Nuklearmedizin-nuclear Medicine最新文献

{"title":"Clinical impact of whole-body 68Ga-PSMA I&T PET/CT: lesion frequency and added benefit in lower extremities.","authors":"Lara Franziska Stolzenbach,&nbsp;Florian Löcherbach,&nbsp;Katharina Wargenau,&nbsp;Randi Pose,&nbsp;Thomas Steuber,&nbsp;Zhe Tian,&nbsp;Lars Budäus,&nbsp;Derya Tilki,&nbsp;Markus Graefen,&nbsp;Daniel Köhler,&nbsp;Pierre I Karakiewicz,&nbsp;Markus Sauer,&nbsp;Ivayla Ilieva Apostolova,&nbsp;Tobias Maurer,&nbsp;Christoph Berliner","doi":"10.1055/a-1542-6064","DOIUrl":"https://doi.org/10.1055/a-1542-6064","url":null,"abstract":"<p><strong>Aim: </strong>Few small-scaled studies performed systematic analysis of the benefits of extending prostate specific membrane antigen positron-emission tomography/ computed tomography (⁶⁸Ga-PSMA I&T PET/CT) to the lower extremities in prostate cancer (PCa) patients. We hypothesized that ⁶⁸Ga-PSMA I&T PET/CT positive lesions are rare in lower extremities of prostate cancer (PCa) patients, the clinical implication is negligible and may therefore be omitted.</p><p><strong>Methods: </strong>We retrospectively analyzed 1,068 PCa patients who received ⁶⁸Ga-PSMA I&T PET/CT in a single institution (2016-2018). Of those, 285 (26.7%) were newly diagnosed, 529 (49.5%) had biochemical recurrence (BCR) and 254 (23.8%) were castration-resistant prostate cancer (CRPC) patients.</p><p><strong>Results: </strong>Of 1,068 ⁶⁸Ga-PSMA I&T PET/CTs, positive lesions in the lower extremities were identified in 6.9% patients (n=74). Positive lesions in the lower extremities were most common in CRPC patients (19.7%; n=50), followed by newly diagnosed (3.2%; n=9) and BCR (2.8%; n=15) PCa patients. Only 3 patients presented with exclusive lesions in the lower extremities, respectively 0.8% (n=2) in CRPC and 0.4% (n=1) in newly diagnosed PCa. Both CRPC (94.1%, n=47) and BCR (80.0%, n=12) patients with PSMA-positive lesions predominantly received systemic therapy.</p><p><strong>Conclusion: </strong>Identification of lower extremities lesions with PSMA PET/CT is uncommon and exclusive lesions are rare. PSMA PET/CT findings of the lower extremities did not change therapy management. Thus, scanning of the lower extremities can be omitted in standard protocols.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39330372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No association of Brain-derived neurotrophic factor with striatal dopamine transporter availability in healthy subjects.","authors":"Hyun-Yeol Nam,&nbsp;Seongho Seo,&nbsp;Myung Jun Lee,&nbsp;Keunyoung Kim,&nbsp;In Joo Kim,&nbsp;Kyoungjune Pak","doi":"10.1055/a-1521-8572","DOIUrl":"https://doi.org/10.1055/a-1521-8572","url":null,"abstract":"<p><strong>Objective: </strong>Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays a key role in brain plasticity, synaptic function, neuronal survival, learning, and memory formation. We aimed to investigate the association of BDNF with dopamine transporter (DAT) availabilities measured by positron emission tomography (PET) in healthy subjects.</p><p><strong>Methods: </strong>Thirty-five healthy, male subjects without brain injury, neuropsychological disorders were included in this study. The emission data were acquired over 90 mins with 50 frames after injection of 18F-FP-CIT using PET. Binding potentials (BP_NDs) of ventral striatum (VST), caudate nucleus, putamen were measured with the simplified reference tissue method. The serum BDNF level (pg/mL) was measured through enzyme-linked immunosorbent assay method.</p><p><strong>Results: </strong>Thirty-five healthy males with a mean age of 24.4 ± 2.7 years were included in this study. Multiple regression was done to investigate the association between striatal BPNDs from VST, caudate nucleus, putamen and serum BDNF after adjusting for age. None of striatal BPNDs from VST (p=0.8450), caudate nucleus (p=0.4783), and putamen (p=0.7994) were associated with serum BDNF.