Neuro-Ophthalmology最新文献_第6页

Outer Retinal Layer Assessment in Patients with Relapsing-Remitting Multiple Sclerosis: Multifocal Field Electroretinography and Optical Coherence Tomography. 复发-缓解型多发性硬化症患者视网膜外层评估：多焦场视网膜电图和光学相干断层扫描。

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Neuro-Ophthalmology Pub Date : 2025-06-13 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2025.2498406

Alaa A Meshref, Hanan Hosny, Hossam Khalil, Mona Hussein, Asmaa Samir, Rehab Elanwar, Rehab Magdy

{"title":"Outer Retinal Layer Assessment in Patients with Relapsing-Remitting Multiple Sclerosis: Multifocal Field Electroretinography and Optical Coherence Tomography.","authors":"Alaa A Meshref, Hanan Hosny, Hossam Khalil, Mona Hussein, Asmaa Samir, Rehab Elanwar, Rehab Magdy","doi":"10.1080/01658107.2025.2498406","DOIUrl":"10.1080/01658107.2025.2498406","url":null,"abstract":"Relapsing remitting multiple sclerosis (RRMS) may cause primary retinopathy, which reflects central nervous system atrophy. This study aimed to assess the outer retinal layers in RRMS patients with and without optic neuritis (ON) functionally by multifocal electroretinography (mf-ERG) and structurally by spectral-domain optical coherence tomography (OCT). This case-control study evaluated the eyes of 30 RRMS patients and 30 age - and sex-matched healthy subjects using mf-ERG and OCT. There was a significantly lower amplitude and delayed peak time of all five retinal rings in MS-ON and MS-non-ON eyes than in controls (p-values ≤ 0.05). However, most mf-ERG parameters showed no statistically significant difference between ON and non-ON eyes, except for a delayed peak time in R2 (p-value = 0.004) and a lower amplitude in R3 (p-value = 0.012) in MS-ON eyes compared to MS-non-ON eyes. The thickness of the outer and inner retina was significantly decreased in MS-ON and MS-non-ON eyes compared to controls (p < 0.001), with no significant difference between MS-ON and MS-non-ON eyes. Functional and structural alterations of the bipolar and photoreceptor layers in the outer retina are present in RRMS with or without ON. Therefore, the outer retina could be a site for primary pathology in MS unrelated to the optic nerve affection.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"49 5","pages":"374-381"},"PeriodicalIF":0.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Recurrent Painful Ophthalmoplegic Neuropathy with Frequent Relapses and Prophylaxis with High-Dose Vitamin B2 Supplementation. 反复发作的疼痛性眼截瘫神经病1例及大剂量补充维生素B2预防。

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Neuro-Ophthalmology Pub Date : 2025-05-27 eCollection Date: 2026-01-01 DOI: 10.1080/01658107.2025.2508870

Misa Masaoka, Ken Fukuda, Takuzo Marukane, Rika Shoji, Kenji Yamashiro

{"title":"A Case of Recurrent Painful Ophthalmoplegic Neuropathy with Frequent Relapses and Prophylaxis with High-Dose Vitamin B2 Supplementation.","authors":"Misa Masaoka, Ken Fukuda, Takuzo Marukane, Rika Shoji, Kenji Yamashiro","doi":"10.1080/01658107.2025.2508870","DOIUrl":"10.1080/01658107.2025.2508870","url":null,"abstract":"Recurrent painful ophthalmoplegic neuropathy (RPON) is characterized by recurrent unilateral headache associated with ipsilateral ophthalmoplegia due to palsy of one or more ocular cranial nerves, including the oculomotor, trochlear, and abducens nerves. Herein, we report a case of RPON with frequent recurrence over a short period, wherein further recurrence was prevented using high-dose riboflavin. The patient was a 6-year-old boy who presented with a 3-day history of headache, right eye pain, vomiting, and right oculomotor nerve palsy. He had a similar episode 3 years earlier, which resolved spontaneously after 1 month. Initial treatment with intravenous methylprednisolone alleviated eye pain, ocular motility disorder, and ptosis, but not the dilated pupil. Despite steroid treatment, the patient experienced frequent relapses triggered by infectious diseases, resulting in side effects such as moon face and weight gain. High-dose riboflavin (200 mg/day) was initiated as prophylaxis after other treatments, including lower doses of riboflavin and sodium valproate, failed to prevent relapses. The patient remained relapse-free for 9 months after increasing the riboflavin dose. Although it remains unclear whether high-dose riboflavin alone or in combination with valproic acid was effective, this case suggests that high-dose riboflavin might be an effective prophylactic treatment for RPON.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"50 3","pages":"273-276"},"PeriodicalIF":0.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13166243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147931229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Take Caution of Normal Visual Acuity in Posterior Cortical Atrophy! 当心后皮质萎缩患者的正常视力！

