Nuklearmedizin-nuclear Medicine最新文献

{"title":"The value of (18)F-FDG PET/CT in Diagnosis and Evaluation of Response to Treatment in Retroperitoneal Fibrosis.","authors":"Mehmet Tarik Tatoglu, Hatice Uslu, Ebru Ibisoglu","doi":"10.1055/a-1429-2237","DOIUrl":"https://doi.org/10.1055/a-1429-2237","url":null,"abstract":"A 34-year-old male patient with abdominal pain and weight loss, without any known chronic disease, was referred to our clinic for Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) scan for malignant etiology due to the detection of a mass lesion in abdominal computed tomography (CT). Sedimentation: 34mm/hour, CRP: 8.3mg/dl, PPD test and sputum ARB test were negative. Abdominal CT showed a mass lesion with soft tissue density extending from the infrarenal level of bilateral iliac artery bifurcation, surrounding the aorta, inferior vena cava, bilateral common iliac veins and ureters, and bilateral Grade 1 hydronephrosis was observed. (18)F-FDG PET/ CT imaging showed intense hypermetabolism with the heterogeneous character in the mass lesion with soft tissue density, which was measured approximately 83 × 61 × 39mm in size on CT sections of the abdomen (SUVmax: 8.7). The appearance was considered in favor of malignancy and histopathological examination was recommended. However, the histopathological examination could not be performed because the patient’s consent could not be obtained. Idiopathic retroperitoneal fibrosis (RF) were considered considering the clinical, laboratory, and imaging findings of the case. Methylprednisolone was started at 64mg/day, the dose was decreased according to the clinical response and discontinued during the sixth month. In the fourth month, 50mg of Azathioprine was added, and patient follow-up continued. After six months of treatment, the patient’s clinical and laboratory findings improved. (18)F-FDG PET/CT examination was performed in terms of control and response to treatment. (18)F-FDG PET/CT showed that the hypermetabolic mass lesion in the retroperitoneal area of the abdomen was metabolically and morphologically completely regressed (▶ Fig. 1). Idiopathic RF is a rare disease also known as Ormond’s disease [1, 2]. RF causes inflammation and fibrosis by surround▶ Fig. 1 Before therapy (18)F-FDG PET/CT axial fusion a, c, e, coronal g sagittal i images show a hypermetabolic mass lesion with soft tissue density extending from infrarenal level to bilateral iliac artery bifurcation, surrounding the aorta, inferior vena cava, bilateral common iliac veins, and ureters, after therapy axial fusion b, d, f, coronal h sagittal j images show the hypermetabolic mass lesion in the retroperitoneal area of the abdomen metabolically and morphologically completely regress. Case Report","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"60 5","pages":"381-382"},"PeriodicalIF":1.5,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25575351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and staging of hepatobiliary malignancies: Potential incremental value of (18)F-FDG-PET/MRI compared to MRI of the liver.","authors":"Verena Carola Obmann,&nbsp;Nils Grosse-Hokamp,&nbsp;Ian Alberts,&nbsp;Nicholas Fulton,&nbsp;Negin Rassouli,&nbsp;Christopher Siegel,&nbsp;Norbert Avril,&nbsp;Karin Anna Herrmann","doi":"10.1055/a-1486-3671","DOIUrl":"https://doi.org/10.1055/a-1486-3671","url":null,"abstract":"<p><strong>Objective: </strong> The purpose of the study was to investigate the potential added value of ¹⁸F-FDG-PET/MRI (functional information derived from PET) over standard diagnostic liver MRI (excellent soft tissue characterization) in diagnosing and staging suspected primary hepatobiliary malignancies including extrahepatic cholangiocarcinoma (ECC), intrahepatic cholangiocellular carcinoma (ICC) and gallbladder cancer (GBCA).</p><p><strong>Methods: </strong> Twenty consecutive patients with suspected hepatobiliary malignancy were included in this retrospective study. All patients underwent combined whole-body (WB) ¹⁸F-FDG-PET/MRI including contrast-enhanced MRI of the liver, contrast-enhanced WB-MRI and WB ¹⁸F-FDG-PET. Two experienced readers staged hepatobiliary disease using TNM criteria: first based on MRI alone and then based on combined ¹⁸F-FDG-PET/MRI. Subsequently, the impact of FDG-PET/MRI on clinical management compared to MRI alone was recorded. Histopathologic proof served as the reference standard.