Neuro-Ophthalmology最新文献

{"title":"Toxic Optic Neuropathy Due to Mercury in Skin Lightening Products","authors":"Richard N. Sather, Michael S. Lee","doi":"10.1080/01658107.2023.2251580","DOIUrl":"https://doi.org/10.1080/01658107.2023.2251580","url":null,"abstract":"ABSTRACTMercury has been described as been in daily household items such as soaps, skin-lightening creams (SLC), and topical disinfectants. Mercury exposure can reportedly cause damage to the optic nerve and retina. A 30-year-old Somali woman presented with decreased vision and was found to have bilateral optic atrophy. Neuroimaging and laboratory work-up for nutritional deficiencies, heavy metals, and syphilis were performed. Evaluation revealed normal neuroimaging and laboratory work-up except for elevated serum and urine mercury levels. Mercury levels at the initial blood test was 11.1 ug/L (normal limits < 10.0 ug/L) and was 15.7 ug/L on repeat testing. A 24-h urine test showed elevated mercury at 16 ug/24 h (normal limits < 2 ug/24 h). Evaluation of an unlabelled SLC that she was using showed the presence of mercury. It is worth testing for heavy metals in the work-up of bilateral optic atrophy. Clinicians should consider cosmetic products as a potential source of mercury exposure and recommend discontinuation if mercury is present.KEYWORDS: Toxic optic neuropathymercury toxicityoptical coherence tomographyretinal nerve fibre layercosmetic products Disclosure statementNo potential conflict of interest was reported by the authors.Supplementary materialSupplemental data for this article can be accessed online at https://doi.org/10.1080/01658107.2023.2251580.Additional informationFundingThe authors reported there is no funding associated with the work featured in this article.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134911341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical Coherence Tomography in a Morning Glory Disc Anomaly with a Peripapillary Choroidal Neovascular Membrane","authors":"Shikha Talwar Bassi, Aditya Verma","doi":"10.1080/01658107.2023.2255665","DOIUrl":"https://doi.org/10.1080/01658107.2023.2255665","url":null,"abstract":"The purpose of this case report is to describe the optical coherence tomography (OCT) features of a peripapillary choroidal neovascular membrane (PPCNVM) in an eye with morning glory disc anomaly (MGDA). A PPCNVM appears as a hyper-reflective mass in the peripapillary area. It should be distinguished from peripapillary hyper-reflective ovoid mass-like structures, which are markers of axoplasmic flow stasis. This case report describes the distinguishing features between the two. The presence of intraretinal cystic spaces are indicative of an active PPCNVM. In conclusion, MGDA can be associated with PPCNVM and OCT can be used in its detection.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135938897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seizures as the Initial Manifestation of Idiopathic Intracranial Hypertension Spectrum Disorder","authors":"Nisreen Al-Balushi, Walid Bouthour, Ana Banc, Rasha Mosleh, Amit M. Saindane, Nancy J. Newman, Valérie Biousse","doi":"10.1080/01658107.2023.2251579","DOIUrl":"https://doi.org/10.1080/01658107.2023.2251579","url":null,"abstract":"ABSTRACT Idiopathic intracranial hypertension (IIH) is a syndrome of isolated elevated intracranial pressure of unknown aetiology. The IIH spectrum has evolved over the past decade making the diagnosis and management more challenging. The neurological examination in IIH is typically normal except for papilloedema and possible cranial nerve 6 palsy. Recent publications have highlighted skull base thinning and remodelling in patients with chronic IIH. Resulting skull base defects can cause meningo-encephalocoeles, which are potential epileptogenic foci. We describe the clinical and radiological characteristics of five IIH patients with seizures and meningo-encephalocoeles as the presenting manifestations of IIH spectrum disorder.