Neuropeptides最新文献_第3页

Trefoil factor 1 (TFF1) reduces cerebral edema and gastric mucosal injury by regulating the EGFR/Src/FAK pathway in an intracerebral hemorrhage rat model 三叶草因子 1（TFF1）通过调节表皮生长因子受体/Src/FAK 通路减轻脑出血大鼠模型的脑水肿和胃黏膜损伤

IF 2.5 3区医学

Neuropeptides Pub Date : 2024-08-03 DOI: 10.1016/j.npep.2024.102460

Chao Huang , Likun Wang , Guofeng Wu

{"title":"Trefoil factor 1 (TFF1) reduces cerebral edema and gastric mucosal injury by regulating the EGFR/Src/FAK pathway in an intracerebral hemorrhage rat model","authors":"Chao Huang , Likun Wang , Guofeng Wu","doi":"10.1016/j.npep.2024.102460","DOIUrl":"10.1016/j.npep.2024.102460","url":null,"abstract":"<div><p>The destruction of the blood-brain barrier and damage to the gastrointestinal mucosa after intracerebral hemorrhage (ICH) are important reasons for its high disability and mortality rates. However, the exact etiology is not yet clear. In addition, there are currently no effective treatments for improving cerebral edema and gastric mucosal damage after ICH. Trefoil factor 1 (TFF1) is a secretory protein that plays a crucial role in maintaining the integrity and barrier function of the gastric mucosa, and it has been reported to have a protective effect on brain damage induced by various causes. This study utilized a rat model of ICH induced by type IV collagenase was utilized, and intervened with recombinant TFF1 protein from an external institute to investigate the protective mechanisms of TFF1 against brain edema and gastric mucosal damage after ICH. The results demonstrated that TFF1 alleviated the neurological function and gastric mucosal damage in the rat model of ICH induced by type IV collagenase. TFF1 may ensure the integrity of the blood-brain and gastric mucosal barriers by regulating the EGFR (epidermal growth factor receptor)/Src (non-receptor tyrosine kinase)/FAK (focal adhesion kinase) pathway. Clearly, the disruption of the blood-brain barrier and the destruction of the gastric mucosal barrier are key pathological features of ICH, and TFF1 can improve the progression of blood-brain barrier and gastric mucosal barrier disruption in ICH by regulating the EGFR/Src/FAK pathway. Therefore, TFF1 may be a potential target for the treatment of ICH.</p></div>","PeriodicalId":19254,"journal":{"name":"Neuropeptides","volume":"107 ","pages":"Article 102460"},"PeriodicalIF":2.5,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0143417924000593/pdfft?md5=e91a9ee599634bd01394d82cfcaedaf9&pid=1-s2.0-S0143417924000593-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141978268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The protective effects of orexin B in neuropathic pain by suppressing inflammatory response 奥曲肽 B 通过抑制炎症反应对神经病理性疼痛的保护作用