</p><p><strong>Results: </strong> Hepatobiliary neoplasms were present in 16/20 patients (ECC n = 3, ICC n = 8, GBCA n = 5), two patients revealed benign disease, two were excluded. TNM staging with ¹⁸F-FDG-PET/MRI was identical to MRI alone in 11/18 (61.1 %) patients and correctly changed the stage in 4/18 (22.2 %), resulting in a change in management for 2/4 patients (11.1 %). ¹⁸F-FDG-PET/MRI was false-positive in 3/18 cases (16.7 %). Both MRI and ¹⁸F-FDG-PET/MRI were falsely positive in 1 case without malignancy.</p><p><strong>Conclusions: </strong> A small incremental benefit of ¹⁸F-FDG-PET/MRI over standard MRI of the liver was observed. However, in some cases ¹⁸F-FDG-PET/MRI may lead to false-positive findings. Overall there is seemingly limited role of ¹⁸F-FDG-PET/MRI in patients with suspected hepatobiliary malignancy.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"60 5","pages":"355-367"},"PeriodicalIF":1.5,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39074869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nachruf für Prof. Dr. rer. nat. Dr. med. Wolfgang Müller-Schauenburg.","authors":"Wolfgang Burchert,&nbsp;Jörg van den Hoff,&nbsp;Sibylle Ziegler,&nbsp;Lilli Geworski","doi":"10.1055/a-1616-9342","DOIUrl":"https://doi.org/10.1055/a-1616-9342","url":null,"abstract":"Geboren am 2.01.1940 in einer Lehrerfamilie in Berlin, wuchs er in Berlin-Tempelhof auf. Nach seinem Abitur an der Askanischen Oberschule 1959 studierte er zunächst Physik an der TU Berlin (Vordiplom), führte dann in Marburg das Physikstudium fort und promovierte 1967 zum Dr. rer. nat. 1966 begann er das Studium der Humanmedizin in Marburg (Physikum 1968) und setzte dann das klinische Studium in Tübingen fort, welches er 1971 mit dem Staatsexamen abschloss. Die Approbation erfolgte 1972.","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"60 5","pages":"383-384"},"PeriodicalIF":1.5,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39485356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalia.","authors":"","doi":"10.1055/a-1593-5449","DOIUrl":"https://doi.org/10.1055/a-1593-5449","url":null,"abstract":"","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"60 5","pages":"386-387"},"PeriodicalIF":1.5,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39485361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morbidity and quality of life in patients with vulvar cancer after inguinal sentinel lymphadenectomy compared to radical inguinofemoral lymphadenectomy.","authors":"Fabinshy Thangarajah,&nbsp;Kristina Rogeé,&nbsp;Caroline Pahmeyer,&nbsp;Kathrin Kuhr,&nbsp;Matthias Schmidt,&nbsp;Claudius Fridrich,&nbsp;Bernd Morgenstern","doi":"10.1055/a-1491-6405","DOIUrl":"https://doi.org/10.1055/a-1491-6405","url":null,"abstract":"<p><strong>Aim: </strong> Probability of survival of patients with vulvar cancer directly depends on the lymph node status. Surgery of lymph nodes can be performed as radical inguinofemoral lymphadenectomy or in cases with certain conditions as sentinel lymph node surgery. The aim of this study is to obtain an overview of the intervention-related morbidity and quality of life in patients with vulvar carcinoma after lymphadenectomy.</p><p><strong>Methods: </strong> Quality of life and morbidity was compared between patients who underwent radical inguinofemoral lymphadenectomy with those who underwent sentinel lymph node surgery.</p><p><strong>Results: </strong> All recorded postoperative complications occur more frequently in the non-sentinel group, Significant difference was shown for the occurrence of lymphedema (p-value = 0.024) and sensitivity loss (p-value = 0.024). Recurrence of disease was more frequent in the non-sentinel group (38 % vs. 20 %, p = 0.621, n.s.) and satisfaction with groin surgery is slightly higher in the sentinel group (94 % vs. 89 %, p = 1.000, n.s.).</p><p><strong>Conclusion: </strong> We could demonstrate a significantly lower morbidity of sentinel lymphadenectomy compared to conventional inguinofemoral lymphadenectomy while maintaining the same oncological safety. The low morbidity of sentinel- lymphadenectomy does not seem to influence the postoperative quality of life significantly. However, recording of the individual burden of lymphadenectomy by questionnaires should be optimized.