Northern Clinics of Istanbul最新文献

{"title":"Intestinal obstruction due to phytobezoar induced in the Meckel’s diverticulum-report of two cases","authors":"N. Firat, B. Mantoglu, F. Altıntoprak, A. Muhtaroğlu, Mertcan Akcay","doi":"10.14744/nci.2020.89656","DOIUrl":"https://doi.org/10.14744/nci.2020.89656","url":null,"abstract":"Meckel’s diverticulum is generally asymptomatic, but it may become symptomatic due to various reasons and maybe the etiology of the acute abdominal syndrome. Bezoars are formed by the combination of non-digestible substances in the gastrointestinal tract, and which are among the rare causes of intestinal obstruction. The formation of bezoars in Meckel’s diverticulum and subsequent intestinal obstruction is a rare condition. In this article, two cases with intestinal obstruction due to bezoar in Meckel’s diverticulum and their surgical treatment had presented.","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"23 1","pages":"180 - 182"},"PeriodicalIF":1.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76955278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-cultural adaptation and validation of the Turkish version of the sinus and nasal quality of life survey (SN-5)","authors":"Berkay Çaytemel, Can Doruk, L. Aydemir, H. Kara, Ş. Çomoğlu, M. Turel","doi":"10.14744/nci.2021.94547","DOIUrl":"https://doi.org/10.14744/nci.2021.94547","url":null,"abstract":"Objective: The Sinus and Nasal Quality of Life (QoL) Survey (SN-5) is a valid questionnaire that evaluates the QoL of the pediatric population associated with sinonasal diseases and symptoms. The aims of this study were to translate the SN-5 test to Turkish language (SN-5t), evaluate the internal consistency of the test and test-retest reliability and validate the translation for further use in studies in Turkish language. Methods: In this prospective study, 50 healthy subjects and 50 patients, age between 2 and 12, with sinonasal symptoms prolonged over 1 month were included to the study. Families of healthy subjects were asked to fill the SN-5t twice with 1-week interval. The patient group completed test once prior the treatment and once 4 weeks after the treatment. Cronbach’s test was performed to test internal consistency and Spearman’s test was performed to evaluate test-retest validity. Results: The median value of the pre-treatment tests of the patient group and control group was 25 (23–28) and 14.25 (12–16), respectively. A statistically significant difference was found between groups (p<0.001). Area under the receiver operating characteristics (ROC) curve (Aroc) value was calculated as 0.992 which stated the strong diagnostic accuracy, and the cutoff point was defined as 16.5. Cronbach’s alpha value of 0.75 was found. The Spearman’s rank correlation coefficient value (Spearman’s rho) was calculated as 0.946. Conclusion: The Turkish translation of the SN-5 is a consistent and valid test with high sensitivity and specificity that can be used in studies including Turkish speaking population.","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"45 1","pages":"149 - 155"},"PeriodicalIF":1.0,"publicationDate":"2022-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81775248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ranibizumab therapy for predominantly hemorrhagic neovascular age-related macular degeneration","authors":"O. Dikmetas, S. Kadayıfçılar, B. Eldem, Ulkar Feyzullayeva","doi":"10.14744/nci.2021.52323","DOIUrl":"https://doi.org/10.14744/nci.2021.52323","url":null,"abstract":"Objective: Predominantly hemorrhage represents one of the possible manifestations of choroidal neovascularisation (CNV) in eyes with age-related macular degeneration (AMD). The purpose of this study is to evaluate the effecte of ranibizumab treatment in patients with predominantly hemorrhagic CNV secondary to AMD. Methods: Twenty-five patients with predominantly hemorrhagic choroidal neovascularization due to AMD with at least three ranibizumab injections and followed up for at least 12 months were included in the study. The months of follow-up were recorded (baseline, 3rd, 6th, and 12th months). The change in central macular thickness (CMT) on optical coherence tomography, visual acuity (VA) in ETDRS letters, and lesion size on fundus fluorescein angiography were evaluated. Results: The mean age of the patients was 68.1±5.7 (range: 63–82) years, the mean follow-up was 19.9±14.5 (range: 12–67) months, and the mean number of injections was 4.0±1.4 (range: 3–15). The initial VA was 39.3±17.9 (range: 1–65) letters, CMT was 272.7±104 (range: 164–587) μm, and the initial lesion width was 11.4±10.5 (range: 1.3–45.7) mm2. The VA was 41.4±20.1 (range: 5–75) and 36.9±21.8 (range: 4–80) letters (p=0.150), CMT was 270.7±110 (range: 159–570) and 230.4±108 (range: 109–667) μm (p=0.009) and the lesion width was 10.9±11.5 (range: 1.1–39.7) and 10.4±11.6 (range: 1.2–44.3) mm2 at 6th and 12th month, respectively. No factor was found to be associated with final CMT. Conclusion: Although the final visual outcome is limited by the progression of the