Neuro-Ophthalmology最新文献_第5页

Unilateral Complete Ophthalmoplegia and Ptosis as Primary Presentation of Giant Cell Arteritis: A Case Report. 巨细胞动脉炎的主要表现为单侧完全性眼麻痹和上睑下垂1例。

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Neuro-Ophthalmology Pub Date : 2024-06-27 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2024.2367078

Abdullah Younis, Haaris A Shiwani, Haya Razzouk, Filofteia Tacea, Ali Yagan

{"title":"Unilateral Complete Ophthalmoplegia and Ptosis as Primary Presentation of Giant Cell Arteritis: A Case Report.","authors":"Abdullah Younis, Haaris A Shiwani, Haya Razzouk, Filofteia Tacea, Ali Yagan","doi":"10.1080/01658107.2024.2367078","DOIUrl":"10.1080/01658107.2024.2367078","url":null,"abstract":"A 79-year-old woman presented with a one-week history of left ptosis and diplopia. These symptoms were preceded by an evolving headache, jaw claudication and one episode of transient loss of vision, all of which had resolved by the time of presentation. Examination revealed unilateral complete ophthalmoplegia, ptosis and a minimally reactive pupil. The right eye was unaffected and visual acuity was normal bilaterally. Raised inflammatory markers and positive ultrasound doppler of temporal arteries confirmed the diagnosis of giant cell arteritis (GCA). The patient responded well to oral corticosteroid therapy, showing near resolution of symptoms during 3-week follow-up. Complete ophthalmoplegia and ptosis secondary to multiple cranial nerve (CN) palsies, with sparing of vision, is a rare presentation of GCA as per the literature. In reported cases of CN palsies in GCA, there is often some degree of accompanying visual impairment and rarely are multiple CNs affected. Such a presentation holds a better prognosis as visual loss in this setting is often permanent whereas ocular CN palsies respond well to corticosteroid therapy.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"49 1","pages":"95-98"},"PeriodicalIF":0.8,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripapillary Microvascular and Structural Parameters in Atrophic Nonarteritic Anterior Ischemic Optic Neuropathy, Unaffected Fellow Eyes and Controls in an Indian Population. 萎缩性非动脉性前缺血性视神经病变的乳头周围微血管和结构参数，印度人群中未受影响的眼睛和对照。

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Neuro-Ophthalmology Pub Date : 2024-06-27 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2024.2367055

Sharanya R, V R Saravanan, Karthik Kumar Mani, Virna M Shah

{"title":"Peripapillary Microvascular and Structural Parameters in Atrophic Nonarteritic Anterior Ischemic Optic Neuropathy, Unaffected Fellow Eyes and Controls in an Indian Population.","authors":"Sharanya R, V R Saravanan, Karthik Kumar Mani, Virna M Shah","doi":"10.1080/01658107.2024.2367055","DOIUrl":"10.1080/01658107.2024.2367055","url":null,"abstract":"Nonarteritic ischemic optic neuropathy (NAION) is believed to be an ischemic insult to the optic nerve head and is one of the most common acute optic neuropathies of adulthood. Prevention of NAION in the fellow eye has not yet been accomplished. Optical coherence tomography angiography (OCTA) is a new and emerging non-invasive technology that provides microvascular information that complements the structural data. This prospective study is aimed to fill the lacunae in data that is available in the Indian population. We included 36 patients with NAION, their 36 fellow eyes and 37 healthy controls. The peripapillary perfusion index, peripapillary flux, peripapillary retinal nerve fibre layer (RNFL) thickness values and disc volumes of eyes were evaluated. The NAION eyes had lower peripapillary perfusion index, flux and RNFL thickness values in all sectors compared with both the fellow and the healthy control eyes (p = < .05). A statistically significant difference was found in disc volume between control eyes and fellow eyes, which included eyes with disc at risk configuration as well as normal disc configuration. Eyes with disc at risk configuration had a numerically lower disc volume than eyes with normal disc configuration. Fellow eyes overall had numerically lower perfusion index, higher RNFL thickness, and similar flux which was statistically non-significant compared with the healthy eyes. Correlation between the localization of visual field defects and the quadrants showing impairments of perfusion index and peripapillary RNFL were also assessed. These findings may indicate the potential vascular risk factors for the development of NAION in fellow eyes.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"49 1","pages":"35-42"},"PeriodicalIF":0.8,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Captured Manifestation of Uhthoff's Phenomenon on Automated Perimetry. 乌霍夫现象在自动视界上的捕捉表现。

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Neuro-Ophthalmology Pub Date : 2024-06-17 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2024.2366386

Roberto Ebner, Liliam Alves, John J Chen

引用次数: 0

Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Polymyalgia Rheumatica Presenting with Double Vision. 甲氨蝶呤相关淋巴细胞增生性疾病在风湿病多肌痛患者中表现为复视。

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Neuro-Ophthalmology Pub Date : 2024-06-17 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2024.2365262

Gabriele Berman, Rasoul Amel-Kashipaz, Prem Mahendra, Satheesh Ramalingam, Benjamin Rhodes, Susan Mollan, Ajay Patil

