Neurourology and Urodynamics最新文献

{"title":"Prevalence and Risk Factors of Overactive Bladder Among Military Healthcare Workers in an Academic Hospital in Thailand: Implications for Workplace Productivity.","authors":"Pasin Charnviboon, Satit Siriboonrid, Nattapong Binsri, Sarayut Kanjanatarayon, Weerayut Wiriyabanditkul, Thanisorn Pattanasuwon, Vittaya Jiraanankul","doi":"10.1002/nau.70153","DOIUrl":"https://doi.org/10.1002/nau.70153","url":null,"abstract":"<p><strong>Introduction: </strong>Overactive bladder (OAB) is a common clinical syndrome known to significantly impact individuals' quality of life and work productivity. This study aimed to determine the prevalence and risk factors of OAB among military healthcare workers in an academic hospital in Thailand, with a focus on its effects on workplace productivity.</p><p><strong>Materials and method: </strong>A cross-sectional observational study was conducted among military healthcare workers undergoing annual health checks in 2023. The diagnosis of OAB was made using the validated Thai version of the Overactive Bladder Symptoms Score (OABSS-T). Participants with abnormal urine analysis results (RBC ≥ 3/hpf and/or WBC ≥ 3/hpf) were excluded. Data on demographics, symptoms, and relevant risk factors were collected via self-report questionnaires.</p><p><strong>Results: </strong>Among 923 participants, the overall prevalence of OAB was 15.8%, with no significant difference between sexes. OAB-dry and OAB-wet were identified as 7.1% and 8.7% of participants, respectively. Participants with OAB reported significantly higher bladder discomfort scores than those without OAB (mean score: 2.44 ± 1.18 vs. 1.29 ± 0.61; p < 0.001). After adjusting for multiple risk factors, OAB was associated with a significant reduction in work hours, with affected individuals working an average of 4.20 fewer hours per week (p = 0.037). Multivariable analysis identified several risk factors, including a BMI ≥ 25, lower education, sedentary work, limited restroom access, a history of UTIs, and smoking. Conversely, caffeine consumption is associated with a lower likelihood of OAB, likely due to avoidance by symptomatic individuals.</p><p><strong>Conclusion: </strong>This study demonstrates a moderate prevalence of OAB among Thai military healthcare workers and reveals its potential negative impact on workplace productivity. Identifying modifiable risk factors presents opportunities for targeted interventions to reduce symptom burden and support occupational well-being in this workforce.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Critical Study Investigating the Impact of Preoperative Urodynamics on Treatment in Women With Pelvic Organ Prolapse.","authors":"Mustafa Gülmen, Ali Furkan Batur","doi":"10.1002/nau.70150","DOIUrl":"https://doi.org/10.1002/nau.70150","url":null,"abstract":"","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Effectiveness of Extracorporeal Magnetic Stimulation in the Treatment of Pelvic Floor Dysfunction: A Systematic Review and Meta-Analysis\".","authors":"Paola Emilia Ferrara, Alberto Cutaia, Eliana Rampulla, Rossella Calciano, Gianpaolo Ronconi","doi":"10.1002/nau.70151","DOIUrl":"https://doi.org/10.1002/nau.70151","url":null,"abstract":"","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applicability of Creatinine- and Cystatin C-Based Estimated Glomerular Filtration Rate Equations in Patients With Neurogenic Lower Urinary Tract Dysfunction.","authors":"Yuanyuan Wei, Shuang Li, Dong An, Liang Chen, Zhizhong Liu, Yingchun Ma, Limin Liao","doi":"10.1002/nau.70147","DOIUrl":"https://doi.org/10.1002/nau.70147","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the applicability of Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations and Chinese eGFR Investigation Collaboration (C-eGFR) equations in estimating glomerular filtration rate (GFR) in patients with neurogenic lower urinary tract dysfunction (NLUTD). These equations are based on serum creatinine, cystatin C, or combined creatinine and cystatin C.