Neurourology and Urodynamics最新文献

{"title":"Sleep Patterns and Risk of New-Onset Stress Urinary Incontinence: The UK Biobank Prospective Cohort Study.","authors":"Yuyang Yuan, Xu Hu, Hanbin Yang, Fuchun Zheng, Lizhi Zhou, Bin Fu","doi":"10.1002/nau.70134","DOIUrl":"https://doi.org/10.1002/nau.70134","url":null,"abstract":"<p><strong>Objective: </strong>The association between sleep behaviors and stress urinary incontinence (SUI) risk remains uncertain. We aimed to evaluate the relationship between sleep patterns, based on a combination of five major sleep behaviors, and the risk of new-onset SUI.</p><p><strong>Methods: </strong>The study included 406 921 participants from the UK Biobank who were free of SUI at baseline. A healthy sleep score was created by combining five major sleep behaviors: chronotype, sleep duration, insomnia, snoring, and daytime sleepiness. The primary outcome was new-onset SUI.</p><p><strong>Results: </strong>During a median follow-up of 12.0 years, 6948 (1.7%) participants developed new-onset SUI. Compared to participants with poor sleep patterns (healthy sleep score 0 to 1), those with healthy sleep patterns (healthy sleep score 4 to 5) had a significantly lower risk of new-onset SUI (HR: 0.70; 95% CI: 0.58-0.84).</p><p><strong>Conclusions: </strong>Among the general population, a healthy sleep pattern was associated with a significantly lower risk of new-onset SUI.</p><p><strong>Clinical trial registration: </strong>The study utilizes data from the UK Biobank, which is an observational research resource containing deidentified participant data collected without any intervention. According to ICMJE guidelines and WHO standards, purely observational studies (such as cohort analyses using existing datasets) do not require clinical trial registration as they involve no experimental interventions or assignment of participants to specific exposures. This position is consistent with current practices in epidemiological research using biobank data.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights Into the Application of Microablative Radiofrequency for the Treatment of Female Stress Urinary Incontinence: A Structured Appraisal.","authors":"Ali Furkan Batur","doi":"10.1002/nau.70141","DOIUrl":"https://doi.org/10.1002/nau.70141","url":null,"abstract":"","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Efficacy of Vibegron and Fesoterodine for Neurogenic Detrusor Overactivity in Individuals With Spinal Cord Lesion: A Single-Center Prospective Randomized Crossover Trial.","authors":"Ryosuke Takahashi, Kenjiro Imada, Tomoko Maki","doi":"10.1002/nau.70136","DOIUrl":"https://doi.org/10.1002/nau.70136","url":null,"abstract":"<p><strong>Introduction: </strong>To compare the efficacy of the β3 agonist vibegron and the anticholinergic agent fesoterodine in the management of neurogenic detrusor overactivity (NDO) in individuals with spinal cord lesion (SCL).</p><p><strong>Materials and methods: </strong>This was a single-center, prospective, open-label, randomized, crossover study. A total of 41 individuals with SCL undergoing clean intermittent catheterization, who required pharmacological treatment for NDO confirmed by cystometrogram (CMG), were enrolled in the study. Most patients were < 6 months from SCL. Patients were randomly assigned to receive either vibegron (50 mg) or fesoterodine (4 mg) in a crossover design for 4 weeks each, with no washout period between treatments. The efficacy of the two medications was evaluated during the first 4 weeks using CMG parameters and the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF). At the end of the second 4-week period, participants were surveyed on their preference for the continuation of either drug, based on efficacy, adverse events, and overall satisfaction.</p><p><strong>Results: </strong>During the first 4 weeks, CMG parameters, including detrusor pressure and cystometric capacity, significantly improved in both groups, with no significant differences observed between the groups. The ICIQ-SF scores also demonstrated significant improvements in almost all items in both groups; however, the improvements in Q3 (Overall impact of UI) and the total score were significantly better in the vibegron group. At the end of the second 4-week period, participant survey results indicated that 58% preferred vibegron, 6% preferred fesoterodine, and 36% rated both as equivalent for future continuation therapy.</p><p><strong>Conclusion: </strong>Vibegron significantly improved CMG parameters in addition to alleviating UI symptoms, demonstrating efficacy that was not inferior to that of fesoterodine. With a lower incidence of adverse events and high patient satisfaction, vibegron may serve as a useful therapeutic option for the treatment of NDO in individuals with SCL.