Neuro-Ophthalmology最新文献_第3页

Cavernous Angioma Originating Directly from the Oculomotor Nerve: To Treat or Not to Treat? 直接起源于动眼神经的海绵状血管瘤：治疗还是不治疗？

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Neuro-Ophthalmology Pub Date : 2024-09-09 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2024.2394830

Carlos Martínez-Macho, Ricardo Gil-Simoes, Patricia González-Tarno, Adrián Martín-Segura, Amelia Álvarez-Sala, Alejandra Madero-Pohlen, José Antonio Fernández Alén

{"title":"Cavernous Angioma Originating Directly from the Oculomotor Nerve: To Treat or Not to Treat?","authors":"Carlos Martínez-Macho, Ricardo Gil-Simoes, Patricia González-Tarno, Adrián Martín-Segura, Amelia Álvarez-Sala, Alejandra Madero-Pohlen, José Antonio Fernández Alén","doi":"10.1080/01658107.2024.2394830","DOIUrl":"10.1080/01658107.2024.2394830","url":null,"abstract":"Cavernous angiomas (CA) affecting cranial nerves (CN) are exceptionally rare. Most reported cases involve the optic nerves, with even fewer occurrences in other CN. In this report, the authors describe a case of an extra-axial CA affecting the oculomotor nerve, which was managed conservatively. The authors also review the outcomes of other therapeutic options based on cases documented in the existing literature. Case report: 36-year-old woman presented to the Emergency Department with a headache in the left temporal region, predominantly at night, along with mild left palpebral ptosis and binocular diplopia of 2 months duration. Brain MRI revealed a lesion exhibiting typical characteristics of CA in the left lateral region of the interpeduncular cistern, in close contact with the left oculomotor nerve. After considering treatment options and in consultation with the patient, a conservative management plan with periodic MRI follow-up was chosen. After 2 years of follow-up, the patient showed favorable progress. Although exceptional, CA should be considered in the differential diagnosis of other more common extra-axial lesions involving CN. The therapeutic management of a CA of the oculomotor nerve remains controversial due to the limited number of cases described in the literature. The authors suggest that for individuals with asymptomatic or mildly symptomatic CA affecting the oculomotor nerve, a conservative treatment approach is the most suitable choice to preserve neurological function. In cases characterized by progressive symptoms, a history of recurrent bleeding, or evidence of lesion enlargement on sequential imaging assessments, total microsurgical resection should be considered.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"49 2","pages":"171-178"},"PeriodicalIF":0.8,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erythropoietin for the Treatment of Methanol Toxic Optic Neuropathy: Does It Really Work? A Case Series. 促红细胞生成素治疗甲醇毒性视神经病变：真的有效吗？案例系列。

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Neuro-Ophthalmology Pub Date : 2024-08-19 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2024.2391436

Nooran O Badeeb, Shaima Alharazi, Asmaa Mohammedsaleh, Hasan Hijazi, Nihal M Sadaga, Manal Hadrawi

{"title":"Erythropoietin for the Treatment of Methanol Toxic Optic Neuropathy: Does It Really Work? A Case Series.","authors":"Nooran O Badeeb, Shaima Alharazi, Asmaa Mohammedsaleh, Hasan Hijazi, Nihal M Sadaga, Manal Hadrawi","doi":"10.1080/01658107.2024.2391436","DOIUrl":"10.1080/01658107.2024.2391436","url":null,"abstract":"Erythropoietin (EPO) has demonstrated neuroprotective properties and has been used in small case series to treat methanol optic neuropathy. This study aims to evaluate the effectiveness of EPO. This retrospective case series included data from patients diagnosed with methanol optic neuropathy between November 2022 and December 2023 from two centers in Jeddah, Saudi Arabia. Demographic information, time of consumption of methanol to EPO treatment, and other treatments administered were collected. Vision assessment was performed before and after EPO treatment. A total of 8 male patients were included, with an average age of 38.25 ± 7.15 years. The median duration of the follow-up was 66 days, ranging from 13 to 660 days. The means of vision in the logMAR of both eyes before EPO treatment was 1.98 ± 1.08, which changed to 1.87 ± 0.89 after EPO treatment. Patient's presenting vision before EPO treatment is a significant positive predictor for the vision after treatment with coefficient = 0.782 and 95% CI = 0.349, 0.936. Time to EPO treatment was not statistically significant in defining end vision. Treating methanol optic neuropathy is challenging and time sensitive. In this case series, EPO and adjuvant steroids showed variable effects on visual improvement. Although the vision improved after the treatment, these differences were not statistically significant. Repeat EPO did not give better outcomes. Long-term follow-up is needed to determine the overall impact of EPO treatment.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"49 2","pages":"132-136"},"PeriodicalIF":0.8,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leber's Hereditary Optic Neuropathy with Retinal Hemorrhage. 利伯氏遗传性视神经病变伴视网膜出血。

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Neuro-Ophthalmology Pub Date : 2024-08-19 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2024.2389957

Yasuyuki Takai, Akiko Yamagami, Mayumi Iwasa, Kenji Inoue, Ryoma Yasumoto, Hitoshi Ishikawa, Masato Wakakura

