Neurourology and Urodynamics最新文献

{"title":"Development of a Predictive Tool for Midterm Success of Sacral Neuromodulation in Non-Neurogenic Overactive Bladder Syndrome.","authors":"Samy Hafez, Morgane Pere, Louise Olivier, Benjamin Carolus, Marie-Liesse De Guerry, Jérôme Rigaud, Xavier Biardeau, Marie-Aimée Perrouin-Verbe","doi":"10.1002/nau.70041","DOIUrl":"10.1002/nau.70041","url":null,"abstract":"<p><strong>Objectives: </strong>To identify factors that can predict both test phase and midterm success of sacral neuromodulation (SNM) in refractory non-neurogenic overactive bladder syndrome (nnOAB) based on preoperative clinical and urodynamic data.</p><p><strong>Materials and methods: </strong>We conducted a two-center retrospective study and included all individuals with nnOAB who underwent a test phase between 2005 and 2021, with or without subsequent implantation of an SNM device. Only those with preoperative urodynamic assessment data were included. SNM success was defined as <math> <semantics><mrow><mo>≥</mo></mrow> </semantics> </math>  50% improvement in one of the bladder diary parameters, associated with <math> <semantics><mrow><mo>≥</mo></mrow> </semantics> </math>  50% symptom improvement. Individuals underwent follow-up evaluation at 2 years.</p><p><strong>Results: </strong>In total, 191 individuals were included (163 women), 69% of whom underwent SNM device implantation. At the preoperative urodynamic exam, 115 individuals had detrusor overactivity (DO). Test phase success was associated with younger age (p = 0.009). 24-month SNM success was associated with lower maximal detrusor pressure at DO (Pdet max DO) at baseline (p = 0.045). Other predictive factors for success at 2 years were female (p = 0.03), a history of stress incontinence surgery (p = 0.01), a low maximum urethral closure pressure (MUCP) (p = 0.04), a low volume at first DO (VFDO) (p = 0.03), and a high maximum cystometric capacity (MCC) (p = 0.03). We developed a tool to predict success at 2 years. The following threshold values were significantly associated with treatment success: MUCP < 58 cmH₂O, VFDO < 170 mL, and MCC > 254 mL.</p><p><strong>Conclusion: </strong>Age predicted test phase success. Pdet max DO, gender, history of incontinence surgery, high MUCP, MCC, and VFDO predicted midterm success of SNM in people with nnOAB.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"997-1006"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Magnetic Stimulation in Men With Urinary Incontinence After Radical Prostatectomy: A Randomized, Quadruple-Blind, Sham-Controlled Clinical Trial.","authors":"Burak Unal, Ayşe Sarsan, Necmettin Yıldız, Hakan Alkan","doi":"10.1002/nau.70055","DOIUrl":"10.1002/nau.70055","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of MStim on incontinence-related clinical parameters, quality of life (QoL), sexual function, depression and anxiety in patients with UI after RP.</p><p><strong>Methods: </strong>Forty men with UI after RP were randomized into two groups using the random numbers generator as follows: Group 1 received MStim (n: 20), and Group 2 Sham-MStim (control) (n: 20). MStim and Sham-Mstim were performed with MStim therapy armchair (Novamag NT60), 2 days a week, 20 min a day, a total of 16 sessions for 8 weeks. Men were evaluated in terms of improvement rates (primary outcome), severity of incontinence (24 h-pad test), frequency of voiding, nocturia, incontinence episodes, number of pads, (3-day bladder diary) anxiety-depression (HADS), QoL (IIQ-7), sexual function (IIEF), and continence rates and treatment satisfaction.</p><p><strong>Results: </strong>While there was a statistically significant improvement in all parameters except erectile function, sexual desire, and intercourse satisfaction and overall satisfaction subgroups of sexual function and depression Group 1, a statistically significant improvement was found only in the severity of incontinence and bladder diary parameters in Group 2 at the 8th week compared to the baseline values (p < 0.05). At the end of treatment; the severity of incontinence, nocturia, incontinence episodes, QoL, total and orgasmic function subgroups of sexual function and anxiety were significantly improved in Group 1 compared to Group 2 at the 8th week (p < 0.05). The improvement rates (75.0% vs. 26.3%), continence rates (45.0% vs. 15.8%), and treatment satisfaction (effect size: d = 1.23) were significantly higher in Group 1 than in Group 2 (p < 0.05).</p><p><strong>Conclusion: </strong>MStim is a clinically feasible treatment option that is well tolerated with no serious side effects and is more effective than sham on both UI related clinical parameters and QoL, anxiety and sexual function in men with UI after RP.