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Neuro-Ophthalmology Pub Date : 2025-05-22 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2025.2507407

Tristan Jurkiewicz, Maité Formaglio, Sarah Verrecchia, Caroline Froment, Laure Pisella

{"title":"Take Caution of Normal Visual Acuity in Posterior Cortical Atrophy!","authors":"Tristan Jurkiewicz, Maité Formaglio, Sarah Verrecchia, Caroline Froment, Laure Pisella","doi":"10.1080/01658107.2025.2507407","DOIUrl":"10.1080/01658107.2025.2507407","url":null,"abstract":"Higher-order visual symptoms of patients with posterior cortical atrophy (PCA) are not well recognized in routine ophthalmological examination. More specifically, vision as assessed by the Snellen or Monoyer chart may not be sensitive enough. We hypothesized increased visual difficulties related to 1) visual crowding and to 2) short distances/larger stimuli. We therefore aimed at comparing 1) far visual acuity measures using the Monoyer (each line is presented separately) and the ETDRS charts (all lines are presented at the same time), as well as 2) far and closer visual acuity using the ETDRS chart (at 4 and at 2 meters). These tests were performed in a group of patients with PCA (PCA-AD) and a group of typical amnesic form (T-AD as a control group) of Alzheimer disease (AD) without any ophthalmologic pathology. While the Monoyer chart did not allow to distinguish between the two groups, the PCA-AD group specifically displayed a decrease of visual acuity when the ETDRS chart, rather than the Monoyer chart, was tested at 4 meters (effect of visual crowding), and another decrease when the ETDRS chart was tested at 2 meters, rather than at 4 meters (effect of stimulus size/distance). This uncommon decrease of visual acuity with closer distance correlated with a score of higher-order visual symptoms (Q-ACP). The present study incites ophthalmologists to pay attention to the possible discrepancy between different conditions of visual acuity assessment and preconizes to combine these conditions for a better evaluation.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"49 5","pages":"391-396"},"PeriodicalIF":0.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Papilledema and Pseudopapilledema in Alagille Syndrome: A Case Report. Alagille综合征的乳头水肿和假乳头水肿1例报告。

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Neuro-Ophthalmology Pub Date : 2025-05-21 eCollection Date: 2026-01-01 DOI: 10.1080/01658107.2025.2495293

Muhammad A Khan, Danica Joseph, Chamil Dayajeewa, Timothy Ang, Krishna Tumuluri, Kate Reid

{"title":"Papilledema and Pseudopapilledema in Alagille Syndrome: A Case Report.","authors":"Muhammad A Khan, Danica Joseph, Chamil Dayajeewa, Timothy Ang, Krishna Tumuluri, Kate Reid","doi":"10.1080/01658107.2025.2495293","DOIUrl":"10.1080/01658107.2025.2495293","url":null,"abstract":"Alagille syndrome (ALGS) is a rare, multisystem, autosomal dominant disorder of variable penetrance, typically dominated by the consequences of bile duct paucity and congenital heart disease. Neuro-ophthalmic findings include optic disc swelling and cerebral vascular anomalies. Here, we discuss the care of a lean young man with ALGS and extreme optic disc swelling. He had significant systemic co-morbidities, in the form of renal failure and anticoagulation after cardiac surgery. His disc swelling proved to be due to a combination of pseudopapilledema from ALGS glial proliferation with possible drusen, and true papilledema, with cerebrospinal fluid (CSF) opening pressure of 31 cm H2O at lumbar puncture. Despite renally adjusted acetazolamide and topiramate, field loss beyond blind spot enlargement emerged. CSF shunting was deemed unwise, due to the high revision rate which so often follows. Bilateral optic nerve sheath fenestration was therefore undertaken, and succeeded in reversing the new field loss. Disc swelling did not decline dramatically, due to the ALGS pseudopapilledema as well as the presumed chronicity of the patient's papilledema. Since pseudopapilledema and papilledema can co-exist in ALGS, it is important to adequately distinguish them, ensuring that the emerging visual threat from true papilledema is not overlooked. Systemic comorbidities of the syndrome will need thoughtful care from a co-ordinated multidisciplinary team when treating the papilledema. Screening for cerebral aneurysm is another important principle in the care of patients with ALGS.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"50 2","pages":"173-179"},"PeriodicalIF":0.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12990938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vogt-Koyanagi-Harada Disease Mimicking Idiopathic Intracranial Hypertension. 模拟特发性颅内高压的Vogt-Koyanagi-Harada病。

