Neuro-Ophthalmology最新文献_第7页

Transient Pourfour du Petit Syndrome as the Presenting Sign of Internal Carotid Artery Aneurysm. 短暂性Pourfour du Petit综合征是颈内动脉瘤的表现。

IF 0.6

Neuro-Ophthalmology Pub Date : 2025-05-15 eCollection Date: 2026-01-01 DOI: 10.1080/01658107.2025.2504035

Henry C Skrehot, Joshua T Skrehot, Osama Al Deyabat, Saif Alryalat, Noor A Laylani, Peter Mortensen, Andrew G Lee

{"title":"Transient Pourfour du Petit Syndrome as the Presenting Sign of Internal Carotid Artery Aneurysm.","authors":"Henry C Skrehot, Joshua T Skrehot, Osama Al Deyabat, Saif Alryalat, Noor A Laylani, Peter Mortensen, Andrew G Lee","doi":"10.1080/01658107.2025.2504035","DOIUrl":"10.1080/01658107.2025.2504035","url":null,"abstract":"Pourfour du Petit syndrome (PdPS) is a rare oculosympathetic hyperactivity syndrome characterized by ipsilateral mydriasis, eyelid retraction, and hyperhidrosis. We report a case of a 36-year-old female who presented to the emergency department with a chief complaint of a dilated pupil with photosensitivity and blurred vision in the left eye (OS). On examination, the best corrected visual acuity was 20/20 in both eyes (OU). Anisocoria was observed with the right pupil measuring 4 mm in the dark and 2 mm in the light and the larger left pupil measuring 6 mm in the dark with minimal constriction in the light. There was no relative afferent pupillary defect (RAPD). Magnetic resonance angiography (MRA) and digital subtraction angiogram (DSA) of the head showed a 7 mm left paraclinoid ICA aneurysm. Neurovascular neurosurgery placed a flow diverting stent into the left ICA. Repeat DSA demonstrated near-complete resolution of the left ICA ophthalmic segment aneurysm status post-flow diversion. At the last follow-up one year later, the patient was stable clinically and radiographically with no further recurrences. Clinicians should be aware that anisocoria can be a potentially life-threatening presentation of intracranial vascular lesions.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"50 3","pages":"264-267"},"PeriodicalIF":0.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13166233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147931894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age-Associated Differences in Optic Disc Findings of Leber's Hereditary Optic Neuropathy. Leber遗传性视神经病变视盘表现的年龄相关性差异。

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Neuro-Ophthalmology Pub Date : 2025-05-09 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2025.2501053

Yasuyuki Takai, Akiko Yamagami, Mayumi Iwasa, Kenji Inoue, Ryoma Yasumoto, Hitoshi Ishikawa, Masato Wakakura

{"title":"Age-Associated Differences in Optic Disc Findings of Leber's Hereditary Optic Neuropathy.","authors":"Yasuyuki Takai, Akiko Yamagami, Mayumi Iwasa, Kenji Inoue, Ryoma Yasumoto, Hitoshi Ishikawa, Masato Wakakura","doi":"10.1080/01658107.2025.2501053","DOIUrl":"10.1080/01658107.2025.2501053","url":null,"abstract":"We aimed to investigate the relationship between age and acute-phase optic disc findings in Leber's Hereditary Optic Neuropathy (LHON). We examined 27 LHON patients (27 eyes) with the m.11778 G>A mutation within two months of onset, with acute-phase optic disc findings. We analyzed the relationship between age and three key optic disc features: peripapillary telangiectasia, disc hyperemia, and retinal nerve fiber layer (RNFL) swelling. The median age of onset was 37 years (range: 10-68), with 22 males and five females. Peripapillary telangiectasia was observed in 23 eyes (85.2%), disc hyperemia in 21 eyes (77.8%), and RNFL swelling in 16 eyes (53.9%). Patients without RNFL swelling were significantly older than those with RNFL swelling (median age 54 vs. 24.5 years, p = .003; Mann-Whitney U test). RNFL swelling was less common in patients aged 50 and above (20.0% vs. 82.4% in those under 50; odds ratio 0.06; 95% CI 0.04-0.51, p = .003; Fisher's exact test). Age at onset was not significantly associated with peripapillary telangiectasia or disc hyperemia. Among acute-phase optic disc findings in LHON, RNFL swelling was less common in older patients. Clinicians should know that atypical optic disc presentations may occur in older LHON patients.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"49 5","pages":"359-365"},"PeriodicalIF":0.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case Report of Late-Onset Leber's Hereditary Optic Neuropathy Diagnosed Following Vision Loss After Cataract Surgery. 白内障术后视力丧失后诊断迟发性Leber遗传性视神经病变1例。