disease, hemorrhagic lesions treated with ranibizumab have stable anatomical outcome.","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"78 5 1","pages":"173 - 179"},"PeriodicalIF":1.0,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87917672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which is the best for the warfarin monitoring: Following up by fixed or variable physician?","authors":"L. D. Asarcikli, H. Kafes, T. Şen, E. G. Ipek, O. Beton, A. Temizhan, M. Yılmaz","doi":"10.14744/nci.2021.06981","DOIUrl":"https://doi.org/10.14744/nci.2021.06981","url":null,"abstract":"Objective: Warfarin therapy has some difficulties in terms of close monitoring and dosage. This study aims to evaluate the effect of same-fixed versus different-variable physician-based monitoring of warfarin therapy on treatment quality and clinical end-points. Methods: A total of 625 consecutive patients requiring warfarin treatment were enrolled at seven centers. INR values of the patients measured at each visit and registered to hospital database were recorded. Time in therapeutic range (TTR) was calculated using linear interpolation method (Rosendaal’s method). A TTR value of ≥65% was considered as effective warfarin treatment. If a patient was evaluated by the same-fixed physician at each INR visit, was categorized into the same-physician (SP) group. In contrast, if a patient was evaluated by different-variable physicians at each INR visit, was categorized into variable physician (VP) group. Enrolled patients were followed up for bleeding and embolic events. Results: One hundred and fifty-six patients (24.9%) were followed by SP group, 469 (75.1%) patients were followed by VP group. Median TTR value of the VP group was lower than that of SP group (56.2% vs. 65.1%, respectively, p=0.009). During median 25.5 months (9–36) of follow-up, minor bleeding, major bleeding and cerebral embolic event rates were higher in VP group compared to SP group (p<0.001, p=0.023, p<0.001, respectively). In multivariate analysis, INR monitoring by VP group was found to be an independent predictor of increased risk of bleeding events (OR 2.55, 95% CI 1.64–3.96, p<0.001) and embolism (OR 3.42, 95% CI 1.66–7.04, p=0.001). Conclusion: INR monitoring by same physician was associated with better TTR and lower rates of adverse events during follow-up. Hence, it is worth encouraging an SP-based outpatient follow-up system at least for where warfarin therapy is the only choice.","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"49 1","pages":"93 - 101"},"PeriodicalIF":1.0,"publicationDate":"2022-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87586673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letters to the Editor / Author’s reply","authors":"Mikail Ozdemir, C. Ilgın, M. Karavuş, S. Hıdıroğlu, N. E. Luleci, P. Ay, A. Sarioz, D. Save","doi":"10.14744/nci.2022.98958","DOIUrl":"https://doi.org/10.14744/nci.2022.98958","url":null,"abstract":"To the Editor, We would like to acknowledge Ozgur and Eser for their valuable comments regarding our article entitled “Adaptation of the knowledge about childhood autism among health workers questionnaire: Turkish version” [1, 2]. In their letter, Ozgur and Eser [2] indicate that removing some items from the original scale during adaptation might impair the content validity and thus should be avoided. While this view is legitimate, we should be aware that it also has some exceptions. Modifications in validated scales might be needed due to the developments in the scientific field and also the changing needs in a community. The scale that is the subject of this discussion was developed by Bakare et al. [3] in Nigeria in 2008, and its adaptation to our community certainly required some modifications. As is known, autism spectrum disorder and childhood-onset schizophrenia have overlapping symptomatology, but currently are defined as two separate entities [4]. We should also note that individuals with autism spectrum disorder might have a range of IQ, varying from low to above average [5]. The link of autism to autoimmunity is still questionable and warrants further evidence [6]. Hence, the fourth domain focusing on autoimmunity as a cause, and identifying autism as childhood schizophrenia and as a form of mental retardation might be misleading. Moreover, Ozgur and Eser [2] also draw attention to the insufficient internal consistency in the fourth domain and indicated that the scores of this domain should be evaluated with caution. While developing scales, a special care should be taken not to stigmatize the affected individuals through the questions used. Autism is surrounded with huge stigma [7]. We were concerned that Domain 4 might lead to false information and even more stigmatizing attitudes, which also influenced our decision of removing this section. Another item was removed from the questionnaire since; all participants provided full and correct answers to it. The permission for the adaptation of the questionnaire was obtained from Dr. Muideen Bakare in 2015, who was the first author in the