Neuro-Ophthalmic Literature Review

is an inflammatory demyelinating disease affecting the central nervous system, which most commonly causes optic neuritis, transverse myelitis, and area postrema syndrome. Antibodies directed against aquaporin 4, a water channel expressed on the astrocytic membrane, are detected in approximately 80% of cases. In this article, the authors discuss a case of a 76-year-old woman with a 2-month history of confusion, dysar-thria, and progressive bilateral leg weakness, which was associated with adenocarcinoma. They conclude that signs of NMOSD in elderly patients should arouse the suspicion of a paraneoplastic aetiology. The authors report an 11-year-old girl who noted gradual visual loss in the right eye for 1 year to 20/100 in the right eye, compared with 20/ 20 in the left eye, with subfoveal yellow deposits in both eyes. Optical coherence tomography, electro-oculography, electro-retinography and colour fundus photographs illustrate the findings,which were in-keeping with Best’s disease, the second most common hereditary macular dystrophy. It is char-acterised by the accumulation of lipofuscin-like materials on the retinal pigment epithelium cell-photoreceptor interface. The disorder’s associated mutations may contribute to apoptosis of the retinal pigment epithelial cells by targeting Caspase-3 (a protein encoded by the CAPS3 gene) that may be one of the mechanisms in bestrophinopathies. and T1-WI A chi-square test used compare both sequences and the inter-rater agreement was calculated. Results : Thirty-five magnetic resonance imaging (MRI) sessions were performed before treatment, including 19 post-contrast FLAIR in 17 patients and 25 post-contrast T1-WIs in 19 patients. In terms of patients, LME was on all 17 post-contrast FLAIR images versus post-contrast T1-WIs < In LME on all post-contrast FLAIR versus 16/25 of post-contrast T1-WIs < LME disseminated both and infratentorial post-contrast FLAIR, compared post-contrast Inter-rater