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135982247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-Ophthalmic Literature Review","authors":"D. Bellows, John J. Chen, Hui-Chen Cheng, M. Vaphiades, Xiaojun Zhang","doi":"10.1080/01658107.2023.2216613","DOIUrl":"https://doi.org/10.1080/01658107.2023.2216613","url":null,"abstract":"Neuro-Ophthalmic Literature Review David A. Bellows, John J. Chen, Hui-Chen Cheng, Michael S. Vaphiades, and Xiaojun Zhang The Medical Eye Center, Manchester, New Hampshire, USA; Departments of Ophthalmology and Neurology, Mayo Clinic, Rochester, Minnesota, USA; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Ophthalmology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Departments of Ophthalmology, Neurology, and Neurosurgery, UAB Callahan Eye Hospital, Birmingham, AL, USA; Department of Neurology, Ohio State University Medical Center, Ohio, USA; Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China Characteristics of 110 Patients with Functional Visual Loss Sverdlichenko I, Brossard-Barbosa N, Micieli JA, Margolin E. Characteristics of 110 patients with functional visual loss. Am J Ophthalmol. 2023;250 171–176. Five to 15% of patients who present to a neuroophthalmology practice with a complaint of vision loss are diagnosed with functional visual loss (FVL). To complicate matters, as many as 53% of these patients are also diagnosed with a coexistent organic cause for their loss of vision. To identify the characteristics of patients with FVL, the authors reviewed the records of 110 patients who were diagnosed with FVL at university-affiliated neuroophthalmology clinics. The majority (73.8%) of patients were women with a mean age of 37 ± 15 years. The most common complaints were decreased vision (71.8%) followed by visual field defects (21.8%). In more than half of the patients the complaint was bilateral. Visual acuity improved in 95.9% of patients when tested with fogging and/or a bottom-up technique. The most common visual field defects were generalised depression (42.5%) followed by concentric constriction/tunnel vision (12.5%). Many patients had concurrent mental illness including depression (23.6%) and anxiety (22.7%) as well as other mental health conditions. A history of preceding trauma was present in 35% of patients. These patients incur considerable costs to the health care system. They averaged 4.6 health care visits with 3.7 of these being to medical specialists. They also averaged 2.2 neuroimaging studies in addition to other testing. The authors point out the fact that there can be considerable savings in terms of cost and patient anxiety if these patients are referred promptly for neuro-ophthalmological consultation. David Bellows GLP-1 Receptor Agonists: The Miracle Pill for IIH? Mitchell JL, Lyons HS, Walker JK, Yiangou A, Grech O, Alimajstorovic Z, et al. The effect of GLP-1RA exenatide on idiopathic intracranial hypertension: A randomized clinical trial. Brain. 13 March 2023: awad003. doi: 10.1093/brain/awad003. Epub ahead of print. PMID: 36,907,221. Glucagon-like peptide-1 (GLP-1) receptor agonists are currently used as a treatment for diabetes and weight loss. The Birmingham, United Kingdom group previously sho","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"687 1","pages":"232 - 236"},"PeriodicalIF":0.8,"publicationDate":"2023-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76857006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-Ophthalmic Literature Review","authors":"D. Bellows, N. Chan, John J. Chen, Hui-Chen Cheng, P. Jindahra, P. Macintosh, Collin M. McClelland, M. Vaphiades, Xiaojun Zhang","doi":"10.1080/01658107.2023.2201136","DOIUrl":"https://doi.org/10.1080/01658107.2023.2201136","url":null,"abstract":"Neuro-Ophthalmic Literature Review David A. Bellows, Noel C. Y. Chan, John J. Chen, Hui-Chen Cheng, Panitha Jindahra, Peter W. MacIntosh, Collin McClelland, Michael S. Vaphiades, and Xiaojun Zhang The Medical Eye Center, Manchester, New Hampshire, USA; Department of Ophthalmology & Visual Sciences, Prince of Wales Hospital & Alice Ho Miu Ling Nethersole Hospital, Hong Kong; Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong; Departments of Ophthalmology and Neurology, Mayo Clinic, Rochester, Minnesota, USA; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Ophthalmology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Neurology, Mahidol University, Bangkok, Thailand; Department of Ophthalmology, Illinois Ear and Eye Infirmary, Chicago, Illinois, USA; Department of Ophthalmology, University of Minnesota, Minneapolis, Minnesota, USA; Departments of Ophthalmology, Neurology, and Neurosurgery, UAB Callahan Eye Hospital, Birmingham, Alexandria, USA; Department of Neurology, Ohio State University Medical Center, Columbus, Ohio, USA; Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, Hebei, China Peripapillary Hyperreflective Ovoid Mass-Like Structures: Multimodal Imaging – A Review Jeffery RCH, Chen FK. Peripapillary hyperreflective ovoid mass-like structures: Multimodal imaging-A review. Clin Exp Ophthalmol. 