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Variation in the Definitions of Urinary Retention in Studies of Intravesical Botulinum Toxin for Idiopathic Overactive Bladder: A Narrative Systematic Review.
IF 1.8 3区 医学
Neurourology and Urodynamics Pub Date : 2025-02-17 DOI: 10.1002/nau.70017
Stephanie Stavrou, Jessica A Paynter, Thomas Carins, Kirby R Qin, Janelle Brennan
{"title":"Variation in the Definitions of Urinary Retention in Studies of Intravesical Botulinum Toxin for Idiopathic Overactive Bladder: A Narrative Systematic Review.","authors":"Stephanie Stavrou, Jessica A Paynter, Thomas Carins, Kirby R Qin, Janelle Brennan","doi":"10.1002/nau.70017","DOIUrl":"https://doi.org/10.1002/nau.70017","url":null,"abstract":"<p><strong>Purpose: </strong>To categorise and quantify definitions of urinary retention reported in studies assessing botulinum toxin (BoNT) injections for idiopathic overactive bladder (iOAB) syndrome.</p><p><strong>Materials and methods: </strong>A narrative systematic review was conducted using three databases: EMBASE (via Ovid), PubMed, and SCOPUS. Inclusion criteria comprised studies published as full-text articles in English involving adults receiving BoNT injections (any formulation) for iOAB syndrome, where urinary retention was reported as an outcome.</p><p><strong>Results: </strong>From 1986 screened studies, 135 were assessed, and 57 met the eligibility criteria for the narrative systematic review. Reported rates of urinary retention varied widely, ranging from 0% to 42.6%. A definition of urinary retention was provided in 33 studies (57.9%), which were broadly categorised as follows. 1. Post-void residual (PVR) volume threshold: 14 studies (21.5%). 2. Inability to void: 6 studies (9.2%). 3. Initiation of clean intermittent catheterisation (CIC): 6 studies (9.2%). 4. PVR volume threshold and initiation of CIC/indwelling catheterisation (IDC): 6 studies (9.2%). 5. Bladder symptoms and PVR volume threshold and initiation of CIC/IDC: 6 studies (9.2%). 6. Bladder symptoms and PVR volume threshold: 3 studies (4.6%). Notably, 24 studies (42.1%) omitted a definition altogether.</p><p><strong>Conclusions: </strong>Urinary retention rates varied significantly between studies, likely due to the heterogeneous definitions used. The omission of definitions in nearly half of studies further complicates efforts to accurately inform and consent patients regarding the risk of urinary retention and the need for CIC/IDC after intravesical BoNT injection. Standardised definitions are urgently needed to enhance research, improve clinical practice, and support informed patient counselling.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using a Back-Worn Accelerometer to Capture Nocturia Frequency in Parkinson's: An Exploratory Study.
IF 1.8 3区 医学
Neurourology and Urodynamics Pub Date : 2025-02-17 DOI: 10.1002/nau.70011
Anisha Cullen, Matthew D Smith, Emily J Henderson
{"title":"Using a Back-Worn Accelerometer to Capture Nocturia Frequency in Parkinson's: An Exploratory Study.","authors":"Anisha Cullen, Matthew D Smith, Emily J Henderson","doi":"10.1002/nau.70011","DOIUrl":"https://doi.org/10.1002/nau.70011","url":null,"abstract":"","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship Between the First Undisturbed Sleep Period and Diuretic and Urine Storage States of the First Void After Sleep.