</p><p><strong>Methods: </strong>This prospective study enrolled 142 adult patients with NLUTD. GFR was measured using the dual plasma ⁹⁹mTc-DTPA plasma clearance method. We compared the bias, precision, accuracy and correct classification percentage of six estimated glomerular filtration rate (eGFR) equations, including CKD-EPI creatinine equation (CKD-EPIcr), C-eGFR creatinine equation (C-eGFRcr), CKD-EPI creatinine-cystatin C equation (CKD-EPIcr-cys), C-eGFR creatinine-cystatin C equation (C-eGFRcr-cys), CKD-EPI cystatin C equation (CKD-EPIcys), and C-eGFR cystatin C equation (C-eGFRcys).</p><p><strong>Results: </strong>The median (interquartile range [IQR]) of measured GFR (mGFR) was 60.54 (34.66-86.28) mL/min/1.73 m². Both CKD-EPIcr and C-eGFRcr significantly overestimated GFR (median differences of 17.20 and 13.60 mL/min/1.73 m², respectively; both p < 0.01), and P₃₀ values (percentage of estimated GFR within 30% of mGFR) were 51% and 57%, respectively. CKD-EPIcr-cys demonstrated superior performance than C-eGFRcr-cys (median difference: 2.07 vs 9.13 mL/min/1.73 m²; both p < 0.01; P₃₀: 84% vs 69%). CKD-EPIcys achieved the highest P₃₀ (88%), while C-eGFRcys showed minimal bias (median difference: 0.42 mL/min/1.73 m²; p = 0.69). CKD-EPIcr-cys, CKD-EPIcys, and C-eGFRcys all achieved acceptable P₃₀ values and correct classification percentage. CKD-EPIcr-cys performed optimally at mGFR ≥ 60 mL/min/1.73 m², whereas CKD-EPIcys was superior at mGFR < 60 mL/min/1.73 m².</p><p><strong>Conclusion: </strong>Creatinine-based equations systematically overestimate GFR in NLUTD patients and should be used with caution. In contrast, cystatin C-based equations-whether used alone (e.g., CKD-EPIcys, C-eGFRcys) or combined with creatinine (e.g., CKD-EPIcr-cys)-demonstrate superior accuracy and should be preferred for GFR estimation in NLUTD patients.</p><p><strong>Clinical trial registration: </strong>The Chinese clinical trial registration number is ChiCTR2100054934.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower Urinary Tract Symptoms in Male Multiple Sclerosis: Accounting for Confounders and Treatment Effects.","authors":"Christian Messina","doi":"10.1002/nau.70148","DOIUrl":"https://doi.org/10.1002/nau.70148","url":null,"abstract":"","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Biomarkers in the Diagnosis and Treatment of Interstitial Cystitis/Bladder Pain Syndrome: What Does Current Evidence Reveal?","authors":"Yu-Chen Chen, Pradeep Tyagi, Marianna Alperin, Joel N H Stern, A Lenore Ackerman, Hann-Chorng Kuo","doi":"10.1002/nau.70144","DOIUrl":"https://doi.org/10.1002/nau.70144","url":null,"abstract":"<p><strong>Aims: </strong>This narrative expert review aims to elucidate the role of biomarkers in the diagnosis and treatment of interstitial cystitis/bladder pain syndrome (IC/BPS), highlighting their potential to enhance patient care by enabling more precise and individualized therapeutic strategies.</p><p><strong>Methods and results: </strong>We performed a comprehensive review of literature focused on biomarkers relevant to IC/BPS, including bladder capacity, symptom intensity, bladder wall thickness, as well as serum and urinary inflammatory cytokines and other biomarkers of inflammation, oxidative stress, and urothelial and extracellular matrix remodeling. Evidence indicates that biomarkers such as TNF-α, IL-8, and bladder capacity can differentiate between Hunner lesion and non-Hunner lesion IC subtypes, predict treatment responses, and guide effective interventions. Furthermore, advanced statistical methods and machine learning applications show promise in improving diagnostic accuracy and treatment outcome predictions through clustering of the biomarker data.</p><p><strong>Conclusions: </strong>Reliable biomarkers are vital for improving diagnostic precision and tailoring therapies for IC/BPS patients. Ongoing research and validation of these biomarkers are essential for advancing understanding, guiding treatment decisions, and enhancing the quality of life for individuals affected by this complex syndrome. The need for integrated biomarker profiles and multipronged research approaches is crucial for the future of IC/BPS management.