2023;51:67–80. Prior to the establishment of the Optic Disk Drusen Consortium the ovoid peripapillary structures detected on optical coherence tomography (OCT) were felt to be buried optic disk drusen. These structures have since been redefined as peripapillary hyperreflective ovoid mass-like structures (PHOMS) and identified as a manifestation of axoplasmic stasis. The authors discuss the characteristic findings of PHOMS on multimodal OCT and review the literature pertaining to the co-existence of PHOMS with diseases other than optic disk drusen. These include papilloedema, anterior ischaemic optic neuropathy, tilted disk syndrome, inflammatory demyelinating disorders as well as retinal and orbital diseases. David Bellows Anti-Hypertensive Medications – Before Bed or Not? Labowsky MT, Rizzo III JF. The controversy of chronotherapy: Emerging evidence regarding bedtime dosing of antihypertensive medications in non-arteritic anterior ischaemic optic neuropathy. Semin Ophthalmol. 2023;38:99–104. This is a review article highlighting the marked conflict between therapeutic recommendations published in the ophthalmology and cardiology literature, with the former arguing against taking anti-hypertensive medications at bedtime to reduce risk of sequential non-arteritic anterior ischaemic optic neuropathy (NAION) while the latter arguing in favour of bedtime dosing to reduce the risk of cardiovascular disease (CVD). The observation of “blinding upon awakening” in patients with NAION has prom","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"11 1","pages":"171 - 176"},"PeriodicalIF":0.8,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79995194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-Ophthalmic Literature Review","authors":"D. Bellows, John J. Chen, Hui-Chen Cheng, P. Jindahra, Collin M. McClelland, M. Vaphiades, Xiaojun Zhang","doi":"10.1080/01658107.2023.2169555","DOIUrl":"https://doi.org/10.1080/01658107.2023.2169555","url":null,"abstract":"Neuro-Ophthalmic Literature Review David A. Bellows, John J. Chen, Hui-Chen Cheng, Panitha Jindahra, Collin McClelland, Michael S. Vaphiades, and Xiaojun Zhang The Medical Eye Center, Manchester, New Hampshire, USA; Departments of Ophthalmology and Neurology, Mayo Clinic, Rochester, MN, USA; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Ophthalmology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Neurology, Mahidol University, Bangkok, Thailand; Department of Ophthalmology, University of Minnesota, Minneapolis, MN, USA; Departments of Ophthalmology, Neurology, and Neurosurgery, UAB Callahan Eye Hospital, Birmingham, AL, USA; Department of Neurology, Ohio State University Medical Center, Ohio, USA; Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China Oral fluorescein angiography for the diagnosis of papilloedema versus pseudopapilledema in children Elhusseiny AM, Fong JW, Hsu C, Grigorian F, Grigorian AP, Soliman MK, et al. Oral fluorescein angiography for the diagnosis of papilloedema versus pseudopapilledema in children. Am J Ophthalmol 2023;245: 8–13. This study was designed to determine if the use of oral fluorescein angiography is accurate and safe in differentiating papilloedema from pseudopapilloedema in paediatric patients. Two masked specialists (a paediatric ophthalmologist and retina specialist) reviewed the oral fluorescein angiogram images of 45 patients (90 eyes). They evaluated the optic discs and assigned them to three categories: leakage; no leakage; or “borderline” leakage of fluorescein, at least 30 minutes following ingestion of the medication. The determinations made by the masked observers