</p><p><strong>Conclusion: </strong>Striatal DAT availabilities measured from PET were not associated with the serum BDNF in healthy subjects.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9983580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thymic squamous cell carcinoma mimicking lymphoma on 68Ga-FAPI PET/CT.","authors":"Xiao Yang,&nbsp;Zhouxiang You,&nbsp;Yue Chen,&nbsp;Tianyang Dai,&nbsp;Huipan Liu","doi":"10.1055/a-1561-2014","DOIUrl":"https://doi.org/10.1055/a-1561-2014","url":null,"abstract":"A 33-year-old man presented with progressive enlargement of supraclavicular fossa mass for 2 years. Recently, the patient feels neck pain when swallowing food. Previous chest CT imaging revealed an anterior mediastinal soft tissue mass without any evidence for adjacent vascular or lung invasion (approximately 4.1 cm × 3.4 cm in size), indicating a mediastinal tumor; therefore, malignancy could not be ruled out. With the consent of the patient, we enrolled him in a clinical trial of 68Ga-FAPI-04 PET/CT in tumors (ChiCTR2100044131). 68Ga-FAPI-04 PET/CT scan (▶ Fig. 1A-D) detected that the anterior mediastinal mass had intense FAPI uptake (SUVmax of 12.0). Based on these PET/CT findings, the lesion was suspected to be a mediastinal lymphoma. Subsequently, the patient underwent surgical resection of soft tissue mass. Immunohistochemistry revealed CK (+), CK19 (+), P63 (+), CD1a (+), TdT (+), CD5 (+), CD20 (+), CD117 (+), P53 (+, 50 %), Ki-67 (+, 40 %). However, the findings were consistent with thymic squamous cell carcinoma (SCC). Finally, the patient was well at the six-month follow-up visit.","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39320903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FDG uptake in axillary lymph nodes after COVID-19 vaccination - a pitfall in a case of highly suspicious lymph node metastases of malignant melanoma.","authors":"Clemens Mingels,&nbsp;Ian Alberts,&nbsp;Claudia Fischlin,&nbsp;Jan Wartenberg,&nbsp;Ali Afshar-Oromieh,&nbsp;Axel Rominger","doi":"10.1055/a-1561-2046","DOIUrl":"https://doi.org/10.1055/a-1561-2046","url":null,"abstract":"","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39326914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Analysis of Multimodal Skeletal SPECT/CT Reconstructions in Diagnosing Medication-related Osteonecrosis of the Jaw.","authors":"Michael Thomas Beck,&nbsp;Gregor Rugel,&nbsp;Julia Reinfelder,&nbsp;Torsten Kuwert,&nbsp;Philipp Ritt,&nbsp;Sebastian Kreissel,&nbsp;Tilo Schlittenbauer","doi":"10.1055/a-1525-7621","DOIUrl":"https://doi.org/10.1055/a-1525-7621","url":null,"abstract":"<p><strong>Aim: </strong>Our goal was to assess visual and quantitative aspects of multimodal skeletal SPECT/CT reconstructions (recon) in differentiating necrotic and healthy bone of patients with suspected MRONJ.</p><p><strong>Methods: </strong>Prior to surgery, 20 patients with suspected MRONJ underwent SPECT/CT of the jaw 3-4 hours after injection of Tc-99m-DPD (622±112.4 MBq). SPECT/CT data were reconstructed using the multimodal xSPECT Bone and xSPECT Quant algorithms as well as the OSEM-algorithm FLASH 3D. For analysis, we divided the jaw into 12 separate regions. Both xSPECT Bone and FLASH 3D datasets were scored on a four-point scale (VIS xSPECT; VIS F3D), based on the intensity of localized tracer uptake. In F3D and xSPECT Quant datasets, local tracer uptake of each region was recorded as semi-quantitative uptake ratio (SQR F3D) or SUVs, respectively. ROC analysis was performed. Postoperative histologic results served as gold standard.