Neuropsychopharmacology Reports最新文献_第10页

Antidepressants available in Japan for older people with major depressive disorder: A systematic review and meta-analysis. 日本为患有重度抑郁症的老年人提供的抗抑郁药：系统回顾和荟萃分析。

IF 2

Neuropsychopharmacology Reports Pub Date : 2024-03-01 Epub Date: 2024-02-06 DOI: 10.1002/npr2.12422

Taro Kishi, Kenji Sakuma, Masakazu Hatano, Takenori Okumura, Masaki Kato, Hajime Baba, Nakao Iwata

{"title":"Antidepressants available in Japan for older people with major depressive disorder: A systematic review and meta-analysis.","authors":"Taro Kishi, Kenji Sakuma, Masakazu Hatano, Takenori Okumura, Masaki Kato, Hajime Baba, Nakao Iwata","doi":"10.1002/npr2.12422","DOIUrl":"10.1002/npr2.12422","url":null,"abstract":"Aim: To update the major depressive disorder (MDD) treatment guidelines of the Japanese Society of Mood Disorders, we conducted a systematic review and pairwise meta-analysis of double-blind, randomized, placebo-controlled trials of available antidepressants in Japan for older adults with MDD.Methods: Outcome measures included response rate (primary), improvement in depressive symptom scale score, remission rate, all-cause discontinuation, discontinuation due to adverse events, and at least one adverse event. A random-effects model was used to calculate the risk ratio (RR) and standardized mean difference (SMD) with a 95% confidence interval (95% CI).Results: Nine double-blind, randomized, placebo-controlled trials (n = 2145) were identified. No study has been conducted in Japan. Our meta-analysis included the following antidepressants: duloxetine, escitalopram, imipramine, sertraline, venlafaxine, and vortioxetine. Antidepressants have significantly higher response rates than placebo (RR [95% CI] = 1.38 [1.04, 1.83], p = 0.02). Antidepressants outperformed placebo in terms of improving depressive symptom scale score (SMD [95% CI] = -0.62 [-0.92, -0.33], p < 0.0001). However, antidepressants were associated with a higher discontinuation rate due to adverse events (RR [95% CI] = 1.94 [1.30, 2.88], p = 0.001) and a higher incidence of at least one adverse event (RR [95% CI] = 1.11 [1.02, 1.21], p = 0.02) compared to placebo. The groups did not differ significantly in terms of remission rate or all-cause discontinuation.Conclusions: Our meta-analysis concluded that treatment with antidepressants available in Japan is only weakly recommended for moderate to severe MDD in older adults.","PeriodicalId":19137,"journal":{"name":"Neuropsychopharmacology Reports","volume":" ","pages":"267-271"},"PeriodicalIF":2.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10932767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does dietary intake of caffeine have an effect on transient global amnesia? 膳食中摄入咖啡因会对短暂性全局失忆产生影响吗？

IF 2.5

Neuropsychopharmacology Reports Pub Date : 2024-03-01 Epub Date: 2023-12-22 DOI: 10.1002/npr2.12408

Mobina Zeinalabedini, Zahra Mousavi, Arezoo Amjadi, Mahsa Shapouri, Bahareh Aminnezhad Kavkani, Mohammad Masoumvand, Khadijeh Abbasi Mobarakeh, Maryam Gholamalizadeh, Neda Valisoltani, Saeideh Mohammadi, Sara Khoshdooz, Saeid Doaei, Akram Kooshki