IF 2.5 3区医学

Neuropeptides Pub Date : 2024-07-30 DOI: 10.1016/j.npep.2024.102458

Zuqing Zhu , Gang Chen , Jiangtao He , Yuanting Xu

{"title":"The protective effects of orexin B in neuropathic pain by suppressing inflammatory response","authors":"Zuqing Zhu , Gang Chen , Jiangtao He , Yuanting Xu","doi":"10.1016/j.npep.2024.102458","DOIUrl":"10.1016/j.npep.2024.102458","url":null,"abstract":"<div><p>Chronic pain induced by pathological insults to the sensorimotor system is a typical form of neuropathic pain (NP), and the underlying mechanism is complex. Currently, there are no successful therapeutic interventions for NP. Orexin B is a neuropeptide with a wide range of biological functions. However, the pharmacological function of orexin B in chronic neuropathic pain has been less studied. Here, we aim to examine the neuroprotective effects of orexin B in chronic constriction injury (CCI)- induced NP. Firstly, we found that orexin type 2 receptor (OX2R) but not orexin type 1 receptor (OX1R) was reduced in the spinal cord (SC) of CCI-treated rats. Mechanical withdrawal threshold and thermal withdrawal latency assays display that administration of orexin B clearly ameliorated CCI-evoked neuropathic pain dose-dependently. Notably, orexin B treatment also effectively prevented microglia activation by reducing the levels of IBA1. Additionally, orexin B was also found to suppress the inflammatory response in the SC tissue by reducing the levels of IL-6, TNF-α, iNOS, and COX-2 as well as the production of NO and PGE<sub>2</sub> in CCI-treated rats. Furthermore, orexin B administration attenuated oxidative stress (OS) by increasing the activity of SOD and the levels of GSH. Mechanically, orexin B prevented activation of JNK/NF-κB signaling in the SC of CCI-treated rats. Based on these findings, we conclude that orexin B might have a promising role in ameliorating CCI-evoked neuropathic pain through the inhibition of microglial activation and inflammatory response.</p></div>","PeriodicalId":19254,"journal":{"name":"Neuropeptides","volume":"108 ","pages":"Article 102458"},"PeriodicalIF":2.5,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142162195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress on the protection and mechanism of active peptides in Alzheimer's disease and Parkinson's disease 关于阿尔茨海默病和帕金森病中活性肽的保护作用和机制的研究进展。

IF 2.5 3区医学

Neuropeptides Pub Date : 2024-07-25 DOI: 10.1016/j.npep.2024.102457

Xuying Ding , Yutong Chen , Xiaojun Zhang , Yanming Duan , Guojing Yuan , Chang Liu

{"title":"Research progress on the protection and mechanism of active peptides in Alzheimer's disease and Parkinson's disease","authors":"Xuying Ding , Yutong Chen , Xiaojun Zhang , Yanming Duan , Guojing Yuan , Chang Liu","doi":"10.1016/j.npep.2024.102457","DOIUrl":"10.1016/j.npep.2024.102457","url":null,"abstract":"<div><p>Neurodegenerative diseases are the main causes of death and morbidity among elderly people worldwide. From the pathological point of view, oxidative stress, neuroinflammation, mitochondrial damage and apoptosis are the causes of neuronal diseases, and play a harmful role in the process of neuronal cell death and neurodegeneration. The most common neurodegenerative diseases are Alzheimer's disease(AD) and Parkinson's disease(PD), and there is no effective treatment. The physiological role of active peptides in the human body is significant. Modern medical research has found that animal and plant peptides, natural peptides in human body, can act on the central nervous system, and their active components can improve learning and memory ability, and play the roles of antioxidation, anti-inflammation, anti-apoptosis and maintaining the structure and function of mitochondria. This review reviews the reports on neurodegenerative diseases such as AD and PD by active peptides from animals and plants and natural peptides from the human body, and summarizes the neuroprotective mechanism of peptides. A theoretical basis for further research and development of active peptides was provided by examining the research and application of peptides, which provided a theoretical basis for further research and development.</p></div>","PeriodicalId":19254,"journal":{"name":"Neuropeptides","volume":"107 ","pages":"Article 102457"},"PeriodicalIF":2.5,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biochemical characterization of Prokineticin 2 binding to Prokineticin receptor 1 in zebrafish 斑马鱼促红细胞生成素 2 与促红细胞生成素受体 1 结合的生化特征

IF 2.5 3区医学

Neuropeptides Pub Date : 2024-07-25 DOI: 10.1016/j.npep.2024.102456

Roberta Lattanzi , Maria Rosaria Fullone , Alessio De Biase , Daniela Maftei , Martina Vincenzi , Rossella Miele

