Northern Clinics of Istanbul最新文献_第7页

Serum fibrinopeptide A is increased in patients with acute coronary syndrome. 急性冠脉综合征患者血清纤维蛋白肽A升高。

IF 1

Northern Clinics of Istanbul Pub Date : 2023-01-01 DOI: 10.14744/nci.2021.12499

Ahmet Seyda Yilmaz, Abdulkadir Uslu, Faruk Kara, Fatih Kahraman, Omer Faruk Cirakoglu

{"title":"Serum fibrinopeptide A is increased in patients with acute coronary syndrome.","authors":"Ahmet Seyda Yilmaz, Abdulkadir Uslu, Faruk Kara, Fatih Kahraman, Omer Faruk Cirakoglu","doi":"10.14744/nci.2021.12499","DOIUrl":"https://doi.org/10.14744/nci.2021.12499","url":null,"abstract":"Objective: Acute coronary syndrome (ACS) is one of the leading causes of mortality, globally. Atherosclerosis is an underlying factor in ACS process and coagulative cascade is activated secondary to atherosclerotic plaque rupture. Fibrinopeptide A (FPA) takes an active role in thrombus formation and is an indicator of coagulative process. We aimed to evaluate serum FPA level in patients with ACS.Methods: Patients diagnosed with ACS and chronic coronary syndrome (CCS), with non-obstructive coronary artery disease as a control group, were included in the study. Blood samples and demographic data of all patients were obtained at admission. Obtained data were compared between ACS and control groups.Results: The study consisted of 107 patients with ACS and 69 patients with CCS. ACS group was older (p<0.001) with male preponderance (p<0.001), more likely to had hypertension (p<0.001), and had a higher smoking rate (p<0.001). Serum FPA level was highest in the ST elevated myocardial infarction group (p<0.001). FPA>3.38 ng/mL predicted ACS with 89.7% sensitivity and 78% specificity (AUC: 0.825, 95% CI 0.745-0.905; p<0.001).Conclusion: Serum FPA may be used for the differential diagnosis of ACS. In addition, patients with increased FPA may be considered to be given more aggressive antithrombotic medication.","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"10 1","pages":"17-23"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/17/07/NCI-10-017.PMC9996658.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9102076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New-onset of juvenile systemic lupus erythematosus following COVID-19 vaccination: First case report. 新冠肺炎疫苗接种后新发青少年系统性红斑狼疮1例报告

IF 1

Northern Clinics of Istanbul Pub Date : 2023-01-01 DOI: 10.14744/nci.2022.93899

Jozélio Freire de Carvalho

引用次数: 1

Cost of diabetes mellitus and related macrovascular complications in Turkiye. 土耳其糖尿病及相关大血管并发症的成本。

IF 1

Northern Clinics of Istanbul Pub Date : 2023-01-01 DOI: 10.14744/nci.2023.24922

Suayip Birinci, Haydar Sur

{"title":"Cost of diabetes mellitus and related macrovascular complications in Turkiye.","authors":"Suayip Birinci, Haydar Sur","doi":"10.14744/nci.2023.24922","DOIUrl":"https://doi.org/10.14744/nci.2023.24922","url":null,"abstract":"Objective: This study aimed to identify the costs and resources used for diabetes mellitus (DM) and macrovascular complications in Turkiye.Methods: The \"Cost of Illness\" method and a bottom-up costing approach were used in this study. We used e-Nabiz to identify patients with DM and collected their data from 2016 to 2020. We also examined macrovascular complications such as acute coronary syndrome, unstable angina, coronary artery disease, cerebrovascular events, transient ischemic attacks, carotid artery syndrome, intracranial hemorrhage, diabetic foot, heart failure, atrial fibrillation, and peripheral vascular disease using relevant ICD codes. No sampling was done; costs were calculated based on the entire population. When calculating per patient costs, all outpatient/inpatient, medication, intervention, and laboratory/screening tests were considered.Results: Between 2016 and 2020, the e-Nabiz database recorded 7,656,700 people diagnosed with diabetes, a prevalence of 10.4%. The total 2020 cost for treating diabetes was $4,526,212,569 (31,276,128,849 TL), with an average patient cost of $591.145. The health-care expense for 991,945 people diagnosed with major vascular complications due to diabetes was $1,013,004,565.0 (6,999,861,544.16 TL) in 2020, with a per patient average cost also of $591.145 (4048.81 TL). Breakdown of the total cost is 44% for healthcare, 34% for medication, 12% for insulin, 6% for oral antidiabetic drugs, and 1% for testing supplies. Women have a complication rate of 11.2%, while men have a higher rate of 20.8%.Conclusion: DM is both a significant disease burden and an important economic burden. The findings will be a guide the development of effective strategies and sound health policies.","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"10 4","pages":"418-427"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f2/af/NCI-10-418.PMC10500234.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10307946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Should children with psoriasis be consulted to a rheumatologist? Result from pediatric rheumatology-dermatology collaboration. 患有牛皮癣的儿童是否应该咨询风湿病专家?结果来自儿科风湿病-皮肤病学合作。

