Neurourology and Urodynamics最新文献

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Do We Need to Re-Focus on Functional Female Urethral Disorders in Lower Urinary Tract Dysfunction? ICI-RS 2024. 下尿路功能障碍是否需要重新关注功能性女性尿道障碍?ICI-RS 2024。
IF 1.8 3区 医学
Neurourology and Urodynamics Pub Date : 2025-03-01 Epub Date: 2024-11-28 DOI: 10.1002/nau.25633
Christopher J Chermansky, Jeremy L Ockrim, George Bou Kheir, Christopher R Chapple, Rohna Kearney, Bogdan Toia, Roger R Dmochowski, Alan J Wein, Paul Abrams
{"title":"Do We Need to Re-Focus on Functional Female Urethral Disorders in Lower Urinary Tract Dysfunction? ICI-RS 2024.","authors":"Christopher J Chermansky, Jeremy L Ockrim, George Bou Kheir, Christopher R Chapple, Rohna Kearney, Bogdan Toia, Roger R Dmochowski, Alan J Wein, Paul Abrams","doi":"10.1002/nau.25633","DOIUrl":"10.1002/nau.25633","url":null,"abstract":"<p><strong>Aims: </strong>Insights into the role of the urethra in maintaining continence and in normal voiding have been provided with advances in imaging techniques. Also, functional urethral testing is used to understand which treatments are optimal for women with functional bladder outlet obstruction (BOO), but which testing is better for which treatment? This review aims to describe our current understanding of female urethral function and dysfunction and to provide future research directions for treating functional female urethral disorders.</p><p><strong>Materials and methods: </strong>This is a consensus report of the proceedings of a research proposal discussed at the annual International Consultation on Incontinence-Research Society (ICI-RS), 6th-8th June 2024 (Bristol, UK): \"Do we need to re-focus on functional female urethral disorders in lower urinary tract dysfunction? ICI-RS 2024\".</p><p><strong>Results: </strong>Regarding female urethral nomenclature, it was agreed that the same terminology should be used in the orientation of the female urethra as in the male. Also, functional MRI and computer modeling could aid further understanding of urethral function in women with voiding dysfunction and OAB symptoms. As for functional urethral assessment, options include video-urodynamics with leak point pressure (LPP) testing, urethral pressure profilometry (UPP), and striated urethral sphincter electromyography (EMG). Future testing may include the use of modalities (borrowed from cardiologic assessment of vascular structures such as resistive measures obtained with ultrasound) for the purpose of assessing urethral closure. UPP testing has limitations in measurement and reproducibility in assessing urethral pressure. Urethral sphincter EMG is difficult to perform and reproduce. LPP also has limitations related to testing and to patient effort, in addition to being influenced by factors such as bladder volume and compliance. When performing urethral surgery, it is imperative to dissect in tissue planes that preserve urethral function. Regarding therapeutic modalities for the treatment of functional female urethral dysfunction, conservative management includes pelvic floor muscle training with or without biofeedback, electrical stimulation, and extracorporeal magnetic stimulation. Furthermore, there was a robust discussion on the use of cognitive-behavioral therapy to address psychological comorbidities, thereby improving female LUTD. The evidence supporting long-term pharmacologic treatment of female urethral LUTD remains scarce. As for invasive management options, the evidence supporting the use of botulinum toxin in female LUTD is limited. Finally, the very existence of BNO and the validity of its diagnosis was discussed. Furthermore, bladder neck incision as a treatment of BNO was debated, and the indications for this procedure include a therapeutic decision balancing benefit to complications.</p><p><strong>Conclusion: </strong>Improving","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"558-567"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What Is Needed to Determine and Potentially Improve the Clinical Effectiveness and Cost-Effectiveness of Robot-Assisted Reconstructive Urinary Tract and Pelvic Floor Surgery?-ICI-RS 2024. 确定并潜在地提高机器人辅助尿道和盆底重建手术的临床效果和成本效益需要哪些条件?