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Videoflow: Uroflowmetry in Children Exploiting Standard Care Video Urodynamic Imaging.","authors":"Wouter van Dort, Peter F W M Rosier, Ruud C Wortel, Rogier P J Schroeder, Thomas R F van Steenbergen, Bernard J Geurts, Laetitia M O de Kort","doi":"10.1002/nau.70135","DOIUrl":"https://doi.org/10.1002/nau.70135","url":null,"abstract":"<p><strong>Introduction: </strong>Pressure-flow study, consisting of flow rate combined with detrusor pressure, is the gold standard to determine bladder outflow obstruction and evaluate the detrusor voiding contraction. In very young children, not able to sit on a uroflowmetry device, the flow rate cannot be measured. This results in an incomplete evaluation of bladder and urethral functions. The aim of this study is to derive the flow rate using standard care video-urodynamic study X-ray images.</p><p><strong>Methods: </strong>We retrospectively included 50 video urodynamic studies in children able to void on a uroflowmetry toilet, to correlate the outcome with standard uroflowmetry. The X-ray images taken during voiding were manually segmented and algorithmically converted into a flow rate, called \"videoflow\". This videoflow was compared with the measured (standard) uroflowmetry.</p><p><strong>Results: </strong>An excellent cross-correlation of 0.98 was found between the videoflow and normal uroflowmetry outcomes. The videoflow maximum flow rate (Q_max) was accurate with a not significant bias of +0.1 mL/s difference with standard uroflowmetry.</p><p><strong>Conclusions: </strong>In conclusion, the proposed videoflow is found feasible and accurate in children who are able to void in a uroflowmetry toilet. This method paves the way to measure urine flow rate in very young children who cannot yet sit upright. For the first time, this new technique will enable the validation of a pressure-flow-based urethral resistance measurement in this very young age group.</p><p><strong>Trial registration: </strong>Clinical Registration Number: 23U-0621.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Outcomes of Indwelling Urethral Versus Suprapubic Catheters in Elderly Patients: A Retrospective Within-Subject Study.","authors":"Dolev Perez, Dvorah Sara Shapiro, Davina Bohm, Avital Zeldin, Boris Chertin, Ilan Z Kafka","doi":"10.1002/nau.70133","DOIUrl":"https://doi.org/10.1002/nau.70133","url":null,"abstract":"<p><strong>Aims: </strong>To compare the incidence of catheter-associated urinary tract infections (CAUTIs), antibiotic resistance, and other complications between indwelling urethral catheters (UCs) and suprapubic catheters (SPCs) in elderly patients.</p><p><strong>Methods: </strong>This retrospective cohort study included 37 elderly patients who had used a UC for at least 1 year and subsequently transitioned to an SPC for at least 1 year. Each patient served as their own control. Data were extracted from electronic health records, including CAUTI rates, emergency department visits, catheter obstruction, hematuria, and microbial resistance patterns. McNemar's and Wilcoxon signed-rank tests were used for statistical analysis.</p><p><strong>Results: </strong>SPCs were associated with a significantly lower incidence of CAUTIs (38% vs. 86%, p < 0.001) and reduced emergency department visits (35% vs. 68%, p < 0.001) compared to UCs. SPC use also resulted in fewer catheter obstructions (p = 0.003), lower hematuria rates (p = 0.003), and a reduced prevalence of antibiotic-resistant organisms (p = 0.015). No significant differences were found in accidental dislodgement or leakage rates.</p><p><strong>Conclusion: </strong>Suprapubic catheterization was associated with improved clinical outcomes in elderly patients requiring long-term catheterization. These findings suggest SPCs may reduce complications and healthcare utilization in this vulnerable population. Prospective studies are warranted to guide practice guidelines.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: \"Comparative Risk of Developing Interstitial Cystitis With Childhood Gastrointestinal, Urological, Autoimmune, or Psychiatric Disorders\".","authors":"Muhammad Huzaifa Sabir, Muhammad Owais, Muhammad Nouman Javed","doi":"10.1002/nau.70132","DOIUrl":"https://doi.org/10.1002/nau.70132","url":null,"abstract":"","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Bladder Dysfunction Outcomes Among Standardized Bladder Shapes in Children With Spina Bifida.","authors":"Zoe S Gan, Joey Logan, Ariana L Smith, David Ostrowski, Christopher Long, Dana Weiss, Jason Van Batavia, Stephen Zderic, John Weaver, Gregory Tasian","doi":"10.1002/nau.70131","DOIUrl":"https://doi.org/10.1002/nau.70131","url":null,"abstract":"<p><strong>Objectives: </strong>To (1) propose standardized terminology for bladder shapes on fluoroscopic images in a pediatric spina bifida population and (2) determine if bladder shape is associated with filling pressures and other measures of bladder dysfunction. We hypothesized that oblong, trabeculated, and \"Christmas tree\" bladders would have higher filling pressures and worse bladder function (higher filling pressures; higher presence of vesicoureteral reflux, leakage, detrusor-external sphincter dyssynergia, and hydronephrosis) than smooth and round-shaped bladders.