Neuro-Ophthalmology最新文献

{"title":"Isolated Inferior Division Oculomotor Nerve Palsy as the First Manifestation of Human Immunodeficiency Virus and Syphilis Co-Infection: A Rare Case Report","authors":"Pelin Kiyat, Dilek Top Karti, Omer Karti","doi":"10.1080/01658107.2023.2276183","DOIUrl":"https://doi.org/10.1080/01658107.2023.2276183","url":null,"abstract":"ABSTRACTHuman immunodeficiency virus (HIV) and syphilis are two sexually transmitted diseases that continue to pose significant public health challenges globally. HIV and syphilis can be seen together; individuals with one of these infections are at risk of developing the other. Sharing common risk factors such as sexual transmission or intravenous drug use makes their coincidence likely. Syphilis, an infection caused by a spirochaete (Treponema pallidum), is a great mimicker and can present with a wide variety of clinical manifestations. Syphilis can cause various neurological symptoms including complete oculomotor nerve palsy; however, it is not a common manifestation. Here, we report for the first time a case of persistent incomplete oculomotor nerve palsy with pupillary involvement caused by the involvement of the inferior division of the oculomotor nerve, secondary to HIV and syphilis co-infection.KEYWORDS: Diplopiahuman immunodeficiency virussyphilisoculomotor nerve palsymagnetic resonance imaging Disclosure statementNo potential conflict of interest was reported by the authors.Author contributionsAll authors contributed significantly to the creation of this manuscript; each fulfilled criteria as established by the ICMJE.Additional informationFundingThe authors reported that there is no funding associated with the work featured in this article.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135819541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Feasibility Study on a Portable Vision Device for Patients with Stroke and Brain Tumours","authors":"Arina Nisanova, Laurel Barrios, Tanvi Chokshi, Mark Mannis, Orin Bloch, Yin Allison Liu","doi":"10.1080/01658107.2023.2273471","DOIUrl":"https://doi.org/10.1080/01658107.2023.2273471","url":null,"abstract":"This prospective, single-centre cohort study aimed to evaluate the impact of a portable vision reading device, OrCam Read, on vision-related quality-of-life and independent functional status in patients with low vision due to stroke or brain tumours. Six patients with poor visual acuity or visual field defects due to a stroke or a brain tumour were enrolled at a U.S. Ophthalmology Department. Participants were trained to use OrCam Read and given a loaner device for the 1 month duration of the study. Various assessments, including daily function tests, the National Eye Institute Visual Function Questionnaire-25, and the 10-item neuro-ophthalmic supplement, were administered at the first and last visits. Patients’ experience with the device was evaluated with weekly telephone and end-of-study satisfaction surveys. The main outcome measures were the patient satisfaction with OrCam and the mean assessment scores between enrolment and final visits. The intervention with OrCam significantly improved patients’ ability to complete daily tasks and participants reported good satisfaction with the device. The results also show non-significant improvement with distant activities, dependency, and role difficulties. Our findings demonstrate the feasibility of studying vision-related quality-of-life using a portable vision device in this patient population and pave the way for a larger study to validate the results of this study.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135873060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoglossal Canal Dural Arteriovenous Fistula: A Rare Cause of Ocular Proptosis","authors":"Laurence Cox, Stella Hristova, Maria Filyridou, Anastasia Pilat","doi":"10.1080/01658107.2023.2267125","DOIUrl":"https://doi.org/10.1080/01658107.2023.2267125","url":null,"abstract":"","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135871204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-Ophthalmic Literature Review","authors":"David A. Bellows, Noel C.Y. Chan, John J. Chen, Hui-Chen Cheng, Panitha Jindahra, Peter W. MacIntosh, Collin McClelland, Michael S. Vaphiades, Xiaojun Zhang","doi":"10.1080/01658107.2023.2271803","DOIUrl":"https://doi.org/10.1080/01658107.2023.2271803","url":null,"abstract":"","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135810181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Third Nerve Paresis with Migraine: A Case Report and Review of the Literature","authors":"Sujit Kumar, Sharath Kumar Goddu Govindappa, Abdul Rawoof Bolar, Chaitra Parameshwara Adiga, Ravi Mohan Rao Basrur, Manithody Narayan Bhat Pramod, Santosh Kumar Pendyala, Jagadish Basavaraj Agadi, Rohit Shetty","doi":"10.1080/01658107.2023.2276191","DOIUrl":"https://doi.org/10.1080/01658107.2023.2276191","url":null,"abstract":"","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135871961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Pharmacologic