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov number: NCT04644614.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"1140-1148"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Holm and Cordoba Urinary Tract Infection Score: Translation, Linguistic and Content Validation of the German Version of a Patient-Reported Outcome Measure to Assess Symptoms, Bothersomeness and Impact of Uncomplicated Urinary Tract Infections in Women.","authors":"Katharina Piontek, Sophie Nestler, Ebru Özkan, Anne Holm, John Brandt Brodersen, Christian Apfelbacher","doi":"10.1002/nau.70066","DOIUrl":"10.1002/nau.70066","url":null,"abstract":"<p><strong>Background: </strong>The Danish Holm and Cordoba Urinary Tract Infection Score (HCUTI) assessing symptom severity, bothersomeness and impact of uncomplicated urinary tract infections (uUTIs) on daily activities in women is a promising patient-reported outcome measure (PROM) for use in future research. For potential application in Germany, the present study aimed (i) to perform translation and linguistic validation of the HCUTI, and (ii) to assess content validity of the German version of the HCUTI.</p><p><strong>Methods: </strong>Translation and linguistic validation was performed using the dual-panel method. A bilingual panel of nonprofessional Danish-German speaking persons translated the HCUTI, and the translated version was evaluated regarding comprehensibility by a lay panel of native German-speaking women with past uUTI. Content validity of the German version of the HCUTI was assessed according to the criteria of the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology. In individual cognitive interviews, women with a history of uUTI and experts from different medical fields rated the instructions, items, response options and recall period of the HCUTI in terms of relevance, comprehensiveness and comprehensibility.</p><p><strong>Results: </strong>Translation and linguistic validation resulted in a German version of the HCUTI which lay persons considered easy to understand. In content validity assessments, participants rated the questionnaire as generally relevant and comprehensive. One item was removed due to lack of relevance. The response options were linguistically modified, and a dichotomous scale was introduced for 10 items on symptoms. To enhance comprehensibility, eight items on symptoms and bothersomeness, and one item on daily activities were slightly reformulated. After modification, the German version of the HCUTI includes 18 items on symptoms, 18 items on bothersomeness, and six items on impact on daily activities. The study team reviewed and linguistically standardized the final version of the questionnaire to ensure consistency in wording and sentence structure across all items.</p><p><strong>Conclusions: </strong>The German version of the HCUTI is a suitable tool to assess symptoms, bothersomeness and impact of uUTIs in women. Data on psychometric properties of the instrument will be collected in a subsequent survey among women with uUTIs.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"1064-1070"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor: Conformity of ChatGPT Recommendations With the AUA/SUFU Guideline on Postprostatectomy Urinary Incontinence.","authors":"Vicktor Bruno Pereira Pinto, Jose de Bessa, Cristiano Mendes Gomes","doi":"10.1002/nau.70033","DOIUrl":"10.1002/nau.70033","url":null,"abstract":"","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"1221-1222"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the Gap in Patient Guidance: Quality Analysis of Kegel Exercise Videos on YouTube.","authors":"Nazım Furkan Gunay, Sedat Cakmak, Mucahit Gelmis, Caglar Dizdaroglu","doi":"10.1002/nau.70070","DOIUrl":"10.1002/nau.70070","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the content and quality of YouTube videos on Kegel exercises, focusing on their reliability for patients managing conditions such as premature ejaculation, urinary incontinence, and post-pelvic surgery recovery.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted using the keyword \"Kegel exercises\" on YouTube. The top 100 videos were screened, and 60 met the inclusion criteria. Videos were evaluated using the Kegel Video Evaluation Score (KVES) and the Global Quality Scale (GQS). Video metrics such as duration, views, likes, and comments were recorded, and statistical analyses were performed to assess correlations and inter-rater reliability.</p><p><strong>Results: </strong>The mean KVES and GQS scores were 17.26 ± 4.38 and 3.36 ± 1.09, respectively, with 60% of videos categorized as high quality. Nonphysician health professionals uploaded the highest-quality videos for instructional content. A strong correlation between KVES and GQS was observed (Spearman's ρ = 0.924, p < 0.001), validating the evaluation tool. Video duration positively impacted content comprehensiveness, while views and likes did not correlate with quality.