Neuro-Ophthalmology最新文献

{"title":"Post-concussion Syndrome Light Sensitivity: A Case Report and Review of the Literature","authors":"Mohammad Abusamak, H. Alrawashdeh","doi":"10.1080/01658107.2021.1983612","DOIUrl":"https://doi.org/10.1080/01658107.2021.1983612","url":null,"abstract":"ABSTRACT Photophobia is considered the second most common symptom of both concussion and post-concussion syndrome. Soldiers on duty experience photophobia after blast-related concussions or mild traumatic brain injury in 60–75% of instances. In addition, soldiers report other symptoms, such as asthenopia, squinting, dry eyes and headaches, for which they are considered to be at high risk. According to the International Brain Injury Association, some concussed patients report indirect symptoms such as multi-tasking difficulties, dizziness, vertigo, and fatigue. Moreover, some concussed individuals experience photophobia for approximately 6 months or indefinitely. We present the case of a 23-year-old soldier who presented with severe photophobia after a mild traumatic head injury. His photophobia was alleviated after the administration of topical anaesthetic drops in the eyes in the absence of any ocular surface pathology. He was diagnosed with post-concussion syndrome light sensitivity and was managed successfully with rose-coloured special photophobia glasses tinted with FL-41. Photophobia is a common neurological symptom in military personnel that needs more attention as it affects body and mind. We have reported an uncommon pathway of photophobia, which may unveil an unrecognised mechanism that may play a role in post-concussion photophobia.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"24 1","pages":"85 - 90"},"PeriodicalIF":0.8,"publicationDate":"2021-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76735868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Olfactory Neuroblastoma: An Unusual Ocular Presentation","authors":"D. AlQahtani, Abdulaziz A Alshamrani, Raniah Alqawahmed, S. Elkhamary, Huda AlGhadeer","doi":"10.1080/01658107.2021.1958872","DOIUrl":"https://doi.org/10.1080/01658107.2021.1958872","url":null,"abstract":"ABSTRACT We report a case of 51–year–old medically healthy male who presented with gradual painless diminution of vision in both eyes for 3 months. His visual acuity was hand movement perception in the right eye, and no light perception in the left eye. The intraocular pressure, external eye examination, ocular motility and anterior segment examinations were normal. Fundus examination revealed severe bilateral papilloedema and engorged tortuous veins in both eyes. Imaging exhibited a large intracranial tumour causing raised intracranial pressure. This was debulked by neurosurgery and histological examination revealed that the tumour was an olfactory neuroblastoma (ONB). This case is noteworthy since ONBs rarely present with isolated papilloedema without any accompanying ophthalmoplegia, proptosis, epistaxis, nasal, or neurological symptoms.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"15 1","pages":"182 - 185"},"PeriodicalIF":0.8,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85375096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population-based Rate and Patterns of Diplopia in Giant Cell Arteritis","authors":"Clara M. Castillejo Becerra, C. Crowson, M. Koster, K. Warrington, M. Bhatti, John J. Chen","doi":"10.1080/01658107.2021.1965627","DOIUrl":"https://doi.org/10.1080/01658107.2021.1965627","url":null,"abstract":"ABSTRACT Giant cell arteritis (GCA) is the most common vasculitis in older adults with permanent vision loss as a feared complication. Diplopia has been reported in a small percentage of patients with visual manifestations. The goal of this study was to determine the population-based rates and patterns of binocular diplopia from GCA. The Rochester Epidemiology Project (REP), a medical records linkage system was used to identify all residents of Olmsted County, Minnesota, USA, diagnosed with GCA between January 1, 1950 and December 31, 2019. Medical records were then reviewed to identify patients with binocular diplopia from GCA. There were 301 incident cases of GCA from 1950 to 2019. Fourteen (5%) patients presented with binocular diplopia. Of these 14 patients, nine (3%) had constant diplopia and five (2%) had transient diplopia. Among patients with constant diplopia, cranial nerve VI involvement was suspected in four (44%) cases. Systemic symptoms and inflammatory markers were similar in patients with and without diplopia. There was no difference in the rate of anterior ischaemic optic neuropathy between the two groups (7% vs. 7%, p = 1.00). In conclusion, this population-based study showed that binocular diplopia was present in 5% of patients with GCA, which could either be transient or constant. GCA patients with diplopia had similar systemic manifestations and risk of vision loss as GCA patients without diplopia.