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triathletes and Urinary Incontinence: An Investigation of Prevalence and Associated Factors.","authors":"Tais Schwamberger, Thuane Huyer da Roza, Eliane Regina Mendoza Arbieto, Isabela Cardoso Ferreira, Letícia Beatrice Tramontin Schuler, Luiz Henrique Cabral Duarte, Soraia Cristina Tonon da Luz","doi":"10.1002/nau.70145","DOIUrl":"https://doi.org/10.1002/nau.70145","url":null,"abstract":"<p><strong>Aims: </strong>This study aimed to investigate the prevalence of urinary incontinence (UI) among Brazilian female triathletes and to identify associated factors, focusing on demographic, obstetric, and sports-related variables.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with 90 female triathletes. Data on age, body mass index (BMI), pregnancy history, parity, delivery type, training frequency, and weekly training volume were collected through in-person interviews and an online questionnaire. UI severity was assessed using the International Consultation on Incontinence Questionnaire - Short Form (ICIQ-SF). Ordinal logistic regression was used to analyze factors associated with UI severity, and multinomial logistic regression examined associations between training volume and UI type.</p><p><strong>Results: </strong>The prevalence of UI was 43.3%. Stress urinary incontinence (SUI) was the most common type (25.6%). A greater number of deliveries was associated with increased UI severity (OR = 1.577; 95% CI: 1.047-2.374), while higher training frequency was protective against UI (OR = 0.761; 95% CI: 0.607-0.954). Increased running volume was associated with greater odds of presenting mixed UI (OR = 1.004; 95% CI: 1.001-1.006). Weekly training frequency was inversely associated with both stress and mixed UI.</p><p><strong>Conclusions: </strong>UI was reported by 43.3% of triathletes, with SUI being the most prevalent type at 25.6%. Parity was the only sociodemographic factor significantly associated with UI. Higher weekly frequency in all disciplines appeared to reduce the likelihood of UI, especially SUI. In contrast, running volume showed a minimal or no association with an increased risk of MUI.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Developments in Orexin Pharmacology: Implications for Nocturia and Sleep.","authors":"Donald L Bliwise, Jeffrey P Weiss, Alan J Wein","doi":"10.1002/nau.70143","DOIUrl":"https://doi.org/10.1002/nau.70143","url":null,"abstract":"","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence-Based Analysis of Uroflowmetry Patterns in Children: A Machine Learning Perspective.","authors":"Faruk Arslan, Omer Algorabi, Onur Can Ozkan, Yusuf Sait Turkan, Ersin Namli, Yunus Emre Genc, Cagri Akin Sekerci, Selcuk Yucel, Kamil Cam, Tufan Tarcan","doi":"10.1002/nau.70139","DOIUrl":"https://doi.org/10.1002/nau.70139","url":null,"abstract":"<p><strong>Aim: </strong>Uroflowmetry (UF) is one of the most commonly used noninvasive tests in the evaluation of children with lower urinary tract symptoms (LUTS). However, studies have highlighted a weak agreement among experts interpreting voiding patterns. This study aims to assess the impact of Machine Learning (ML) models, which have become increasingly prevalent in medicine, on the interpretation of voiding patterns.</p><p><strong>Materials and methods: </strong>The study included UF tests of children aged 4-17 years who were referred to our clinic with LUTS. Voiding patterns were independently interpreted by three experts in pediatric urology. Discrepancies in interpretations were jointly re-evaluated by these three observers, and a consensus was reached. Voiding volume (VV), voiding duration (VD), and urine flow rates at 0.5-s intervals were converted into numerical data for analysis. Eighty percent of the data set was used as training data for ML, while the remaining 20% was reserved for testing. A total of five different ML models were employed for classification: Decision Tree, Random Forest, CatBoost, XGBoost, and LightGBM. The models that most accurately identified each voiding pattern were determined.