Neuro-Ophthalmology最新文献_第4页

Ophthalmic Presentation of Diffuse Intrinsic Pontine Glioma in Children (Case Series and Literature Review). 儿童弥漫性内禀脑桥胶质瘤的眼科表现（病例系列和文献回顾）。

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Neuro-Ophthalmology Pub Date : 2024-09-16 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2024.2402726

Elizaveta Bayramova, Lorraine Manklow, Maria Filyridou, Anastasia Pilat

{"title":"Ophthalmic Presentation of Diffuse Intrinsic Pontine Glioma in Children (Case Series and Literature Review).","authors":"Elizaveta Bayramova, Lorraine Manklow, Maria Filyridou, Anastasia Pilat","doi":"10.1080/01658107.2024.2402726","DOIUrl":"10.1080/01658107.2024.2402726","url":null,"abstract":"Diffuse intrinsic pontine glioma (DIPG) is a rare aggressive brainstem lesion, affecting mainly young children. This report describes sixth cranial nerve palsy as the initial ophthalmic presentation in children with this pathology. Case series and literature review. All children presented with sixth nerve palsy were consecutively recruited from the pediatric clinic at the East Sussex NHS Healthcare Trust within the last 10 years. Full ophthalmic examination, orthoptic assessment, and refraction check were done in three patients. Magnetic Resonance Imaging was carried out using 1.5 Tesla (Siemens Symphony, Erlangen, Germany) to establish the diagnosis. The patients' age ranged from 5 to 14 years at the time of presentation. All presented with sudden onset esotropia and limited abduction, suggestive of presence of sixth nerve palsy, requiring urgent medical attention. On detailed questioning and assessment, all children showed various neurological symptoms including nystagmus, liquid dysphagia, balance problems, and nocturnal enuresis. Two out of three patients died within 7 months following diagnosis. Sudden onset esotropia, especially due to sixth nerve palsy in children, should be considered a red flag symptom, prompting proper urgent specialist assessment. Sixth nerve palsy in patients with DIPG was associated with severely reduced life expectancy in this case series of three patients, shorter than in reported non-ophthalmic presentations.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"49 3","pages":"200-205"},"PeriodicalIF":0.8,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optic Nerve Head Pigmentation: Case Report and Literature Review. 视神经头色素沉着：1例报告及文献复习。

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Neuro-Ophthalmology Pub Date : 2024-09-12 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2024.2362751

Meshaal Aljebreen, Wael A Alsakran

引用次数: 0

Predictors of Permanent Vision Loss in Giant Cell Arteritis. 巨细胞动脉炎永久性视力丧失的预测因素。

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Neuro-Ophthalmology Pub Date : 2024-09-12 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2024.2389934

Susan M Tucker, Sara J Haas, Tasneem Zaihra Rizvi

{"title":"Predictors of Permanent Vision Loss in Giant Cell Arteritis.","authors":"Susan M Tucker, Sara J Haas, Tasneem Zaihra Rizvi","doi":"10.1080/01658107.2024.2389934","DOIUrl":"10.1080/01658107.2024.2389934","url":null,"abstract":"To report on the occurrence and characteristics of eye manifestations and determine the predictors of permanent vision loss (PVL) in patients with giant cell arteritis. Case-control study. Retrospective cohort study of 258 patients diagnosed with giant cell arteritis (GCA) over a 20- year period at a single institution. Eighty nine of 258 patients (34.5%) with GCA had vision symptoms and 56 (21.7%) developed PVL. Acute loss of vision with no preceding ocular symptoms occurred in 28.5%; for those with symptoms, median time to vision loss was 4.5 days. Bilateral clinical eye involvement was present in 38%, mostly anterior ischemic optic neuropathy (AION), rarely vascular occlusions. Vision loss was severe with acuity of count fingers or less or mean deficit -20 decibels or less in at least one eye in 80% of patients with PVL. Following initiation of GC treatment, 23% of patients continued to have further vision loss and only 5% showed improvement. We found predictors of PVL by multivariate analysis to be increased age (OR 1.05, p0.040), jaw claudication (OR 2.29, p = .040), diplopia (OR 2.74, p = .039), increased platelets (OR 2.98, p = .020) and lower CRP (OR 0.63, p = .004). We found there is a 27.3% decrease in the odds of having PVL when CRP value is doubled, keeping all other variables fixed. Permanent vision loss was 3.07 times more likely in the absence of polymyalgia rheumatica and 4.25 times more likely in patients without headaches. Ocular involvement in GCA is common, usually severe with little chance of recovery. Detailed analysis of visual acuity and visual field loss in our PVL cohort adds valuable data to the literature which lacks this information. Older patients with jaw claudication, diplopia, and increased platelets are at higher risk for permanent vision loss, especially when PMR and headache are absent and acute phase reactants lower.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"49 1","pages":"60-68"},"PeriodicalIF":0.8,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proceedings of the 46^th Annual Upper Midwest Neuro-Ophthalmology Group Meeting. 第 46 届上中西部神经眼科小组年会论文集。