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"322 1","pages":"75 - 79"},"PeriodicalIF":0.8,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77506918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Blepharospasm with Oromandibular Dystonia Associated with Cerebral Amyloid Angiopathy","authors":"A. Carey, N. Miller","doi":"10.1080/01658107.2021.1958871","DOIUrl":"https://doi.org/10.1080/01658107.2021.1958871","url":null,"abstract":"ABSTRACT A case of atypical blepharospasm with oromandibular dystonia is presented in a patient found to have cerebral amyloid angiopathy on magnetic resonance imaging and a shared mechanism is discussed.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"11 1","pages":"178 - 181"},"PeriodicalIF":0.8,"publicationDate":"2021-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75329747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-Ophthalmic Literature Review","authors":"D. Bellows, N. Chan, John J. Chen, Hui-Chen Cheng, J. N. Nij Bijvank, M. Vaphiades, K. Weber, S. Wong, Xiaojun Zhang","doi":"10.1080/01658107.2021.1957604","DOIUrl":"https://doi.org/10.1080/01658107.2021.1957604","url":null,"abstract":"Greater attenuation of retinal atrophy may occur after 12 months of rituximab treatment, following which time GCIPL atrophy rates are similar to those observed among natalizumab-treated patients with RRMS and HCs. I Xiaojun Zhang i Visuomotor performance as the proxy of training-related function recovery in patients with mu... Lipp I, Foster C, Stickland R, Sgarlata E, Tallantyre EC, Davidson AE, Robertson NP, Jones DK, Wise RG, Tomassini V. Predictors of training-related improvement in visuomotor performance in patients with multiple sclerosis: A behavioural and MRI study. I Michael S. Vaphiades i Modulation of retinal atrophy with rituximab in multiple sclerosis Lambe J, Risher H, Filippatou AG, Murphy OC, Sotirchos ES, Ehrhardt H, Ogbuokiri E, Pellegrini N, Toliver B, Luciano NJ, Davis S, Fioravante N, Kwakyi O, Prince JL, Calabresi PA, Fitzgerald KC, Saidha S. Modulation of Retinal Atrophy With Rituximab in Multiple Sclerosis. This study conducted by a British multidisciplinary group of researchers chose visuo-motor performance as the proxy of functional recovery of multiple sclerosis (MS) patients after undergoing a 4-weeks homebased training session, combing demographic with baseline clinical features and magnetic resonance imaging (MRI) measures to predict function recovery of MS patients. [Extracted from the article] Copyright of Neuro-Ophthalmology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"118 1","pages":"350 - 359"},"PeriodicalIF":0.8,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79399416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optic Neuropathy Revealing Severe Superficial Siderosis in the Setting of Long-standing Low-grade Intracranial Neoplasm","authors":"C. Hemptinne, A. Coche, T. Duprez, P. Demaerel, C. Raftopoulos, A. Boschi","doi":"10.1080/01658107.2021.1958870","DOIUrl":"https://doi.org/10.1080/01658107.2021.1958870","url":null,"abstract":"ABSTRACT Two cases of optic neuropathy due to superficial siderosis (SS) are reported in two patients, aged 29 and 38 years, operated for intracranial neoplasms, the first one with a desmoplasic infantile ganglioglioma excised in 1991, and the other one with a pilocytic astrocytoma, operated on in 1997, 1998 and 2016. Both patients presented with progressive loss of visual acuity, as a result of bilateral optic nerve atrophy, as well as unsteadiness, ataxic gait and hearing loss. Magnetic resonance imaging (MRI) of the brain and spine, including gradient echo (GRE) T2-weighted acquisitions, revealed thin optic nerves and strong hypointensity with susceptibility artefacts corresponding to haemosiderin deposits within the meningeal layers of the spine, the infra- and supratentorial spaces of the brain and the peri-optic sheaths in both patients. The cerebrospinal fluid (CSF) was macroscopically haemorrhagic in one patient, who underwent a dynamic myelography, which failed to reveal any trans-dural CSF leakage. Neuro-ophthalmological symptoms due to SS, such as visual acuity loss, have been scarcely reported. MRI using GRE T2-weighted sequences highlighting the presence of haemosiderin deposits plays a key role in the diagnosis of this condition. Treatment should aim at preventing haemosiderin deposition by treating the cause of the subarachnoid bleeding.