Nuklearmedizin-nuclear Medicine最新文献

{"title":"Resveratrol treatment does not reduce arterial inflammation in males at risk of type 2 diabetes: a randomized crossover trial.","authors":"Ellen Boswijk,&nbsp;Marlies de Ligt,&nbsp;Marie-Fleur J Habets,&nbsp;Alma M A Mingels,&nbsp;Wouter D van Marken Lichtenbelt,&nbsp;Felix M Mottaghy,&nbsp;Patrick Schrauwen,&nbsp;Joachim E Wildberger,&nbsp;Jan Bucerius","doi":"10.1055/a-1585-7215","DOIUrl":"https://doi.org/10.1055/a-1585-7215","url":null,"abstract":"<p><strong>Purpose: </strong>Resveratrol has shown promising anti-inflammatory effects in in vitro and animal studies. We aimed to investigate this effect on arterial inflammation in vivo.</p><p><strong>Methods: </strong>This was an additional analysis of a double-blind randomized crossover trial which included eight male subjects with decreased insulin sensitivity who underwent an ¹⁸F-fluoroxyglucose (¹⁸F-FDG) PET/CT after 34 days of placebo and resveratrol treatment (150 mg/day). ¹⁸F-FDG uptake was analyzed in the carotid arteries and the aorta, adipose tissue regions, spleen, and bone marrow as measures for arterial and systemic inflammation. Maximum target-to-background ratios (TBR_max) were compared between resveratrol and placebo treatment with the non-parametric Wilcoxon signed-rank test. Median values are shown with their interquartile range.</p><p><strong>Results: </strong>Arterial ¹⁸F-FDG uptake was non-significantly higher after resveratrol treatment (TBR_max all vessels 1.7 (1.6-1.7)) in comparison to placebo treatment (1.5 (1.4-1.6); p=0.050). Only in visceral adipose tissue, the increase in ¹⁸F-FDG uptake after resveratrol reached statistical significance (p=0.024). Furthermore, CRP-levels were not significantly affected by resveratrol treatment (p=0.091).</p><p><strong>Conclusions: </strong>Resveratrol failed to attenuate arterial or systemic inflammation as measured with ¹⁸F-FDG PET in subjects at risk of developing type 2 diabetes. However, validation of these findings in larger human studies is needed.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"61 1","pages":"33-41"},"PeriodicalIF":1.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39846663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aggressive systemic mastocytosis with diffuse bone marrow 18F-FDG uptake.","authors":"Renata Koukalová,&nbsp;Jiří Vašina,&nbsp;Jiří Štika,&nbsp;Michael Doubek,&nbsp;Petr Szturz","doi":"10.1055/a-1650-9704","DOIUrl":"https://doi.org/10.1055/a-1650-9704","url":null,"abstract":"<p><p>Mastocytosis is a clonal hematopoietic disorder characterized by proliferation of abnormal mast cells in various organs including the skin, digestive system, lymph nodes, and bone marrow. We report on a 75-year-old woman presenting with abdominal pain, vomiting, diarrhoea, myalgia, and weight loss. Abdominal CT showed hepatosplenomegaly with heterogeneous splenic parenchyma, lymphadenopathy, and osteopenia with areas of osteosclerosis but no primary tumour. An ¹⁸F-FDG PET/CT revealed an overall low metabolic activity of the lesions with a diffuse bone marrow involvement raising suspicion of a haematological neoplasm. Subsequently, bone marrow and peripheral blood examinations confirmed the diagnosis of aggressive systemic mastocytosis.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"61 1","pages":"58-61"},"PeriodicalIF":1.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39678364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teaching of Nuclear Cardiology in Times of Pandemic: Transfer of a Case-based Interactive Course from Classroom to Distance Learning.","authors":"Laura Bell,&nbsp;Martin Lemos,&nbsp;Felix M Mottaghy,&nbsp;Oliver Lindner,&nbsp;Alexander Heinzel","doi":"10.1055/a-1697-7795","DOIUrl":"https://doi.org/10.1055/a-1697-7795","url":null,"abstract":"<p><strong>Aim: </strong>While methods of independent study, such as problem-based learning, have been shown beneficial to students' learning outcome and motivation to self-educate, these concepts are currently challenged by the pandemic. The aim of the current study was the evaluation of the transfer of an interactive nuclear cardiology teaching module to an online, distance learning setting<i>.