reddy, V. Sachdeva","doi":"10.1080/01658107.2021.1912113","DOIUrl":"https://doi.org/10.1080/01658107.2021.1912113","url":null,"abstract":"ABSTRACT We report the case of a young female with pyrexia of unknown origin, cutaneous macules and an incomplete third cranial nerve palsy, that led to the diagnosis of systemic lupus erythematosus (SLE) with neurological manifestations. Her visual acuity was normal. Fundus examination showed cotton wool spots in both eyes. Neuroimaging was also normal. Systemic work up revealed pancytopaenia, hypocomplementaemia, and the presence of multiple autoantibodies including anti-double stranded deoxyribonucleic acid and lupus anticoagulant. She was effectively treated with intravenous pulsed corticosteroid therapy, cyclophosphamide, and oral hydroxychloroquine. This case highlights the uncommon involvement of cranial nerve mononeuropathy in SLE, the importance of systemic examination and autoimmune workup in young patients with such a presentation.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"os7 1","pages":"109 - 114"},"PeriodicalIF":0.8,"publicationDate":"2021-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88399915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Post COVID-19 Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis COVID-19后髓鞘少突胶质细胞糖蛋白抗体相关性视神经炎
IF 0.8
Neuro-Ophthalmology Pub Date : 2021-05-24 DOI: 10.1080/01658107.2021.1916044
Daniela Rojas-Correa, J. A. Reche-Sainz, A. Insausti-García, C. Calleja-García, M. Ferro-Osuna
{"title":"Post COVID-19 Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis","authors":"Daniela Rojas-Correa, J. A. Reche-Sainz, A. Insausti-García, C. Calleja-García, M. Ferro-Osuna","doi":"10.1080/01658107.2021.1916044","DOIUrl":"https://doi.org/10.1080/01658107.2021.1916044","url":null,"abstract":"ABSTRACT Neurological manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are relatively common. Although some may be consequences of direct cellular viral invasion (neurotropism), many represent post-infectious inflammation mediated by autoimmune mechanisms. We herein report the case of a 69-year-old diabetic male who presented with bilateral sub-acute, progressive loss of vision 45 days after suffering a presumed SARS-CoV-2 related pneumonia. He had bilateral optic disc oedema. Magnetic resonance imaging showed uniform contrast enhancement of both optic nerves without spinal cord involvement. He tested positive for SARS-CoV-2 IgG and myelin oligodendrocyte glycoprotein (MOG) IgG antibodies. He was treated with intravenous methylprednisolone for 5 days. The optic disc oedema resolved within 6 weeks with improvement in visual acuity, although optic atrophy developed by week 16. The MOG-IgG antibody test turned negative after 24 weeks.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"21 ","pages":"115 - 121"},"PeriodicalIF":0.8,"publicationDate":"2021-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01658107.2021.1916044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72541841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Non-Arteritic Anterior Ischaemic Optic Neuropathy with Progressive Macular Ganglion Cell Atrophy due to COVID-19 COVID-19所致非动脉性前缺血性视神经病变伴进行性黄斑神经节细胞萎缩
IF 0.8
Neuro-Ophthalmology Pub Date : 2021-05-19 DOI: 10.1080/01658107.2021.1909075
B. Yüksel, F. Bıçak, F. Gümüş, T. Küsbeci