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"20 1","pages":"171 - 177"},"PeriodicalIF":0.8,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79240403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lyme Neuroborreliosis Presenting as Multiple Cranial Neuropathies","authors":"Aishwarya Sriram, S. Lessen, K. Hsu, Cheng C Zhang","doi":"10.1080/01658107.2021.1951769","DOIUrl":"https://doi.org/10.1080/01658107.2021.1951769","url":null,"abstract":"ABSTRACT Neuroborreliosis can manifest with cranial nerve (CN) palsies, commonly CN VII. Rarely have isolated or multiple palsies been reported. We describe a case of a young female from a Lyme endemic region who presented with bilateral CN VI palsies and a dilated right pupil, possibly a partial CN III palsy. She later developed CN VII palsy and bilateral enhancement of multiple cranial nerves on neuroimaging. She was diagnosed with Lyme disease by serological testing, with gradual improvement on antibiotics. Our case illustrates that neuroborreliosis can present as any or multiple CN palsies, and should be considered particularly in endemic areas.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"8 1","pages":"131 - 135"},"PeriodicalIF":0.8,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85267337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strabismus Surgery","authors":"Veeral S. Shah","doi":"10.1080/01658107.2021.1951770","DOIUrl":"https://doi.org/10.1080/01658107.2021.1951770","url":null,"abstract":"During my paediatric ophthalmology fellowship, I commonly turned to the perennial Wright’s “Color Atlas of Strabismus Surgery”. While it continues to serve as a traditional reliable source for trainees and practising ophthalmologists to understand strabismus patterns and deviations, it lacks some of the current methodology and clinical experiential details for complex strabismus. Dr Ludwig’s Strabismus Surgery book is a refreshing unique manual that addresses strabismus patterns with regards to the underlying mechanisms. This unconventional organisation includes 36 chapters in which strabismus topics are addressed by clinical experts with relevant clinical pearls, representative cases, and overall editor comments. In addition, a clear strength of this book is that these well-written chapters are supplemented by 636 germane illustrations, and 91 effective strabismus videos. In particular, the strabismus diagnosis and surgical treatment section includes excellent and distinctive chapters on collagen and healing, injection of eye muscles to treat Strabismus, and Strabismus related to central nervous system disorders (Duane’s syndrome, nystagmus surgery, disassociated vertical deviations and cranial nerve palsies). For the surgeon’s appetite, the following chapters of advanced techniques include pulley surgeries, injection techniques, adjustable sutures/hang-back suture techniques, miniprocedures/compartmental surgery for small angle strabismus, and transpositions are quite satiating. Dr Ludwig’s book has a comprehensive approach to strabismus surgery and discussion in terms of surgical decision making that not only caters to trainees in terms of resident and paediatric ophthalmology fellows, but addresses issues that veteran strabismus surgeons would find applicable, especially the botulinum toxin and traumatic strabismus sections. After reviewing the book, I had my paediatric ophthalmology fellow look at the book and who favourably noted that this book would be “great for paediatric ophthalmology fellows”. While the clear strength of this book is the involvement of numerous clinical experts, there are several presented topics that are controversial, and as editor, Dr Ludwig admirably balances her comments with these diverse points of views. Overall, this is an excellent strabismus surgery book with up-to-date illustrations and videos, that will prove useful to any future and current strabismus surgeons.