</p><p><strong>Conclusions: </strong>In contrast to previous studies highlighting low-quality medical content on YouTube, this study shows that high-quality Kegel exercise videos are prevalent, suggesting their potential as reliable educational resources. Clinician involvement is essential in guiding patients to trustworthy content and fostering collaboration with content creators to improve digital health information.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"1156-1162"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transvaginal Electrical Stimulation for Treatment of Overactive Bladder Without Incontinence: A Pilot Cross-Over Clinical Trial.","authors":"Michele Torosis, Lynn Stothers, Crystal Cisneros, Georgina Dominique, A Lenore Ackerman","doi":"10.1002/nau.70034","DOIUrl":"10.1002/nau.70034","url":null,"abstract":"<p><strong>Objectives: </strong>Few studies look at therapeutic efficacy specifically in the OAB population that lacks urgency incontinence (OAB-dry). Transvaginal electrical stimulation (TES) improves urgency incontinence in OAB-wet by targeting the detrusor muscle by reflex inhibition but has not yet been trialed for the improvement of urgency and frequency symptoms alone without incontinence. This study sought to measure the efficacy of an at-home TES program on urgency and frequency symptoms alone in OAB-dry.</p><p><strong>Methods: </strong>This was a prospective, randomized, cross-over, controlled trial of women > 18 years old presenting to a urogynecology clinic with urinary urgency and frequency without incontinence. Participants were randomized to receive 4 weeks of sham, followed by a 3-week washout period, and then 4 weeks of intervention (Arm 1), or the reverse (Arm 2). Intervention included 15 min/day of TES using a TENS unit and transvaginal probe with stimulation width of 100 µs, rate of 12 Hz, and amplitude set by participant based on sensation. Baseline bladder symptoms were captured with voiding diaries and standardized questionnaires. Standardized pelvic floor muscle exam was performed at the beginning and end of treatment. Participants were categorized as responders if the participants stated they planned to continue the TES as their primary treatment after study completion. Outcomes were compared using t-tests, χ², and Fisher exact tests.</p><p><strong>Results: </strong>In total, 19 enrolled and 15 (79%) completed the study and had primary outcomes data available for analysis. There were no demographic differences between arms. Mean OAB-q scores for all at baseline was 25.1, post-sham was 22.9, and post-TES was 17.60, for a mean change of -7.73 points (95% CI, -21.5 to 5.9), p = 0.007). There was a reduction in voids per 24 h from 11.3 (± 3.7) to 9.0 (± 3.6) posttreatment (p = 0.048). Response, defined as continuation of therapy, had a significant association with lack of pelvic floor tenderness on baseline standardized exam (OR 0.96, CI 0.94-0.99).</p><p><strong>Conclusions: </strong>These data suggest there are two phenotypes within OAB-dry, those with pelvic floor myofascial dysfunction that do not respond to bladder directive therapy, and those who represent a population of less severe OAB-wet with detrusor overactivity, which respond to bladder directive therapy. TES is a viable treatment option for this population, resulting in clinically significant improvements in urinary symptoms and patient-reported disease severity.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov: NCT04957524.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"977-986"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Artificial Urinary Sphincter (AMS 800, Boston Scientific, USA) Have Any Impact on Sexuality in Women?","authors":"Anne Denormandie, Juliette Cotte, Alexia Even, Pierre Mozer, Aurélien Beaugerie, Emmanuel Chartier-Kastler","doi":"10.1002/nau.70045","DOIUrl":"10.1002/nau.70045","url":null,"abstract":"<p><strong>Purpose: </strong>Artificial urinary sphincter (AUS) AMS 800 has been used for many years in women in Europe for the treatment of stress urinary incontinence. However, there is a lack of studies evaluating its impact on women's sexual function. This study aimed to assess impacts of AUS implantation on women's sexual activity.