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Neuro-Ophthalmology Pub Date : 2025-05-06 eCollection Date: 2026-01-01 DOI: 10.1080/01658107.2025.2495295

Hiroki Kawano, Masanori Nakazawa, Koji Kawano, Hiroto Terasaki, Taiji Sakamoto

{"title":"A Case Report of Late-Onset Leber's Hereditary Optic Neuropathy Diagnosed Following Vision Loss After Cataract Surgery.","authors":"Hiroki Kawano, Masanori Nakazawa, Koji Kawano, Hiroto Terasaki, Taiji Sakamoto","doi":"10.1080/01658107.2025.2495295","DOIUrl":"10.1080/01658107.2025.2495295","url":null,"abstract":"Leber's Hereditary Optic Neuropathy (LHON) is a rare mitochondrial disorder characterized by acute to subacute vision loss, predominantly affecting young males. We report a case of a 65-year-old male diagnosed with late-onset LHON after experiencing significant vision decline following cataract surgery. The patient initially presented with decreased vision in the left eye. His best corrected visual acuity (BCVA) was 20/16 in the right eye and 20/600 in the left eye, with normal intraocular pressure. Thinning of the ganglion cell complex (GCC) and a central scotoma were observed in the left eye. As head MRI showed no abnormalities, some form of retinal vasculopathy was suspected. Two months later, he returned complaining of increased glare and visual impairment in the right eye. Since no changes except for cataracts had been detected, cataract surgery was performed on the right eye three and a half months after the initial visit, but the BCVA dropped to 20/63. At this point, thinning of the GCC in the papillomacular bundle area and a central scotoma in the right eye were also observed. Genetic testing confirmed the m.11778 G>A mutation, leading to a diagnosis of LHON. The impact of intraocular surgery on the progression of LHON remains unclear; however, it may negatively influence the disease course.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"50 2","pages":"180-185"},"PeriodicalIF":0.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12990941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ocular Neuromyotonia in Thyroid Eye Disease. 甲状腺眼病的眼神经肌强直。

IF 0.6

Neuro-Ophthalmology Pub Date : 2025-04-30 eCollection Date: 2026-01-01 DOI: 10.1080/01658107.2025.2498407

André Sobral-Pinho, Diana Festas Silva, Daniela Pereira, Sara Matos, Ana Inês Martins, André Jorge, Guilherme Castela, João Lemos

{"title":"Ocular Neuromyotonia in Thyroid Eye Disease.","authors":"André Sobral-Pinho, Diana Festas Silva, Daniela Pereira, Sara Matos, Ana Inês Martins, André Jorge, Guilherme Castela, João Lemos","doi":"10.1080/01658107.2025.2498407","DOIUrl":"10.1080/01658107.2025.2498407","url":null,"abstract":"Ocular neuromyotonia (ONM) in thyroid eye disease (TED) seems to be a rare finding. We present the case of a 61-year-old male TED patient who developed spontaneous transient neuromyotonic infradeviation of the right eye every ~1 minute in the setting of prominent enlargement of the right inferior rectus muscle and restriction of supraduction. Neither carbamazepine or lacosamide were able to abate ONM. Following subsequent TED worsening with almost complete restriction of the right eye, ONM was no longer observed. ONM has been described in 7 TED cases, either in conjunction with underlying restrictive strabismus or in isolation. Chronic compression and inflammation seem to lead to nerve hyperirritability, demyelination, and/or axonal damage and predispose to ONM in TED. Importantly, ONM might develop during active or inactive TED. Voltage gated sodium channel blockers should be used in TED-related ONM, albeit clinical response might be incomplete, suggesting the presence of other mechanism(s), besides ephaptic transmission. Newer neuronal membrane stabilizers acting on sodium and calcium channels (e.g. lamotrigine, oxcarbazepine) as well as newer monoclonal antibodies (e.g. teprotumumab, tocilizumab, infliximab) might play a role in TED-related ONM and their potential therapeutic effect should be investigated in future studies.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"50 2","pages":"186-193"},"PeriodicalIF":0.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12990933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuro-Ophthalmic Manifestations of Suprasellar Pilomyxoid Astrocytoma. 鞍上毛粘液样星形细胞瘤的神经眼科表现。