{"title":"Leber's Hereditary Optic Neuropathy with Retinal Hemorrhage.","authors":"Yasuyuki Takai, Akiko Yamagami, Mayumi Iwasa, Kenji Inoue, Ryoma Yasumoto, Hitoshi Ishikawa, Masato Wakakura","doi":"10.1080/01658107.2024.2389957","DOIUrl":"10.1080/01658107.2024.2389957","url":null,"abstract":"Leber's hereditary optic neuropathy (LHON) causes subacute visual loss, and, in the acute phase, the optic disc shows hyperemia, peripapillary telangiectasia, and swelling of the retinal nerve fiber layer (RNFL). Rarely, retinal hemorrhage may be present. In this study, we investigated LHON cases with retinal hemorrhage in the acute phase. Among 82 cases (164 eyes) of LHON who visited the Inoue Eye Hospital, retinal hemorrhage was observed in 5 cases (5 eyes). The age at onset was 36 (27-46) years, with 4 male cases. Mitochondrial DNA analysis revealed the presence of the m.11778G > A variant in four patients and the m.14484T > C variant in one patient. There was no medical history and no excessive smoking or alcohol consumption in any of the cases. In all cases, retinal hemorrhages were observed in the RNFL, accompanying the characteristic optic disc findings of LHON. Fluorescein angiography performed in three cases showed no leakage from the optic disc or blood vessels. While rare, the presence of retinal hemorrhage along the RNFL during the acute phase of LHON should be recognized, as it may warrant consideration of alternative diagnoses.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"49 2","pages":"127-131"},"PeriodicalIF":0.8,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optic Disc Edema as the Initial Presentation of Bing-Neel Syndrome. 视盘水肿作为Bing-Neel综合征的首发表现。

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Neuro-Ophthalmology Pub Date : 2024-08-07 eCollection Date: 2025-01-01 DOI: 10.1080/01658107.2024.2387727

Kennedy Belangee, Shayna R Sarosiek, Vasiliki Poulaki, Ahsan Hussain, Joseph Kane

引用次数: 0

Evaluation of Patients with Painful Ophthalmoplegia for Benign and Secondary Etiologies. 评估疼痛性眼肌麻痹患者的良性和继发性病因。

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Neuro-Ophthalmology Pub Date : 2024-04-29 eCollection Date: 2024-01-01 DOI: 10.1080/01658107.2024.2336270

Esra Ertilav, Ali Akyol

{"title":"Evaluation of Patients with Painful Ophthalmoplegia for Benign and Secondary Etiologies.","authors":"Esra Ertilav, Ali Akyol","doi":"10.1080/01658107.2024.2336270","DOIUrl":"10.1080/01658107.2024.2336270","url":null,"abstract":"This study aims to establish the final definite etiology among patients with long-term follow-up for painful ophthalmoplegia. The data of 44 cases (16 females, 28 females) were examined. In the first diagnosis, subjects were scanned in terms of benign and secondary etiologies. Clinical and radiological follow-up results of patients were recorded. During the follow-up period, data on clinical outcomes (relapse or progression), treatment responses, and final diagnoses were evaluated In total, 49 episodes of painful ophthalmoplegia (44 patients) were evaluated. Secondary etiologies were identified in 21 patients benign/secondary tumours causes in 10, inflammatory in 1, infectious in 3, vascular in 3, demyelinating disease in 1, autoimmune in 2, drug-related cause in 1. 23 patients with benign etiologies; 11 had Tolosa-Hunt syndrome (THS), 2 had Recurrent Painful Ophthalmoplegic Neuropathy (RPON), and 10 had diabetic ophthalmoparesis (DO). 7 of 11 patients with THS met the International Classification Headache Disorders 3rd edition (ICHD-3 beta) criteria, 4 were with a normal MRI, and 1 had a recurrence. 9 of 10 patients with benign/secondary tumours causes were malignant, and 7 died due to disease progression during the treatment process. One of ten patient was followed with diabetic ophthalmoparesis and was diagnosed with cavernous sinus involvement of B-cell lymphoma as a result of clinical progression during follow-up. Painful ophthalmoplegia is a complex clinical condition with a broad differential diagnosis with malignant and benign etiologies. A detailed clinical examination, imaging, and long-term follow-up are essential for accurate diagnosis and treatment management.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"48 5","pages":"338-347"},"PeriodicalIF":0.8,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11321404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seven, a Magic Number. 七，一个神奇的数字

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Neuro-Ophthalmology Pub Date : 2024-02-12 eCollection Date: 2024-01-01 DOI: 10.1080/01658107.2024.2314194

Dan Milea

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Ave Atque Vale. Ave Atque Vale.

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Neuro-Ophthalmology Pub Date : 2024-02-12 eCollection Date: 2024-01-01 DOI: 10.1080/01658107.2024.2305810

Walter M Jay

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Correction. 更正。

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Neuro-Ophthalmology Pub Date : 2024-02-12 eCollection Date: 2024-01-01 DOI: 10.1080/01658107.2024.2313445

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Meningeal Carcinomatosis Presenting with Bilateral Loss of Vision 出现双侧视力丧失的脑膜癌瘤病

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Neuro-Ophthalmology Pub Date : 2024-01-08 DOI: 10.1080/01658107.2023.2290537

Ryuta Ohki, Hiromitsu Kunimi, Shingo Hosoda, Tomohiro Okamoto, Yukari Tsuneyoshi, Shunsuke Hayashi, Kaoruko Yoshida, Masatsugu Ueda, K. Negishi

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Thrombolytic Therapy for Central Retinal Artery Occlusion in an Academic Multi-Site Stroke Centre 一家学术性多站点卒中中心的视网膜中央动脉闭塞溶栓疗法

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Neuro-Ophthalmology Pub Date : 2024-01-04 DOI: 10.1080/01658107.2023.2290536

Nour Alhayek, Jacob M. Sobczak, Aimen Vanood, Cumara B. O’Carroll, Bart M. Demaerschalk, John J. Chen, O. Dumitrascu

引用次数: 0