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Neuro-Ophthalmology Pub Date : 2025-05-19 eCollection Date: 2026-01-01 DOI: 10.1080/01658107.2025.2507403

Raed Behbehani, Ali Esmail

引用次数: 0

Toluene-Related Toxic Optic Neuropathy: A Case Report. 甲苯相关中毒性视神经病变1例报告。

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Neuro-Ophthalmology Pub Date : 2025-05-19 eCollection Date: 2026-01-01 DOI: 10.1080/01658107.2025.2502084

Fatih Gümüş, Tuncay Kusbeci, Okan Akmaz

{"title":"Toluene-Related Toxic Optic Neuropathy: A Case Report.","authors":"Fatih Gümüş, Tuncay Kusbeci, Okan Akmaz","doi":"10.1080/01658107.2025.2502084","DOIUrl":"10.1080/01658107.2025.2502084","url":null,"abstract":"The study aimed to present the clinical features and follow-up of a patient with toxic optic neuropathy after toluene exposure. A 35-year-old male patient was admitted with the complaint of painless vision loss in both eyes after exposure to inhaled cellulosic thinner. Visual acuities were measured at the level of counting fingers at 1 meter on the right and counting fingers at 10 centimeters on the left. The anterior segment was normal in both eyes. The fundoscopic examination revealed that optic disc borders and macula had a natural appearance in both eyes. Cranial computed tomography, diffusion magnetic resonance imaging (MRI), cranial MRI and orbital MRI were normal. As a result of the examinations, the patient was diagnosed with toxic optic neuropathy. In the 2-month follow-up of the patient pallor developed in both optic discs and optical coherence tomography imaging revealed atrophy in the ganglion cell complex and retinal nerve fiber layer thicknesses and bilateral centrocecal scotoma in the 30/2 humphrey Visual Field test. Although toxic optic neuropathy associated with toluene exposure is rare, it should be considered among other nutritional and toxic optic neuropathies because it causes permanent visual impairment.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"50 3","pages":"255-259"},"PeriodicalIF":0.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13166231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147931912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual Loss from Leber's Optic Neuropathy Presenting in a 76-Year-Old Man with the 14484 Mutations. Leber视神经病变导致的视力丧失一例76岁男性14484基因突变。

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Neuro-Ophthalmology Pub Date : 2025-05-19 eCollection Date: 2026-01-01 DOI: 10.1080/01658107.2025.2487842

Laura Goldfarb Cyrino, Bianca Jimena Saldaña Lagos, Pedro Henrique Varalta Martins, Julia F Bonato Cavalcanti, Leonardo E Ariello, Mario Luiz Ribeiro Monteiro

{"title":"Visual Loss from Leber's Optic Neuropathy Presenting in a 76-Year-Old Man with the 14484 Mutations.","authors":"Laura Goldfarb Cyrino, Bianca Jimena Saldaña Lagos, Pedro Henrique Varalta Martins, Julia F Bonato Cavalcanti, Leonardo E Ariello, Mario Luiz Ribeiro Monteiro","doi":"10.1080/01658107.2025.2487842","DOIUrl":"10.1080/01658107.2025.2487842","url":null,"abstract":"Leber's Hereditary Optic Neuropathy (LHON) is an important hereditary optic neuropathy that typically causes bilateral visual loss, predominantly in male patients. While it usually manifests in young adults, it can uncommonly present in older individuals without a family history, potentially leading to diagnostic confusion. The mechanisms underlying why some individuals with these mutations develop optic neuropathy while others remain asymptomatic are still under investigation. Factors such as heteroplasmy, epigenetic modifications, and environmental triggers, including alcohol consumption, are thought to contribute. However, the exact triggers that convert carriers into symptomatic individuals remain poorly understood, with cigarette smoking and alcohol intake being potential contributors. The purpose of this paper is to describe a 76-year-old patient who experienced, painless bilateral visual loss progressing over 4 weeks. Despite extensive evaluation, including imaging, blood tests, and genetic testing, a mitochondrial mutation (T14484C) associated with LHON was identified. Although LHON is rare, especially in the elderly, and usually presents in younger males, this case highlights the need for clinicians to consider LHON as a potential diagnosis in older patients presenting with unexplained visual loss.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"50 2","pages":"159-166"},"PeriodicalIF":0.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12990940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

24-Hour Blood Pressure Patterns in NAION: Exploring the Impact of Dipping Classifications and Comorbidities. 24小时血压模式在全国：探索浸分级和合并症的影响。