</i> METHODS: Two-hundred-forty medical students completed and evaluated the teaching module in a classroom and 127 students in the distance learning setting.</p><p><strong>Results: </strong>The interactive, problem-based teaching module was transferred well into the distance learning setting during the pandemic. However, while the presented results suggest that distance learning is a good substitute for classroom teaching when in-person teaching is not possible, the distance teaching module was perceived less efficient in its course didactics, demands as well as applicability than the same module in a classroom setting.</p><p><strong>Conclusion: </strong>Although distance learning thus cannot entirely replace classroom education, it does provide a well-suited alternative method to teach particularly nuclear medicine and medicine in general. Future applications should offer introductory sessions, provide learning materials in advance and slow down the teaching pace to facilitate online, distance learning.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"61 1","pages":"6-15"},"PeriodicalIF":1.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39889484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Diagnostic Value of Bone SPECT/CT Using 99mTc-Methylene Diphosphonate in Patients with Unspecified Chest Wall Pain.","authors":"Soo Bin Park, Chae Hong Lim, Won Ho Chang, Jung Hwa Hwang, Ji Young Lee, Young Hwan Kim, Jung Mi Park","doi":"10.1055/a-1728-8828","DOIUrl":"10.1055/a-1728-8828","url":null,"abstract":"","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39847023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No association of Brain-derived neurotrophic factor with striatal dopamine transporter availability in healthy subjects.","authors":"Hyun-Yeol Nam,&nbsp;Seongho Seo,&nbsp;Myung Jun Lee,&nbsp;Keunyoung Kim,&nbsp;In Joo Kim,&nbsp;Kyoungjune Pak","doi":"10.1055/a-1521-8572","DOIUrl":"https://doi.org/10.1055/a-1521-8572","url":null,"abstract":"<p><strong>Objective: </strong>Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays a key role in brain plasticity, synaptic function, neuronal survival, learning, and memory formation. We aimed to investigate the association of BDNF with dopamine transporter (DAT) availabilities measured by positron emission tomography (PET) in healthy subjects.</p><p><strong>Methods: </strong>Thirty-five healthy, male subjects without brain injury, neuropsychological disorders were included in this study. The emission data were acquired over 90 mins with 50 frames after injection of 18F-FP-CIT using PET. Binding potentials (BP_NDs) of ventral striatum (VST), caudate nucleus, putamen were measured with the simplified reference tissue method. The serum BDNF level (pg/mL) was measured through enzyme-linked immunosorbent assay method.</p><p><strong>Results: </strong>Thirty-five healthy males with a mean age of 24.4 ± 2.7 years were included in this study. Multiple regression was done to investigate the association between striatal BPNDs from VST, caudate nucleus, putamen and serum BDNF after adjusting for age. None of striatal BPNDs from VST (p=0.8450), caudate nucleus (p=0.4783), and putamen (p=0.7994) were associated with serum BDNF.</p><p><strong>Conclusion: </strong>Striatal DAT availabilities measured from PET were not associated with the serum BDNF in healthy subjects.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"60 6","pages":"434-437"},"PeriodicalIF":1.