{"title":"Does dietary intake of caffeine have an effect on transient global amnesia?","authors":"Mobina Zeinalabedini, Zahra Mousavi, Arezoo Amjadi, Mahsa Shapouri, Bahareh Aminnezhad Kavkani, Mohammad Masoumvand, Khadijeh Abbasi Mobarakeh, Maryam Gholamalizadeh, Neda Valisoltani, Saeideh Mohammadi, Sara Khoshdooz, Saeid Doaei, Akram Kooshki","doi":"10.1002/npr2.12408","DOIUrl":"10.1002/npr2.12408","url":null,"abstract":"Aim: Amnesia is a cognitive disorder that may lead to memory loss. Caffeine is a psychoactive substance which have an effect on memory and cognitive functions. This study aimed to assess the association of transient global amnesia (TGA) with dietary intake of caffeine.Methods: This cross-sectional study was conducted on the Sabzevar Persian cohort data of 258 patients with TGA and 520 healthy individuals in Sabzevar, Iran. The Nutritional data were gathered in face-to-face interviews using a valid Food Frequency Questionnaire. Different models of logistic regression were used to determine the association between TGA and dietary caffeine intake after adjusting the confounders including age, sex, education, job, marital status, physical activity, BMI, and calorie intake.Results: There was no significant difference in terms of dietary calorie intake of (2279.5 ± 757.9 vs. 2365.5 ± 799.5, p = 0.19), protein (70.79 ± 25.27 vs. 72.94 ± 24.83, p = 0.31), fat (59.97 ± 23.79 vs. 60.13 ± 26.38, p = 0.93), carbohydrate (376 ± 134 vs. 393.1 ± 137.8, p = 0.14), and caffeine (196.4 ± 127.9 vs. 186.3 ± 128.5, p = 0.36) between the groups. No significant association was found between TGA and dietary intake of caffeine (OR: 0.99, 95% CI: 0.99-1.01, p = 0.36). The results did not change after adjusting the confounders.Conclusions: No significant association was found between TGA and dietary intake of caffeine. Further prospective studies are required to confirm this finding.","PeriodicalId":19137,"journal":{"name":"Neuropsychopharmacology Reports","volume":" ","pages":"143-148"},"PeriodicalIF":2.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10932796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138830753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of chronic haloperidol treatment on the expression of fear memory and fear memory extinction in the cued fear-conditioned rats. 慢性氟哌啶醇治疗对诱导恐惧条件反射大鼠恐惧记忆表达和恐惧记忆消退的影响

IF 2.5

Neuropsychopharmacology Reports Pub Date : 2024-03-01 Epub Date: 2024-02-14 DOI: 10.1002/npr2.12418

Kosuke Enomoto, Kazuro Shibata, Hiroyuki Muraoka, Masahiko Kawano, Ken Inada, Jun Ishigooka, Katsuji Nishimura, Hidehiro Oshibuchi

{"title":"Effects of chronic haloperidol treatment on the expression of fear memory and fear memory extinction in the cued fear-conditioned rats.","authors":"Kosuke Enomoto, Kazuro Shibata, Hiroyuki Muraoka, Masahiko Kawano, Ken Inada, Jun Ishigooka, Katsuji Nishimura, Hidehiro Oshibuchi","doi":"10.1002/npr2.12418","DOIUrl":"10.1002/npr2.12418","url":null,"abstract":"Aim: Impairments in emotional memory are frequently observed in several mental disorders, highlighting their significance as potential therapeutic targets. Recent research on the cued fear conditioning model has elucidated the neural circuits involved in fear memory processing. However, contradictory findings have been reported concerning the role of dopamine and the impact of dopamine D2 receptor (D2R) antagonists. There is notably limited knowledge regarding the clinical utility of chronic D2R antagonist treatments. This study aimed to uncover how such treatments affect fear memory processing.Methods: We utilized a cued fear conditioning rat model and conducted chronic haloperidol treatment for 14 days. Subsequently, to investigate the effect of chronic haloperidol treatment on fear-conditioned memory expression and extinction, we observed freezing behavior under exposure to a conditioned stimulus for 14 days.Results: Chronic haloperidol treatment suppressed freezing time on the fear memory expression. In contrast, a single haloperidol administration enhanced the freezing time on fear memory expression and delayed extinction.Conclusion: The results of this study suggest that chronic administration of antipsychotic drugs affects fear memory processing differently from single-dose administration. This indicates that the effects of chronic D2R antagonist treatment are distinct from the nonspecific effects of the drugs. This study provides fundamental insights that may contribute to our understanding of therapeutic mechanisms for fear memory disorders related to D2R in the future.","PeriodicalId":19137,"journal":{"name":"Neuropsychopharmacology Reports","volume":" ","pages":"197-205"},"PeriodicalIF":2.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10932774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139735735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of the Japanese version of the Ego-Dissolution Inventory (EDI). 开发日语版自我解体量表（EDI）。

IF 2.5

Neuropsychopharmacology Reports Pub Date : 2024-03-01 Epub Date: 2024-02-06 DOI: 10.1002/npr2.12419

Keisuke Kusudo, Hideaki Tani, Kengo Yonezawa, Shinichiro Nakajima, Matthew M Nour, Robin Carhart-Harris, Hiroyuki Uchida