IF 1.8 3区 医学
Neurourology and Urodynamics Pub Date : 2025-03-01 Epub Date: 2024-11-19 DOI: 10.1002/nau.25625
Michel Wyndaele, Arun Sahai, George Bou Kheir, François Hervé, D Carolina Ochoa, Kevin Rademakers, Thomas van Steenbergen, Qi-Xiang Song, Alan Wein, Paul Abrams
{"title":"What Is Needed to Determine and Potentially Improve the Clinical Effectiveness and Cost-Effectiveness of Robot-Assisted Reconstructive Urinary Tract and Pelvic Floor Surgery?-ICI-RS 2024.","authors":"Michel Wyndaele, Arun Sahai, George Bou Kheir, François Hervé, D Carolina Ochoa, Kevin Rademakers, Thomas van Steenbergen, Qi-Xiang Song, Alan Wein, Paul Abrams","doi":"10.1002/nau.25625","DOIUrl":"10.1002/nau.25625","url":null,"abstract":"<p><strong>Introduction: </strong>Robot-assisted (RA) surgery has many advantages for urinary tract and pelvic floor reconstruction (UTPFR) but its application is only slowly increasing. Studies are limited in number, patients and follow-up duration. The low-volume high-complexity nature of UTPFR warrants specific research to evaluate the potential role of the RA approach.</p><p><strong>Methods: </strong>During its 2024 meeting in Bristol, the International Consultation on Incontinence-Research Society (ICI-RS) reviewed the current literature on RA UTPFR. Priority research questions and strategies were explored in a proposal.</p><p><strong>Results: </strong>Four different topics were discussed. (1) Large multicentre prospective studies on RA UTPFR are needed to evaluate clinical effectiveness and safety. The RA approach needs to be prioritized in specific procedures and patients, to first improve patient care where gains are highest. (2) Models for cost-utility analysis for RA UTPFR are needed to (re)direct limited resources as efficiently as possible in a quickly changing technological field. (3) A modular curriculum for training UTPFR surgeons to become RA certified needs to be developed, to allow valid interpretation and comparison of outcomes. (4) Technological improvements to address tissue handling, accessibility, efficiency and sustainability are needed. Digitalization can be a gamechanger for RA UTPFR through telesurgery (training and expertize coverage), augmented reality and artificial intelligence providing intra-operative assistance, assessment and feedback.</p><p><strong>Conclusions: </strong>The proposal discussed the need for studies on clinical and cost effectiveness, safety, and training curriculum development for RA UTPFR. Recent technological developments hold great promise for RA UTPFR. High-priority research questions were identified.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"683-690"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can We Prevent Recurrent UTIs Without Antibiotics, in Both Those Who Do and Do Not Use Catheters? ICI-RS 2024. 我们能在没有抗生素的情况下预防尿路感染复发吗?ICI-RS 2024。
IF 1.8 3区 医学
Neurourology and Urodynamics Pub Date : 2025-03-01 Epub Date: 2024-12-24 DOI: 10.1002/nau.25641
Christopher Harding, Francesco Clavica, Marcio Augusto Averbeck, Anasofia Da Silva, Marcus John Drake, Jerzy Bogdan Gajewski, Vik Khullar, Michael Pozniak, Angie Marie Rantell, Tufan Tarcan, Glenn Thomas Werneburg, Ilias Giarenis
{"title":"Can We Prevent Recurrent UTIs Without Antibiotics, in Both Those Who Do and Do Not Use Catheters? ICI-RS 2024.","authors":"Christopher Harding, Francesco Clavica, Marcio Augusto Averbeck, Anasofia Da Silva, Marcus John Drake, Jerzy Bogdan Gajewski, Vik Khullar, Michael Pozniak, Angie Marie Rantell, Tufan Tarcan, Glenn Thomas Werneburg, Ilias Giarenis","doi":"10.1002/nau.25641","DOIUrl":"10.1002/nau.25641","url":null,"abstract":"<p><strong>Aims: </strong>Urinary tract infections are one of the most common reasons for antibiotic prescription. The widespread use of antibiotic treatments contributes to the global health problem of antimicrobial resistance development. To slow down the progression of antimicrobial resistance, it is essential that we explore nonantibiotic preventive treatments for this common condition. We aim to report discussions regarding nonantibiotic preventive strategies for recurrent urinary tract infections in both catheterized and non-catheterized patients that took place at the International Consultation on Incontinence-Research Society meeting in Bristol in 2024.