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Neuro-Ophthalmology Pub Date : 2024-09-09 eCollection Date: 2024-01-01 DOI: 10.1080/01658107.2024.2392180

Sabrina Poonja, Natthapon Rattanathamsakul, Peter W MacIntosh, John J Chen

引用次数: 0

EUNOS 2024: Conference Report Rotterdam, The Netherlands, 3rd-6th June 2024. EUNOS 2024：会议报告 2024 年 6 月 3-6 日，荷兰鹿特丹。

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Neuro-Ophthalmology Pub Date : 2024-09-09 eCollection Date: 2024-01-01 DOI: 10.1080/01658107.2024.2394088

Pavel Loginovic, Simon J Hickman

引用次数: 0

Cavernous Angioma Originating Directly from the Oculomotor Nerve: To Treat or Not to Treat? 直接起源于动眼神经的海绵状血管瘤：治疗还是不治疗？

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Neuro-Ophthalmology Pub Date : 2024-09-09 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2024.2394830

Carlos Martínez-Macho, Ricardo Gil-Simoes, Patricia González-Tarno, Adrián Martín-Segura, Amelia Álvarez-Sala, Alejandra Madero-Pohlen, José Antonio Fernández Alén

{"title":"Cavernous Angioma Originating Directly from the Oculomotor Nerve: To Treat or Not to Treat?","authors":"Carlos Martínez-Macho, Ricardo Gil-Simoes, Patricia González-Tarno, Adrián Martín-Segura, Amelia Álvarez-Sala, Alejandra Madero-Pohlen, José Antonio Fernández Alén","doi":"10.1080/01658107.2024.2394830","DOIUrl":"10.1080/01658107.2024.2394830","url":null,"abstract":"Cavernous angiomas (CA) affecting cranial nerves (CN) are exceptionally rare. Most reported cases involve the optic nerves, with even fewer occurrences in other CN. In this report, the authors describe a case of an extra-axial CA affecting the oculomotor nerve, which was managed conservatively. The authors also review the outcomes of other therapeutic options based on cases documented in the existing literature. Case report: 36-year-old woman presented to the Emergency Department with a headache in the left temporal region, predominantly at night, along with mild left palpebral ptosis and binocular diplopia of 2 months duration. Brain MRI revealed a lesion exhibiting typical characteristics of CA in the left lateral region of the interpeduncular cistern, in close contact with the left oculomotor nerve. After considering treatment options and in consultation with the patient, a conservative management plan with periodic MRI follow-up was chosen. After 2 years of follow-up, the patient showed favorable progress. Although exceptional, CA should be considered in the differential diagnosis of other more common extra-axial lesions involving CN. The therapeutic management of a CA of the oculomotor nerve remains controversial due to the limited number of cases described in the literature. The authors suggest that for individuals with asymptomatic or mildly symptomatic CA affecting the oculomotor nerve, a conservative treatment approach is the most suitable choice to preserve neurological function. In cases characterized by progressive symptoms, a history of recurrent bleeding, or evidence of lesion enlargement on sequential imaging assessments, total microsurgical resection should be considered.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"49 2","pages":"171-178"},"PeriodicalIF":0.8,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erythropoietin for the Treatment of Methanol Toxic Optic Neuropathy: Does It Really Work? A Case Series. 促红细胞生成素治疗甲醇毒性视神经病变：真的有效吗？案例系列。

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Neuro-Ophthalmology Pub Date : 2024-08-19 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2024.2391436

Nooran O Badeeb, Shaima Alharazi, Asmaa Mohammedsaleh, Hasan Hijazi, Nihal M Sadaga, Manal Hadrawi