{"title":"Development of the Japanese version of the Ego-Dissolution Inventory (EDI).","authors":"Keisuke Kusudo, Hideaki Tani, Kengo Yonezawa, Shinichiro Nakajima, Matthew M Nour, Robin Carhart-Harris, Hiroyuki Uchida","doi":"10.1002/npr2.12419","DOIUrl":"10.1002/npr2.12419","url":null,"abstract":"Aim: Psychedelics have recently gained attention as potential therapeutic agents for various psychiatric disorders. Previous research has highlighted that a diminished sense of self, commonly termed \"ego-dissolution\" is a pivotal feature of the psychedelic-induced state. While the Ego-Dissolution Inventory (EDI) is a widely acknowledged instrument for measuring this phenomenon, no Japanese version has been available. This study aimed to develop a Japanese version of the EDI.Methods: We adhered to the \"Guidelines for Best Practices in the Translation and Cultural Modification Process for Patient-Reported Outcomes Instruments: Document from the ISPOR Committee on Translation and Cultural Modification\" during our translation approach. Two Japanese psychiatrists independently conducted initial translations, and a consolidated version was achieved via mutual agreement. This version was then back-translated to English and assessed by the original authors for consistency. The repetitive modification process was conducted in continuous dialogues with the original authors until they accepted the concluding back-translated version.Results: The finalized, approved back-translated version of the EDI is presented in the accompanying figure. In addition, the authorized Japanese version of the EDI is included in the Appendix.Conclusions: In this study, we successfully developed the Japanese version of the EDI. This instrument will assist in assessing ego-dissolution experiences associated with psychedelic-assisted therapy among Japanese speakers. Additional studies are necessary to evaluate the reliability and validity of this newly translated instrument.","PeriodicalId":19137,"journal":{"name":"Neuropsychopharmacology Reports","volume":" ","pages":"292-297"},"PeriodicalIF":2.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10932788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Marked alteration of phosphoinositide signaling-associated molecules in postmortem prefrontal cortex with bipolar disorder. 双相情感障碍患者死后前额叶皮层磷脂信号相关分子的明显变化

IF 2

Neuropsychopharmacology Reports Pub Date : 2024-03-01 Epub Date: 2024-01-22 DOI: 10.1002/npr2.12409

Mizuki Hino, Yasuto Kunii, Risa Shishido, Atsuko Nagaoka, Junya Matsumoto, Hiroyasu Akatsu, Yoshio Hashizume, Hideki Hayashi, Akiyoshi Kakita, Hiroaki Tomita, Hirooki Yabe

{"title":"Marked alteration of phosphoinositide signaling-associated molecules in postmortem prefrontal cortex with bipolar disorder.","authors":"Mizuki Hino, Yasuto Kunii, Risa Shishido, Atsuko Nagaoka, Junya Matsumoto, Hiroyasu Akatsu, Yoshio Hashizume, Hideki Hayashi, Akiyoshi Kakita, Hiroaki Tomita, Hirooki Yabe","doi":"10.1002/npr2.12409","DOIUrl":"10.1002/npr2.12409","url":null,"abstract":"Aim: The etiology of bipolar disorder (BD) remains unknown; however, lipid abnormalities in BD have received increasing attention in recent years. In this study, we examined the expression levels of enzyme proteins associated with the metabolic pathway of phosphoinositides (PIs) and their downstream effectors, protein kinase B (Akt1) and glycogen synthase kinase 3β (GSK3β), which have been assumed to be the targets of mood stabilizers such as lithium, in the postmortem brains of patients with BD.Methods: The protein expression levels of phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1C), phosphatidylinositol 4-kinase alpha (PIK4CA), phosphatase and tensin homolog deleted from chromosome 10 (PTEN), Akt1, and GSK3β were measured using enzyme-linked immunosorbent assays and multiplex fluorescent bead-based immunoassays in the prefrontal cortex (PFC). Specifically, PTEN, Akt1, GSK3β, and PIP5K1C were measured in seven BD patients and 48 controls. Additionally, PIK4CA was analyzed in 10 cases and 34 controls.Results: PTEN expression levels were markedly decreased in the PFCs of patients with BD, whereas those of Akt and GSK3β were prominently elevated. Moreover, patients medicated with lithium exhibited higher Akt1 expression levels and lower PTEN expression levels in comparison with the untreated group.Conclusion: Our results suggest that the expression levels of Akt1/GSK3β and its upstream regulator PTEN are considerably altered.","PeriodicalId":19137,"journal":{"name":"Neuropsychopharmacology Reports","volume":" ","pages":"121-128"},"PeriodicalIF":2.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10932789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139521712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association study of a single nucleotide polymorphism in the hypoxia response element of the macrophage migration inhibitory factor gene promoter with suicide completers in the Japanese population. 巨噬细胞迁移抑制因子基因启动子缺氧反应元件中的单核苷酸多态性与日本人群自杀完成者的关联研究。