IF 1

Northern Clinics of Istanbul Pub Date : 2023-01-01 DOI: 10.14744/nci.2021.77785

Serife Gul Karadag, Figen Cakmak, Zeynep Topkarci, Hafize Emine Sonmez, Ayse Tanatar, Muge Kepekci Erdugan, Esin Aldemir, Neval Topal, Mustafa Cakan, Nuray Aktay Ayaz

{"title":"Should children with psoriasis be consulted to a rheumatologist? Result from pediatric rheumatology-dermatology collaboration.","authors":"Serife Gul Karadag, Figen Cakmak, Zeynep Topkarci, Hafize Emine Sonmez, Ayse Tanatar, Muge Kepekci Erdugan, Esin Aldemir, Neval Topal, Mustafa Cakan, Nuray Aktay Ayaz","doi":"10.14744/nci.2021.77785","DOIUrl":"https://doi.org/10.14744/nci.2021.77785","url":null,"abstract":"Objective: The objectives of this study were to determine the musculoskeletal (MSK) conditions associated with pediatric psoriasis (Pso) and to evaluate the thickness of Achilles tendon of children with Pso and healthy controls (HCs).Methods: Pso patients who were followed-up in dermatology outpatient clinic were referred to a pediatric rheumatology center. All patients and healthy peers were evaluated with standardized forms. Both patients and controls underwent ultrasonographic evaluation for Achilles tendon thickness.Results: A total of 55 pediatric Pso and 46 healthy children were included in the study. Of patients with Pso 56.4% had arthralgia, 25.5% had lower back pain, 18.2% had heel pain, 12.7% had hip pain, and 10.9% described morning stiffness. Arthritis was detected in 7.3%, sacroiliac tenderness in 12.7%, and enthesitis in 9.1% of the patients. Arthralgia, lower back pain, and heel pain were significantly frequent in Pso group than healthy children median left and right Achilles tendon thicknesses of Pso patients who were significantly greater than that of HCs prevalence of psoriatic arthritis (PsA) among Pso patients was 7.3%.Conclusion: Evaluation of a child with Pso regularly for the MSK complaints is critical for the early recognition of PsA. Ultrasonography is a useful technique for screening Pso patients for early detection of enthesopaty.","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"10 1","pages":"59-66"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/11/8e/NCI-10-059.PMC9996663.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9100913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A possible alternative to Opiorphin and its stable analogues for treating fibromyalgia pain: A clinical hypothesis. 一种可能替代Opiorphin及其稳定的类似物治疗纤维肌痛:一个临床假设。

IF 1

Northern Clinics of Istanbul Pub Date : 2023-01-01 DOI: 10.14744/nci.2022.92603

Debaraj Roy, Hindustan Abdul Ahad, Haranath Chinthaginjala, Ganthala Aravind Kumar, Gummadisani Govardhan Reddy, Amminga Siddartha Tharun Teja