Anisocoria in Systemic Glycopyrrolate Use from Presumed Local Ocular Inoculation","authors":"Daniel Adamkiewicz, Maja Magazin, Dilip Thomas","doi":"10.1080/01658107.2023.2273473","DOIUrl":"https://doi.org/10.1080/01658107.2023.2273473","url":null,"abstract":"ABSTRACTAnisocoria is a common finding in ophthalmic clinical practice. History taking and examination is critical in appropriately diagnosing and managing anisocoria, as the differential can be extensive ranging from benign to life-threatening entities. This case discusses the presentation of a 22-year-old female with a history of myopia and hyperhidrosis who presented with pharmacologic anisocoria which was presumed to be from inadvertent topical exposure to conventional glycopyrrolate tablets. To our knowledge, pharmacologic mydriasis from exposure to residue from conventional glycopyrrolate tablets has not been reported in the English literature. This case highlights the importance of medication and contact lens handling with anticholinergic agents.KEYWORDS: Anisocoriaoral glycopyrrolatemydriasisanticholinergicpharmacologic dilation Disclosure statementNo potential conflict of interest was reported by the authors.ConsentNo identifiable patient information is included. Our patient consented to the submission of this manuscript.Additional informationFundingThe authors reported there is no funding associated with the work featured in this article.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135809289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated Benign Unilateral Episodic Mydriasis in Relation to Anxiety: A Case Report","authors":"Renato Correia Barbosa, Bruna Vieira, José Alberto Lemos","doi":"10.1080/01658107.2023.2273477","DOIUrl":"https://doi.org/10.1080/01658107.2023.2273477","url":null,"abstract":"","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135870060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Japanese Case of Leber’s Hereditary Optic Neuropathy with the m.13051G>A Pathogenic Variant","authors":"Yasuyuki Takai, Mayumi Iwasa, Akiko Yamagami, Kenji Inoue, Ryoma Yasumoto, Hitoshi Ishikawa, Masato Wakakura","doi":"10.1080/01658107.2023.2273480","DOIUrl":"https://doi.org/10.1080/01658107.2023.2273480","url":null,"abstract":"ABSTRACTLeber’s hereditary optic neuropathy (LHON) is one of the hereditary optic neuropathies and is principally caused by three frequent mitochondria deoxyribonucleic acid (DNA) pathogenic variants (m.11778 G>A, m.3460 G>A, and m.14484T>C). These pathogenic variants account for 90% of LHON cases, with rare pathogenic variants accounting for the remaining cases. We report the first Japanese case of LHON with the m.13051 G>A pathogenic variant, which is a rare primary pathogenic variant of LHON. A 24-year-old woman developed subacute visual loss in both eyes over several months. The best corrected visual acuity (BCVA) was 6/120 in her right eye (OD) and 6/7.5 in her left eye (OS). A relative afferent pupillary defect was not detected. Humphrey visual field testing revealed a central scotoma OD and a temporal paracentral scotoma OS. Fundus examination showed the presence of a pale optic disc OD and optic disc swelling with peripapillary microangiopathy OS. Orbital magnetic resonance imaging showed no abnormal findings. As the mitochondrial DNA gene testing demonstrated the m.13051 G>A pathogenic variant, the patient was diagnosed with LHON. Subsequently, her BCVA worsened to 6/600 in each eye, followed by a nearly plateau-like progression thereafter. This mutation has been primarily reported in Europe but has not yet been confirmed in the Asian region. This case also indicates the importance of examining the whole mitochondrial DNA gene for pathogenic variants in cases where one of the three major pathogenic variants has not been not detected.KEYWORDS: Leber’s hereditary optic neuropathyoptic neuropathym.13051G>A pathogenic variantmitochondrial diseasegenetic testing AcknowledgmentsThe authors would like to thank the patient for her collaboration.Disclosure statementNo potential conflict of interest was reported by the authors.Data availability statementAll data generated or analysed during this study are included in this article. Further enquiries can be directed to the corresponding author.Statement of ethicsThe patient provided oral and written consent for publishing the data. The report does not include personal information that could identify the patient directly or indirectly. All medical interventions have been carried out according to the latest therapeutic protocols. All aspects of the present study are following the Declaration of Helsinki.Additional informationFundingThe authors reported there is no funding associated with the work featured in this article.