IF 0.6

Neuro-Ophthalmology Pub Date : 2025-04-30 eCollection Date: 2026-01-01 DOI: 10.1080/01658107.2025.2486757

Nicholas Panzo, Pamela Davila Siliezar, Noor Noor Laylani, Hamza Memon, Andrew G Lee

{"title":"Neuro-Ophthalmic Manifestations of Suprasellar Pilomyxoid Astrocytoma.","authors":"Nicholas Panzo, Pamela Davila Siliezar, Noor Noor Laylani, Hamza Memon, Andrew G Lee","doi":"10.1080/01658107.2025.2486757","DOIUrl":"10.1080/01658107.2025.2486757","url":null,"abstract":"This case report highlights a case of suprasellar pilomyxoid astrocytoma (PMA) presenting with the diencephalic syndrome (DS) that was initially diagnosed as pilocytic astrocytoma (PA) but had subsequent histopathological re-classification as PMA. A 14-year-old male treated with four subtotal resections for PMA and post-operative radiation therapy presented with bilateral visual loss. The patient was initially diagnosed with PA until the fourth craniotomy was performed and the histopathology was revised from PA to PMA. The patient's ocular examination was remarkable for right cranial nerve III and VI nerve palsy and bilateral optic atrophy. This unique case demonstrated the behavior of a rare and aggressive variant of PA. Awareness of this glioma may help ophthalmologists distinguish PMA from PA. Due to the many histopathological similarities, previously diagnosed cases of PA may be the more aggressive variant, PMA. As PMA progresses, it affects the patient's vision; therefore, an ophthalmological evaluation should be included to monitor disease progression and vision loss.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"50 1","pages":"92-95"},"PeriodicalIF":0.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversible Cortical Visual Symptoms of Hyperosmolar Hyperglycemic State May Occur in Patients with Borderline Serum Osmolality. 血清渗透压达到临界水平的患者可能出现可逆性高渗性高血糖状态的皮质视觉症状。

IF 0.6

Neuro-Ophthalmology Pub Date : 2025-04-29 eCollection Date: 2026-01-01 DOI: 10.1080/01658107.2025.2495304