{"title":"Erythropoietin for the Treatment of Methanol Toxic Optic Neuropathy: Does It Really Work? A Case Series.","authors":"Nooran O Badeeb, Shaima Alharazi, Asmaa Mohammedsaleh, Hasan Hijazi, Nihal M Sadaga, Manal Hadrawi","doi":"10.1080/01658107.2024.2391436","DOIUrl":"10.1080/01658107.2024.2391436","url":null,"abstract":"Erythropoietin (EPO) has demonstrated neuroprotective properties and has been used in small case series to treat methanol optic neuropathy. This study aims to evaluate the effectiveness of EPO. This retrospective case series included data from patients diagnosed with methanol optic neuropathy between November 2022 and December 2023 from two centers in Jeddah, Saudi Arabia. Demographic information, time of consumption of methanol to EPO treatment, and other treatments administered were collected. Vision assessment was performed before and after EPO treatment. A total of 8 male patients were included, with an average age of 38.25 ± 7.15 years. The median duration of the follow-up was 66 days, ranging from 13 to 660 days. The means of vision in the logMAR of both eyes before EPO treatment was 1.98 ± 1.08, which changed to 1.87 ± 0.89 after EPO treatment. Patient's presenting vision before EPO treatment is a significant positive predictor for the vision after treatment with coefficient = 0.782 and 95% CI = 0.349, 0.936. Time to EPO treatment was not statistically significant in defining end vision. Treating methanol optic neuropathy is challenging and time sensitive. In this case series, EPO and adjuvant steroids showed variable effects on visual improvement. Although the vision improved after the treatment, these differences were not statistically significant. Repeat EPO did not give better outcomes. Long-term follow-up is needed to determine the overall impact of EPO treatment.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"49 2","pages":"132-136"},"PeriodicalIF":0.8,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leber's Hereditary Optic Neuropathy with Retinal Hemorrhage. 利伯氏遗传性视神经病变伴视网膜出血。

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Neuro-Ophthalmology Pub Date : 2024-08-19 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2024.2389957

Yasuyuki Takai, Akiko Yamagami, Mayumi Iwasa, Kenji Inoue, Ryoma Yasumoto, Hitoshi Ishikawa, Masato Wakakura

{"title":"Leber's Hereditary Optic Neuropathy with Retinal Hemorrhage.","authors":"Yasuyuki Takai, Akiko Yamagami, Mayumi Iwasa, Kenji Inoue, Ryoma Yasumoto, Hitoshi Ishikawa, Masato Wakakura","doi":"10.1080/01658107.2024.2389957","DOIUrl":"10.1080/01658107.2024.2389957","url":null,"abstract":"Leber's hereditary optic neuropathy (LHON) causes subacute visual loss, and, in the acute phase, the optic disc shows hyperemia, peripapillary telangiectasia, and swelling of the retinal nerve fiber layer (RNFL). Rarely, retinal hemorrhage may be present. In this study, we investigated LHON cases with retinal hemorrhage in the acute phase. Among 82 cases (164 eyes) of LHON who visited the Inoue Eye Hospital, retinal hemorrhage was observed in 5 cases (5 eyes). The age at onset was 36 (27-46) years, with 4 male cases. Mitochondrial DNA analysis revealed the presence of the m.11778G > A variant in four patients and the m.14484T > C variant in one patient. There was no medical history and no excessive smoking or alcohol consumption in any of the cases. In all cases, retinal hemorrhages were observed in the RNFL, accompanying the characteristic optic disc findings of LHON. Fluorescein angiography performed in three cases showed no leakage from the optic disc or blood vessels. While rare, the presence of retinal hemorrhage along the RNFL during the acute phase of LHON should be recognized, as it may warrant consideration of alternative diagnoses.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"49 2","pages":"127-131"},"PeriodicalIF":0.8,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optic Disc Edema as the Initial Presentation of Bing-Neel Syndrome. 视盘水肿作为Bing-Neel综合征的首发表现。

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Neuro-Ophthalmology Pub Date : 2024-08-07 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2024.2387727

Kennedy Belangee, Shayna R Sarosiek, Vasiliki Poulaki, Ahsan Hussain, Joseph Kane

引用次数: 0

Perineural Invasion of Occult Cutaneous Squamous Cell Carcinoma Mimicking Tolosa-Hunt Syndrome. 模拟Tolosa-Hunt综合征的隐匿性皮肤鳞状细胞癌的神经周围浸润。

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Neuro-Ophthalmology Pub Date : 2024-06-27 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2024.2367054

Alex Stubbing-Moore, Hussein Uraiby, Vincent Lam, Samira Anwar-Bhatti

引用次数: 0