{"title":"Biochemical characterization of Prokineticin 2 binding to Prokineticin receptor 1 in zebrafish","authors":"Roberta Lattanzi , Maria Rosaria Fullone , Alessio De Biase , Daniela Maftei , Martina Vincenzi , Rossella Miele","doi":"10.1016/j.npep.2024.102456","DOIUrl":"10.1016/j.npep.2024.102456","url":null,"abstract":"<div><p>Prokineticin 2 (PK2) binds to prokineticin receptor 1 and prokineticin receptor 2 (PKR1 and PKR2, respectively), two G protein-coupled receptors (GPCRs) that can mediate multiple signalling pathways by promoting the elevation of intracellular calcium and cAMP levels, phosphorylation of Akt and activation of ERK and STAT3. This work aims to evidence the conservation of protein sequence and the mechanism of PK2 binding to PKR1 to use the zebrafish model for the identification of new drugs as targets of prokineticin receptors. To this end, we first demonstrated that the zebrafish genes <em>pk2</em> and <em>pkr1</em> are phylogenetically related to orthologous mammalian genes by constructing evolutionary trees and performing syntenic analyses. Subsequently, by comparing the amino acid sequences, we showed that the interaction sites with PK2 are conserved in the zPKR1. Using GST pull-down and cross-linking experiments, we demonstrated the crucial role of the N-terminal region of zPKR1 for binding to the PK2. Finally, by expressing zPKR1 in CHO cells, we demonstrated the ability of zPKR1 to induce the activation of ERK and STAT3.</p></div>","PeriodicalId":19254,"journal":{"name":"Neuropeptides","volume":"107 ","pages":"Article 102456"},"PeriodicalIF":2.5,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141842171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bromelain decreases oxidative stress and Neuroinflammation and improves motor function in adult male rats with cerebellar Ataxia induced by 3-acetylpyridine 菠萝蛋白酶能降低氧化应激和神经炎症，改善 3-乙酰基吡啶诱发的小脑共济失调成年雄性大鼠的运动功能

IF 2.5 3区医学

Neuropeptides Pub Date : 2024-07-23 DOI: 10.1016/j.npep.2024.102455

Reza Bahar , Maryam Jahani Chegeni , Azin Tahvildari , Mojtaba Sani , Yaser Khakpour , Maryam Hashemabady , Mastooreh Sagharichi , Nika Balaghirad , Mohammad Taghizadeh , Maryam Mehranpour , Amir-Hossein Bayat , Mobina Fathi , Kimia Vakili , Susan Roustaee , Seyedeh Naghmeh Nourirad , Mohammad Reza Babaei , Abbas Aliaghaei , Neda Eskandari , Hormoz Lahiji

{"title":"Bromelain decreases oxidative stress and Neuroinflammation and improves motor function in adult male rats with cerebellar Ataxia induced by 3-acetylpyridine","authors":"Reza Bahar , Maryam Jahani Chegeni , Azin Tahvildari , Mojtaba Sani , Yaser Khakpour , Maryam Hashemabady , Mastooreh Sagharichi , Nika Balaghirad , Mohammad Taghizadeh , Maryam Mehranpour , Amir-Hossein Bayat , Mobina Fathi , Kimia Vakili , Susan Roustaee , Seyedeh Naghmeh Nourirad , Mohammad Reza Babaei , Abbas Aliaghaei , Neda Eskandari , Hormoz Lahiji","doi":"10.1016/j.npep.2024.102455","DOIUrl":"10.1016/j.npep.2024.102455","url":null,"abstract":"<div><p>Bromelain is a plant-based molecule with antioxidant, antithrombotic, anticancer, and anti-inflammatory properties. Bromelain has been shown to reduce the release of inflammatory cytokines. This study aimed to determine whether bromelain can prevent ataxia in rats caused by 3-acetylpyridine (3-AP). Thirty-six albino rats were divided into the control, 3-AP, and 3-AP + Brom groups. In the 3-AP + Brom group, bromelain was injected intraperitoneally at 40 mg/kg daily for 30 days. Various techniques such as rotarod, electromyography (EMG), elevated plus maze, IHC, and Sholl analysis were used to evaluate the possible effects of bromelain on cerebellar neurons and glial cells. The results demonstrated significant improvements in most of the 3-AP + Brom, including motor coordination, neuromuscular response, anxiety, oxidative capacity, microgliosis, astrogliosis, cell death, and morphological variables compared to the 3-AP group. The mechanism of action of bromelain in restoring cerebellar ataxia needs further investigation, but it may be a candidate to help restore degeneration in animals with ataxia.</p></div>","PeriodicalId":19254,"journal":{"name":"Neuropeptides","volume":"107 ","pages":"Article 102455"},"PeriodicalIF":2.5,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141779570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemogenetic activation ofarcuate nucleus NPY and NPY/AgRP neurons increases feeding behaviour in mice 用化学方法激活阿尔卡特核NPY和NPY/AgRP神经元可增加小鼠的摄食行为