</p><p><strong>Methods: </strong>We undertook a think-tank session during this multidisciplinary meeting specifically designated for discussion regarding both established and emerging nonantibiotic treatments for UTI prevention in both catheterized and non-catheterized patients. This led to the generation of pertinent research questions, which hope to shape future UTI research.</p><p><strong>Results: </strong>We describe the discussions that took place and document the important research questions that were proposed during the International Consultation on Incontinence-Research Society meeting in Bristol in 2024.</p><p><strong>Conclusions: </strong>There is a range of established UTI preventative strategies for UTI prevention in both catheterized and non-catheterized patients. Emerging UTI prevention treatments have varying levels of evidence to support their use, and in many areas, further research is needed to establish their place in clinical pathways.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"637-643"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do We Have Sufficient Evidence to Derive Innovative Approaches to Assessing Unmet Need, Delivering Education on Bladder and Bowel Continence Health, and Providing a Better Environment for Joint Decision-Making? ICI-RS 2024. 我们是否有足够的证据来获得创新的方法来评估未满足的需求,提供关于膀胱和肠道失禁健康的教育,并为联合决策提供更好的环境?ICI-RS 2024。
IF 1.8 3区 医学
Neurourology and Urodynamics Pub Date : 2025-03-01 Epub Date: 2025-01-13 DOI: 10.1002/nau.25654
Nikki Cotterill, Michael Samarinas, Angie Rantell, Caroline Selai, Salvador Arlandis, Kathryn Jones, Paul Abrams, D Robinson, Adrian Wagg
{"title":"Do We Have Sufficient Evidence to Derive Innovative Approaches to Assessing Unmet Need, Delivering Education on Bladder and Bowel Continence Health, and Providing a Better Environment for Joint Decision-Making? ICI-RS 2024.","authors":"Nikki Cotterill, Michael Samarinas, Angie Rantell, Caroline Selai, Salvador Arlandis, Kathryn Jones, Paul Abrams, D Robinson, Adrian Wagg","doi":"10.1002/nau.25654","DOIUrl":"10.1002/nau.25654","url":null,"abstract":"<p><strong>Context: </strong>Improved continence outcomes are reliant on identification of unmet need, education delivery, and shared decision-making. The evidence base on which to derive innovative approaches in these areas was unclear.</p><p><strong>Methods: </strong>A debate held at the International Consultation on Incontinence-Research Society meeting, held in Bristol in June 2024, considered ways to improve research requirements to advance these areas.</p><p><strong>Results and conclusion: </strong>Artificial intelligence solutions and digital approaches to healthcare are emerging at pace and offer possibilities to improve these three key areas but this must be driven by person-centered approaches. Care must be taken to avoid increasing inequality through digital exclusion and language barriers. Research questions are highlighted to derive innovation in these three key areas.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"644-650"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do We Have the Evidence to Produce Tools to Enable the Identification and Personalization of Management of Women's Pelvic Floor Health Disorders Through the Perinatal and Perimenopausal Periods? ICI-RS 2024. 我们是否有证据来提供工具,使围生期和围绝经期妇女盆底健康疾病的识别和个性化管理成为可能?ICI-RS 2024。
IF 1.8 3区 医学
Neurourology and Urodynamics Pub Date : 2025-03-01 Epub Date: 2025-02-23 DOI: 10.1002/nau.70019
Rohna Kearney, Stefano Salvatore, Vik Khullar, Christopher Chapple, Annika Taithongchai, Alan Uren, Paul Abrams, Alan Wein