</p><p><strong>Results: </strong>VIS F3D, VIS xSPECT and SQR F3D did not differ significantly in diagnostic accuracy (VIS xSPECT sensitivity=0.64; specificity=0.89). Of the quantitative parameters, SUVpeak yielded the best interobserver reproducibility. SUVpeak was 9.9±7.1 (95%CI: 7.84-11.95) in MRONJ regions, as opposed 3.6±1.8 (95% CI:3.36-3.88) elsewhere, with a cutpoint of 4.5 (sensitivity=0.83; specificity=0.80). Absolute quantitation significantly surpassed VIS and SQR (p<0.05) in accuracy and interobserver agreement (SUVpeak: κ=0.92; VIS xSPECT: κ=0.61; SQR F3D κ=0.66).</p><p><strong>Conclusion: </strong>Absolute quantitation proved significantly more accurate than visual and semi-quantitative assessment in diagnosing MRONJ, with higher interobserver agreement.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39301735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Oldies (but Goldies): Peritoneal Scintigraphy in Chronic Peritoneal Dialysis Patients].","authors":"Christoph Berliner,&nbsp;Kristina Boss,&nbsp;Anke Pape,&nbsp;Andreas Kribben,&nbsp;Wolfgang Fendler,&nbsp;Ken Herrmann","doi":"10.1055/a-1542-6247","DOIUrl":"https://doi.org/10.1055/a-1542-6247","url":null,"abstract":"Die Peritonealhöhle wird von der größten und komplexesten serösen Haut des Menschen, dem Peritoneum, ausgekleidet. Das Peritoneum ermöglicht die Mobilität der intestinalen Strukturen und spielt eine Rolle beim intraabdominellen Flüssigkeitsaustausch. In diesem Zusammenhang wird das Peritoneum medizinisch auch für Dialyse eingesetzt [1]. Die Peritonealdialyse ist ein elegantes und relativ komplikationsarmes Verfahren, welches sich die hohe Permeabilität des Peritoneums zunutze macht. Nichtsdestotrotz treten auch bei diesem Verfahren Komplikationen auf, welche mit der Peritonealszintigrafie weiter abgeklärt werden können. Klassische Indikation ist die Evaluation einer pleuroperitonealen, skrotalen oder extraperitonealen Leckage [2, 3]. Ebenso können Katheterdysfunktionen durch Adhäsionen oder Obstruktionen mittels Peritonealszintigrafie abgeklärt werden [4]. Die Peritonealszintigrafie ist ein funktionelles Verfahren zur Darstellung der Peritonealhöhle mittels Einbringens einer geringen Menge radioaktiv markierten Tracers über einen intraperitoneal einliegenden Zugang/Katheter. Abgesehen von der geringeren räumlichen Auflösung hat die Szintigrafie als dynamisches Verfahren viele Vorteile gegenüber alternativen Techniken wie CT, MRT oder Sonografie. In der Kombination mit einer SPECT/CT ist auch die 3-dimensionale Zuordnung Artefakt-frei möglich. Zur Durchführung wird ein Zugang zur Peritonealhöhle benötigt. Idealerweise wird der einliegende Peritonealdialysekatheter (PD-Katheter) verwendet. Adaptiert an die Fragestellung werden 120–300MBq 99mTc-Human Serumalbumin (HSA) zusammen mit der Peritonealdialyselösung injiziert. Initial erfolgt eine dynamische Aufnahme alle 10 Sekunden über 5 Minuten zur Beurteilung von Katheterleckagen oder einer Fehllage in der Bauchwand. Anschließend erfolgen statische Aufnahmen nach 10 Minuten und einer Stunde. Bei Auffälligkeiten oder zum Abschluss der Untersuchung sollte eine SPECT/CT erfolgen. Je nach Fragestellung werden Spätaufnahmen nach 24 oder 48 Stunden ergänzt (▶ Tab. 1). Nachfolgend präsentieren wir 4 Peritonealdialysepatienten, die im Zeitraum von August 2020 bis März 2021 untersucht worden sind.","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39345673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are radiopharmaceuticals self-sterilizing? Radiation effect of gallium-68 and lutetium-177 on bacillus pumilus and staphylococcus succinus.","authors":"Simon Poetzsch,&nbsp;Winfried Brenner,&nbsp;Sarah Spreckelmeyer","doi":"10.1055/a-1547-0628","DOIUrl":"https://doi.org/10.1055/a-1547-0628","url":null,"abstract":"<p><strong>Background: </strong>For radiopharmaceuticals, aseptic preparation in combination with filtration is the most commonly used sterilizing method. In general, the production of radiopharmaceuticals needs to fulfil the requirements of good manufacturing practice. In the scope of this work, we focused on the positron emitter gallium-68 and on the therapeutically used beta- and gamma-emitter lutetium-177, as they are routinely used for in-house synthesis of radiopharmaceuticals in nuclear medicine departments. Our hypothesis is, that radiopharmaceuticals might be self-sterilizing due to a high radioactivity concentration and high-energy radionuclides in the preparation for intravenous injections.