</p><p><strong>Materials and methods: </strong>This retrospective cohort study included all women seen in clinics between February 2019 and April 2020 for follow-up after an AMS 800 AUS's implantation. The primary outcome was the modification of sexuality, comparing sexual function before and after implantation of the device using a Likert scale called PGII (Patient Global Impression of Improvement). Our secondary outcomes were the assessment of sexual function (Questionnaries FSFI and ICIQ-FLUTSsex) and continence (number of pads). Two groups were separately assessed: patients who were sexually active at the time of surgery and those who were not sexually active at the time of surgery.</p><p><strong>Results: </strong>A total of 55 women were included from a single large tertiary center. The median time from the first implantation of AUS was 7.5 years (5.3-14.2). 60% of patients reported no change on sexual activity after the implantation of the AMS 800 AUS. There was a modification of sexual activity in 40% of patients: 20% showing improvement, 20% showing deterioration. In patients having sexual intercourse before AUS implantation, the rate of change in sexuality was higher (61.7%). Regarding postoperative improvement, 91% of women attributed it to the disappearance of coital incontinence. For patients experiencing deterioration in their sexuality, all reported that it was related to the presence of the AUS.</p><p><strong>Conclusions: </strong>This study suggests that AMS 800 AUS implantation can modify the sexuality of women. Talking about the subject of sexuality, assessing sexual function, and educating patients are necessary before the surgery.</p><p><strong>Trial registration: </strong>The clinical trial was registered at the \"Commission Nationale de l'Informatique et des Libertés\" (CNIL) under the number 20201020155100.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"1126-1133"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy and Safety of Dimethyl Sulfoxide Into the Bladder for the Treatment of Interstitial Cystitis/Bladder Pain Syndrome: A Systematic Review and Meta-Analysis.","authors":"Hai-Rui Li, Si-Hong Shen, Xiao-Shuai Gao, Liao Peng, De-Yi Luo","doi":"10.1002/nau.70036","DOIUrl":"10.1002/nau.70036","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the efficacy and safety of intravesical DMSO instillation for the treatment of interstitial cystitis/bladder pain syndrome.</p><p><strong>Method: </strong>The following databases were searched for relevant studies: PubMed, EMBASE, MEDLINE, Cochrane Library, and Web of Science (updated August 10, 2024). All studies on intravesical DMSO met the inclusion criteria and were evaluated using various quality assessment methods based on the type of study. Data were then analyzed using Review Manager 5.4 (Cochrane Collaboration software). The primary outcomes and indicators included the Interstitial Cystitis Symptom Index, the Interstitial Cystitis Problem Index, and Pain Scores. The secondary outcomes were bladder diary metrics and Pelvic Pain and Urgency/Frequency Symptom Scale (PUF).</p><p><strong>Results: </strong>This systematic review and meta-analysis included 5 randomized controlled trials and 9 single-arm or cohort studies, involving 554 patients. The combined statistics indicated an average pretreatment Interstitial Cystitis Symptom Index score was 14.27, an average Interstitial Cystitis Problem Index Score was 12.72, and an average Pain Score was 7.06. Compared to pretreatment values, the results indicated that the Interstitial Cystitis Symptom Index score decreased by 5.59 (95% CI: -6.68 to -4.50, p < 0.00001), the Interstitial Cystitis Problem Index score decreased by 5.14 (95% CI: -6.45 to -3.83, p < 0.00001), and the Pain Score decreased by 3.27 (95% CI: -3.95 to -2.60, p < 0.00001). Additionally, the overall incidence rate of adverse events in patients was 37.6%. Although 37% of cases had adverse events, the majority were considered mild and acceptable.</p><p><strong>Conclusion: </strong>Evidence-based statistical analysis of the literature on intravesical DMSO treatment for interstitial cystitis/bladder pain syndrome indicates that this therapy is both effective and safe. Therefore, intravesical DMSO instillation can be considered a standard treatment method for interstitial cystitis/bladder pain syndrome.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"1036-1046"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Mechanisms of Microenergy Acoustic Pulse Therapy for the Treatment of Female Stress Urinary Incontinence-Part II.","authors":"Guiting Lin, Liangyu Zhao, Chen Yang, Emily Xing, Tian Bai, Thomas Cao, Guifang Wang, Lia Banie, Yingchun Zhang, Yuxin Tang, Tom F Lue","doi":"10.1002/nau.70048","DOIUrl":"10.1002/nau.70048","url":null,"abstract":"<p><strong>Aims: </strong>While previous studies showed that micro-energy acoustic pulse (MAP) therapy restores urethral structure and function in adult stress urinary incontinence (SUI) rats, the underlying mechanisms remain unclear. This study aimed to explore the effect of MAP therapy in a rat model of vaginal birth injury-induced SUI at single cell resolution.