{"title":"A possible alternative to Opiorphin and its stable analogues for treating fibromyalgia pain: A clinical hypothesis.","authors":"Debaraj Roy, Hindustan Abdul Ahad, Haranath Chinthaginjala, Ganthala Aravind Kumar, Gummadisani Govardhan Reddy, Amminga Siddartha Tharun Teja","doi":"10.14744/nci.2022.92603","DOIUrl":"https://doi.org/10.14744/nci.2022.92603","url":null,"abstract":"The work aimed to explore the clinical hypothesis on the possible alternative to Opiorphin and its stable analogues for treating fibromyalgia pain. Fibromyalgia is a condition characterized by chronic pain triggered by an interplay of biological and psychosocial variables, although the exact pathogenesis is still controversial. Standard therapy for low threshold tender point pain includes NSAIDs and opioid analgesics, both of which have serious adverse profiles after long-term exposure, highlighting the need for an intermediate compound capable of bridging the gap between NSAIDs and opioid analgesics. Opiorphin is an anti-nociceptive modulator which inhibits the enzyme responsible for the degradation of natural endogenous opioid neuropeptides. This paper hypothesizes and concludes that Opiorphin and its stable analogues (Sialorphine, STR-324) can be an alternative for the treatment of chronic long-standing low-threshold tender point pain associated with fibromyalgia.","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"10 1","pages":"122-126"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6d/16/NCI-10-122.PMC9996662.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9102078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does systemic immune inflammation index have predictive value in gastric cancer prognosis? 全身免疫炎症指数对胃癌预后有预测价值吗?

IF 1

Northern Clinics of Istanbul Pub Date : 2023-01-01 DOI: 10.14744/nci.2021.71324

Hakan Uzunoglu, Selcuk Kaya

{"title":"Does systemic immune inflammation index have predictive value in gastric cancer prognosis?","authors":"Hakan Uzunoglu, Selcuk Kaya","doi":"10.14744/nci.2021.71324","DOIUrl":"https://doi.org/10.14744/nci.2021.71324","url":null,"abstract":"Objective: Some studies have reported that the systemic immune inflammatory index (SII) and neutrophil/lymphocyte ratio (NLR) provide predictive data on prognosis in gastric cancer patients. In the present study, it was aimed to examine the diagnostic and prognostic values of SII and NLR in gastric cancer.Methods: A total of 152 patients, operated with the diagnosis of gastric cancer and followed up in the General Surgery Department of our hospital between January 2012 and April 2018, and 152 healthy controls were included in the study.Results: The mean SII (989±685) and the mean NLR (3.9±5.2) were significantly higher in gastric cancer patients than the healthy control group (433±203 and 1.9±0.8, respectively) (p<0.001 for both). In the receiver operating characteristic analyzes, a threshold value of 892 for SII had a sensitivity of 66.7% and a specificity of 62.7% in terms of predicting 5-year survival (AUC: 0.637; p=0.076; LB: 0.475; UB: 0.799; CI 95%). The 5-year survival rate was found to be significantly higher in those with a SII of above 892 than those with a SII of 892 and below (p=0.026). The 5-year mortality risk was 0.67-fold lower in those with SII above 892 (p=0.111; 95% CI 0.4-1.1).Conclusion: The present study findings show that SII and NLR are far from providing reliable data on gastric cancer prognosis.","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"10 1","pages":"24-32"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/08/9a/NCI-10-024.PMC9996656.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9109202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The validity and reliability of Turkish adaptation of the Fear-Avoidance Beliefs Questionnaire in patients with neck pain. 土耳其人对颈痛患者恐惧回避信念问卷的适应度和信度。