</p><p><strong>Results: </strong>Incubation with gallium-68 and lutetium-177 for both 30 minutes and 5 hours post-dispensing did not cause any significant effect on bacteria growth. As the theoretical dose is only 0.1-0.6 % of the Ph. Eur. recommended dose of 25 kGy, we conclude that the beta and positron energy of lutetium-177 and gallium-68 as used for standard radiopharmaceutical in-house production is not sufficient to decrease the number of colony forming units compared to the control values.</p><p><strong>Conclusions: </strong>Based on these findings, gallium-68 and lutetium-177 labeled radiopharmaceuticals are not self-sterilizing under the tested conditions with respect to bacillus pumilus and staphylococcus succinus. Consequently, strict aseptic preparation conditions in addition to end-sterilization of the radiopharmaceutical e.g. through membrane filtration are strongly advised for in-house productions.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39330370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose estimates of occupational radiation exposure during radioguided surgery of Tc-99m-PSMA-labeled lymph nodes in recurrent prostate cancer.","authors":"Daniel Schmidt,&nbsp;Jirka Grosse,&nbsp;Roman Mayr,&nbsp;Maximilian Burger,&nbsp;Dirk Hellwig","doi":"10.1055/a-1614-6938","DOIUrl":"https://doi.org/10.1055/a-1614-6938","url":null,"abstract":"<p><strong>Aim: </strong> [^99mTc]Tc-PSMA-based radioguided surgery (TPRS) represents a curative approach for localized relapse of prostate cancer. For its simplified regulatory permission, the radiation protection authorities require a ^99mTc- activity below the exemption limit of 10 MBq at the time of surgery. Our aim was to determine the optimal amount of radioactivity (OAR) to comply with that limit and to estimate the maximum number of TPRS procedures per year and surgeon without triggering the full monitoring obligations.</p><p><strong>Methods: </strong> In this retrospective study, a dose rate meter was calibrated using measurements on phantoms and from recently injected (1 min p. i.) patients to determine the activity in the patient from measured dose rates. The effective half-life of ^99mTc-PSMA-I&S in patients was determined from repeated dose rate measurements to estimate dose parameters of relevance for radiation protection. External exposures of the surgeons were measured with personal dosimeters calibrated in H_p(10). The surgeon's finger dose H_p(0.07) is estimated from radioactivity measured in resected lymph nodes. Potenzial incorporations were estimated for an activity of 10 MBq.</p><p><strong>Results: </strong> From the first 6 subsequent patients, an effective half-life of 4.15 h was observed. Assuming an operation time 24 h p. i., the OAR was 550 MBq. Operations lasting in average 2 h in a distance of 0.25 m to the patient imply a body dose for surgeons of 4.16 µSv per procedure. Based on these estimates, the surgeon's H_p(10) is less than 1 mSv per year with up to 241 operations per year. H_p(0.07) and potential incorporation of activity do not lead to further limitations.</p><p><strong>Summary: </strong> All radiation protection regulations are met with adherence to OAR recommended here without triggering the full monitoring obligations from radiation protection regulations.