Neurourology and Urodynamics最新文献

{"title":"Effect of Intravesical Administration of Steroid Enemas on an Experimental Autoimmune Interstitial Cystitis-Like Mouse Model.","authors":"Kimio Sugaya, Saori Nishijima, Katsumi Kadekawa, Katsuhiro Ashitomi, Seiji Matsumoto","doi":"10.1002/nau.70303","DOIUrl":"https://doi.org/10.1002/nau.70303","url":null,"abstract":"<p><strong>Aim: </strong>Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic, non-bacterial cystitis presenting with bladder pain, frequent urination, and Hunner's lesions. Current therapies, including dimethyl sulfoxide (DMSO) instillation, provide temporary relief but often cause procedural pain. Steroid enemas, used for ulcerative colitis and suitable for self-administration, may offer a novel intravesical treatment option.</p><p><strong>Methods: </strong>An experimental autoimmune interstitial cystitis (EAIC) mouse model was induced by immunization with bladder homogenate. Four weeks later, EAIC mice received intravesical phosphate-buffered saline (PBS), 50% DMSO, or a steroid enema formulation containing prednisolone phosphate (Predonema®). Controls received PBS. Outcomes included locomotor activity, cystometry, histopathology, and bladder gene expression by RT-qPCR.</p><p><strong>Results: </strong>EAIC mice showed increased locomotor activity, shortened bladder contraction intervals, urothelial irregularity, and upregulated inflammatory cytokines (IL-1β, IL-6), chemokines (CCL2, CXCL1, CXCL10), COX-2, NGF, VEGF-A, vimentin, and uroplakin-2. DMSO transiently reduced locomotor activity, worsened epithelial thickening, cellular infiltration, and decreased body weight. In contrast, steroid enema instillation preserved urothelial architecture, reduced inflammation, suppressed gene upregulation, normalized bladder function, and alleviated hyperactivity without adverse effects.</p><p><strong>Conclusions: </strong>EAIC mice reproduce pathological and functional features of IC/BPS. Intravesical steroid enema administration showed superior anti-inflammatory and functional benefits compared with DMSO, without apparent tissue damage or disease-associated hyperactivity. Although the effectiveness of steroid enemas might be partially influenced by the effect of thickening agents used as enema additives, this approach could represent a practical, patient-friendly therapy for IC/BPS, supporting further preclinical and clinical evaluation.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Underlying Choice and Change of Absorbent Incontinence Products in Women With Urinary Incontinence.","authors":"Sarah Qureshi, Saima Rajabali, Adrian Wagg","doi":"10.1002/nau.70305","DOIUrl":"https://doi.org/10.1002/nau.70305","url":null,"abstract":"<p><strong>Background and objective: </strong>Urinary incontinence (UI) is common in women. For up to 77%, the use of absorbent continence products (pads) is central to management. Pad changes are common and reasons for change are not fully described. We hypothesized that women change their pads for many reasons other than wetness and at saturation levels well below advertised capacity.</p><p><strong>Methods: </strong>A sample of 11 community dwelling women aged 65-95 (mean 78.1, SD 8.2) years was included. Participants completed a bespoke questionnaire on satisfaction with their current pads; UI severity and quality of life were measured. Participant's pad use and degree of saturation was recorded. Women then participated in a qualitative interview exploring their pad choices and use.</p><p><strong>Results: </strong>The sample median ICIQ-SF score was 16/21 (IQR 10-17). Median satisfaction of pad use score was 9/20 (IQR 8-12). Median ICIQ LUTS QoL score was 62/76 (IQR 55-67). The median number of pads used per day was 2.3 (IQR 1-4) The median saturation at pad change was 9.5% (IQR 7-19). Qualitative analysis resulted in 43 codes categorized into 7 categories and collapsed into 3 themes \"Product factors,\" \"Lifestyle,\" and \"UI and other health factors.\"</p><p><strong>Conclusion: </strong>Women appear to \"overuse\" absorbent products and change them for diverse reasons, often simply to fit in with their daily routine. Individualized education and support in usage would be beneficial.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Symptom Relief and Practice Setting Variation in Bulkamid Injections for Stress Urinary Incontinence\".","authors":"Malik Zubair Hussain, Anas Ahmed, Majid Khattak, Palwasha Khan","doi":"10.1002/nau.70302","DOIUrl":"https://doi.org/10.1002/nau.70302","url":null,"abstract":"<p><strong>Background: </strong>Urethral bulking agents such as Bulkamid are increasingly used for the management of stress incontinence, with emerging real world evidence supporting their effectiveness.