Neuro-Ophthalmology最新文献_第5页

Letter to the Editor: Comment on Tsiogka Et al.'s "Compound Heterozygosity for the C6777T Mutation of the MTHFR Gene and the FII G20210A Mutation of the Prothrombin Gene in Sequential Bilateral Anterior Ischemic Optic Neuropathy". 致编者信：对Tsiogka等人的“序列性双侧前缺血性视神经病变中MTHFR基因C6777T突变和凝血酶原基因FII G20210A突变的复合杂合性”的评论。

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Neuro-Ophthalmology Pub Date : 2025-08-01 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2025.2538138

Kemal Örnek

引用次数: 0

Disulfiram-Induced Optic Neuropathy: Prognostic Factors, Literature Review and Comparison with Alcohol-Tobacco Induced Optic Neuropathy. 双硫仑诱发的视神经病变：预后因素、文献回顾及与烟酒诱发的视神经病变的比较。

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Neuro-Ophthalmology Pub Date : 2025-08-01 eCollection Date: 2026-01-01 DOI: 10.1080/01658107.2025.2538132

Juan Alcalá Torres, María Carmen Sánchez Sánchez, Teresa Gracia García-Miguel, Carlos Santos Martín, José Alberto Reche Sainz, Manuel Ferro Osuna

{"title":"Disulfiram-Induced Optic Neuropathy: Prognostic Factors, Literature Review and Comparison with Alcohol-Tobacco Induced Optic Neuropathy.","authors":"Juan Alcalá Torres, María Carmen Sánchez Sánchez, Teresa Gracia García-Miguel, Carlos Santos Martín, José Alberto Reche Sainz, Manuel Ferro Osuna","doi":"10.1080/01658107.2025.2538132","DOIUrl":"10.1080/01658107.2025.2538132","url":null,"abstract":"Disulfiram is a known cause of toxic optic neuropathy (ON), although there are few cases reported in literature. Our objective is to describe a series of patients with disulfiram-associated ON, and compare them with patients with alcohol-tobacco induced ON. We performed a retrospective cohort of patients with toxic ON, either disulfiram-associated or alcohol-tobacco induced (follow-up: 12 months). Data were extracted from a Spanish tertiary hospital, between 2018 and 2024. Visual acuity (VA) and papillary optic coherence tomography (OCT) were performed at baseline and during the follow-up. A statistical analysis was done, including, Chi-square, Fisher's exact, Mann-Whitney U, and Spearman R tests. Eighteen patients were analyzed (17 males). The mean age of onset was 51.1 years. Seven patients were in active treatment with disulfiram at symptom onset (mean dose received: 204 g). Patients with active disulfiram use had a lower baseline VA (20/77 vs 20/50, p = .049), but this difference equalized at 12 months. Patients that received more than 200 g had a tendency to have a dose-dependent effect (p = .056). Initiation of vitamin therapy suggested a tendency toward visual improvement, whereas cessation of alcohol and withdrawal of disulfiram did not reach statistical significance. Patients with diabetes mellitus did not improve their VA (p = .008). No significant differences in OCT findings were observed between patients with active disulfiram and the rest of patients. In conclusion, most patients with disulfiram-associated ON occurred on middle-age males. Toxicity of disulfiram is probably dose-dependent, and partially reversible after withdrawal. Initiation of vitamin therapy was linked to better visual prognosis.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"50 1","pages":"13-23"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paediatric IIH: Are There Differences in Visual Outcomes and Recurrence Rates? 儿童IIH：视力结果和复发率有差异吗？

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Neuro-Ophthalmology Pub Date : 2025-07-29 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2025.2498403

Jenna Rock, Jacqueline K Shaia, Jeffrey Chu, Taseen Alam, Ilene Trinh, Rishi P Singh, Katherine E Talcott, Devon A Cohen