original validation study. Subsequently, we consulted Dr. Muideen Bakare for the removal and changes in the items and also received an approval for the new version. Finally; researchers can decide which version of the scale to use, taking into consideration their objectives. A version which is useful for a group of researchers might not serve others. In this respect, we believe that an environment discussing the advantages and disadvantages of different versions would be more fruitful instead of advising which version to use.","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"106 1","pages":"92 - 92"},"PeriodicalIF":1.0,"publicationDate":"2022-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76144444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mean platelet volume can indicate dietary adherence and disease severity of celiac disease","authors":"E. Gerçeker, A. Baykan, S. Cerrah, H. Yuceyar","doi":"10.14744/nci.2021.56313","DOIUrl":"https://doi.org/10.14744/nci.2021.56313","url":null,"abstract":"Objective: At present, there is no reliable indicator for dietary compliance and disease severity in patients with celiac disease (CD). The aim of this study is to evaluate mean platelet volume (MPV) level as a biomarker for detection of disease activation, dietary adherence, and assessment of disease severity. Methods: Eighty-one patients with CD and 50 healthy subjects were enrolled in this study. The diagnosis of CD was established by both positive antibodies against endomysium or gliadin and histopathological criteria (lymphocytic infiltration and total villous atrophy in duodenal biopsies). Results: MPV was observed to be significantly higher among CD patients when compared to healthy controls (8.14±0.26 fL vs. 7.82±0.29 fL and p=0.001). Overall dietary adherence rate was 72.8% (58/81 CD patients). After induction of a gluten-free diet, the MPV was significantly lower in the dietary adherent group than non-adherent patients (7.86±0.17 fL vs. 8.07±0.30 fL and p=0.001). The increase of MPV was correlated with Marsh classification (Marsh 3 active CD vs. Marsh 2 active CD vs. Marsh 1 active CD; 8.32±0.27 fL vs. 8.12±0.19 fL vs. 7.98±0.19 fL; p=0.004 and p=0.009). Conclusion: Based on these data, we believe that increased MPV can provide additional benefit to screening in patients with CD. It can indicate the activation of the disease and adherence to the diet.","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"37 1","pages":"41 - 46"},"PeriodicalIF":1.0,"publicationDate":"2022-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84832610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the effects of COVID-19 on pregnancy, fetus and newborn, and treatment management","authors":"Ş. Çomoğlu, Sinan Ozturk, M. Ozer, B. Ertunç","doi":"10.14744/nci.2021.45577","DOIUrl":"https://doi.org/10.14744/nci.2021.45577","url":null,"abstract":"Objective: During pregnancy, changes occur in many systems, including the immune system. In line with our experience in the previous years, COVID-19 infections have negative effects on pregnancy. In our study, it was aimed to evaluate the effects of COVID-19 on pregnancy, fetus and newborn, and treatment management. Methods: In our study, 63 patients followed up between April 1, 2020 and April 1, 2021, were evaluated. Demographic data, symptoms, laboratory data, treatments, clinical course and delivery characteristics of the patients, as well as pathologies in the fetus and newborn were investigated retrospectively. The obtained data were statistically analyzed with Statistical Package for the Social Sciences. Results: In this study, 63 pregnant COVID-19 patients aged 19–37 years were included in the study. Fifty of the patients had symptoms of COVID-19 at the time of admission. At the time of admission, 13 patients required oxygen, and ten of these patients had severe radiological involvement. Seven patients were admitted to the intensive care unit, and three of them required invasive mechanical ventilation and deceased afterward. All newborns were found negative for the COVID-19 polymerase chain reaction test. Low birth weight has been detected in eight newborns and low Apgar score in 2 of them. Respiratory distress was observed in four newborns and they were discharged from intensive. Conclusion: Pregnant women have more disadvantages in the course of COVID-19 and have worse maternal outcomes. In addition, treatments such as Lopinavir/Ritonavir and hydroxychloroquine did not have any effect. These patients should be carefully evaluated and followed up.","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"3 1","pages":"30 - 34"},"PeriodicalIF":1.0,"publicationDate":"2022-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79649606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Young age and shorter duration of Crohn’s disease are associated with non-adherence to taking medication","authors":"H. Yilmaz","doi":"10.14744/nci.2021.08634","DOIUrl":"https://doi.org/10.14744/nci.2021.08634","url":null,"abstract":"Objective: The mainstay of Crohn’s disease treatment is