IF 2.5 3区医学

Neuropeptides Pub Date : 2024-07-03 DOI: 10.1016/j.npep.2024.102454

Neda Rafiei , Caitlin S. Mitchell , Caitlin R. Tedesco , Jessica Chen , Eun A. Choi , Stephanie Roughley , Philip Jean-Richard-dit-Bressel , Natasha N. Kumar , Gavan P. McNally , Herbert Herzog , Denovan P. Begg

{"title":"Chemogenetic activation ofarcuate nucleus NPY and NPY/AgRP neurons increases feeding behaviour in mice","authors":"Neda Rafiei , Caitlin S. Mitchell , Caitlin R. Tedesco , Jessica Chen , Eun A. Choi , Stephanie Roughley , Philip Jean-Richard-dit-Bressel , Natasha N. Kumar , Gavan P. McNally , Herbert Herzog , Denovan P. Begg","doi":"10.1016/j.npep.2024.102454","DOIUrl":"https://doi.org/10.1016/j.npep.2024.102454","url":null,"abstract":"<div><p>Neuropeptide Y (NPY) plays a crucial role in controlling energy homeostasis and feeding behaviour. The role of NPY neurons located in the arcuate nucleus of the hypothalamus (Arc) in responding to homeostatic signals has been the focus of much investigation, but most studies have used AgRP promoter-driven models, which do not fully encompass Arc NPY neurons. To directly investigate NPY-expressing versus AgRP-expressing Arc neurons function, we utilised chemogenetic techniques in NPY-Cre and AgRP-Cre animals to activate Arc NPY or AgRP neurons in the presence of food and food-related stimuli. Our findings suggest that chemogenetic activation of the broader population of Arc NPY neurons, including AgRP-positive and AgRP-negative NPY neurons, has equivalent effects on feeding behaviour as activation of Arc AgRP neurons. Our results demonstrate that these Arc NPY neurons respond specifically to caloric signals and do not respond to non-caloric signals, in line with what has been observed in AgRP neurons. Activating Arc NPY neurons significantly increases food consumption and influences macronutrient selection to prefer fat intake.</p></div>","PeriodicalId":19254,"journal":{"name":"Neuropeptides","volume":"107 ","pages":"Article 102454"},"PeriodicalIF":2.5,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141543415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute sleep deprivation (ASD) and cardioprotection: Impact of ASD on oxytocin-mediated sympathetic nervous activation preceding myocardial infarction 急性剥夺睡眠（ASD）与心脏保护：急性睡眠剥夺对心肌梗死前催产素介导的交感神经激活的影响。

IF 2.5 3区医学

Neuropeptides Pub Date : 2024-06-27 DOI: 10.1016/j.npep.2024.102453

Marjan Aghajani , Mozhgan Aghajani , Ehsan Kazemi Moghaddam , Mahdieh Faghihi , Alireza Imani

{"title":"Acute sleep deprivation (ASD) and cardioprotection: Impact of ASD on oxytocin-mediated sympathetic nervous activation preceding myocardial infarction","authors":"Marjan Aghajani , Mozhgan Aghajani , Ehsan Kazemi Moghaddam , Mahdieh Faghihi , Alireza Imani","doi":"10.1016/j.npep.2024.102453","DOIUrl":"10.1016/j.npep.2024.102453","url":null,"abstract":"<div><h3>Introduction</h3><p>This study explored how acute sleep deprivation (ASD) before myocardial ischemia influences oxytocin release from paraventricular (PVN) neurons and its correlation with sympathetic nervous system (SNS) activity post-acute sleep loss, impacting subsequent left ventricular (LV) remodeling following myocardial infarction (MI).</p></div><div><h3>Methods</h3><p>The study was conducted in two phases: induction of ASD, inducing MI, blood sampling, euthanizing animals and collecting their heart and brain for histological and gene expression evaluations. The animals in first and second phase were euthanized 24 h and 14 days after MI, respectively.</p></div><div><h3>Results</h3><p>Pre-MI ASD, accompanied by increased serum epinephrine levels within 24 h of MI, upregulated oxytocin and cFos expression in the PVN. Also, pre-MI ASD resulted in decreased serum PAB levels 14 days post-MI (<em>P</em> < 0.001). While notable echocardiographic changes were seen in MI versus sham groups, ASD demonstrated protective effects. This was evidenced by reduced infarct size, elevated TIMP1, MMP2, and MMP9 in the LV of SD + MI animals versus MI alone (<em>P</em> < 0.05). Additionally, histological analysis showed reduced LV fibrosis in pre-MI ASD subjects (P < 0.05).</p></div><div><h3>Conclusion</h3><p>Our study supports the notion that activation of oxytocin neurons within the PVN subsequent to ASD interacts with autonomic centers in the central nervous system. This enhanced sympathetic outflow to the heart prior to MI triggers a preconditioning response, thereby mediating cardioprotection through decreased oxidative stress biomarkers and regulated extracellular matrix (ECM) turnover.</p></div>","PeriodicalId":19254,"journal":{"name":"Neuropeptides","volume":"107 ","pages":"Article 102453"},"PeriodicalIF":2.5,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liangxue Tongyu prescription attenuates neuroinflammation by increasing cholecystokinin octapeptide in acute intracerebral hemorrhage rats 良药通瘀方通过增加胆囊收缩素八肽减轻急性脑出血大鼠的神经炎症反应