</p><p><strong>Methods: </strong>We conducted a cross-sectional study of pediatric and adolescent patients with spina bifida who underwent video urodynamics (VUDS) at a tertiary center from July 2016 to June 2022. Representative fluoroscopic bladder images from the earliest available VUDS were categorized by unsupervised cluster analysis. Five urologists also determined standardized classifications for bladder shape (round, oblong, and \"Christmas tree\") and contour (smooth or trabeculated/diverticulated), which were applied to the bladder images. Bladder filling pressures and clinical measures of bladder function were compared among bladder shapes.</p><p><strong>Results: </strong>Four hundred seventeen patients with a median age of 2.6 years (IQR 0.4-8.0 years) were included. For the machine learning cluster analysis of bladder shape, clusters with more trabeculated-appearing bladders had higher filling pressures. For expert clinician classification, round trabeculated, oblong trabeculated, and \"Christmas tree\" bladders had higher filling pressures than round smooth and oblong smooth bladders, a difference that was statistically significant. Statistically significant differences were noted among bladder shapes for the presence of vesicoureteral reflux, leakage, detrusor-external sphincter dyssynergia, and hydronephrosis. Moderate and severe bladder dysfunction were present across all bladder shape clusters.</p><p><strong>Conclusions: </strong>We established a standardized bladder shape nomenclature in children and adolescents with spina bifida. Higher bladder filling pressures are associated with trabeculations and \"Christmas tree\" appearance versus smooth contour, but not oblong versus round shape. Bladder shape alone does not appear to consistently differentiate the presence of hydronephrosis, vesicoureteral reflux, leakage, detrusor-external sphincter dyssynergia, or bladder dysfunction severity.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing the Injection Schema for Higher Doses of OnabotulinumtoxinA (BTX-A) in the Office Setting: A Randomized Prospective Trial for Patients With Neurogenic Lower Urinary Tract Dysfunction and Idiopathic Overactive Bladder.","authors":"Annie Chen, Julie Stewart, Ricardo R Gonzalez, Argyrios Stampas, Kathleen Kobashi, Rose Khavari","doi":"10.1002/nau.70130","DOIUrl":"https://doi.org/10.1002/nau.70130","url":null,"abstract":"<p><strong>Background: </strong>OnabotulinumtoxinA (BTX-A) decreases urge urinary incontinence (UUI) and improves quality of life for patients with idiopathic overactive bladder (IOAB) and neurogenic lower urinary tract dysfunction (NLUTD). Limited research exists optimizing injection techniques for higher doses (200- or 300-units) of BTX-A in the clinic setting. Optimization with less injections could improve satisfaction and willingness to repeat injections while maintaining effectiveness.</p><p><strong>Methods: </strong>This is a prospective, single-blinded, parallel randomized controlled trial of patients undergoing higher doses of BTX-A for treatment of refractory IOAB or NLUTD in the office setting. Patients were randomized to either 5- or 20-injections. The primary outcome was patients' willingness to repeat the procedure. Secondary outcomes included pain, symptomatology, and adverse events (AEs) assessments.</p><p><strong>Results: </strong>For N = 78 participants (N = 39 per arm), no difference was seen in patients' willingness to repeat the procedure between the 5- or 20-injection groups before and after injection (Mean difference = 0.18, p = 0.57) or at 6-8 week follow-up (Mean difference = 0.06, p = 0.83). There was a significant increase in immediate post-procedural pain after 20 (M = 3.39, SD 3.01) compared to five injections (M = 0.57, SD = 2.07) (Mean difference = 2.83, p > 0.00002). N = 55/78 (71%) completed follow-up. N = 16 experienced AEs (N = 8/26 for 5-injections, N = 7/29 for 20-injections).</p><p><strong>Conclusions: </strong>Despite a significant increase in pain for patients with NLUTD and IOAB receiving 20 injections compared to 5, patients in both groups were equally willing to repeat BTX-A injections. There were no significant differences in AEs or secondary outcomes. This suggests decreasing the number of injections from 20 to 5 will improve pain scores when higher doses of BTX-A are used in the office setting with affecting efficacy.</p><p><strong>Clinical trial number: </strong>NCT06059066.