{"title":"Non-Arteritic Anterior Ischaemic Optic Neuropathy with Progressive Macular Ganglion Cell Atrophy due to COVID-19","authors":"B. Yüksel, F. Bıçak, F. Gümüş, T. Küsbeci","doi":"10.1080/01658107.2021.1909075","DOIUrl":"https://doi.org/10.1080/01658107.2021.1909075","url":null,"abstract":"ABSTRACT A 72-year-old man with type II diabetes mellitus presented with sudden painless vision loss and an inferior visual field defect in his right eye. He had previously tested positive for COVID-19 disease with the symptoms starting 13 days before the onset of vision loss. His decimal visual acuity, 55 days after the onset of visual symptoms, was 0.3 and this decreased over the following week to counting fingers. 24–2 visual field analysis revealed an inferior altitudinal defect. Dilated fundus examination revealed mild optic disc swelling in the right eye. The left eye was normal. He was diagnosed with non-artertic anterior ischaemic optic neuropathy (NAION). On spectral domain optical coherence tomography there was retinal thinning in the supero-temporal foveal area. Macular ganglion cell layer – inner plexiform retinal layer complex analysis showed progressive atrophy that developed from the supero-temporal to the infero-nasal fovea. COVID-19 infection may lead to NAION.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"26 1","pages":"104 - 108"},"PeriodicalIF":0.8,"publicationDate":"2021-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87906189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
An Atypical Case of Miller Fisher Syndrome with Multiple Autoimmunity 米勒费雪综合征合并多重自身免疫的非典型病例
IF 0.8
Neuro-Ophthalmology Pub Date : 2021-05-19 DOI: 10.1080/01658107.2021.1916045
C. Mercado, Mario Perez-Rueda
{"title":"An Atypical Case of Miller Fisher Syndrome with Multiple Autoimmunity","authors":"C. Mercado, Mario Perez-Rueda","doi":"10.1080/01658107.2021.1916045","DOIUrl":"https://doi.org/10.1080/01658107.2021.1916045","url":null,"abstract":"ABSTRACT Miller Fisher syndrome (MFS) is a rare variant of Guillain–Barré syndrome that is characterised by ataxia, ophthalmoplegia, and areflexia. Its relation with other autoimmune diseases is scarcely found in the literature, and in those few cases, treatment has been especially difficult. We report a case of a 28-year-old woman who presented with ophthalmoplegia and ptosis, later developing facial palsy and hyporeflexia. She had positive GD1a, GT1a, GQ1b antibodies confirming MFS. She also had positive antinuclear and lupus anticoagulant antibodies confirming antiphospholipid syndrome. She had a mild clinical course. MFS can present with multiple autoimmunity; it is unclear if there is cross-reactivity due to myelin damage.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"37 1","pages":"122 - 125"},"PeriodicalIF":0.8,"publicationDate":"2021-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78877179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Neuro-Ophthalmic Book Review: The Retina Illustrated 神经眼科书评:视网膜图解
IF 0.8
Neuro-Ophthalmology Pub Date : 2021-05-06 DOI: 10.1080/01658107.2021.1891263
Sean M. Gratton
{"title":"Neuro-Ophthalmic Book Review: The Retina Illustrated","authors":"Sean M. Gratton","doi":"10.1080/01658107.2021.1891263","DOIUrl":"https://doi.org/10.1080/01658107.2021.1891263","url":null,"abstract":"In neuro-ophthalmology, the saying goes, “if it comes from retina, then it’s probably the retina”. While this aphorism might not be universally true, it is a pearl of wisdom that hints at an import...","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"17 1","pages":"349 - 349"},"PeriodicalIF":0.8,"publicationDate":"2021-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75584076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuro-Ophthalmic Literature Review 神经眼科文献综述
IF 0.8
Neuro-Ophthalmology Pub Date : 2021-05-04 DOI: 10.1080/01658107.2021.1904764
D. Bellows, N. Chan, John J. Chen, Hui-Chen Cheng, P. Macintosh, J. N. Nij Bijvank, M. Vaphiades, K. Weber, S. Wong