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39616021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostate incidentaloma on 18F-fluorodeoxyglucose positron emission tomography: Diagnostic value of volumetric positron emission tomography parameters.","authors":"Özlem Şahin,&nbsp;Buğra Kaya,&nbsp;Zeynep Aydın,&nbsp;Ahmet Eren Şen,&nbsp;Mehmet Sinan İyisoy,&nbsp;Arif Aydın","doi":"10.1055/a-1525-7607","DOIUrl":"https://doi.org/10.1055/a-1525-7607","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate whether volumetric PET parameters such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG) contributed to maximum standardized uptake value (SUVmax) in predicting prostate carcinoma in the prostate incidentalomas (PI) in 18F-FDG PET/CT.</p><p><strong>Materials and methods: </strong>This retrospective study comprised 107 patients with PI of 4723 male patients who had undergone 18F-FDG PET/CT. SUVmax and volumetric PET parameters of PIs were assessed. MTV and TLG were acquired with each SUV threshold as 2.5, 3.0, 3.5, 4.0, 4.5, and 5.0.</p><p><strong>Results: </strong>The PI incidence was 2.3%, and the malignancy ratio of PI was 15.9%. According to further analysis results, 17 patients were in the malignant group, and 46 patients were in the benign group. Malignant PIs had higher SUVmax (10.6 vs. 6.4 and p<0.01), MTV (all p < 0.01) and TLG (all p < 0.01) than benign incidentalomas. All volumetric PET parameters had higher area under the curve (AUC) than SUVmax. SUVmax AUC was 0.835 [95% confidence interval (CI): 0.728-0.942]. MTV 2.5 and TLG 2.5 had the highest performance for predicting malignant PI.MTV2.5 AUC was 0.871 (95% CI: 0.775-0.968), and TLG2.5 AUC was 0.882 (95% CI: 0.797-0.967). Using TLG 2.5 greater than 29.8 as the cut-off point, the sensitivity and specificity for malignancy prediction were 94.1% and 82.6%, respectively.</p><p><strong>Conclusion: </strong>In this study, in which the effectiveness of volumetric parameters in the diagnosis of PI was evaluated for the first time, it was shown that they could potentially have clinical value along with SUVmax.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39169479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Absorbed Dose Evaluation of [177Lu]Lu-IBA as a Bone Palliative Candidate.","authors":"Hassan Ranjbar,&nbsp;Zahra Pourhabib","doi":"10.1055/a-1486-3683","DOIUrl":"https://doi.org/10.1055/a-1486-3683","url":null,"abstract":"<p><p>The role of lutetium-177 among bone-seeking radionuclides in targeted therapy is noteworthy. The clinical pharmacokinetics of ibandronate (IBA) indicates that this bisphonate has powerful bone mineral affinity. The aim of this study was to evaluate of [¹⁷⁷Lu]Lu-IBA efficacy as a new compound.The [¹⁷⁷Lu]Lu-IBA was prepared by radiolabeling of IBA ligand to ¹⁷⁷LuCl3 that was obtained by thermal neutron irradiation of enriched Lu2O3 sample. Produced [¹⁷⁷Lu]Lu-IBA with high radiochemical purity was administered intravenously to mice. Biodistribution data were collected at 1, 4, 24, 48 h and 7 d post injections. With calculating accumulated activities in each organ and extrapolating mouse's organs to human's organs by the RADAR method and using OLINDA/EXM software the injected dose in various human organs was achieved.[¹⁷⁷Lu]Lu-IBA was produced with radiochemical purity nearly 96 %. Its biodistribution data showed the high uptake and durability in the skeletal tissues without significant uptake in other major organs.The results showed that [¹⁷⁷Lu]Lu-IBA has considerably good properties as a bone-seeking radiopharmaceutical and therefore can be a candidate for bone pain palliative therapy in skeletal metastases; however, further biological studies are still needed.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39074870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}