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Updated Systematic Review and Meta-Analysis on the Prevalence of Female Urinary Incontinence in Developing Countries-A Collaborative Report by the International Continence Society (Developing World Committee) and the Iranian Research Center for Evidence-Based Medicine.","authors":"Parisa Rostami, Hadi Mostafaei, Hanieh Salehi-Pourmehr, Sakineh Hajebrahimi","doi":"10.1002/nau.70127","DOIUrl":"https://doi.org/10.1002/nau.70127","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Hypothesis/aims of study: &lt;/strong&gt;Urinary incontinence (UI) remains a substantial public health issue, particularly for women residing in developing nations, significantly impacting their economic stability and overall quality of life. Despite its considerable burden, a thorough understanding of the current prevalence of UI and its various subtypes across these regions is still not fully clear. This updated systematic review and meta-analysis aims to build upon previous research. Our primary objective is to determine the pooled prevalence of both overall UI and its specific subtypes among adult women in developing countries, utilizing data from population-based studies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study design, materials, and methods: &lt;/strong&gt;This study involved an updated systematic review and meta-analysis. A comprehensive search was conducted across several electronic databases, including PubMed, Medline, Web of Science, Scopus, and Google Scholar, to identify relevant population-based studies published from January 2018 through October 2024. To ensure the breadth of coverage, data from our prior project, which encompassed studies up to 2020, were also integrated. Studies were considered for inclusion if they reported the prevalence of UI or its subtypes in adult women (generally aged 18 years or older, with exceptions justified by the original study) residing in developing countries and employed population-based research methodologies. Conversely, studies that focused on specific demographic cohorts (e.g., pregnant or recently postpartum women, or individuals with particular medical conditions) were systematically excluded. The methodological quality of each selected study was rigorously assessed using the Joanna Briggs Institute Meta-Analysis of Statistics, Evaluation, and Review Instrument (JBI MASTARI), a standardized tool for critical appraisal. For the meta-analysis, a random-effects model was employed to appropriately account for the expected variability and heterogeneity among the included studies. Furthermore, subgroup analyses were performed to investigate the influence of various factors on the reported prevalence rates, including the recall period (e.g., past 3 months, past 12 months), the overall quality of the studies, and whether validated or nonvalidated questionnaires were utilized.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Our meta-analysis incorporated 83 population-based studies. These studies collectively included data from 252 698 women, ranging in age from 10 to 90 years, across numerous developing countries, all meeting the predefined inclusion criteria. The reported prevalence of overall UI exhibited substantial heterogeneity, ranging from a low of 2.8% in Nigeria to a high of 64.1% in Jordan. The pooled prevalence of overall UI in adult women residing in developing countries was estimated to be 27.4% (95% confidence interval [CI]: 24.5-30.5). Subtype-specific analyses revealed pooled prevalence rates of 20.1% (95% CI: 17.7-22.7)","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artifacts in Urodynamic Studies: A Narrative Review.","authors":"Farzad Pourghazi, Brian J Linder, Azra Alizad, Mostafa Fatemi","doi":"10.1002/nau.70128","DOIUrl":"10.1002/nau.70128","url":null,"abstract":"<p><strong>Background: </strong>Urodynamic studies (UDS) are integral to the evaluation and management of lower urinary tract dysfunction. However, artifacts are frequently encountered, affecting both clinical interpretation and research reliability.</p><p><strong>Objective: </strong>This expert narrative review examines the prevalence, classification, and clinical relevance of artifacts encountered during UDS, based on findings from the existing literature.</p><p><strong>Methods: </strong>A focused literature review was conducted, analyzing studies that reported data on the sources and impact of UDS artifacts, particularly from the patient perspective. Emphasis was placed on identifying both technical and patient-related contributors to artifact generation.</p><p><strong>Results: </strong>Artifacts are common in UDS despite adherence to Good Urodynamic Practices recommended by the International Continence Society. Technical artifacts may stem from equipment-related issues such as calibration errors, catheter displacement, and device variability. Patient-related artifacts can arise from physical movement or test-induced detrusor overactivity. These artifacts may lead to misinterpretation, misdiagnosis, and inappropriate interventions in clinical practice. Furthermore, they may affect the validity of research findings related to diagnostic tools for lower urinary tract symptoms.</p><p><strong>Conclusion: </strong>Identifying and addressing UDS artifacts during the procedure or in post-test interpretation is critical for accurate clinical decision-making and reliable research outcomes. Efforts to minimize artifacts should be prioritized to improve the quality and utility of UDS.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}