</p><p><strong>Methods: </strong>Rat model of SUI was established using vaginal balloon dilation plus ovariectomy combined with β-aminopropionitrile treatment. Subsequently, MAP therapy was administered twice weekly for a total of 4 weeks. At the end of the treatment, single-cell sequencing was performed to analyze changes of cell heterogeneity and signaling in the urethral tissue microenvironment. Functional evaluations, including leak point pressure (LPP) measurements, electromyography, and electrophysiological studies, were conducted to confirm the effects of MAP therapy on urethral repair and muscle reinnervation.</p><p><strong>Results: </strong>MAP enhanced the transcription levels of various cell proliferation markers, including Pcna, Mki67, and Ccne2. The MAP treatment group exhibited higher muscle fiber content and structural integrity in the urethral sphincter compared to the untreated SUI model group. MAP also improved LPP, reduced sudden jumps in the CMAP value, and activated pathways such as \"ribosome\" in muscle cells. Additionally, MAP reduced senescence-associated beta-galactosidase levels in the urethral epithelium and influenced the expression of multiple transcription factors.</p><p><strong>Conclusions: </strong>MAP therapy effectively promotes urethral repair by modulating cellular aging and improving muscle reinnervation. These findings provide valuable insights into urethral repair mechanisms and lay the groundwork for developing novel therapies for SUI.</p><p><strong>Clinical trial registration: </strong>This study is based on an animal model and does not require a clinical trial registration.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"1193-1202"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Application of T1ρ Magnetic Resonance Imaging for Noninvasive Assessment of Bladder Hyperpermeability Biomarkers: A Focus on Glycosaminoglycan Content.","authors":"Julie A Suyama, Sheronda M Statum, Aurea V R Mohana-Borges, Xin Cheng, Yajun Ma, Jeffrey D Esko, Jennifer T Anger, Christine B Chung, Marianna Alperin","doi":"10.1002/nau.70058","DOIUrl":"10.1002/nau.70058","url":null,"abstract":"<p><strong>Purpose: </strong>Bladder wall hyperpermeability due to glycosaminoglycan depletion is implicated in interstitial cystitis/bladder pain syndrome pathogenesis. This study sought to validate T1ρ MRI as a noninvasive imaging sequence for assessing bladder wall hyperpermeability biomarkers, with a focus on bladder glycosaminoglycan content, in protamine sulfate-induced models of interstitial cystitis/bladder pain syndrome.</p><p><strong>Materials and methods: </strong>Rat bladders (n = 8) treated with saline (control), protamine sulfate, pentosan polysulfate, or protamine sulfate + pentosan polysulfate (rescue) were imaged in situ using T1ρ and standard MRI sequences. Predominant bladder glycosaminoglycans, chondroitin and heparan sulfate, were measured in subsequently harvested rat bladders via aniline tagging coupled with mass spectrometry. Human bladder biopsies (n = 12) were similarly imaged before and after protamine sulfate treatment, and post-imaging glycosaminoglycan analysis was performed. Data were compared between groups using one-way ANOVA or paired Student t-test. T1ρ relaxivity was correlated with chemically measured glycosaminoglycan content using linear regression.</p><p><strong>Results: </strong>Protamine sulfate-treated rat bladders had decreased glycosaminoglycans and higher T1ρ relaxivity relative to controls. Pentosan polysulfate also decreased glycosaminoglycans versus controls and did not mitigate protamine-mediated glycosaminoglycan depletion. Importantly, T1ρ relaxivity correlated with chemical glycosaminoglycan quantification (chondroitin sulfate: r = 0.86, p < 0.01; heparan sulfate r = 0.80, p = 0.02). In human biopsies, T1ρ relaxivity increased after protamine sulfate treatment versus baseline (154.2 ± 5.9 vs. 131.0 ± 4.4 ms, p < 0.001), consistent with decreased glycosaminoglycans, while chemical analyses failed to capture statistically significant changes in bladder glycosaminoglycans.</p><p><strong>Conclusions: </strong>T1ρ MRI accurately measured glycosaminoglycans in rat bladders and differentiated protamine sulfate-treated bladder biopsies from unperturbed specimens in humans. T1ρ MRI warrants further investigation as a novel biomarker of bladder glycosaminoglycan content in interstitial cystitis/bladder pain syndrome.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"1081-1089"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}