IF 2.5

Neuropsychopharmacology Reports Pub Date : 2024-03-01 Epub Date: 2024-01-24 DOI: 10.1002/npr2.12410

Toshiyuki Shirai, Satoshi Okazaki, Takaki Tanifuji, Ikuo Otsuka, Masao Miyachi, Shohei Okada, Ryota Shindo, Tadasu Horai, Kentaro Mouri, Motonori Takahashi, Takeshi Kondo, Yasuhiro Ueno, Akitoyo Hishimoto

{"title":"Association study of a single nucleotide polymorphism in the hypoxia response element of the macrophage migration inhibitory factor gene promoter with suicide completers in the Japanese population.","authors":"Toshiyuki Shirai, Satoshi Okazaki, Takaki Tanifuji, Ikuo Otsuka, Masao Miyachi, Shohei Okada, Ryota Shindo, Tadasu Horai, Kentaro Mouri, Motonori Takahashi, Takeshi Kondo, Yasuhiro Ueno, Akitoyo Hishimoto","doi":"10.1002/npr2.12410","DOIUrl":"10.1002/npr2.12410","url":null,"abstract":"Background: More than 800 000 people die by suicide annually. The heritability of suicide is 30%-50%. We focused on the hypoxia response element (HRE), which promotes the expression of macrophage migration inhibitory factor (MIF) via the hypoxia-inducible factor (HIF) pathway, important in neurogenesis and neuroprotection. We examined a genetic polymorphism of rs17004038, a single-nucleotide polymorphism (SNP), in suicide completers and controls.Methods: The study population included 1336 suicide completers and 814 unrelated healthy controls. All participants were Japanese. We obtained peripheral blood, extracted DNA, and genotyped the patients for SNP rs17004038 (C > A).Results: No significant differences were observed between the two groups in either the allele or genotype analyses. Subgroup analyses by sex, age (<40 or ≥40), and suicide method (violent or nonviolent suicide) were performed with similar results.Conclusion: No association was observed between SNP rs17004038 and suicide completion. Although it is challenging to collect a large number of samples from suicide completers, further MIF-related genetic studies, including those of rs17004038, are necessary with larger sample sizes.","PeriodicalId":19137,"journal":{"name":"Neuropsychopharmacology Reports","volume":" ","pages":"262-266"},"PeriodicalIF":2.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10932791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139547030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics of over-the-counter (OTC) drug abusers in psychiatric practice in Japan: Comparison of single and multiple OTC product abusers. 日本精神科非处方药（OTC）滥用者的临床特征：单一和多种非处方药滥用者的比较。

IF 2.5

Neuropsychopharmacology Reports Pub Date : 2024-03-01 Epub Date: 2024-02-01 DOI: 10.1002/npr2.12415

Yuko Tanibuchi, Soichiro Omiya, Takashi Usami, Toshihiko Matsumoto

{"title":"Clinical characteristics of over-the-counter (OTC) drug abusers in psychiatric practice in Japan: Comparison of single and multiple OTC product abusers.","authors":"Yuko Tanibuchi, Soichiro Omiya, Takashi Usami, Toshihiko Matsumoto","doi":"10.1002/npr2.12415","DOIUrl":"10.1002/npr2.12415","url":null,"abstract":"Objective: To examine the clinical characteristics of over-the-counter (OTC) drug abusers in psychiatric practice in Japan.Method: We examined the attributes, ICD-10 subcategory, and comorbid mental disorders of patients who mainly abuse OTC products and compared the clinical characteristics of single product and multiple products abusers, using the database of the \"2022 Nationwide Mental Hospital Survey of Drug-related Disorders.\"Results: Among the 2468 subjects included in this survey, 273 (11.1%) used OTC products as main drugs. Of these, 209 (78.3%) and 58 (21.7%) were classified into the single product group and the multiple products group, respectively. Six were excluded for unknown ingredients. By comparing these groups, we found that many of the multiple products group consisted of young women who were recently treated for drug problems. Many subjects in the group also had a short treatment period. No differences were observed between the groups regarding the ICD-10 F1 subcategory, but many subjects in the multiple products group fulfilled the criteria of F6 \"disorders of adult personality and behavior.\"Conclusion: OTC products are easily accessible drugs of abuse for young women in Japan. The results of this study indicate the necessity to reconsider the educational approach for preventing drug abuse, which has focused on illicit drugs. The study also indicates that some OTC products, which contain ingredients banned overseas due to their harmful effects, are still sold in Japan and that abusers for those products exist. Measures by the government are considered urgently needed.","PeriodicalId":19137,"journal":{"name":"Neuropsychopharmacology Reports","volume":" ","pages":"176-186"},"PeriodicalIF":2.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10932778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139651281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anxious-depressive attack and rejection sensitivity-Toward a new approach to treatment-resistant depression. 焦虑抑郁发作和排斥敏感性——一种治疗难治性抑郁症的新方法。