IF 1.8 3区 医学
Neurourology and Urodynamics Pub Date : 2025-02-12 DOI: 10.1002/nau.70008
Yasunori Akashi, Koji Miki, Keisuke Kiba, Yutaka Yamamoto, Kazutoshi Fujita, Akihide Hirayama
{"title":"Relationship Between the First Undisturbed Sleep Period and Diuretic and Urine Storage States of the First Void After Sleep.","authors":"Yasunori Akashi, Koji Miki, Keisuke Kiba, Yutaka Yamamoto, Kazutoshi Fujita, Akihide Hirayama","doi":"10.1002/nau.70008","DOIUrl":"https://doi.org/10.1002/nau.70008","url":null,"abstract":"<p><strong>Objective: </strong>To explore why older men awaken to urinate within 3 h after falling asleep, we examined diuretic and urine storage states associated with the first void after falling asleep.</p><p><strong>Methods: </strong>We enrolled 102 male patients, 50 years or older, hospitalized for prostate biopsy between November 2021 and September 2023. Patients were grouped based on their first undisturbed sleep period (FUSP): FUSP < 3 h or FUSP ≥ 3 h. A 24-h frequency-volume chart (FVC) was recorded. Urinary sodium, creatinine, and osmolality were measured from the first urine after sleep and upon waking. Free water clearance (FWC) and sodium clearance (SC) of the first urine after sleep were recorded. The urine storage state was calculated as the ratio of urine volume at first nocturnal voiding to the maximum voided volume (VV) according to 24-h FVC.</p><p><strong>Results: </strong>Overall, 86 cases were analyzed. FWC was elevated in the first urine after sleep. It was significantly higher in the FUSP < 3 h group (p = 0.041). SC was elevated in the FUSP < 3 h group for both the first urine after sleep and the urine upon waking. The urine storage state tended to be lower in the FUSP < 3 h group (p = 0.057). Multivariate analysis revealed that FWC, SC, and the urine storage state independently associated with FUSP < 3 h.</p><p><strong>Conclusion: </strong>Decreased urine storage function, increased water diuresis, and increased sodium diuresis in the first urine after sleep are independent factors associated with FUSP < 3 h. Management of these factors may improve nocturia.</p><p><strong>Trial registration: </strong>Institutional Review Board Certification Number: 679.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive Factors for Complete Response to Desmopressin Treatment in Children With Primary Monosymptomatic Nocturnal Enuresis.
IF 1.8 3区 医学
Neurourology and Urodynamics Pub Date : 2025-02-10 DOI: 10.1002/nau.70012
Gunal Ozgur, Cagri Akin Sekerci, Yiloren Tanidir, Tufan Tarcan, Selcuk Yucel
{"title":"Predictive Factors for Complete Response to Desmopressin Treatment in Children With Primary Monosymptomatic Nocturnal Enuresis.","authors":"Gunal Ozgur, Cagri Akin Sekerci, Yiloren Tanidir, Tufan Tarcan, Selcuk Yucel","doi":"10.1002/nau.70012","DOIUrl":"https://doi.org/10.1002/nau.70012","url":null,"abstract":"<p><strong>Objectives: </strong>Primary monosymptomatic nocturnal enuresis (MNE) is a common problem in pediatric urology and desmopressin is the first-line medical treatment. We aimed to evaluate the predictive factors of complete response to desmopressin and the effect of desmopressin on urinary electrolyte levels in children with primary MNE.</p><p><strong>Methods: </strong>Children with MNE who were started on sublingual 120 mcg of desmopressin treatment included in the study. Children were evaluated by physical examination, urinalysis, voiding dysfunction symptom score, voiding diary and uroflowmetrics with postvoid residuals. 24-h urine was collected for density and electrolyte measurements before and at the first and third months of treatment. The children were divided into two groups according to wetting episodes at the third month, as those with complete response to the treatment (group 1) and the others (resistant or partial-response) (group 2).