{"title":"Paediatric IIH: Are There Differences in Visual Outcomes and Recurrence Rates?","authors":"Jenna Rock, Jacqueline K Shaia, Jeffrey Chu, Taseen Alam, Ilene Trinh, Rishi P Singh, Katherine E Talcott, Devon A Cohen","doi":"10.1080/01658107.2025.2498403","DOIUrl":"10.1080/01658107.2025.2498403","url":null,"abstract":"Paediatric IIH is a rare condition in children where prepubertal and post-pubertal disease appear distinct. There are major gaps in the literature regarding if these populations have different treatments, visual outcomes, or recurrence rates. The purpose of this study was to characterize the differences in prepubertal/post-pubertal disease while analysing the risk of papilloedema recurrence. Records at a single tertiary institution were screened between 1 June 2012 and September, 2023 for having an ICD code of IIH or papilloedema. All patients were between the ages of 0-18 and stratified by pubertal status. Patients met the revised Dandy diagnostic criteria and secondary causes of IIH were excluded. Demographics, treatment, and visual outcomes data was collected at baseline and 1 year after diagnosis. The incidence of papilloedema resolution and recurrence were collected. All data analysis was performed in R Studio and Excel with a p value of < .05 being significant. Of the 719 IIH patients, 128 (17%) were paediatric with 79 (62%) post-pubertal and 49 (38%) prepubertal at diagnosis. A higher percentage of post-pubertal patients were overweight/obese (77.2%) and female (77%) compared to prepubertal patients (p < .05). Overall, 6 (4.7%) patients had a poor visual outcome; however, this did not differ regarding pubertal status (p > .05). Papilloedema recurrence occurred in 24% of the population. There was no difference in recurrence rates between prepubertal and post-pubertal patients (p > .05). Although post-pubertal and prepubertal disease may differ in demographics and presenting features, there was no significant difference in visual outcomes and recurrence rates.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"49 5","pages":"366-373"},"PeriodicalIF":0.6,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decompression Surgery in Bilateral Compressive Optic Neuropathy Secondary to Vitamin A Deficiency. 双侧压缩性视神经病变继发于维生素A缺乏的减压手术。

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Neuro-Ophthalmology Pub Date : 2025-07-21 eCollection Date: 2026-01-01 DOI: 10.1080/01658107.2025.2530473

Shveta Bansal, Mohammad Aljayyousi, Mohanned Mustafa, Sachin Mathur, John de Carpentier

引用次数: 0

Optical Coherence Tomography Angiography (OCTA) Analysis of Ischemic vs Non-Ischemic Optic Disc Edema. 光学相干断层血管造影（OCTA）分析缺血性与非缺血性视盘水肿。

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Neuro-Ophthalmology Pub Date : 2025-07-14 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2025.2521785

Anthony C Arnold, Giulia Corradetti, Federico Corvi, Srinivas R Sadda

{"title":"Optical Coherence Tomography Angiography (OCTA) Analysis of Ischemic vs Non-Ischemic Optic Disc Edema.","authors":"Anthony C Arnold, Giulia Corradetti, Federico Corvi, Srinivas R Sadda","doi":"10.1080/01658107.2025.2521785","DOIUrl":"10.1080/01658107.2025.2521785","url":null,"abstract":"This study was designed to compare optical coherence tomography angiography (OCTA) microvasculature characteristics of the optic disc and peripapillary retina in ischemic and non-ischemic optic disc edema and to compare them to normals. We hypothesized that ischemic edema would show significantly decreased vascular density when compared with non-ischemic edema and normals. Swept source OCTA imaging (Zeiss PLEX 9000) centered on the optic disc (6 X 6 mm) was performed in 17 eyes with acute ischemic optic disc edema, 22 eyes with acute optic disc edema from other causes, and 26 eyes with normal optic disc and retina. Vessel density (VD) within the superficial (SVC) and deep (DVC) vascular retinal complexes were computed. The mean superficial VD for the optic nerve in ischemic edema cases was 31.86%, compared to 36.10% in non-ischemic edema cases (p = .002) and 35.64% in normals (p = .0019); for the peripapillary retina, the means were 34.50% compared to 37.02% (p = .0006) and 34.70% (p = .8177). The mean deep VD for the optic nerve in ischemic edema cases was 30.41%, compared to 33.29% for non-ischemic cases (p = .0234) and 36.01% in normals (p = .0001); for the peripapillary retina, the means were 31.28% compared to 33.62% (p = .0217) and 35.31% (p = .0001). The optic disc and peripapillary VD were statistically significantly decreased in ischemic vs non-ischemic optic disc edema at both SVC and DVC. The findings highlight a possible role of the central retinal artery-derived circulation in ischemic optic nerve edema.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"49 6","pages":"456-463"},"PeriodicalIF":0.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12674231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145678189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

B-Cell Acute Lymphoblastic Leukemia Relapse Presenting as Choroidal Infiltration Confirmed by Choroidal Biopsy Along with Ipsilateral Optic Nerve Involvement. b细胞急性淋巴细胞白血病复发表现为脉络膜浸润，脉络膜活检证实伴同侧视神经受累。

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Neuro-Ophthalmology Pub Date : 2025-07-14 eCollection Date: 2026-01-01 DOI: 10.1080/01658107.2025.2526040

Brandon Bates, Damodaran Narayanan, Raven Cooksey, Moe Hein Aung, Shelley Day Ghafoori

引用次数: 0

Exploring Optic Glioma and Type 1 Neurofibromatosis: A Literature Review of Case Reports. 探讨视神经胶质瘤和1型神经纤维瘤病：病例报告的文献回顾。

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Neuro-Ophthalmology Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2025.2521770

