类风湿关节炎合并牙周炎患者Epstein-Barr病毒、白色念珠菌及一些牙周病原体的检测。

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL
Tugce Paksoy, Gulbahar Ustaoglu, Murat Tasci, Mehmet Demirci, Ozge Unlu, Mustafa Fatih Yasar
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引用次数: 0

摘要

目的:比较类风湿关节炎患者与健康人群牙周状况及龈下生物膜(SBS)微生物负荷。方法:120名受试者分为不同的队列:健康(H-C);牙周炎伴全身健康(hp);类风湿关节炎(RA)和良好的牙周健康(RA- c);牙周炎伴RA (RA- p)。记录牙周参数,收集SBS,采用逆转录聚合酶链反应(RT-PCR)检测牙周病原菌,包括eb病毒(EBV)和白色念珠菌。结果:与DAS28评分较低的受试者相比,疾病病程较长的受试者口腔健康状况较差(菌斑指数较高、牙龈指数较高、探诊时出血、探诊深度较大、临床附着丧失过多)。RA-P组齿状密螺旋体(T. denticola)患病率较高。环瓜氨酸肽与齿状弧菌和直弯曲杆菌的发生有关。使用c反应蛋白的DAS28 (DAS28- crp)与牙龈嗜碳细胞吞噬和EBV有显著相关性。RA疾病的持续时间与齿状霉的存在有关。结论:龈下微生物差异可可靠地区分RA与健康人。特别地,牙牙分枝杆菌和EBV可能在与RA相关的牙周炎中起关键作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of Epstein-Barr virus, Candida albicans, and some periodontal pathogens in rheumatoid arthritis patients with periodontitis.
OBJECTIVE To comparatively investigate the periodontal results and microbial load in subgingival biofilm samples (SBS) in rheumatoid arthritis subjects and healthy volunteers. METHODS One hundred twenty subjects were classified into different cohorts: healthy (H-C); periodontitis with good systemic health (H-P); rheumatoid arthritis (RA) and good periodontal health (RA-C); and periodontitis with RA (RA-P). The periodontal parameters were recorded, and SBS were collected to determine periodontal pathogens including Epstein–Barr Virus (EBV) and Candida albicans using reverse transcription-polymerase chain reaction (RT-PCR). RESULTS Subjects that had greater disease course, determined by moderate or high disease activity scores 28 (DAS28), suffered from worse oral health conditions (higher plaque index, gingival index, bleeding on probing, probing depth, and excessive clinical attachment loss) than those with low DAS28 scores. A higher prevalence of Treponema denticola (T. denticola) was observed in the RA-P group. Cyclic citrullinated peptide was associated with the occurrence of T. denticola and Campylobacter rectus. DAS28 using C-reactive protein (DAS28-CRP) had a significant association with Capnocytophaga gingivalis and EBV. The duration of the RA disease was associated with the presence of T. denticola. CONCLUSION Subgingival microbial difference could reliably discriminate RA from healthy individuals. Especially, T. denticola and EBV may play a key role in periodontitis associated with RA.
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来源期刊
Northern Clinics of Istanbul
Northern Clinics of Istanbul MEDICINE, GENERAL & INTERNAL-
CiteScore
0.40
自引率
0.00%
发文量
48
审稿时长
10 weeks
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