</p><p><strong>Results: </strong>Thirty-four children (24 boys, 10 girls) were included in the study. Median age was 8 (5-15) years. There was no difference between the urinary density, sodium, potassium, and calcium values before and during treatment (first and third months) (p = 0.737, 0.549, 0.166, 0.386 respectively). The number of wet nights in a month and the number of wetting at a night were found as the predictive factors for complete response to desmopressin (p = 0.027, p = 0.003, respectively). The number of 17 wet nights per month was calculated as the optimized cut-off point for predicting desmopressin treatment failure (p = 0.027, sensitivity = 92.3%, specificity = 47.6%, AUC [95%]: 0.729 [0.552-0.906]). Age, gender, family history, maximum voided volume in voiding diary (MVV)/expected bladder capacity (EBC) ratio, maximum bladder capacity (MBC)/EBC ratio and pretreatment urinary density, sodium, potassium, calcium levels could not predict complete response (p = 0.292, 0.051, 0.533, 0.552, 0.101, 0.570, 0.326, 0.735, 0.246 respectively).</p><p><strong>Conclusions: </strong>Desmopressin treatment had no effect on urine density and urinary sodium, potassium, calcium electrolytes similar to the literature. Urine density and electrolyte levels are not helpful in predicting desmopressin treatment response in enuretic children. Low frequency of wet nights (< 17) in a month and single bedwetting at a night are the significant factors to predict complete response to desmopressin treatment in children with primary MNE.</p><p><strong>Clinical trial registration: </strong>The study does not have a clinical trial registration number, because the study was not a randomized controlled trial and the data in the study were collected retrospectively.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the Link Between Free Androgen Index and Nocturia in Women: Findings From National Health and Nutrition Examination Survey.
IF 1.8 3区 医学
Neurourology and Urodynamics Pub Date : 2025-02-10 DOI: 10.1002/nau.70006
Shang Gao, Lianhui Fan, Jingteng He, Hongtao Liu, Renli Tian
{"title":"Investigating the Link Between Free Androgen Index and Nocturia in Women: Findings From National Health and Nutrition Examination Survey.","authors":"Shang Gao, Lianhui Fan, Jingteng He, Hongtao Liu, Renli Tian","doi":"10.1002/nau.70006","DOIUrl":"https://doi.org/10.1002/nau.70006","url":null,"abstract":"<p><strong>Background: </strong>Nocturia is the most prevalent lower urinary tract symptom in women, affecting approximately 54.5% of female patients and significantly impacting the quality of life. While the androgen levels may be related to urinary function, its association with nocturia in women remains unclear. This study aims to explore the relationship between androgen levels and nocturia in women.</p><p><strong>Methods: </strong>This study utilized data from the 2013-2016 National Health and Nutrition Examination Survey (NHANES), including 4531 women aged 20 and above. The level of androgen is reflected by the total testosterone (TT) and free androgen index (FAI). Weighted logistic regression models were employed to analyze the association between FAI, TT, and nocturia.</p><p><strong>Results: </strong>After comprehensive adjustment for confounding factors, higher FAI levels were significantly associated with a reduced risk of nocturia (OR = 0.84, 95% CI: 0.74-0.95). Women in the highest FAI tertile had a significantly lower incidence of nocturia compared to those in the lowest tertile (OR = 0.75, 95% CI: 0.60-0.93). Trend analysis indicated a significant decrease in nocturia occurrence with increasing FAI levels (P for trend = 0.0177). No significant association was found between TT levels and nocturia.</p><p><strong>Conclusions: </strong>Higher FAI levels are significantly inversely associated with nocturia in women, suggesting that bioavailable testosterone may have a protective effect against nocturia. This finding underscores the importance of considering FAI levels in research and clinical practice, and future studies should explore the potential benefits of modulating FAI levels in women with nocturia.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Bladder Sensor for Adults With Urinary Incontinence.