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"60 5","pages":"368-374"},"PeriodicalIF":1.5,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39037660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Clinical impact of whole-body 68Ga-PSMA I&T PET/CT: lesion frequency and added benefit in lower extremities.","authors":"Lara Franziska Stolzenbach, Florian Löcherbach, Katharina Wargenau, Randi Pose, Thomas Steuber, Zhe Tian, Lars Budäus, Derya Tilki, Markus Graefen, Daniel Köhler, Pierre I Karakiewicz, Markus Sauer, Ivayla Ilieva Apostolova, Tobias Maurer, Christoph Berliner","doi":"10.1055/a-1626-6669","DOIUrl":"10.1055/a-1626-6669","url":null,"abstract":"","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2021-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39382236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual calculation of perfusion activity based on ventilation efficiency for V/P-SPECT.","authors":"Felix Bärenfänger,&nbsp;Andreas Block,&nbsp;Detlef Schmelz,&nbsp;Monia Hamami-Arlinghaus","doi":"10.1055/a-1429-1832","DOIUrl":"https://doi.org/10.1055/a-1429-1832","url":null,"abstract":"<p><strong>Aim: </strong> Implementation of the individual calculation of perfusion activity to ensure the guideline-compliant ratio of perfusion to ventilation (P/V-ratio) of ≥ 3 in the diagnosis of acute pulmonary embolism (PE) using V/P-SPECT.</p><p><strong>Material and methods: </strong> 50 consecutive V/P-SPECT examinations, in which a standard activity of 160 MBq was applied for perfusion imaging, are evaluated retrospectively. Based on this patient group an activity factor is determined, which provides a correlation between the applied perfusion activity and the expected perfusion counts of the gamma camera. Using the mean activity factor, the perfusion activity required for a P/V-ratio of four is calculated using the previously acquired ventilation count rate. This is applied prospectively to the 100 subsequent examinations.</p><p><strong>Results: </strong> The mean perfusion activity factor is (54.56 ± 10.13) cps/MBq. The individually calculated perfusion activities range from 80 MBq to 200 MBq with an average value of (146.9 ± 35.3) MBq and a median of 140 MBq. The individual activity calculation thus reduced the mean perfusion activity by 8.2 % and the median by 12.5 %. In addition, the individual calculation reduced the proportion of P/V ratios < 3 from 14 % to 0 % and the proportion of P/V ratios > 5 from 24 % to 19 %.</p><p><strong>Conclusion: </strong> The presented method for the individual calculation of perfusion activity offers a simple way to ensure a guideline-compliant P/V-ratio. Furthermore, unnecessarily high perfusion activity as a result of inadequate ventilation can be avoided.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"60 4","pages":"278-282"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38879943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalia.","authors":"","doi":"10.1055/a-1529-3890","DOIUrl":"https://doi.org/10.1055/a-1529-3890","url":null,"abstract":"","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"60 4","pages":"309"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39257578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitgliederversammlung der DGN – Protokoll.","authors":"","doi":"10.1055/a-1529-3902","DOIUrl":"https://doi.org/10.1055/a-1529-3902","url":null,"abstract":"Der scheidende Präsident präsentiert einen Rückblick auf die am 30. Juni 2021 endende Legislatur des Präsidiums. Die Legislaturperiode 2016–2018 zeichnete sich durch die proaktive Aufnahme und Gestaltung für das Fachgebiet relevanter Themen sowie die zukunftsorientierte Neuausrichtung durch die Satzungsänderung aus. 2019–2021 bezeichnet er als „Ausnahmelegislatur“, die von folgenden Themen geprägt war: ▪ Finanzielle Situation der DGN ▪ Umstrukturierung der Geschäftsstelle und ▪ Auswirkungen der COVID-19-Krise auf die DGN allgemein und speziell auf die Jahrestagungen 2020 und 2021","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"60 4","pages":"310-314"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39257581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuer DGN-Vorstand nimmt seine Arbeit auf.","authors":"","doi":"10.1055/a-1529-3877","DOIUrl":"https://doi.org/10.1055/a-1529-3877","url":null,"abstract":"Von 2012 bis zu ihrer Überführung in einen Ausschuss stand Herr Professor Luster zudem der Arbeitsgemeinschaft Schilddrüse vor. Derzeit fungiert er als Senior Advisor des „Thyroid Committee“ der Europäischen Gesellschaft für Nuklearmedizin (EANM), ist Executive Board Member der European Thyroid Association (ETA) – Cancer Group, des Committee on Radioiodine Theranostics (CORT) der Society of Nuclear Medicine and Molecular Imaging (SNMMI) und außerdem Mitglied im wissenschaftlichen Beirat der Patientenselbsthilfegruppen „Bundesverband Schilddrüsenkrebs – Ohne Schilddrüse leben e. V.“ (Deutschland) und „Butterfly Trust“ (Vereinigtes Königreich).","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":"60 4","pages":"306-308"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39257576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}