were then compared with the final clinical diagnosis. There was excellent interobserver accordance in grading the images. Oral fluorescein angiography was found to be safe with no ocular, systemic or allergic reactions. The accuracy, however, was suboptimal with only 62 to 69% of images accurately differentiating papilloedema from pseudopapilloedema. However, the sensitivity at detecting leakage increased with the severity of disc swelling and the observers correctly identified papilloedema in 89% of patients who had Frisén grade 2 or 3 swelling. David Bellows Enhanced depth imaging may be the new gold standard for detecting optic disc drusen Youn S, Mfe B, Armstrong JJ, Fraser JA, Hamann S, Bursztyn L. Am J Ophthalmol. 11 December 2022: S0002-9394(22)00485–8. doi: 10.1016/j.ajo.2022. 12.004. Online ahead of print.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"142 1","pages":"123 - 127"},"PeriodicalIF":0.8,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83042651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-Ophthalmic Literature Review","authors":"D. Bellows, N. Chan, John J. Chen, Hui-Chen Cheng, P. Macintosh, Collin M. McClelland, M. Vaphiades, K. Weber, Xiaojun Zhang","doi":"10.1080/01658107.2022.2155453","DOIUrl":"https://doi.org/10.1080/01658107.2022.2155453","url":null,"abstract":"Neuro-Ophthalmic Literature Review David A. Bellows, Noel C.Y. Chan, John J. Chen , Hui-Chen Cheng, Peter W MacIntosh, Collin McClelland, Michael S. Vaphiades, Konrad P. Weber, and Xiaojun Zhang The Medical Eye Center, Manchester, New Hampshire, USA; Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital & Alice Ho Miu Ling Nethersole Hospital, Hong Kong, Hong Kong; Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong; Departments of Ophthalmology and Neurology, Mayo Clinic, Rochester, Minnesota, USA; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Ophthalmology, School of Medicine National Yang Ming Chiao Tung University Hsinchu Taiwan; Department of Ophthalmology, Illinois Ear and Eye Infirmary, Chicago, Illinois, USA; Department of Ophthalmology, University of Minnesota, Minneapolis, Minnesota, USA; Departments of Ophthalmology, Neurology, and Neurosurgery, UAB Callahan Eye Hospital, Birmingham, Alabama, USA; Departments of Neurology and Ophthalmology, University Hospital Zurich, Zürich, Switzerland; Department of Neurology, Ohio State University Medical Center, Columbus, Ohio, USA; Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, Hebei, China Analysis of facial features of patients with sagging eye syndrome and intermittent exotropia compared to controls Kunimi K, Goseki T, Fukaya K, Takahashi S, Ishikawa E, et al. Analysis of facial features of patients with sagging eye syndrome and intermittent exotropia compared to controls. Am J Ophthalmol 18 October 2022;S0002-9394(22)00391–9. doi: 10.1016/j.ajo.2022.10.007. Online ahead of print. Frontal facial photographs of patients who were greater than 60 years of age and had been diagnosed with sagging eye syndrome or intermittent exotropia were evaluated for three characteristics including sunken upper eyelids, blepharoptosis and baggy lower eyelids. The patients were compared to normal controls and a scoring system was used to grade the degree of these three characteristics. A total of 86 patients were included in the study. Of these, 23 were diagnosed with sagging eye syndrome, 28 were diagnosed with intermittent exotropia and 35 were in the control group. All patients were Japanese. The authors noted that only sunken upper eyelids, as opposed to blepharoptosis and baggy lower eyelids, were significantly associated with sagging eye syndrome. This contrasts with previous reports of sagging eye syndrome being associated with blepharoptosis. They also report that baggy lower eyelids were significantly associated with intermittent exotropia. A detailed description is provided of the pathological changes that occur within the orbit leading to these two disorders. David Bellows Serial titre and seroconversion in paediatric myelin oligodendrocyte glycoprotein antibody","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"126 1","pages":"54 - 