IF 1.8 3区 医学
Neurourology and Urodynamics Pub Date : 2025-02-10 DOI: 10.1002/nau.70009
Filine van den Bosch, Paul van Leuteren, Sandra Tobisch, Diederick Duijvesz
{"title":"A Bladder Sensor for Adults With Urinary Incontinence.","authors":"Filine van den Bosch, Paul van Leuteren, Sandra Tobisch, Diederick Duijvesz","doi":"10.1002/nau.70009","DOIUrl":"https://doi.org/10.1002/nau.70009","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Urinary incontinence (UI) is a very common hygiene and health problem in adults which has an enormous impact on quality of life (QoL). Noninvasive treatment options are the first line of treatment. It would be beneficial to know when the bladder reaches its maximum capacity, to enable to prompt going to the bathroom on time and thereby potentially prevent an UI event. Recently, a wearable bladder sensor was developed, the TENA SmartCare Bladder Sensor (Bladder Sensor), which is intended to support children ( ≥ 6 years) and adults (BMI ≤ 25 kg/m&lt;sup&gt;2&lt;/sup&gt;). The Bladder Sensor tracks the bladder filling status and notifies the user when it is time to go to the bathroom by a vibration of the device and/or a notification in an app on a mobile device (e.g., smartphone and/or Apple Watch®). The primary objective of this first pivotal study was to demonstrate that the Bladder Sensor can detect the bladder before urination among adult intended users. The secondary objectives were to collect real-life data to evaluate performance, safety, usability, and subject satisfaction with the device as well as impact on QoL. The primary hypothesis was to evaluate if the median bladder detection rate in the evaluated population is greater than the threshold of 85% (H0: ≤ 0.85, H1: &gt; 0.85, p-value &lt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Patients & methods: &lt;/strong&gt;Adults ( ≥ 18 years) suffering from UI during day and/or night tested the Bladder Sensor independently at home for 1 week. Device performance, safety, usability, user satisfaction and self-reported disease specific information, and QoL were assessed at pre-defined times. Intra-individual results were compared. Any episodes of urination and/or urine loss were documented by subjects in a paper diary. Raw data of the Bladder Sensor was analyzed to evaluate the bladder detection rate and full bladder notification rate(s).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;30 adults (female/male: 67%/33%; median age: 53 years (Interquartile range (IQR) 32-61 years); median BMI of 22.6 kg/m&lt;sup&gt;2&lt;/sup&gt; (IQR 20.7-23.8 kg/m&lt;sup&gt;2&lt;/sup&gt;)) completed the study testing the Bladder Sensor at home for 6.9 days on average. The median bladder detection rate was 89.8% (IQR 82.6-95.3%) in a sample without statistically and clinically identified outliers (n = 28). The null hypothesis was rejected among those (z = 69, p &lt; 0.05). The median actual full bladder notification rate was 63.1% (IQR 50.0-71.4%), and the median perceived full bladder notification rate was 94.4% (IQR 87.0-105.6%). The device showed to have a positive effect on subjects' UI problems (e.g., 67% reduced number of unwanted leakages) and QoL.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;It was demonstrated that the Bladder Sensor can detect the bladder under real-life conditions among its intended users and can support in the prevention of UI. This seemed dependent on anatomical limitations (e.g., BMI and body shape), bladder volume (low bladder detection rate &lt; 100 ","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perineal and Rectal Nerve Recruitment Order Varies During Pudendal Neurostimulator Implant Surgery.