</p><p><strong>Objective: </strong>To critically appraise the recent study by Sze et al. evaluating the symptom relief and practice variation in Bulkamid injections.</p><p><strong>Methods: </strong>This letter is based on a focused critique and discussion of the published study.</p><p><strong>Results: </strong>While the study provides valuable real world insights, several methodological limitations warrant consideration, including lack of stratification by baseline disease severity, absence of adjustment for concomitant pharmacologic therapies, reliance on subjective outcome measures without objective validation, and potential selection bias in comparisons of anesthesia settings. Furthermore, omission of patient centered outcomes such as satisfaction and goal attainment limits interpretation of clinical success.</p><p><strong>Conclusion: </strong>Addressing these limitations through more rigorous study design, incorporation of objective patient centered outcomes, and appropriate adjustment for confounders is essential to better define the true effectiveness and durability of Bulkamid and to support informed clinical decision making in stress and mixed urinary incontinence.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twelfth International Consultation on Incontinence-Research Society 2025: Introduction.","authors":"Paul Abrams, Alan Wein","doi":"10.1002/nau.70297","DOIUrl":"https://doi.org/10.1002/nau.70297","url":null,"abstract":"","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Satisfaction and Decisional Regret After Mesh Versus Non-Mesh Apical Pelvic Organ Prolapse Surgery.","authors":"Helena Bryans, Akash Sharma, Nitya Abraham","doi":"10.1002/nau.70277","DOIUrl":"https://doi.org/10.1002/nau.70277","url":null,"abstract":"<p><strong>Introduction: </strong>Pelvic organ prolapse (POP) is a common condition that can have a significant impact on a woman's quality of life. While surgical success is often measured objectively, patient-centered metrics are equally important.</p><p><strong>Objective: </strong>This study investigated satisfaction, decisional regret, and sexual function in patients who underwent POP surgery with or without mesh to better understand how patients define success.</p><p><strong>Study design: </strong>This is a retrospective review of patients who underwent apical POP surgery from 2015 to 2023 at a single institution serving an ethnically diverse community. Demographic data were collected through chart review and surveys conducted via telephone calls. Patient satisfaction and decisional regret were measured with the validated modified Satisfaction with Decision Scale-Decision Regret Scale for pelvic floor disorders. Sexual function after surgery was measured with the validated 6-question Female Sexual Function Index and open-ended sexual health questions. Patients were compared by use of mesh during surgery (e.g., sacrocolpopexy) versus native tissue repair. Fischer's exact test was used to compare categorical variables and t-tests used to compare continuous variables with p < 0.05 as significant.</p><p><strong>Results: </strong>Of the 250 women contacted who underwent POP surgery between 2015 and 2023, 110 (44%) participated, with a median follow-up of 970 days (IQR 843). Forty (36%) and 70 (64%) patients underwent mesh versus native tissue repair, respectively. There were no significant differences in satisfaction (p = 0.52) and regret (p = 0.83) between mesh and non-mesh groups. Patients who experienced moderate-to-severe decisional regret were significantly more likely to report regret regarding undergoing hysterectomy (p = 0.03) and not having had mesh placed at the time of their POP surgery (p < 0.01), compared to those with mild regret. Fifteen patients (16%) reported sexual health concerns, which were significantly associated with lower satisfaction (p < 0.01).</p><p><strong>Conclusions: </strong>Patients who underwent POP surgery had low regret and high satisfaction with their decision at almost 3 years of follow-up. Regret and satisfaction did not significantly differ based on the use of mesh. Although overall regret was low, open-ended responses revealed nuanced concerns about hysterectomy, mesh, and sexual health, suggesting limitations of current assessment tools. Overall, this study highlights how patient-centered metrics could augment the determination of surgical success and better inform decision-making in patients considering POP surgery.