61"},"PeriodicalIF":0.8,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87706723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Principles of Ocular Imaging, By","authors":"Shira S. Simon","doi":"10.1080/01658107.2022.2143532","DOIUrl":"https://doi.org/10.1080/01658107.2022.2143532","url":null,"abstract":"Drs Gologorsky and Rosen have created a beautifully illustrated, high yield text that ought to become a standard reference for the field of ophthalmology. Offering a concise and comprehensive guide to 22 ocular imaging modalities in just over 200 pages, Principles of Ocular Imaging is meticulously organised from anterior to posterior, with clear divisions for the various specialities. Each section has pages filled with vibrant, high-resolution images of classic patient presentations. Accompanying each photograph are succinct descriptions of critical information for each disease process and the suggested imaging approach. The language is clear and would be helpful at all stages of training and practice as a primer or refresher. In terms of the structure of the book, the main sections are oculoplastics, cornea and refractive, retina, glaucoma, and neuroophthalmology. Now, several years away from my ophthalmology residency, I found the cornea and retina sections’ more recent updates particularly elucidating, from the applications of anterior segment optical coherence tomography (OCT) as a ‘light biopsy’ tool in cornea, to the many uses of OCT angiography and adaptive optics in retinal practice. The key topics discussed in each section are:","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"63 1","pages":"53 - 53"},"PeriodicalIF":0.8,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78881617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-Ophthalmic Literature Review","authors":"D. Bellows, N. Chan, John J. Chen, Hui-Chen Cheng, P. Macintosh, M. Vaphiades, K. Weber, Xiaojun Zhang","doi":"10.1080/01658107.2022.2132065","DOIUrl":"https://doi.org/10.1080/01658107.2022.2132065","url":null,"abstract":"Neuro-Ophthalmic Literature Review David A. Bellows, Noel C. Y. Chan, John J. Chen, Hui-Chen Cheng, Peter W. MacIntosh, Michael S. Vaphiades, Konrad P. Weber, and Xiaojun Zhang The Medical Eye Center, Manchester, New Hampshire, USA; Department of Ophthalmology & Visual Sciences, Prince of Wales Hospital & Alice Ho Miu Ling Nethersole Hospital, Hong Kong; Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong; Departments of Ophthalmology and Neurology, Mayo Clinic, Rochester, Minnesota, USA; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan. Department of Ophthalmology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Ophthalmology, Illinois Ear and Eye Infirmary, Chicago, Illinois, USA; Departments of Ophthalmology, Neurology, and Neurosurgery, UAB Callahan Eye Hospital, Birmingham, AL, USA; Departments of Neurology and Ophthalmology, University Hospital Zurich, Zürich, Switzerland; Department of Neurology, Ohio State University Medical Center, Ohio, USA. Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China Oculomotor Nerve Schwannoma: Case Series and Literature Review Douglas VP, Flores C, Douglas KA, Strominger MB, Kasper E, Torun N. Oculomotor nerve schwannoma: Case series and literature review. Surv Ophthalmol. 2022 Jul–Aug;67(4):1160–1174. There have only been 100 reported cases of oculomotor nerve schwannoma and, due to its rarity, there is no established guideline for the management of these tumours. Based on a review of the literature and their own cases, the authors have developed an algorithm that addresses the indications for treatment and their outcomes Eighty-four cases of oculomotor nerve schwannoma reported between 1980 and 2020 were included in this review. The mean age at diagnosis was 32.7 years (range 2 months to 78 years) with a male-to-female ratio of 2:3. Four of these patients were asymptomatic. The remaining patients reported symptoms of third nerve palsy including diplopia (n = 24) and ptosis (n = 30). Twenty-three of the patients experienced symptoms suggestive of ophthalmoplegic migraine with headache followed by brief periods of diplopia or ptosis. Other symptoms included those related to the mass effect of the tumour including cognitive changes, periorbital pain, and nausea. Patients with