IF 1.8 3区 医学
Neurourology and Urodynamics Pub Date : 2025-02-10 DOI: 10.1002/nau.70010
Po-Ju Chen, Amador C Lagunas, Vanessa Soriano, Priyanka Gupta, Tim M Bruns
{"title":"Perineal and Rectal Nerve Recruitment Order Varies During Pudendal Neurostimulator Implant Surgery.","authors":"Po-Ju Chen, Amador C Lagunas, Vanessa Soriano, Priyanka Gupta, Tim M Bruns","doi":"10.1002/nau.70010","DOIUrl":"https://doi.org/10.1002/nau.70010","url":null,"abstract":"<p><strong>Introduction: </strong>Pudendal nerve stimulation (PNS) is an off-label therapy for patients experiencing pelvic pain and voiding dysfunction. The pudendal nerve has two efferent branches to the rectum and perineum. Only the rectal branch is monitored via external anal sphincter electromyography during the implant procedure to help determine the lead position. We examined intraoperative PNS-driven urethral pressures to infer nerve recruitment order and tracked patient reported outcomes.</p><p><strong>Methods: </strong>Patients receiving PNS for pelvic pain and/or urinary symptoms were recruited. During the implant surgery, urethral pressure was measured with a multi-sensor pressure catheter placed in the lower urinary tract. PNS-driven changes in urethral pressure and external anal sphincter (EAS) electromyography were compared to determine the relative perineal and rectal nerve recruitment order. Participants completed pelvic pain, bladder, bowel, and sexual function surveys before and after the surgery. The primary outcome measure was the relative nerve recruitment order during PNS. Secondary outcome measures were the PNS-driven urethral responses and changes in survey symptom scores due to PNS.</p><p><strong>Results: </strong>Data was collected from thirteen intraoperative sessions. Seven participants had rectal nerve recruitment first, four participants had perineal nerve recruitment first, and two participants had mixed nerve recruitment during intraoperative PNS. The average normalized urethral pressure change was 4.7% at the EAS threshold, 59.2% at twice EAS threshold, and 68.2% at three times the EAS threshold. Urethral pressure changes for each participant often varied between different active PNS electrodes. Participants had significant improvements in pelvic pain and bladder function survey scores with PNS (p < 0.04). There was no relationship between nerve recruitment order and changes in any surveys.</p><p><strong>Conclusion: </strong>PNS can recruit the perineal nerve before the rectal nerve. Each lead electrode may trigger different urethral response patterns within a participant. This study provided new insights into the effect of PNS on the recruitment of nerves in the pelvis and may help guide future surgical placement of PNS systems.</p><p><strong>Clinical trial registration: </strong>This study was registered at clinicaltrials.gov (NCT04236596).</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determinants of Healthcare Seeking Patterns in Women With Pelvic Floor Disorders.
IF 1.8 3区 医学
Neurourology and Urodynamics Pub Date : 2025-02-07 DOI: 10.1002/nau.70004
Rachan Ghandour, Julia Shen, Morgan Bou Zerdan, Sasha Aljamal, Vatche A Minassian
{"title":"Determinants of Healthcare Seeking Patterns in Women With Pelvic Floor Disorders.","authors":"Rachan Ghandour, Julia Shen, Morgan Bou Zerdan, Sasha Aljamal, Vatche A Minassian","doi":"10.1002/nau.70004","DOIUrl":"https://doi.org/10.1002/nau.70004","url":null,"abstract":"<p><strong>Objective: </strong>To determine if sociodemographic and health determinants of women with pelvic floor disorders (PFDs) affect health-seeking behavior, and whether this varies by disease subtype and severity.</p><p><strong>Materials and methods: </strong>We conducted a retrospective cohort study of women with PFDs at an academic urogynecology practice between January 2021 and May 2022. Groups were compared across sociodemographic and clinical variables and by pelvic organ prolapse (POP) stage and urinary incontinence (UI) subtype/severity. The primary outcomes of interest were POP stage and UI severity at initial presentation with duration of symptoms as a key determinant. Statistical significance was set at p < 0.05.</p><p><strong>Results: </strong>The study included 684 [307 POP (44.9%) and 377 UI (55.1%)] women. Of those with POP, 190 (61.9%) presented with stages I/II and 117 (38.1%) with stages III/IV. In women with UI, 188 (49.9%) had mild-moderate UI and 179 (47.5%) had severe UI. Approximately 76% of women reported PFD symptoms for over 6 months and 47% for 2 years or more upon presentation. Women with advanced-stage POP had 1.27 increased odds (95% CI: 1.01-1.61) of delaying care for > 24 months, were older (1.07 adjusted OR, 95% CI: 1.03-1.11), and had fewer healthcare visits (0.95 adjusted OR, 95%: CI: 0.91-0.98) in the prior year. Women with severe UI had 1.88 increased odds (95% CI: 1.52-2.35) of delaying care > 24 months, 1.20 odds with government insurance (CI: 1.01-1.32), and 1.18 odds of other comorbidities (CI: 1.02-1.40).</p><p><strong>Conclusion: </strong>Most women with PFD reported symptoms for over 6 months at presentation. Women with advanced POP or severe UI were more likely to seek care over 24 months after the onset of symptoms.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Night-to-Day Ratio of Excreted Urinary Sodium Concentration Using Spot Urine in Older Adults With Nocturnal Polyuria.