IF 1

Northern Clinics of Istanbul Pub Date : 2023-01-01 DOI: 10.14744/nci.2022.48108

Burcu Ozuberk, Ummuhan Bas Aslan, Gamze Ekici

{"title":"The validity and reliability of Turkish adaptation of the Fear-Avoidance Beliefs Questionnaire in patients with neck pain.","authors":"Burcu Ozuberk, Ummuhan Bas Aslan, Gamze Ekici","doi":"10.14744/nci.2022.48108","DOIUrl":"https://doi.org/10.14744/nci.2022.48108","url":null,"abstract":"Objective: \"Fear-avoidance behavior\" means that the individual avoids a specific activity or movement due to the perception that it may cause injury. Fear of movement associated with pain can reduce individuals' adaptation to exercise programs. This situation may cause individuals to refrain from taking action and increase the existing limitation. Our aim is investigating of Fear-Avoidance Beliefs Questionnaire (FABQ) in patients with neck pain and creating a questionnaire option for clinicians and researchers to evaluate the fear-avoidance behavior in neck pain in Turkish.Methods: The sample of the research was comprised 175 patients between the ages of 18-65, who have a complaint of neck pain that lasted for at least 3 months. The test was applied on patients with neck pain and no treatment, with an interval of 2-7 days. The Visual Analog Scale (VAS), Neck Disability Index (NDI), and Nottingham Health Profile (NHP) were applied on the participants to evaluate the validity of the FABQ.Results: Accordingly, between FABQ and NHP (r=0.227), pain (NHPP) (r=0.214), emotional reactions (r=0.220), and physical activity (NHPPA) (r=0.243), a weak relationship was observed. A weak correlation was observed between physical activity (FABQ-PA) which are subscales of the FABQ questionnaire and NDI (r=0.210), NHPP (r=0.205), and NHPPA (r=0.267).Conclusion: FABQ is a valid and reliable tool for patients with neck pain. In our study, a weak relationship was detected between FABQ, NDI, and NHP, as like VAS.","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"10 3","pages":"322-327"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/49/d0/NCI-10-322.PMC10331245.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9805289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative stress, DNA damage, and inflammation in COVID-19 patients. COVID-19患者的氧化应激、DNA损伤和炎症

IF 1

Northern Clinics of Istanbul Pub Date : 2023-01-01 DOI: 10.14744/nci.2022.00947

Guven Bektemur, Kubra Bozali, Sahin Colak, Selman Aktas, Eray Metin Guler

{"title":"Oxidative stress, DNA damage, and inflammation in COVID-19 patients.","authors":"Guven Bektemur, Kubra Bozali, Sahin Colak, Selman Aktas, Eray Metin Guler","doi":"10.14744/nci.2022.00947","DOIUrl":"https://doi.org/10.14744/nci.2022.00947","url":null,"abstract":"OBJECTIVE Severe inflammation and oxidative stress seen in COVID-19 patients cause cumulative antiviral effects, and serious inflammation increases tissue, oxidative damage, and DNA damage. Therefore, in this study, oxidative stress, DNA damage, and inflammation biomarkers were investigated in patients diagnosed with COVID-19. METHODS In this study, blood samples were obtained from 150 Covid-19 patients diagnosed by polymerase chain reaction and 150 healthy volunteers with the same demographic characteristics. Total oxidant status (TOS), total antioxidant status (TAS), total thiol (TT), native thiol, and myeloperoxidase (MPO) activities were measured by photometric methods. The levels of tumor necrosis factor-alpha (TNF-α), interleukin 1 beta (IL-1β), and interleukin 6 (IL-6), which are inflammation markers, were measured by the ELISA method using commercial kits. The genotoxic effect was evaluated by Comet Assay. RESULTS The oxidative stress biomarkers; Disulfide, TOS, MPO, oxidative stress index, and IL-1β, IL-6, and TNF-α levels of inflammation biomarkers and the DNA damage in COVID-19 patients were increased (p<0.001), and the levels of TAS, TT, and NT In COVID-19 patients were decreased (p<0.001). CONCLUSION In COVID-19 patients, induced DNA damage, inflammation, and oxidative stress can guide the prognosis and treatment strategies of the disease.","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"10 3","pages":"335-340"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7a/19/NCI-10-335.PMC10331251.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9805291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Anti-N-methyl D-aspartate receptor encephalitis presenting with the new-onset refractory status epilepticus. 抗n -甲基d -天冬氨酸受体脑炎表现为新发难愈癫痫持续状态。