IF 2.5 3区医学

Neuropeptides Pub Date : 2024-06-24 DOI: 10.1016/j.npep.2024.102452

Jianxiang Li , Yingying Sun , Wenzhe Qiu , Yu Zhou , Dandan Zhou , Yang Zhao , Anlan Liu , Yuan Yuan , Weifeng Guo

{"title":"Liangxue Tongyu prescription attenuates neuroinflammation by increasing cholecystokinin octapeptide in acute intracerebral hemorrhage rats","authors":"Jianxiang Li , Yingying Sun , Wenzhe Qiu , Yu Zhou , Dandan Zhou , Yang Zhao , Anlan Liu , Yuan Yuan , Weifeng Guo","doi":"10.1016/j.npep.2024.102452","DOIUrl":"10.1016/j.npep.2024.102452","url":null,"abstract":"<div><p>Inflammatory reactions after acute intracerebral hemorrhage (AICH) contribute significantly to a poor prognosis. Liangxue Tongyu Prescription (LTP) has been proven to be clinically effective in treating AICH. Numerous studies have shown that LTP suppresses brain inflammatory damage in AICH, while the internal mechanisms underlying its action remain unclear. The aim of this study was to verify the anti-inflammatory effects of LTP on an AICH rat model and investigate the potential mechanisms. The AICH rat models were created by injecting autologous blood into the right caudate nucleus. LTP markedly decreased cerebral hematoma and brain water content and recovered from neurological deficits. Meanwhile, LTP prevented microglial activation and reduced the inflammatory reaction caused by pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6). Notably, the expression of cholecystokinin octapeptide (CCK-8) in the brain and intestine was increased by LTP or CCK-8 treatment. LTP further suppressed nuclear factor kappa B (NF-κB) in the brains of rats with AICH. Moreover, LTP increased the protein and mRNA expression of Occludin and Claudin-1 in the intestine and decreased the levels of lipopolysaccharide (LPS) and diamine oxidase (DAO) in serum. Furthermore, the results showed that LTP increased the protein and mRNA expression of Claudin-5 and zonula occludens-1 (ZO-1) in the brain. CCK-8 receptor antagonists increased the expression of NF-κB and the concentration of pro-inflammatory cytokines. These findings suggested that LTP attenuated neuroinflammation by increasing CCK-8 in the brain and intestine, and its mechanism might be related to alterations in the gut-brain axis (GBA).</p></div>","PeriodicalId":19254,"journal":{"name":"Neuropeptides","volume":"107 ","pages":"Article 102452"},"PeriodicalIF":2.5,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bezafibrate protects blood-brain barrier (BBB) integrity against traumatic brain injury mediated by AMPK 贝扎贝特能在 AMPK 的介导下保护血脑屏障（BBB）的完整性，防止脑外伤。