IF 1.8 3区 医学
Neurourology and Urodynamics Pub Date : 2025-02-07 DOI: 10.1002/nau.25670
Osamu Natsume, Nobutaka Nishimura, Takuto Shimizu, Kiyohide Fujimoto
{"title":"Night-to-Day Ratio of Excreted Urinary Sodium Concentration Using Spot Urine in Older Adults With Nocturnal Polyuria.","authors":"Osamu Natsume, Nobutaka Nishimura, Takuto Shimizu, Kiyohide Fujimoto","doi":"10.1002/nau.25670","DOIUrl":"https://doi.org/10.1002/nau.25670","url":null,"abstract":"<p><strong>Background: </strong>The diurnal rhythm in water and solute diuresis is known to be disturbed in older adults with nocturia due to nocturnal polyuria. We estimated the prevalence of increased natriuresis in nocturia due to nocturnal polyuria by comparing individuals with and without nocturnal polyuria.</p><p><strong>Methods: </strong>We calculated the night-to-day ratio of excreted urinary sodium and potassium concentrations adjusted for urinary creatinine concentration and urinary osmolality using spot urine samples collected at 2 PM (daytime) and 6 AM (nighttime) and compared results among controls with nocturia and paitents with nocturia with and without nocturnal polyuria.</p><p><strong>Results: </strong>Among 83 patients aged 50 to 86 years, the mean night-to-day ratio of excreted urinary sodium and potassium concentrations in the nocturia group with nocturnal polyuria (n = 40) was 2.5, which was significantly higher (p = 0.034) than those in the control group (n = 23; 0.7) and the nocturia group without nocturnal polyuria (n = 20; 0.9). After adjustment for age, no difference in potassium and urinary osmolality existed among groups. Thirteen patients (33%) in the nocturia group with nocturnal polyuria showed increased natriuresis when a 2.0 night-to-day ratio of excreted urinary sodium was applied as a cut-off for increased natriuresis, whereas only 3 (7%) patients in the combined groups without nocturnal polyuria had increased natriuresis (p = 0.005).</p><p><strong>Conclusions: </strong>One-third of patients with nocturia due to nocturnal polyuria had increased natriuresis. Assessment of a night-to-day ratio of excreted urinary sodium using spot urine samples could facilitate a better understanding of the underlying pathophysiology and optimal management of nocturnal polyuria.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentary on "Occult Urinary Incontinence, Diabetes, Obesity, Prolapse Severity, and Type of Surgical Repair as Risk Factors for De Novo Stress Urinary Incontinence in Women Undergoing Surgical Repair of Pelvic Organ Prolapse".
IF 1.8 3区 医学
Neurourology and Urodynamics Pub Date : 2025-02-06 DOI: 10.1002/nau.25664
Shubham Kumar, Ahmad Neyazi, Rachana Mehta, Ranjana Sah
{"title":"Commentary on \"Occult Urinary Incontinence, Diabetes, Obesity, Prolapse Severity, and Type of Surgical Repair as Risk Factors for De Novo Stress Urinary Incontinence in Women Undergoing Surgical Repair of Pelvic Organ Prolapse\".","authors":"Shubham Kumar, Ahmad Neyazi, Rachana Mehta, Ranjana Sah","doi":"10.1002/nau.25664","DOIUrl":"https://doi.org/10.1002/nau.25664","url":null,"abstract":"","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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