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9983580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of PET imaging for radiation therapy.","authors":"Constantin Lapa,&nbsp;Ursula Nestle,&nbsp;Nathalie L Albert,&nbsp;Christian Baues,&nbsp;Ambros Beer,&nbsp;Andreas Buck,&nbsp;Volker Budach,&nbsp;Rebecca Bütof,&nbsp;Stephanie E Combs,&nbsp;Thorsten Derlin,&nbsp;Matthias Eiber,&nbsp;Wolfgang P Fendler,&nbsp;Christian Furth,&nbsp;Cihan Gani,&nbsp;Eleni Gkika,&nbsp;Anca L Grosu,&nbsp;Christoph Henkenberens,&nbsp;Harun Ilhan,&nbsp;Steffen Löck,&nbsp;Simone Marnitz-Schulze,&nbsp;Matthias Miederer,&nbsp;Michael Mix,&nbsp;Nils H Nicolay,&nbsp;Maximilian Niyazi,&nbsp;Christoph Pöttgen,&nbsp;Claus M Rödel,&nbsp;Imke Schatka,&nbsp;Sarah M Schwarzenboeck,&nbsp;Andrei S Todica,&nbsp;Wolfgang Weber,&nbsp;Simone Wegen,&nbsp;Thomas Wiegel,&nbsp;Constantinos Zamboglou,&nbsp;Daniel Zips,&nbsp;Klaus Zöphel,&nbsp;Sebastian Zschaeck,&nbsp;Daniela Thorwarth,&nbsp;Esther G C Troost","doi":"10.1055/a-1525-7029","DOIUrl":"https://doi.org/10.1055/a-1525-7029","url":null,"abstract":"<p><p>This comprehensive review written by experts in their field gives an overview on the current status of incorporating positron emission tomography (PET) into radiation treatment planning. Moreover, it highlights ongoing studies for treatment individualisation and per-treatment tumour response monitoring for various primary tumours. Novel tracers and image analysis methods are discussed. The authors believe this contribution to be of crucial value for experts in the field as well as for policy makers deciding on the reimbursement of this powerful imaging modality.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"60 5","pages":"326-343"},"PeriodicalIF":1.5,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/a-1525-7029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39183507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Absorbed Dose Evaluation of [177Lu]Lu-IBA as a Bone Palliative Candidate.","authors":"Hassan Ranjbar,&nbsp;Zahra Pourhabib","doi":"10.1055/a-1486-3683","DOIUrl":"https://doi.org/10.1055/a-1486-3683","url":null,"abstract":"<p><p>The role of lutetium-177 among bone-seeking radionuclides in targeted therapy is noteworthy. The clinical pharmacokinetics of ibandronate (IBA) indicates that this bisphonate has powerful bone mineral affinity. The aim of this study was to evaluate of [¹⁷⁷Lu]Lu-IBA efficacy as a new compound.The [¹⁷⁷Lu]Lu-IBA was prepared by radiolabeling of IBA ligand to ¹⁷⁷LuCl3 that was obtained by thermal neutron irradiation of enriched Lu2O3 sample. Produced [¹⁷⁷Lu]Lu-IBA with high radiochemical purity was administered intravenously to mice. Biodistribution data were collected at 1, 4, 24, 48 h and 7 d post injections. With calculating accumulated activities in each organ and extrapolating mouse's organs to human's organs by the RADAR method and using OLINDA/EXM software the injected dose in various human organs was achieved.[¹⁷⁷Lu]Lu-IBA was produced with radiochemical purity nearly 96 %. Its biodistribution data showed the high uptake and durability in the skeletal tissues without significant uptake in other major organs.The results showed that [¹⁷⁷Lu]Lu-IBA has considerably good properties as a bone-seeking radiopharmaceutical and therefore can be a candidate for bone pain palliative therapy in skeletal metastases; however, further biological studies are still needed.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"60 5","pages":"375-380"},"PeriodicalIF":1.5,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39074870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI in nuclear medicine - what, why and how?","authors":"Julian Manuel Michael Rogasch,&nbsp;Tobias Penzkofer","doi":"10.1055/a-1542-6231","DOIUrl":"https://doi.org/10.1055/a-1542-6231","url":null,"abstract":"There have been various attempts to define artificial intelligence (AI), and none is sufficiently precise but at the same time universally applicable. However, in the context of medical imaging, the term machine learning (ML), which is generally considered a subset of AI [1], may describe most applications more appropriately. Here, “learning” relates to the capability of systems to identify complex relationships between data and to predict outcomes in new and unknown data with similar characteristics. With the computing power available today, ML has advanced from classical ML methods, such as decision trees or support vector machines, to more complex architectures, such as deep learning. This uses “deep” artificial neural networks, which are characterized by multiple layers of artificial neurons [2]. In several applications in medical imaging, deep learning has been