{"title":"Do We Have the Evidence to Produce Tools to Enable the Identification and Personalization of Management of Women's Pelvic Floor Health Disorders Through the Perinatal and Perimenopausal Periods? ICI-RS 2024.","authors":"Rohna Kearney, Stefano Salvatore, Vik Khullar, Christopher Chapple, Annika Taithongchai, Alan Uren, Paul Abrams, Alan Wein","doi":"10.1002/nau.70019","DOIUrl":"10.1002/nau.70019","url":null,"abstract":"<p><strong>Introduction: </strong>There is an increasing recognition of the impact of ageing on pelvic floor health and the consequences in populations with rising proportions of women over the age of 65 years. A think tank was held at the ICI-RS 2024 to discuss the evidence to support the personalisation of women's pelvic floor health during the perinatal and perimenopausal period.</p><p><strong>Methods: </strong>Data was collected and presented on the evidence to support the development of tools to personalise pelvic floor health care. Epidemiological, imaging, patient-reported outcomes, and evidence of tool development questionnaires were discussed. The current evidence and research gaps for potential intervention to prevent the pelvic floor disorders of pelvic organ prolapse, overactive bladder, urinary incontinence and faecal incontinence during the perinatal and perimenopasual time periods were discussed and identified.</p><p><strong>Results: </strong>Epidemiological studies highlight that vaginal delivery and in particular operative vaginal delivery is the single biggest modifiable risk factor for the future development of pelvic floor dysfunction. The oestrogen depletion resulting from the perimenopause and menopause can lead to the development of Genitourinary syndrome of menopause (GSM) which is associated with the risk of developing pelvic floor dysfunction. Ultrasound is a useful technique for assessing the pelvic floor and has been used to assess bladder neck mobility, distensibility of the puborectalis muscle and the striated urethral sphincter volume antenatally with some studies reporting a correlation between these measurements and the need for Caesarean section and development of postpartum stress urinary incontinence. Further studies are needed to standardise these measurements. There are no patient reported outcome questionnaires validated for use in the perinatal and postmenopausal period. The UR- choice tool has been developed to counsel women on the risk of postpartum pelvic floor disorders occurring. However, further evaluation in larger numbers is required.</p><p><strong>Conclusion: </strong>There is significant interest in developing tools to counsel women on the risks of developing pelvic floor dysfunction post partum and after the menopause. Further evaluation of the UR-choice tool was considered a research priority. The timepoint of cervical screening for research into interventions such as pelvic floor health education, lifestyle optimisation and perimenopausal vaginal oestrogen supplementation was identified.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"651-660"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is It Possible to Regenerate the Underactive Detrusor? Part 2. Electrical Stimulation Therapies, Treatment of Bladder Outlet Obstruction, Constipation, and Pelvic Floor Disorders - ICI-RS 2024. 有可能使活动不足的逼尿肌再生吗?第 2 部分 电刺激疗法、膀胱出口梗阻、便秘和盆底障碍的治疗 ICI-RS 2024。
IF 1.8 3区 医学
Neurourology and Urodynamics Pub Date : 2025-03-01 Epub Date: 2024-10-07 DOI: 10.1002/nau.25594
Sanjay Sinha, Jerzy B Gajewski, Tufan Tarcan, Andries Van Huele, Francisco Cruz, Esther M Martinez, Mikolaj Przydacz, George Bou Kheir, Riccardo Lombardo, Alan Wein, Paul Abrams
{"title":"Is It Possible to Regenerate the Underactive Detrusor? Part 2. Electrical Stimulation Therapies, Treatment of Bladder Outlet Obstruction, Constipation, and Pelvic Floor Disorders - ICI-RS 2024.","authors":"Sanjay Sinha, Jerzy B Gajewski, Tufan Tarcan, Andries Van Huele, Francisco Cruz, Esther M Martinez, Mikolaj Przydacz, George Bou Kheir, Riccardo Lombardo, Alan Wein, Paul Abrams","doi":"10.1002/nau.25594","DOIUrl":"10.1002/nau.25594","url":null,"abstract":"<p><strong>Introduction: </strong>Detrusor muscle weakness is commonly noted on urodynamics in patients with refractory voiding difficulty. No clinical therapy has been proven to augment the strength of a detrusor contraction.</p><p><strong>Methods: </strong>This subject was discussed at a think-tank at the International Consultation on Incontinence-Research Society (ICI-RS) held in Bristol, June 2024. The discussions of the think-tank are being published in two parts. This second part discusses the role of electrical stimulation therapies, treatment of bladder outlet obstruction, constipation, and pelvic floor disorders, in the enhancement of strength of a detrusor contraction.