larger tumours (mean 27.3 mm) were primarily treated surgically, which frequently resulted in a complete palsy of the third nerve. Patients with smaller tumours did well with stereotactic radiosurgery, which resulted in a reduction in tumour size with no worsening of symptoms. Considering the above findings, the authors proposed the following algorithm. Patients who are asymptomatic can be monitored with no intervention. Patients with smaller tumours, who are symptomatic, can be treated with stereotactic radiosurgery followed by the prescription of spectacles containing a prismatic co","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"21 1","pages":"351 - 358"},"PeriodicalIF":0.8,"publicationDate":"2022-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90052727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dr Satoshi Ishikawa (1932-2022)","authors":"H. Ishikawa","doi":"10.1080/01658107.2022.2108849","DOIUrl":"https://doi.org/10.1080/01658107.2022.2108849","url":null,"abstract":"After graduating from the Tohoku University School of Medicine in 1957 Dr Satoshi Ishikawa (Figure 1) joined the Department of Ophthalmology of the University of Tokyo School of Medicine. In 1958 he became an assistant professor at the Department of Ophthalmology, School of Medicine, University of Tokyo. In 1963 he was awarded a Fulbright Fellowship to study at the New York University. Two years later he became an associate professor there. After returning to Japan in 1965 he became a lecturer at the Department of Ophthalmology, Tokyo University Medical School. In 1971 he was appointed as the first department head of the Ophthalmology Department at the Kitasato University School of Medicine and served as the dean in 1994, the Director of the Kitasato Institute Hospital Environmental Centre in 1998, and Advisor at the Kitasato Institute in 2005. During his initial tenure at the University of Tokyo Dr Ishikawa was interested in Neuroophthalmology, strabismus/amblyopia, and toxicology. He continued in clinical and research work, mainly in these fields, at the New York University. For these endeavours he returned home after having numerous achievements. In 1959 he established the Japan Neuro-ophthalmology Group, which served as the foundation for the Japanese Society of Neuroophthalmology. Moreover, he developed the field of toxicology and focused on the chronic toxicity of organophosphorus. He wrote a paper on the effects of anticholinesterase drugs on esotropia and myasthenia gravis, the point of contact between Neuro-ophthalmology, strabismus/myopia, and toxicology. In 1968 he was awarded the 7th General Medicine Award for ‘Esotropia and Miotic Agents’, and in 1975 the 28th General Medicine Award for ‘Ocular Symptoms of Myasthenia Gravis and Cholinesterase’. Dr Ishikawa remained active in the development of electronic pupillometers and he later perfected the infrared electronic pupillometer, which has been applied in the clinical setting. His research and clinical works went beyond the field of Ophthalmology, covering topics such as visual display terminal syndrome, sick house syndrome, and chemical sensitivity. He also served as the chairman of the scientific research committee of the Ministry of Health, Labour, and Welfare. In 1996 he delivered a special commemorative lecture at the 31st Annual Meeting of the American Academy of Environmental Medicine, where he was the first Japanese recipient of the Jonathan Forman Award. He also received the Japanese Ophthalmological Society Award in 1998 for his ‘Research on Ocular Toxicity of Organophosphorus’. Dr Ishikawa received the Japanese Ophthalmological Society Special Contribution Award in 2003 for his brilliant feats in the development of ophthalmic science. He actively pioneered the field of Neuroophthalmology in Japan by establishing the Japanese Society of Neuro-ophthalmology. He also served as councillor and director of the Japanese Ophthalmological Society, honorary member and director of the ","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"20 1","pages":"349 - 350"},"PeriodicalIF":0.8,"publicationDate":"2022-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82629558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}