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135809287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement Between Virtual Reality Perimetry and Static Automated Perimetry in Various Neuro-Ophthalmological Conditions: A Pilot Study","authors":"Akshay Badakere, Amir Ali Mir, Rahul Negi, Sampada Kulkarni, Ramesh Kekunnaya, Virender Sachdeva","doi":"10.1080/01658107.2023.2255651","DOIUrl":"https://doi.org/10.1080/01658107.2023.2255651","url":null,"abstract":"ABSTRACTOur objective was to compare the agreement between virtual reality perimetry (VRP) (order of magnitude, OM) and static automated perimetry (SAP) in various neuro-ophthalmological conditions. We carried out a retrospective analysis of visual field plots of patients with various neuro-ophthalmological conditions who underwent visual field testing using VRP and SAP and between 1 January and 31 May 2022. Two fellowship-trained neuro-ophthalmologists compared the visual field defects observed on both devices. Per cent agreement was used to compare the interpretation of the two examiners on both techniques. The study criteria were met by 160 eyes from 148 patients (mean age 44 years, range 17–74 years). The most common aetiologies were optic atrophy due to various causes, optic neuritis, ischaemic optic neuropathy, and compressive optic neuropathy. Overall, we found good agreement between VRP and SAP for bitemporal (93.8%), hemianopic (90.8%), altitudinal (79.4%), and generalised visual field defects (86.4%). The agreement was acceptable for central/centrocaecal scotomas and not acceptable for enlarged blind spots. Between the two examiners there was good agreement for bitemporal (92.3%), hemianopic (82%), altitudinal (83%), and generalised field defects (76.4%). The results of our study suggest that VRP gives overall good agreement with SAP in various neuro-ophthalmological conditions, especially those likely to produce hemianopic, altitudinal, and generalised visual field defects. This could be useful in various settings; however, future larger studies are needed to explore real-world utilisation.KEYWORDS: Agreementvirtual realityperimetrystandard automated perimetryneuro-ophthalmology AcknowledgmentsWe thank our optometry team members (namely Masuma, Fatima, Aleena Saji, Gowthami Neredimilli, Mounika Vadithya, and Saurav Ghosh, who helped us with enrolment of the patients, and collected the data), and our team at Centre for Technology Innovation, who helped with various technical aspects.Disclosure statementNo potential conflict of interest was reported by the authors.Additional informationFundingThis study is supported by the intramural funding provided by Hyderabad Eye Research Foundation.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136116355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual Agnosia Mimicking Memory Impairment: A Case Report of Posterior Cortical Atrophy","authors":"Jorge Cárdenas-Belaunzarán, Karen A. Cerrillo-Avila","doi":"10.1080/01658107.2023.2257311","DOIUrl":"https://doi.org/10.1080/01658107.2023.2257311","url":null,"abstract":"ABSTRACTVision specialists will benefit from increased awareness of posterior cortical atrophy (PCA) syndrome. Failure to adequately identify the chief complaint as a visual symptom may lead to incorrect diagnosis or diagnostic delay. A previously healthy, 59-year-old woman presented with a 5-year history of ‘losing her stuff’. Upon psychiatric and neuro-ophthalmological evaluation, this symptom was better recognised as a feature of visual agnosia and simultanagnosia. She also presented with multiple previously unrecognised symptoms indicative of higher visual processing dysfunction, such as alexia without agraphia, ocular motor apraxia, optic ataxia, prosopagnosia, akinetopsia and topographagnosia, so further assessment to investigate for PCA was carried out. After a work-up including cognitive assessment, brain structural/functional imaging, and laboratory tests she was diagnosed with visual-variant Alzheimer’s disease. Patients with PCA merit a detailed review of their symptoms, as well as the use of office tests such as cognitive evaluation tools, different types of perimetry, colour vision tests, and non-delayed psychiatric consultation for correct management and assessment. This report will emphasise five key aspects to be considered when evaluating patients with PCAKEYWORDS: Posterior cortical atrophyAlzheimer’s diseaseAlzheimer’s visual variantvisual agnosiamemory deficitAtypical alzheimer’scase report Authors’ contributionsJCB and KCA drafted the manuscript and collected patient information, JCB critically revised the manuscript for intellectual content and supervised the project. All authors have read and approved the final manuscript.Disclosure statementNo potential conflict of interest was reported by the authors.Consent for publicationWritten informed consent was obtained from the patient.Ethics approval and consent to participateThe study was approved by the internal review board of Asociación para Evitar la Ceguera en México, I. A. P.Additional informationFundingThe authors reported there is no funding associated with the work featured in this article.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135395567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}