Emna Ellouz, Imen Ketata, Rahma Kchaou

{"title":"Exploring Optic Glioma and Type 1 Neurofibromatosis: A Literature Review of Case Reports.","authors":"Emna Ellouz, Imen Ketata, Rahma Kchaou","doi":"10.1080/01658107.2025.2521770","DOIUrl":"10.1080/01658107.2025.2521770","url":null,"abstract":"NF1 is an autosomal dominant neurocutaneous condition caused by mutations in the NF1 gene, with a global prevalence of 1 in 3,000 individuals. Optic pathway gliomas (OPGs) are the primary brain tumours in NF1, affecting 15-20% of cases, mainly in children, with varied symptoms. We aim to explore the clinical, radiological and treatment features of OPGs in paediatric and adult NF1 populations. We conducted a literature review of case reports involving 53 patients diagnosed with NF1 and OPGs. OPGs were more prevalent in children than in adults, and more common in females than males. Vision loss and visual field defects were the most common clinical signs in both groups. Neither exophthalmos nor nystagmus was noted in adults. OPGs were often bilateral in children and more commonly unilateral in adults. The most common feature observed was heightened intensity in T2, with children exhibiting a more fusiform appearance compared to adults. The involvement of the optic nerve was the most common localisation. No significant differences were observed between children and adults regarding brain MRI characteristics. Chemotherapy alone was the most common treatment. Seven cases showed improved vision, 22 exhibited stable symptoms, and 19 experienced decreased vision, with one reporting no light perception. Further adult studies are necessary to elucidate population differences and understand varied symptom onset across age. Collaborative efforts in diagnosis and management are crucial for optimising care in NF1 patients with OPGs.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"49 6","pages":"464-476"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12674311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145678193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Foster Kennedy Syndrome, Euthanasia, and the Purpose of Eponyms. 福斯特·肯尼迪综合症，安乐死，以及名字的用途。

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Neuro-Ophthalmology Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2025.2523909

Curtis E Margo, Lynn E Harman

引用次数: 0

Relapsed Extranodal NK/T-Cell Lymphoma Presenting as Unilateral Third Cranial Nerve Palsy: A Rare Case Report. 结外NK/ t细胞淋巴瘤复发，表现为单侧第三脑神经麻痹1例。

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Neuro-Ophthalmology Pub Date : 2025-07-01 eCollection Date: 2026-01-01 DOI: 10.1080/01658107.2025.2524829

Mohamad Baba, Matthew Fenech, Uzoma Nnajiuba, Austin McCormick

{"title":"Relapsed Extranodal NK/T-Cell Lymphoma Presenting as Unilateral Third Cranial Nerve Palsy: A Rare Case Report.","authors":"Mohamad Baba, Matthew Fenech, Uzoma Nnajiuba, Austin McCormick","doi":"10.1080/01658107.2025.2524829","DOIUrl":"10.1080/01658107.2025.2524829","url":null,"abstract":"Extranodal natural killer/T-cell lymphoma (ENKTL) is a rare and aggressive form of non-Hodgkin lymphoma. It most commonly affects the nasal cavity and sinuses. While only few of cases of third cranial nerve palsy have been reported in association with diffuse large B-cell lymphoma and Burkitt lymphoma, its occurrence as a presenting feature of ENKTL is exceptionally rare. Here, we present a patient with isolated third cranial nerve palsy as the initial manifestation of relapsed ENKTL. A 67-year-old woman with a history of ENKTL in remission was admitted with bilateral periorbital swelling, nasal purulent discharge, and congestion following nasal reconstruction. She was diagnosed with preseptal cellulitis and sinusitis and subsequently treated with IV antibiotics. She later developed a right third nerve palsy with pupillary involvement. A CT angiogram ruled out an aneurysm, however brain MRI showed perineural spread affecting the cavernous sinus. Further cranial nerve involvement prompted a biopsy of the sinus, confirming ENKTL. A PET scan was done. No uptake in the brain, sinuses, or the rest of the body was observed. A bone marrow biopsy was subsequently performed revealing marrow involvement with ENKTL, suggesting metastatic spread beyond the sinuses. Unfortunately, the patient developed sepsis and subsequently passed away. This case emphasizes the importance of early consideration of malignancy who present with atypical neurological symptoms. Given the risk of false-negative imaging results, a multimodal approach is essential. This should include high-resolution MRI coupled with neuroradiological review, biopsy with histopathological analysis when feasible, FDG PET scan and lumbar puncture with CSF analysis.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"50 3","pages":"277-280"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13166223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147931952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compressive Optic Neuropathy Due to Dolichoectatic Ophthalmic Artery. 眼动脉过度扩张致压迫性视神经病变。

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Neuro-Ophthalmology Pub Date : 2025-07-01 eCollection Date: 2026-01-01 DOI: 10.1080/01658107.2025.2526038

Sylvia E Villarreal Navarro, Andrea Naranjo, Robert Dodd, Arian Mashhood, Heather E Moss

引用次数: 0