IF 2.5 3区医学

Neuropeptides Pub Date : 2024-06-22 DOI: 10.1016/j.npep.2024.102450

Xiubao Yang, Qingyong Chang, Yan Wang, Shicang Dong, Kai Qu

{"title":"Bezafibrate protects blood-brain barrier (BBB) integrity against traumatic brain injury mediated by AMPK","authors":"Xiubao Yang, Qingyong Chang, Yan Wang, Shicang Dong, Kai Qu","doi":"10.1016/j.npep.2024.102450","DOIUrl":"10.1016/j.npep.2024.102450","url":null,"abstract":"<div><p>Bezafibrate (BEZ) has displayed a wide range of neuroprotective effects in different types of neurological diseases. However, its pharmacological function in traumatic brain injury (TBI) is still unknown. In the current study, a TBI model was constructed in mice to examine the potential beneficial roles of BEZ. After TBI, mice were daily dieted with BEZ or vehicle solution. The motor function, learning and memory, brain edema, vascular inflammatory factors, the integrity of the blood-brain barrier (BBB), and the expression of the tight junction zona occludens 1 (ZO-1) were assessed. The findings demonstrate that after TBI, BEZ treatment significantly promoted the recovery of motor function and cognitive function deficits. Moreover, BEZ attenuated brain edema by reducing the levels of brain water content. We also found that administration of BEZ alleviated cerebral vascular pro-inflammation by suppressing the expression of ICAM-1, VCAM-1, and <em>E</em>-selectin. Notably, BEZ improved the impaired BBB integrity in TBI mice by restoring the expression of the tight junction (TJ) protein ZO-1. Further in vitro experiments show that treatment with BEZ prevented the aggravation of endothelial permeability and restored the reduction of trans-epithelial electrical resistance (TEER) as well as the expression of ZO-1 in TBI-exposed brain bEnd.3 cells. Mechanistically, we prove that the protective effects of BEZ are mediated by AMPK. Based on these findings, we conclude that BEZ improves TBI-induced BBB injury and it might be considered for the treatment or management of TBI.</p></div>","PeriodicalId":19254,"journal":{"name":"Neuropeptides","volume":"107 ","pages":"Article 102450"},"PeriodicalIF":2.5,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bee venom as a promising therapeutic strategy in central nervous system diseases 蜂毒是一种治疗中枢神经系统疾病的有效方法。

IF 2.5 3区医学

Neuropeptides Pub Date : 2024-06-22 DOI: 10.1016/j.npep.2024.102451

Zeinab Vahidinia , Shirin Barati , Abolfazl Azami Tameh , Saeid Bagheri-Mohammadi , Ali Garshasebi

{"title":"Bee venom as a promising therapeutic strategy in central nervous system diseases","authors":"Zeinab Vahidinia , Shirin Barati , Abolfazl Azami Tameh , Saeid Bagheri-Mohammadi , Ali Garshasebi","doi":"10.1016/j.npep.2024.102451","DOIUrl":"10.1016/j.npep.2024.102451","url":null,"abstract":"<div><p>Central nervous system (CNS) disorders are one of the leading health problems today, accounting for a large proportion of global morbidity and mortality. Most these disorders are characterized by high levels of oxidative stress and intense inflammatory responses in degenerated neuronal tissues. While extensive research has been conducted on CNS diseases, but few breakthroughs have been made in treatment methods. To date, there are no disease-modifying drugs available for CNS treatment, underscoring the urgent need for finding effective medications. Bee venom (BV), which is produced by honeybee workers' stingers, has been a subject of interest and study across various cultures. Over the past few decades, extensive research has focused on BV and its therapeutic potentials. BV consists a variety of substances, mainly proteins and peptides like melittin and phospholipase A2 (PLA2). Research has proven that BV is effective in various medical conditions, including pain, arthritis and inflammation and CNS disorders such as Multiple sclerosis, Alzheimer's disease and Parkinson's disease. This review provides a comprehensive overview of the existing knowledge concerning the therapeutic effects of BV and its primary compounds on various CNS diseases. Additionally, we aim to shed light on the potential cellular and molecular mechanisms underlying these effects.</p></div>","PeriodicalId":19254,"journal":{"name":"Neuropeptides","volume":"107 ","pages":"Article 102451"},"PeriodicalIF":2.5,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0