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Media as a Source of Information on Interstitial Cystitis/Bladder Pain Syndrome: Support Tool or Misinformation?","authors":"Marilena Gubbiotti, Chiara Gilli, Laura Pelizzari, Luisa De Palma, Emanuele Rubilotta, Stefano Rosadi","doi":"10.1002/nau.70298","DOIUrl":"https://doi.org/10.1002/nau.70298","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to evaluate which social media platforms are most frequently used by women with interstitial cystitis/bladder pain syndrome and to assess the scientific reliability of the information shared online.</p><p><strong>Materials and methods: </strong>A cross-sectional analysis was conducted on publicly available posts published on Instagram, Facebook, X, YouTube, and TikTok. Only posts containing informative content were included. Spam, duplicated posts, and advertisements were excluded. Two expert urogynecologists independently assessed the scientific accuracy of each post, classifying them as containing scientific evidence, containing scientifically correct but alarming information, or lacking scientific evidence. For each post, authorship type, thematic category, and user engagement were recorded. Inter-rater reliability was calculated using the Kappa statistic.</p><p><strong>Results: </strong>One hundred and forty-six posts were included: 59 on Instagram, 72 on Facebook, 9 on YouTube, 4 on X, and 2 on TikTok. Most Instagram posts were published by healthcare professionals, while Facebook posts were predominantly published by patients. On Instagram, the most frequent topic was awareness, whereas diagnostic and therapeutic discussions were more common on Facebook. A minority of posts contained scientifically validated information. Instagram generated the highest user engagement. Agreement between reviewers was low for patient-generated content but higher for posts focused on diagnosis and treatment.</p><p><strong>Conclusions: </strong>Instagram is mainly used by healthcare professionals to raise awareness, whereas Facebook functions as a patient-driven space for discussion. The majority of posts lacked scientific accuracy, underscoring the need for healthcare professionals to strengthen their online presence to counter misinformation and support individuals seeking reliable information about bladder pain.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor on \"Relative Impact of Male Urinary Conditions on Overall Quality of Life\".","authors":"Aruna V Sarma","doi":"10.1002/nau.70296","DOIUrl":"https://doi.org/10.1002/nau.70296","url":null,"abstract":"","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological and Psychiatric Issues in Functional Constipation, Fecal Incontinence and Bladder and Bowel Dysfunction-A Revised and Updated Document of the International Children's Continence Society (ICCS).","authors":"Alexander von Gontard, Anka Nieuwhof-Leppink, Ubirajara Barroso, Carol Joinson","doi":"10.1002/nau.70291","DOIUrl":"https://doi.org/10.1002/nau.70291","url":null,"abstract":"<p><strong>Purpose: </strong>The aim is to provide an updated and revised overview of psychological and psychiatric aspects of fecal incontinence (FI), functional constipation (FC), non-retentive FI (NRFI) and bladder and bowel dysfunction (BBD). Clinical behavioral disorders and subclinical psychological symptoms are reviewed. Aspects of screening, assessment, counseling, and in severe cases, treatment are outlined and recommendations are formulated.</p><p><strong>Methods: </strong>Relevant publications on psychological and psychiatric aspects are reviewed. The recommendations passed several rounds of consensus finding and were circulated among ICCS board members.</p><p><strong>Results: </strong>In addition to subclinical effects on self-esteem, quality of life, and stress, the rate of comorbid psychiatric disorders is increased. 30%-50% with FI, FC, and NRFI fulfill the criteria for clinically relevant psychiatric disorders. A special risk group is children with BBD. The concomitant psychiatric disturbances include externalizing, internalizing, and neurodevelopmental disorders. They require assessment and counseling, in severe cases, treatment. They have a negative effect on compliance and outcome if not addressed and left untreated.</p><p><strong>Recommendations: </strong>Because the comorbidity rate is high, screening for psychological symptoms is recommended for all children in all settings with FI, FC, FNRFI and BBD. In addition to clinical observation, exploration and history, standardized, validated broadband behavioral questionnaires are recommended. If problem items in the clinical range are present, a full child psychiatric or psychological assessment is recommended.