found to be equivalent or superior to classical ML methods [3, 4, 5], and it is now the most commonly used ML approach for such tasks. Deep neural networks, and especially convolutional neural networks (yet another subset), are inherently useful for the numerous “visual tasks” involved in image analysis.","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"60 5","pages":"321-324"},"PeriodicalIF":1.5,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39485354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auszeichnungen: Professor Martin Freesmeyer „Kliniker des Jahres 2020“ der Medizinischen Fakultät Jena.","authors":"","doi":"10.1055/a-1593-5433","DOIUrl":"https://doi.org/10.1055/a-1593-5433","url":null,"abstract":"Prof. Dr. Martin Freesmeyer, Chefarzt der Klinik für Nuklearmedizin am Universitätsklinikum Jena, ist erneut von den Studenten mit einem Preis für seine Lehre ausgezeichnet worden. Er wurde zum „Kliniker des Jahres 2020“ gewählt (▶ Abb. 1). Der traditionsreiche Preis wird von den Studierenden des jeweiligen 9./10. Fachsemesters verliehen. Die Studenten würdigten mit der Auszeichnung insbesondere sein kreatives Lehrengagement in Zusammenhang mit der Corona-Pandemie. Professor Freesmeyer habe gezeigt, dass gute Lehre auch in einer Zeit mit maximaler Reduzierung der zwischenmenschlichen Kontakte möglich sei.","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"60 5","pages":"386"},"PeriodicalIF":1.5,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39485358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibroblast activation protein inhibitor (FAPi) positive tumour fraction on PET/CT correlates with Ki-67 in liver metastases of neuroendocrine tumours.","authors":"Barbara Kreppel,&nbsp;Maria Angeles Gonzalez-Carmona,&nbsp;Georg Feldmann,&nbsp;Jim Küppers,&nbsp;Euy Sung Moon,&nbsp;Milka Marinova,&nbsp;Ralph Alexander Bundschuh,&nbsp;Glen Kristiansen,&nbsp;Markus Essler,&nbsp;Frank Roesch,&nbsp;Florian Christoph Gaertner","doi":"10.1055/a-1521-8604","DOIUrl":"https://doi.org/10.1055/a-1521-8604","url":null,"abstract":"<p><strong>Aim: </strong>Gallium-68-labelled inhibitors of the fibroblast activation protein (FAPi) enable positron emission tomography/computed tomography (PET/CT) imaging of fibroblast activation. We evaluated if [⁶⁸Ga]Ga-DATA5m.SA.FAPi PET/CT is related to Ki-67 as a marker of tumour aggressiveness in patients with liver metastases of NET.</p><p><strong>Methods: </strong>Thirteen patients with liver metastases of a histologically confirmed NET who underwent PET/CT with [⁶⁸Ga]Ga-DATA5m.SA.FAPi, [18F]FDG and [⁶⁸Ga]Ga-DOTA-TOC were retrospectively analyzed. PET-positive liver tumour volumes were segmented for calculation of volume, SUVmax and PET-positive tumour fraction (TF). PET parameters were correlated with Ki-67.</p><p><strong>Results: </strong>FDG_SUVmax correlated positively (rho = 0.543, p < 0.05) and DOTATOC_SUVmax correlated negatively (rho = -0.618, p < 0.05) with Ki-67, the correlation coefficients were in the moderate range. There was no significant correlation between FAPi_SUVmax and Ki-67 (rho = 0.382, p > 0.05). FAPi_TF correlated positively (rho = 0.770, p < 0.01) and DOTATOC_TF correlated negatively (rho = -0.828, p < 0.01) with Ki-67, both significantly with high correlation coefficients. FDG_TF also correlated significantly with Ki-67, with a moderate correlation coefficient (rho = 0.524, p < 0.05). The ratio FAPi_VOL:DOTATOC_VOL showed a significant and strong correlation with Ki-67 (rho = 0.808, p < 0.01).</p><p><strong>Conclusion: </strong>The ratio FAPi_VOL:DOTATOC_VOL might serve as a clinical parameter for the assessment of dedifferentiation and aggressiveness of liver metastases in patients with NET. [⁶⁸Ga]Ga-DATA5m.SA.FAPi might hold potential for identification of high-risk patients. Further studies are warranted to evaluate its prognostic significance in comparison to [¹⁸F]FDG in patients with NET.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"60 5","pages":"344-354"},"PeriodicalIF":1.5,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39179586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}