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"26 1","pages":"207 - 207"},"PeriodicalIF":0.8,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80423240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-Ophthalmic Literature Review","authors":"D. Bellows, N. Chan, John J. Chen, Hui-Chen Cheng, P. Macintosh, J. N. Nij Bijvank, M. Vaphiades, K. Weber, S. Wong","doi":"10.1080/01658107.2021.1947658","DOIUrl":"https://doi.org/10.1080/01658107.2021.1947658","url":null,"abstract":"Neuro-Ophthalmic Literature Review David A. Bellows, Noel C.Y. Chan, John J. Chen , Hui-Chen Cheng, Peter W. MacIntosh, Jenny A. Nij Bijvank, Michael S. Vaphiades, Konrad P. Weber, and Sui H. Wong Clinical characteristics of idiopathic intracranial hypertension in patients over 50 years of age: A multicenter clinical cohort study Downie, PA, Chen JJ, Bhatti MT, Melson AT, Van Stavern GP, McClelland CM, Lindgre BR, Sharieff JA, Lee MS. Clinical Characteristics of Idiopathic Intracranial Hypertension in Patients Over 50 Years of Age: A multicenter clinical cohort study. Am Journal Ophthalmol. 2021;224: 96–101. This multicenter study analysed the clinical characteristics of 65 patients over the age of 50 years (median age 54 years) with idiopathic intracranial hypertension (IIH) and compared these to a control group of patients with IIH who were under the age of 50 years (median age 30 years). There were several significant characteristics that distinguish the two groups including sex distribution, symptoms, cerebrospinal fluid pressure, comorbidities, and outcomes. The older age group showed a lower preponderance of females (78.5% vs. 92.3%). In regards to symptoms the older group of patients had fewer headaches (50.8% vs. 80%). However, the incidence of other symptoms such as pulse-synchronous tinnitus, vision changes, transient visual obscurations, and diplopia were similar in both cohorts. The older age group had a higher rate of comorbidities (hypertension, diabetes, and thyroid disease) but there was no difference between the groups in the rates of sleep apnoea, anaemia, or polycystic ovarian syndrome. Older patients were less likely to be on cycline-type antibiotics (0% vs. 10.8%). Interestingly, an older age was not found to be associated with a worse outcome as determined by mean deviation on perimetry or need for surgical intervention. David A. Bellows Titre matters when interpreting MOG-IgG! Sechi E, Buciuc M, Pittock SJ, Chen JJ, Fryer JP, Jenkins SM, Budhram A, Weinshenker BG, LopezChiriboga AS, Tillema J-M, McKeon A, Mills JR, Tobin WO, Flanagan EP. Positive Predictive Value of Myelin Oligodendrocyte Glycoprotein Autoantibody Testing. JAMA Neurol. 2021;78(6):741–746. doi:10.1001/jamaneurol.2021.0912 In the recent decade, neuroinflammatory or demyelinating diseases such as neuromyelitis optica (NMO) and myelin oligodendrocyte glycoprotein (MOG)IgG1 associated disorder (MOGAD) had gained more attention from neurologists and neuroophthalmologists with an increased popularity and acceptance in early testing of related antibodies. The change in ordering practice is understandable given the distinct nature and different managements required for these disorders. However, false-positive results can occur and it might be about time to evaluate the positive predictive value (PPV) of these tests in the real world. In this study, patients who were consecutively tested for MOG-IgG1 by live cell-based flow cytometry during their diagnostic workup in","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"15 11 1","pages":"283 - 291"},"PeriodicalIF":0.8,"publicationDate":"2021-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86665788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral Venous Sinus Thrombosis following Ventriculoperitoneal Shunting for Idiopathic Intracranial Hypertension","authors":"J. P. Luckett, H. Sotoudeh, B. E. Tabibian, J. Markert, L. Kline","doi":"10.1080/01658107.2021.1931351","DOIUrl":"https://doi.org/10.1080/01658107.2021.1931351","url":null,"abstract":"ABSTRACT A 30-year-old woman with idiopathic intracranial hypertension experienced worsening headaches and decreasing vision in her left eye. She underwent an uncomplicated ventriculoperitoneal shunt procedure but the following day was found to have cerebral venous sinus thrombosis. Treatment included venous sinus thrombectomy and anticoagulation. She had a favourable clinical outcome. Extensive evaluation including testing for thrombophilia was unremarkable. Potential causes for this rare association are discussed.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"18 1","pages":"91 - 94"},"PeriodicalIF":0.8,"publicationDate":"2021-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83705045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}