</p><p><strong>Results: </strong>We included a total of 500 UF tests in our study, comprising 221 boys (44.2%) and 279 girls (55.8%). The mean age of the children was 9.17 ± 3.41 years. In the initial assessment, 311 tests (62.2%) were interpreted identically by the observers, while 189 tests (37.8%) were interpreted differently by at least one observer (Fleiss' κ = 0.608). Of the samples used for ML training, 253 (50.6%) exhibited a bell-shaped pattern, 52 (10.4%) a tower pattern, 103 (20.6%) a staccato pattern, 40 (8%) an interrupted pattern, and 52 (10.4%) a plateau voiding pattern. Among the models tested, the highest accuracy was achieved with XGBoost (85.00% ± 2.90), while the lowest accuracy was observed with the Decision Tree model (81.80% ± 1.47). When evaluating voiding patterns individually, the interrupted voiding pattern demonstrated the highest accuracy rates (95%-100%), where as the tower (63.46%-73.08%) and plateau (61.54%-71.15%) patterns had the lowest.</p><p><strong>Conclusion: </strong>The current trial demonstrated, for the first time, that ML models achieved an acceptable accuracy rate in interpreting UF patterns in children. Consequently, artificial intelligence (AI) models have the potential to help standardize the analysis of UF voiding patterns in the future.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov (Ref: NCT06814847).</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Mechanics of the Bladder During Voiding Using MRI.","authors":"Juan Pablo Gonzalez-Pereira, Wade Bushman, Alejandro Roldan-Alzate","doi":"10.1002/nau.70140","DOIUrl":"10.1002/nau.70140","url":null,"abstract":"<p><strong>Purpose: </strong>Uro-Dynamic MRI was used to non-invasively quantify bladder biomechanics, characterizing the fundamental relationship between bladder wall surface area and bladder volume during voiding.</p><p><strong>Methods: </strong>Differential Subsampling with Cartesian Ordering MRI sequence was used to acquire multiple volumetric bladder images during the voiding in five normal male subjects. Images were imported into MIMICS. Bladder volume and bladder wall surface area were obtained using threshold-based image segmentation and the main axes of bladder wall deformation were measured/tracked throughout voiding. Linear anatomical measurements yielded bladder volume estimation using a generalized ellipsoid approximation and facilitated direct comparison with the metrics obtained from the 3D renderings.</p><p><strong>Results: </strong>Ellipsoid volume approximation showed high agreement with volume from 3D renderings; however, this agreement does not hold for flow rates derived from both approaches. Analysis of changes in volume and surface area from 3D renderings show bladder deformation that varies throughout voiding, behaving closer to an idealized spherical bladder past the point of maximum flow. Further analysis suggests an asymmetrical and nonconstant change of bladder dimensions in relation to changes in bladder volume, and a generalized concentric contraction of the bladder wall past maximum flow during the voiding event.</p><p><strong>Conclusion: </strong>Uro-Dynamic MRI allowed time-resolved analysis of the relationship between changes in anatomy-based measurements, volume and surface area of the bladder. This methodology highlights the use of Uro-Dynamic MRI as a powerful tool to comprehensively extract anatomical information of the bladder and correlate this information with novel Noninvasive metrics to evaluate patient specific biomechanics.</p><p><strong>Clinical trial registration: </strong>The patients recruited for this study and data collected for this manuscript are not part of a clinical trial.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}