medical therapy. Failure to comply with medications causes disease activation, loss of response to treatment, and increased hospitalization rates. Drug non-adherence worsens the course of the disease, leading to fistula, stricture, and surgical interventions. The adherence rates to drug therapy in Crohn’s disease patients and the risk factors vary considerably in the literature. The aim of the study was to investigate drug adherence rates and factors affecting adherence to Crohn’s disease medications. Methods: This study was conducted as prospective cohort study at the tertiary health care institution inflammatory bowel disease outpatient clinic within 1 year. Crohn’s disease characteristics and pharmacy records of consecutive patients were evaluated. Medication adherence was assessed by calculating the medication possession ratio using the amount of medication purchased from the pharmacy. Results: A total of 129 patients were included in the study. It was observed that 43.6% of the patients did not comply with their Crohn’s disease medications. It was determined that the patients who did not adhere to the medication were significantly younger (41±12 vs. 48±13, p=0.039). The duration of the disease is shorter in patients who did not comply with the drugs (4.50 [IQR: 3.00–12.00] vs. 6.00 [IQR: 3.00–12.00, p=0.025]). Adherence with medication is lower in patients with higher education levels (35.7% vs. 64.3%, p=0.023). Conclusion: Medication adherence is of critical importance for Crohn’s disease outcomes. Nearly half of Crohn’s disease patients do not comply with drugs. Young and highly educated patients with shorter disease duration should be targeted for measures to increase the rates of medication adherence.","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"338 1","pages":"8 - 13"},"PeriodicalIF":1.0,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80695314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of preoperative anxiety levels and the D-type personality on propolol injection pain","authors":"O. Miniksar, A. Yuksek","doi":"10.14744/nci.2020.61214","DOIUrl":"https://doi.org/10.14744/nci.2020.61214","url":null,"abstract":"Objective: Propofol injection pain (PIP) is a common condition in anesthesia practice and can be detrimental for patients. In this study, we aimed to investigate the effects of preoperative anxiety, depression levels, and D-type personality trait on PIP and to determine predictive factors. Methods: Sixty-eight patients who underwent elective septorhinoplasty under general anesthesia were analyzed. The effects of various factors (preoperative anxiety, depression, D-type personality, venous cannulation pain, gender, and age) on the incidence of PIP were assessed. To identify risk factors associated with PIP, multivariate logistic regression analysis was performed. Results: The incidence of PIP was significantly higher in patients who had preoperative anxiety and venous cannulation pain and who are Type D personality and female. Preoperative anxiety (β, 2.914; p=<0.001), Type D personality (β, 2.225; p=0.022) and venous cannulation pain (β, 1.590; p=0.043) were identified as independent risk factors for development of PIP. Depression, general anesthesia history, marital status, smoking, education status, and age were not significant as risk factors for the PIP. Conclusion: In addition to the physical factors that can predict PIP in anesthesia application, we believe that the presence of preoperative anxiety, Type D personality, and venous cannulation pain is significant, and it will be useful to apply preventive treatments for injection pain.","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"51 1","pages":"1 - 7"},"PeriodicalIF":1.0,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74453284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Key concepts in biosimilar medicines: What physicians must know","authors":"A. Iskit","doi":"10.14744/nci.2021.84669","DOIUrl":"https://doi.org/10.14744/nci.2021.84669","url":null,"abstract":"Biologics’ are a class of medications produced by living cells using recombinant DNA technology. Biologics have had an important impact in many areas of medicine, and in particular in rheumatology and oncology. However, the high cost of these agents is a growing concern, particularly as more products become available and their use for the treatment of immune-mediated inflammatory diseases continues to expand. Biosimilars, also called follow-on biologics, have been viewed as a potential cost-saving alternative to traditional therapies. Currently, a product can be considered biosimilar to a reference product if there are no clinically meaningful differences in terms of safety, purity, and potency. In this review, the most important key concepts about biosimilars were summarized for physicians emphasizing the status in Turkey.","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":"31 2 1","pages":"86 - 91"},"PeriodicalIF":1.0,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83575242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}