IF 1

Northern Clinics of Istanbul Pub Date : 2023-01-01 DOI: 10.14744/nci.2021.70431

Murat Alemdar, Turkan Acar, Sule Dalkilic

{"title":"Anti-N-methyl D-aspartate receptor encephalitis presenting with the new-onset refractory status epilepticus.","authors":"Murat Alemdar, Turkan Acar, Sule Dalkilic","doi":"10.14744/nci.2021.70431","DOIUrl":"https://doi.org/10.14744/nci.2021.70431","url":null,"abstract":"New-onset refractory status epilepticus (NORSE) is a rare entity referring refractory status epilepticus (SE) in a patient without a history of epilepsy or an apparent cause. Herein, we report on a 31-year-old young female of anti-N-methyl D-aspartate (NMDA) receptor encephalitis admitted with NORSE. Her complaints began a week ago with a fever, meaningless movements, restlessness, and talking to herself. She had a history of operation for ovarian teratoma 10 years ago. Electrocardiography, hemogram, biochemistry, and neuroimaging were normal. Due to recurrent seizures despite intravenous diazepam infusions, phenytoin infusion was introduced, reducing the duration and frequency of seizures. Electroencephalogram (EEG) revealed a generalized slow background activity with low voltage and delta waves in left hemisphere derivatives without any epileptiform discharge. Autoimmune encephalitis panel revealed a positive anti-NMDAR receptor antibody. Intravenous immunoglobulins were given for 5 days. She was improved clinically and did not have a recurrent seizure. The history of our case emphasizes the importance of EEG and CSF antibody tests to reach the underlying etiology in patients presenting with refractory SE and neuropsychiatric symptoms of an unknown cause. Application of a proper treatment promptly with this approach could prevent the potential morbidity and mortality in these patients.","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"10 3","pages":"385-389"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a3/07/NCI-10-385.PMC10331237.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9818433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Assessment of Epstein-Barr virus, Candida albicans, and some periodontal pathogens in rheumatoid arthritis patients with periodontitis. 类风湿关节炎合并牙周炎患者Epstein-Barr病毒、白色念珠菌及一些牙周病原体的检测。

IF 1

Northern Clinics of Istanbul Pub Date : 2023-01-01 DOI: 10.14744/nci.2023.58998

Tugce Paksoy, Gulbahar Ustaoglu, Murat Tasci, Mehmet Demirci, Ozge Unlu, Mustafa Fatih Yasar

{"title":"Assessment of Epstein-Barr virus, Candida albicans, and some periodontal pathogens in rheumatoid arthritis patients with periodontitis.","authors":"Tugce Paksoy, Gulbahar Ustaoglu, Murat Tasci, Mehmet Demirci, Ozge Unlu, Mustafa Fatih Yasar","doi":"10.14744/nci.2023.58998","DOIUrl":"https://doi.org/10.14744/nci.2023.58998","url":null,"abstract":"OBJECTIVE To comparatively investigate the periodontal results and microbial load in subgingival biofilm samples (SBS) in rheumatoid arthritis subjects and healthy volunteers. METHODS One hundred twenty subjects were classified into different cohorts: healthy (H-C); periodontitis with good systemic health (H-P); rheumatoid arthritis (RA) and good periodontal health (RA-C); and periodontitis with RA (RA-P). The periodontal parameters were recorded, and SBS were collected to determine periodontal pathogens including Epstein–Barr Virus (EBV) and Candida albicans using reverse transcription-polymerase chain reaction (RT-PCR). RESULTS Subjects that had greater disease course, determined by moderate or high disease activity scores 28 (DAS28), suffered from worse oral health conditions (higher plaque index, gingival index, bleeding on probing, probing depth, and excessive clinical attachment loss) than those with low DAS28 scores. A higher prevalence of Treponema denticola (T. denticola) was observed in the RA-P group. Cyclic citrullinated peptide was associated with the occurrence of T. denticola and Campylobacter rectus. DAS28 using C-reactive protein (DAS28-CRP) had a significant association with Capnocytophaga gingivalis and EBV. The duration of the RA disease was associated with the presence of T. denticola. CONCLUSION Subgingival microbial difference could reliably discriminate RA from healthy individuals. Especially, T. denticola and EBV may play a key role in periodontitis associated with RA.","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"10 4","pages":"490-500"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4b/e2/NCI-10-490.PMC10500248.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10671976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0