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activities of Daily Living Level is Associated With Recovery of Catheter-Free Urination Among Patients Hospitalized in an Acute Care Hospital.","authors":"Takashi Tanaka, Akihiro Kanematsu, Nana Nagai, Hiroe Yoneda, Saya Yamanaka, Yuriko Kou, Toeki Yanagi, Yusuke Yamada, Ryoichi Saito, Kazuhisa Domen, Shingo Yamamoto","doi":"10.1002/nau.70295","DOIUrl":"https://doi.org/10.1002/nau.70295","url":null,"abstract":"<p><strong>Introduction: </strong>To examine the Activities of Daily Living (ADL) level required to achieve catheter-free urination in cases where a urinary catheter was inserted due to urinary retention, urination difficulty, or urinary incontinence in an acute care hospital.</p><p><strong>Methods: </strong>This study included patients who were originally capable of self-urination but required rehabilitative therapy and intervention by the multidisciplinary urination care team for difficulty in removal of indwelled Foley catheter during hospitalization. The primary outcome was catheter-free independent urination. Patients who achieved urinary independence through self-catheterization for prolonged neurogenic bladder dysfunction were excluded. ADL scores before and after the intervention were evaluated using the Functional Independence Measure (FIM), which was consisted of motor FIM (mFIM), cognitive FIM, and total FIM, with and without deduction for urinary control score (-UC). Logistic regression analyses were performed to identify factors associated with independent urination, and Receiver Operating Characteristic (ROC) curve analysis was conducted to determine the appropriate cutoff.</p><p><strong>Results: </strong>The study included 87 cases (72.8 ± 12.4 years old, male:female = 51:36). Catheter-free urination was achieved in 43 (49%) patients. There were no significant differences between the catheter-dependent and catheter-free groups in terms of gender, age, hospitalized departments, treatment methods, total duration of admission, duration of intervention, discharged destination, and comorbidities. At the end of the intervention, the FIM scores were all significantly higher in the catheter-free group than in the catheter-dependent group. To achieve catheter-free urination, mFIM-UC at the end of the intervention was the only statistically significant corelate (p < 0.001). In the ROC analysis, the AUC of mFIM-UC at the end of the intervention was 0.834, and the optimal cutoff value was 30 points (full score 84), with a sensitivity of 0.91 and specificity of 0.66.</p><p><strong>Conclusion: </strong>ADL as represented by mFIM is a major correlate of catheter-free urination.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Outcomes of Sacral Neuromodulation in Patients With Multiple Sclerosis.","authors":"Murat Yavuz Koparal, Stephen Rhodes, David Sheyn, Adonis Hijaz","doi":"10.1002/nau.70292","DOIUrl":"https://doi.org/10.1002/nau.70292","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the revision and removal rates of sacral neuromodulation (SNM) in patients with multiple sclerosis (MS) using a large national administrative dataset.</p><p><strong>Methods: </strong>This was a retrospective cohort study using the Premier Healthcare Database. There were 13 913 patients analyzed between the years of 2006 and 2022), 218 of whom had diagnosis of MS. Patients were categorized into two groups as with MS and without any neurological disorders including MS (controls). The primary outcome was the relationship of MS on the 1- and 5-year device revision/removal rates. Secondary outcomes were associated complication rates within 1 year and beyond 1 year, the association between type of antibiotic prophylaxis and infectious complications.</p><p><strong>Results: </strong>Patients with MS had similarly low rates of mechanical (within 1 year 1.8% vs. 2.1%; p = 0.98, and beyond 1 year 2.8% vs. 4.5%; p = 0.28), infectious (within 1 year 1.4% vs. 0.84%; p = 0.62, and beyond 1 year 0% vs. 0.29%; p = 0.88), and other complications (within 1 year 0.46% vs. 0.73%; p = 0.95, and beyond 1 year 0.46% vs. 0.93%; p = 0.71) within and beyond 1 year compared to controls, respectively. There was no statistically significant difference in revision/removal rates at 1 and 5 years between MS (11.2% and 29.9%) and for control patients (8.1% and 26.9%), respectively. In multivariable Cox proportional hazards models, MS was not found to be associated with removal/revision.</p><p><strong>Conclusion: </strong>Our results suggest that a diagnosis of MS does not appear to impact SNM associated revision/removal rates and is associated with similarly low rates of complications compared to patients without any neurologic condition.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}