</p><p><strong>Results: </strong>Electrical stimulation therapies, specifically sacral neuromodulation, have long been used in the salvage of patients with refractory nonobstructive voiding dysfunction. Clinical improvements can be noted in men following bladder outlet resistance reduction surgery especially, though not limited to those with demonstrable obstruction. Some patients may also show improvement with pelvic floor relaxation therapies and constipation care. However, there is a lack of high-quality urodynamic data to demonstrate an improvement in the strength of a detrusor contraction with these therapies. The think-tank recommends standards for future clinical studies examining treatments aimed at improving an underactive detrusor.</p><p><strong>Conclusions: </strong>Studies need to examine whether clinical improvement following treatment of patients with an underactive detrusor is associated with improvement in strength of the detrusor contraction. New therapeutic options should apply specified standards for assessing and reporting the impact on detrusor contraction.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"585-591"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are We Able to Optimize Outcomes and Predict Complications in Pelvic Floor Surgery With a Better Understanding of Hormonal, Microbial and Other Factors? A Report From the ICI-RS 2024. 通过更好地了解荷尔蒙、微生物和其他因素,我们是否能够优化盆底手术的结果并预测并发症?来自 ICI-RS 2024 的报告。
IF 1.8 3区 医学
Neurourology and Urodynamics Pub Date : 2025-03-01 Epub Date: 2024-12-20 DOI: 10.1002/nau.25645
A Taithongchai, F Reid, E Finazzi Agro, E Rosato, D Bianchi, M Serati, A S Da Silva, I Giarenis, D Robinson, P Abrams
{"title":"Are We Able to Optimize Outcomes and Predict Complications in Pelvic Floor Surgery With a Better Understanding of Hormonal, Microbial and Other Factors? A Report From the ICI-RS 2024.","authors":"A Taithongchai, F Reid, E Finazzi Agro, E Rosato, D Bianchi, M Serati, A S Da Silva, I Giarenis, D Robinson, P Abrams","doi":"10.1002/nau.25645","DOIUrl":"10.1002/nau.25645","url":null,"abstract":"<p><strong>Introduction: </strong>Pelvic organ prolapse (POP) is a common condition, affecting women worldwide and is known to have a significant impact on Health Related Quality of Life (HRQoL). Although there are various treatment options available, including pelvic floor muscle training and support pessaries, many women opt for or require surgery, with a lifetime risk of needing surgery of 12%-19%. As with any operation, this does not come without its complications and the reoperation rate following POP surgery is up to 36%. This International Consultation on Incontinence-Research Society (ICI-RS) report aims to look at the different factors which may play a role in objective and subjective outcomes following pelvic floor surgery and to summarize the evidence and uncertainties regarding prediction of POP surgical outcomes, how to optimize them and the tools available to predict them. Research question proposals to further this field have been highlighted.</p><p><strong>Methods: </strong>At ICI-RS 2024, the evidence for predicting the outcomes from POP surgery and methods to optimize outcomes were discussed and presented in this paper.</p><p><strong>Results: </strong>There are many reasons why POP surgery may fail, such as variations in lifestyle and occupation, persistent constipation, failure in the perineal body, connective tissue types or the shape of the pelvis. There may also be inherent conditions of the vagina, such as hormonal or microbial features. The literature lacks evidence about the potential use of advanced statistical modeling or supervised machine learning in the development of management plans for patients with POP. Furthermore, future research is needed to determine the role of UDS in the preoperative evaluation of POP patients.</p><p><strong>Conclusions: </strong>High-quality powered studies are required to assess optimization for long-term outcomes of pelvic surgery and then, once these are well established, and possible interventions are elucidated, prediction modeling can have a real impact clinically.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"668-675"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Should We Be Treating Affective Symptoms, Like Anxiety and Depression Which May Be Related to LUTD in Patients With OAB? ICI-RS 2024. 我们是否应该治疗可能与OAB患者LUTD相关的情感症状,如焦虑和抑郁?ICI-RS 2024。