{"title":"Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Polymyalgia Rheumatica Presenting with Double Vision.","authors":"Gabriele Berman, Rasoul Amel-Kashipaz, Prem Mahendra, Satheesh Ramalingam, Benjamin Rhodes, Susan Mollan, Ajay Patil","doi":"10.1080/01658107.2024.2365262","DOIUrl":"10.1080/01658107.2024.2365262","url":null,"abstract":"Methotrexate is a commonly employed folate antagonist used as a disease modifying antirheumatic drug. It is recommended by the European League Against Rheumatism Guidelines as an add-on therapy for the treatment of polymyalgia rheumatica. Lymphoproliferative disease developing during methotrexate treatment is recognised as methotrexate-associated lymphoproliferative disorder. We describe a patient with polymyalgia rheumatica on long-term methotrexate treatment presenting with double vision and systemic symptoms concerning for giant cell arteritis. Two months prior, she had noticed a mass of the right nasal dorsum. Neuroimaging showed several lesions of the nasal cavity and a clival lesion. Nasal cavity biopsy revealed diffuse large B-cell lymphoma, and FDG-PET/CT 3 weeks after methotrexate cessation showed significant interval disease regression, confirming the diagnosis of methotrexate-associated lymphoproliferative disorder. Follow-up FDG-PET/CT 4 months after methotrexate cessation showed complete radiological regression of lymphoproliferative lesions. The cumulative incidence of methotrexate-associated lymphoproliferative disorder in patients with rheumatoid arthritis treated with methotrexate has been reported to be up to 4.7% at 10 years in a retrospective study. Cessation of methotrexate resulted in spontaneous regression in 59% of patients. It is important to include methotrexate-associated lymphoproliferative disorder on the differential diagnosis for patients on long-term methotrexate treatment who present with neuro-ophthalmic symptoms and signs as tissue diagnosis prior to commencing steroid treatment is essential to secure the diagnosis and guide treatment.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"49 1","pages":"75-82"},"PeriodicalIF":0.8,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Patients with Painful Ophthalmoplegia for Benign and Secondary Etiologies. 评估疼痛性眼肌麻痹患者的良性和继发性病因。

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Neuro-Ophthalmology Pub Date : 2024-04-29 eCollection Date: 2024-01-01 DOI: 10.1080/01658107.2024.2336270

Esra Ertilav, Ali Akyol

{"title":"Evaluation of Patients with Painful Ophthalmoplegia for Benign and Secondary Etiologies.","authors":"Esra Ertilav, Ali Akyol","doi":"10.1080/01658107.2024.2336270","DOIUrl":"10.1080/01658107.2024.2336270","url":null,"abstract":"This study aims to establish the final definite etiology among patients with long-term follow-up for painful ophthalmoplegia. The data of 44 cases (16 females, 28 females) were examined. In the first diagnosis, subjects were scanned in terms of benign and secondary etiologies. Clinical and radiological follow-up results of patients were recorded. During the follow-up period, data on clinical outcomes (relapse or progression), treatment responses, and final diagnoses were evaluated In total, 49 episodes of painful ophthalmoplegia (44 patients) were evaluated. Secondary etiologies were identified in 21 patients benign/secondary tumours causes in 10, inflammatory in 1, infectious in 3, vascular in 3, demyelinating disease in 1, autoimmune in 2, drug-related cause in 1. 23 patients with benign etiologies; 11 had Tolosa-Hunt syndrome (THS), 2 had Recurrent Painful Ophthalmoplegic Neuropathy (RPON), and 10 had diabetic ophthalmoparesis (DO). 7 of 11 patients with THS met the International Classification Headache Disorders 3rd edition (ICHD-3 beta) criteria, 4 were with a normal MRI, and 1 had a recurrence. 9 of 10 patients with benign/secondary tumours causes were malignant, and 7 died due to disease progression during the treatment process. One of ten patient was followed with diabetic ophthalmoparesis and was diagnosed with cavernous sinus involvement of B-cell lymphoma as a result of clinical progression during follow-up. Painful ophthalmoplegia is a complex clinical condition with a broad differential diagnosis with malignant and benign etiologies. A detailed clinical examination, imaging, and long-term follow-up are essential for accurate diagnosis and treatment management.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"48 5","pages":"338-347"},"PeriodicalIF":0.8,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11321404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seven, a Magic Number. 七，一个神奇的数字

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Neuro-Ophthalmology Pub Date : 2024-02-12 eCollection Date: 2024-01-01 DOI: 10.1080/01658107.2024.2314194

Dan Milea

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Ave Atque Vale. Ave Atque Vale.

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Neuro-Ophthalmology Pub Date : 2024-02-12 eCollection Date: 2024-01-01 DOI: 10.1080/01658107.2024.2305810

Walter M Jay

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Correction. 更正。

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Neuro-Ophthalmology Pub Date : 2024-02-12 eCollection Date: 2024-01-01 DOI: 10.1080/01658107.2024.2313445

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Meningeal Carcinomatosis Presenting with Bilateral Loss of Vision 出现双侧视力丧失的脑膜癌瘤病

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Neuro-Ophthalmology Pub Date : 2024-01-08 DOI: 10.1080/01658107.2023.2290537

Ryuta Ohki, Hiromitsu Kunimi, Shingo Hosoda, Tomohiro Okamoto, Yukari Tsuneyoshi, Shunsuke Hayashi, Kaoruko Yoshida, Masatsugu Ueda, K. Negishi

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Thrombolytic Therapy for Central Retinal Artery Occlusion in an Academic Multi-Site Stroke Centre 一家学术性多站点卒中中心的视网膜中央动脉闭塞溶栓疗法

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Neuro-Ophthalmology Pub Date : 2024-01-04 DOI: 10.1080/01658107.2023.2290536

Nour Alhayek, Jacob M. Sobczak, Aimen Vanood, Cumara B. O’Carroll, Bart M. Demaerschalk, John J. Chen, O. Dumitrascu

引用次数: 0