Alisha Dhallan, Yi-Hsien Yeh, Gregory P Van Stavern, Leanne Stunkel

{"title":"Reversible Cortical Visual Symptoms of Hyperosmolar Hyperglycemic State May Occur in Patients with Borderline Serum Osmolality.","authors":"Alisha Dhallan, Yi-Hsien Yeh, Gregory P Van Stavern, Leanne Stunkel","doi":"10.1080/01658107.2025.2495304","DOIUrl":"10.1080/01658107.2025.2495304","url":null,"abstract":"Hyperosmolar hyperglycemic state (HHS) is a severe complication of uncontrolled diabetes, often presenting with nonlocalizing neurologic symptoms such as encephalopathy. Rarely, focal neurologic deficits like hemianopsia can occur, even with serum osmolality below the diagnostic threshold for HHS. We report two cases of hyperglycemic patients with borderline serum osmolality presenting with neuro-ophthalmologic symptoms. Case 1 involved a 43-year-old male with type 1 diabetes who developed right-sided visual disturbances and was found to have cortical T2/FLAIR hyperintensity and subcortical hypointensity in the left temporal lobe and posterior cingulate gyrus. Case 2 involved a 64-year-old female with untreated type 2 diabetes and hypertension who presented with bright flashes and left homonymous hemianopsia. MRI revealed subtle cortical T2/FLAIR hyperintensity and subcortical hypointensity in the right occipital lobe, findings initially missed on radiological review. In both cases, symptoms resolved with glycemic control and treatment. These cases underscore the importance of recognizing neuro-ophthalmic symptoms as potential manifestations of hyperglycemia, even when serum osmolality is below the diagnostic threshold for HHS. The structural brain changes demonstrated by subtle radiographic findings corresponded to the patients' focal neuro-ophthalmic deficits. The reversibility of these findings with glycemic control highlights the critical need for early recognition and intervention.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"50 2","pages":"194-197"},"PeriodicalIF":0.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12990930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolated Unilateral Internuclear Ophthalmoplegia After Trauma: A Case Report. 创伤后孤立性单侧核间眼麻痹1例。

IF 0.6

Neuro-Ophthalmology Pub Date : 2025-04-21 eCollection Date: 2026-01-01 DOI: 10.1080/01658107.2025.2495291

Suat Demir, Tuba Ozge Karacoban, Fırat Demir

引用次数: 0

A Case of Acute Vision Loss Due to Delayed Onset Herpes Zoster Optic Perineuritis. 迟发性带状疱疹性视神经会阴炎致急性视力丧失1例。

IF 0.6

Neuro-Ophthalmology Pub Date : 2025-04-14 eCollection Date: 2026-01-01 DOI: 10.1080/01658107.2025.2491497

Barbara Cortes, Daniel Barmas-Alamdari, Jamie Mitchell

引用次数: 0

Prolonged Horner's Syndrome After Interscalene Nerve Block: A Case Report and Summary of the Literature. 斜角间神经阻滞后延长霍纳综合征1例报告及文献综述。

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Neuro-Ophthalmology Pub Date : 2025-04-14 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2025.2455053

Bradley McNeely, Gregory P Van Stavern, Leanne Stunkel

引用次数: 0

Clinical Characteristics and Evolution of Ocular Manifestations in Scrub Typhus. 恙虫病的临床特点及眼部表现的演变。

IF 0.6

Neuro-Ophthalmology Pub Date : 2025-04-02 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2024.2424204

Fu Yue, Hui Yang

{"title":"Clinical Characteristics and Evolution of Ocular Manifestations in Scrub Typhus.","authors":"Fu Yue, Hui Yang","doi":"10.1080/01658107.2024.2424204","DOIUrl":"10.1080/01658107.2024.2424204","url":null,"abstract":"Scrub typhus, caused by Orientia tsutsugamushi infection, manifests with fever, rash, eschar, pneumonia, hepatosplenomegaly, and lymphadenopathy. We conducted a review of the ocular manifestations post-infection and found a high incidence (67%) during the recovery phase (2-4 weeks), particularly prevalent in the tropical Tsutsugamushi triangle. Despite China, only three cases of optic neuritis had been reported, suggesting its rarity due to early antibiotic administration, we present the first documented case of binocular optic neuroretinitis due to Orientia tsutsugamushi infection in China. Ophthalmologic screenings should be conducted for patients with systemic scrub typhus infection to rule out ocular involvement. Based on previous literature and our case findings, whether scrub typhus affects the anterior or posterior segment of the eye may be determined by different strains of the pathogen, and this in turn influences the visual prognosis. Early initiation of antibiotics effectively eradicated the pathogens. Studies have indicated that delayed immune inflammation, rather than direct infection, may be the underlying pathogenesis of ocular manifestations. Early and comprehensive corticosteroid therapy during secondary ocular inflammation has shown to effectively curb disease progression and preserve visual function.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"49 3","pages":"218-223"},"PeriodicalIF":0.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0