IF 1.8 3区 医学
Neurourology and Urodynamics Pub Date : 2025-03-01 Epub Date: 2025-01-16 DOI: 10.1002/nau.25662
Mauro Van den Ende, Apostolos Apostolidis, Sanjay Sinha, George Bou Kheir, Rayan Mohamed-Ahmed, Caroline Selai, Paul Abrams, Desiree Vrijens
{"title":"Should We Be Treating Affective Symptoms, Like Anxiety and Depression Which May Be Related to LUTD in Patients With OAB? ICI-RS 2024.","authors":"Mauro Van den Ende, Apostolos Apostolidis, Sanjay Sinha, George Bou Kheir, Rayan Mohamed-Ahmed, Caroline Selai, Paul Abrams, Desiree Vrijens","doi":"10.1002/nau.25662","DOIUrl":"10.1002/nau.25662","url":null,"abstract":"<p><strong>Aims: </strong>To discuss the role of screening and treatment of affective symptoms, like anxiety and depression in patients with LUTD. A review of the literature regarding the bidirectional association and multidisciplinary approaches integrating psychometric assessments with personalized treatment plans to improve diagnostic accuracy and therapeutic outcomes of LUTD.</p><p><strong>Methods: </strong>This review summarizes discussions and a narrative review of (recent) literature during an International Consultation on Incontinence-Research Society 2024 research proposal with respect to the role of screening for anxiety and depression, effect of mental health symptoms on treatment outcomes and future implications.</p><p><strong>Results: </strong>Consensus recognized the importance to incorporate attention to anxiety and depression in relation to LUTD. The awareness of this association can lead to better outcomes. Future research projects are proposed to evaluate the bidirectional relationship.</p><p><strong>Conclusion: </strong>The relationship between affective symptoms and LUTD underscores the need for integrated treatment approaches that address both psychological and urological dimensions. Further research is required to identify specific patient subgroups that would benefit most from these interventions, to develop standardized screening tools, and to refine treatment protocols. Multidisciplinary care, incorporating psychological assessment and personalized treatment strategies, could enhance outcomes for LUTD patients.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"661-667"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can the Bladder Itself "Measure" Volume, and Thereby Help to Determine When Initiation of Voiding Should Occur? ICI-RS 2024. 膀胱本身能“测量”体积,从而帮助确定何时开始排尿吗?ICI-RS 2024。
IF 1.8 3区 医学
Neurourology and Urodynamics Pub Date : 2025-03-01 Epub Date: 2024-12-18 DOI: 10.1002/nau.25638
Gommert Van Koeveringe, Karen D McCloskey, Anthony J Kanai, Mathijs M de Rijk, Pradeep Tyagi, John E Speich, Christopher H Fry, Alan J Wein
{"title":"Can the Bladder Itself \"Measure\" Volume, and Thereby Help to Determine When Initiation of Voiding Should Occur? ICI-RS 2024.","authors":"Gommert Van Koeveringe, Karen D McCloskey, Anthony J Kanai, Mathijs M de Rijk, Pradeep Tyagi, John E Speich, Christopher H Fry, Alan J Wein","doi":"10.1002/nau.25638","DOIUrl":"10.1002/nau.25638","url":null,"abstract":"<p><strong>Aims: </strong>To answer the question of whether the bladder itself can to any extent control or modulate the initiation of voiding.</p><p><strong>Methods: </strong>This subject was discussed at the International Consultation on Incontinence-Research Society (ICI-RS) 2024 conference in Bristol, UK in a proposal session.