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Neuro-Ophthalmology Pub Date : 2025-05-19 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2025.2505616

Ahmet Özdemir, İnci Güngör

{"title":"24-Hour Blood Pressure Patterns in NAION: Exploring the Impact of Dipping Classifications and Comorbidities.","authors":"Ahmet Özdemir, İnci Güngör","doi":"10.1080/01658107.2025.2505616","DOIUrl":"10.1080/01658107.2025.2505616","url":null,"abstract":"Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) is a leading cause of sudden visual loss, particularly in older individuals. Vascular risk factors, including hypertension and diabetes, play a significant role in its pathogenesis. This study explores the association between 24-hour blood pressure patterns, newly diagnosed hypertension, and visual loss in NAION patients, emphasizing the impact of dipping classifications and comorbidities. A retrospective analysis was conducted on 41 NAION patients (aged 27-86 years). Ambulatory blood pressure monitoring (ABPM) over 24 hours categorized patients into four groups: dipper, non-dipper, reverse dipper, and extreme dipper. Blood pressure values were classified into diurnal (08:00-22:59) and nocturnal (23:00-07:59) periods. Visual acuity was assessed using the LogMAR scale, and systemic comorbidities, including hypertension, diabetes, and body mass index (BMI), were recorded. Significant variations in blood pressure patterns were observed, with non-dipper and reverse dipper patients showing the greatest discrepancies between daytime and nighttime blood pressure levels. Visual acuity loss was most severe in reverse dippers (LogMAR 2.00 ± 0.15) and extreme dippers (LogMAR 2.00). Newly diagnosed hypertension was prevalent, emphasizing the importance of ABPM. Nocturnal hypertension was strongly associated with worse visual outcomes, with 83.9% of these patients classified as non-dipper or reverse dipper. Abnormal blood pressure patterns, particularly non-dipper and reverse dipper classifications, correlate with visual loss in NAION. The frequent detection of undiagnosed hypertension supports the integration of routine blood pressure monitoring, particularly nocturnal measurements, into NAION evaluation. A comprehensive vascular assessment in NAION management may improve patient outcomes.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"49 5","pages":"382-390"},"PeriodicalIF":0.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strabismus as the Initial Manifestation of En Coup De Sabre in Adult Patients. 斜视是成人刀突的最初表现。

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Neuro-Ophthalmology Pub Date : 2025-05-19 eCollection Date: 2026-01-01 DOI: 10.1080/01658107.2025.2498408

Rasha Mosleh, Opeyemi O Obiwumi, Aimee J Szewka, Jason H Peragallo

引用次数: 0

Understanding Patterns of Luxury Perfusion on Optical Coherence Tomography Angiography: A Novel Insight. 理解奢侈灌注模式的光学相干断层扫描血管造影：一个新的见解。

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Neuro-Ophthalmology Pub Date : 2025-05-19 eCollection Date: 2026-01-01 DOI: 10.1080/01658107.2025.2502989

Mehakleen Kaur Gill, Shikha Talwar Bassi

{"title":"Understanding Patterns of Luxury Perfusion on Optical Coherence Tomography Angiography: A Novel Insight.","authors":"Mehakleen Kaur Gill, Shikha Talwar Bassi","doi":"10.1080/01658107.2025.2502989","DOIUrl":"10.1080/01658107.2025.2502989","url":null,"abstract":"A 60-year-old male patient came to the outpatient department with the complaint of gradual, painless, progressive diminishing of vision in right eye for two months. His medical history included diabetes mellitus type II, hypertension, and hypercholesterolaemia for eight years. Best corrected visual acuity on snellen's chart for distance was 6/9 in right eye and 6/6 in left eye and for near was N6 in both eyes. Colour vision was intact bilaterally and there was no relative afferent pupillary defect. Anterior segments findings were within normal limits. Fundus examination revealed superior disc pallor and inferiorly showed hyperaemia with dilated vessels. Humphrey visual field testing showed incomplete inferonasal field loss in the right eye which correlated with the disc findings of superior disc pallor. OCT-A showed various pattern changes in the retinal peripapillary capillaries like capillary dropout areas in the temporal region, increase in the vessel density in non-ischaemic areas depicting luxury perfusion, dilatation, and tortuosity of small and large vessels with loss of their radial pattern. Here we describe a unique case where optical coherence tomography angiography (OCT-A) was a helpful investigation in diagnosing luxury perfusion in a patient of Non Arteritic anterior ischaemic optic neuropathy (NAION).","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"50 3","pages":"260-263"},"PeriodicalIF":0.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13166265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147931924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0