{"title":"Neuro-Ophthalmic Literature Review","authors":"D. Bellows, N. Chan, John J. Chen, Hui-Chen Cheng, P. Macintosh, J. N. Nij Bijvank, M. Vaphiades, K. Weber, S. Wong","doi":"10.1080/01658107.2021.1904764","DOIUrl":"https://doi.org/10.1080/01658107.2021.1904764","url":null,"abstract":"Neuro-Ophthalmic Literature Review David A. Bellows, Noel C.Y. Chan, John J. Chen , Hui-Chen Cheng, Peter W. MacIntosh, Jenny A. Nij Bijvank, Michael S. Vaphiades, Konrad P. Weber, and Sui H. Wong Is it giant cell arteritis or is it COVID? Mehta P, Sattui SE, van der Geest K, Brouwer E, Conway R, Putman MS, Robinson PC, Mackie SL. Giant cell arteritis and COVID-19: similarities and discriminators, a systematic literature review. J Rheumatol. 2020. doi: 10.3899/ jrheum.200766. Online ahead of print. Giant Cell Arteritis (GCA) and COVID-19 share several clinical features that may contribute to confusion when formulating a diagnosis. The authors performed two reviews of the published literature to determine the frequency of clinical features that are similar and dissimilar in giant cell arteritis and COVID-19. The authors include a Venn diagram and Excel spreadsheet that can help the practitioner distinguish Giant Cell Arteritis from COVID-19 based on the clinical findings.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"121 1","pages":"211 - 218"},"PeriodicalIF":0.8,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90430610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pallid Disc Oedema in a Young Patient: Clinical and Diagnostic Challenge 一名年轻患者的苍白椎间盘水肿:临床和诊断的挑战
IF 0.8
Neuro-Ophthalmology Pub Date : 2021-04-20 DOI: 10.1080/01658107.2020.1867873
L. Dedina, Mark M. Hassall, S. Jesudason, Sumu Simon
{"title":"Pallid Disc Oedema in a Young Patient: Clinical and Diagnostic Challenge","authors":"L. Dedina, Mark M. Hassall, S. Jesudason, Sumu Simon","doi":"10.1080/01658107.2020.1867873","DOIUrl":"https://doi.org/10.1080/01658107.2020.1867873","url":null,"abstract":"ABSTRACT A mid-thirties male with end-stage renal failure receiving haemodialysis on a background of four failed renal transplants, post-transplant lymphoproliferative disorder,and autonomic dysfunction presented with acute vision change in his left eye. Over days his vision in that eye deteriorated from 20/25 to no light perception. Given his complex medical background he was extensively investigated for infective, inflammatory, infiltrative and vasculitic aetiologies to explain acute vision loss with pallid disc swelling. A final diagnosis of non-arteritic anterior ischaemic optic neuropathy secondary to refractive hypotension and haemodialysis was reached.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"47 1","pages":"95 - 98"},"PeriodicalIF":0.8,"publicationDate":"2021-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75244383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Neuro-Ophthalmic Literature Review 神经眼科文献综述
IF 0.8
Neuro-Ophthalmology Pub Date : 2021-03-04 DOI: 10.1080/01658107.2021.1880179
D. Bellows, N. Chan, John J. Chen, Hui-Chen Cheng, P. Macintosh, J. N. Nij Bijvank, M. Vaphiades, K. Weber, S. Wong
{"title":"Neuro-Ophthalmic Literature Review","authors":"D. Bellows, N. Chan, John J. Chen, Hui-Chen Cheng, P. Macintosh, J. N. Nij Bijvank, M. Vaphiades, K. Weber, S. Wong","doi":"10.1080/01658107.2021.1880179","DOIUrl":"https://doi.org/10.1080/01658107.2021.1880179","url":null,"abstract":"Neuro-Ophthalmic Literature Review David A. Bellows, Noel C. Y. Chan, John J. Chen , Hui-Chen Cheng, Peter W. MacIntosh, Jenny A. Nij Bijvank, Michael S. Vaphiades, Konrad P. Weber, and Sui H. Wong Serum inflammatory biomarkers in patients with nonarteritic anterior ischaemic optic","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"66 1","pages":"139 - 146"},"PeriodicalIF":0.8,"publicationDate":"2021-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83654994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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