</p><p><strong>Results: </strong>Cells in the bladder wall sense the local environment via a diverse array of ion channels and receptors which together provide input to motor-sensory and signal transduction mechanisms. A purinergic signal transduction system provides a high-gain mucosal chemosensitive transduction pathway between bladder wall stretch during filling and graded afferent activation. Recent studies established cross-species similarities in the regulation of urine storage which include the upregulation of aquaporin (water) channels during bladder filling/wall stretch, in the bladder. In addition to the endocrine hypothalamus/pituitary axis production, urothelial production of arginine vasopressin acts on urothelial vasopressin receptors in a paracrine manner causing aquaporin channel upregulation, reducing the bladder volume and delaying sensation of fullness. Bladder shape influences the sensory systems involved in the perception of bladder volume; moreover irregular bladder shapes may correlate with overactive bladder.</p><p><strong>Conclusions: </strong>Volume measuring and signaling threshold-determining mechanisms in the bladder along with shape and permeability act to influence the timing and type of signaling to the CNS; although this is not always followed by a consecutive action. The hierarchical grading of the signals originating from the bladder among other peripheral bodily or central signals are crucial factors that determine whether the bladder is \"allowed\" to initiate voiding.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"568-576"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can We Improve Our Routine Urological Assessment to Exclude Neurogenic Causes for Lower Urinary Tract Dysfunction? ICI-RS 2024. 我们能否改进常规泌尿科评估以排除下尿路功能障碍的神经源性原因?ICI-RS 2024。
IF 1.8 3区 医学
Neurourology and Urodynamics Pub Date : 2025-03-01 Epub Date: 2025-03-10 DOI: 10.1002/nau.70028
Marcus J Drake, Salvador Arlandis, Marcio A Averbeck, Enrico Finazzi Agrò, Claire Hentzen, Giovanni Mosiello, Jalesh Panicker, Matthew Smith, Katie Webb
{"title":"Can We Improve Our Routine Urological Assessment to Exclude Neurogenic Causes for Lower Urinary Tract Dysfunction? ICI-RS 2024.","authors":"Marcus J Drake, Salvador Arlandis, Marcio A Averbeck, Enrico Finazzi Agrò, Claire Hentzen, Giovanni Mosiello, Jalesh Panicker, Matthew Smith, Katie Webb","doi":"10.1002/nau.70028","DOIUrl":"10.1002/nau.70028","url":null,"abstract":"<p><strong>Aims: </strong>After presentation with urinary symptoms, an underlying neurological mechanism sometimes emerges subsequently. Increased awareness may bring earlier diagnosis, improving prognosis and outcomes.</p><p><strong>Methods: </strong>A 2024 International Consultation on Incontinence Research Society think-tank considered the clinical pathway for identification of an undiagnosed neurological or autonomic contribution precipitating urinary symptoms, and the implications for prognosis.</p><p><strong>Results: </strong>Alongside adult-onset neurogenic conditions, potential for missed diagnosis includes congenital and pediatric-acquired neurogenic conditions, which may become symptomatic during a growth spurt due to spinal cord tethering. Detailed assessment is needed, also considering bowel and sexual dysfunction, with timely referral to neurology to reduce preventable progression of disease. In neurological assessment, control of micturition is often poorly characterized compared with other aspects of spinal cord function and the cranial nerves. Screening tools may be used to identify people who have increased likelihood of particular conditions, but currently available tools are either single-system or population specific. In addition to the general pelvic examination, the assessment of sacral reflexes and pelvic sensations can suggest a neurological mechanism, though the sensitivity and specificity of the neuro-urological examination is unknown. Including the results of the neuro-perineal examination in the urodynamic report may improve the interpretation of the results and potentially support a neurological aetiology.</p><p><strong>Conclusion: </strong>Future research should consider the value of neuro-urological examination in diagnosis of occult neurological disease, the development of an occult neurology screening tool/risk scoring based on pelvic organ symptoms, and appropriateness of non-neurologist practitioners requesting neurological investigations such as MRI scanning.</p><p><strong>Clinical trial registration: </strong>Does not apply.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"609-615"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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