IF 2.5

Neuropsychopharmacology Reports Pub Date : 2024-03-01 Epub Date: 2023-12-07 DOI: 10.1002/npr2.12399

Hisanobu Kaiya

{"title":"Anxious-depressive attack and rejection sensitivity-Toward a new approach to treatment-resistant depression.","authors":"Hisanobu Kaiya","doi":"10.1002/npr2.12399","DOIUrl":"10.1002/npr2.12399","url":null,"abstract":"This paper aimed to find clues to treatment-resistant depression (TRD) solutions. Depression comorbid with anxiety is often treatment-resistant where anxious-depressive attack (ADA) often lurks. ADA is a recently proposed clinical idea for just a psychological version of a panic attack. It mostly begins with an abrupt surge of intense anxiety followed by uninterrupted intrusive thoughts; lasting ruminations about regret or worry produced by violent anxiety, agitation, and loneliness. Acting-out behaviors such as deliberate self-injury and over-dose may also be observed during the attack. As the basic psychopathology of ADA, rejection sensitivity (RS) was revealed by a structural equation model. It is said that the presence of RS in depressive disorders implies a poor prognosis. The following biological markers for RS were reviewed in the literature: first, the involvement of the μ-opioid receptor function in RS and, secondly, hypersensitivity of the dopamine D4 receptor (DRD4) in the medial prefrontal cortex. The latter has been suggested in fear-conditioned animal experiments. Manipulation of the μ-opioid receptor function together with the DRD4 function may culminate in a treatment for RS, which could contribute to the development of a treatment for TRD via the improvement of ADA.","PeriodicalId":19137,"journal":{"name":"Neuropsychopharmacology Reports","volume":" ","pages":"17-28"},"PeriodicalIF":2.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10932773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138499003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy of vortioxetine for the delusional disorder of cenesthopathy. 沃替西汀治疗精神分裂症妄想症的疗效。

IF 2.5

Neuropsychopharmacology Reports Pub Date : 2024-03-01 Epub Date: 2023-10-04 DOI: 10.1002/npr2.12384

Shinji Sato, Koubun Imai

引用次数: 0

Asenapine versus olanzapine for the treatment of nausea and vomiting in patients with cancer: A retrospective study. 阿塞那平与奥氮平治疗癌症患者的恶心和呕吐：一项回顾性研究。

IF 2.5

Neuropsychopharmacology Reports Pub Date : 2024-03-01 Epub Date: 2024-01-19 DOI: 10.1002/npr2.12412

Tomohiko Kimura, Akifumi Kanai, Hiroyuki Muraoka, Yuichiro Takahashi, Masatomo Ara, Ken Inada

{"title":"Asenapine versus olanzapine for the treatment of nausea and vomiting in patients with cancer: A retrospective study.","authors":"Tomohiko Kimura, Akifumi Kanai, Hiroyuki Muraoka, Yuichiro Takahashi, Masatomo Ara, Ken Inada","doi":"10.1002/npr2.12412","DOIUrl":"10.1002/npr2.12412","url":null,"abstract":"Aim: Patients with cancer often experience nausea and vomiting (N/V), but may have difficulty using olanzapine (OLZ), a common antiemetic. Asenapine (ASE) is a multi-acting receptor-targeted antipsychotic like OLZ, although there is little evidence that ASE serves as an antiemetic. The aim of this study was to evaluate the efficacy and tolerability of ASE compared to those of OLZ for the treatment of N/V in patients with cancer.Methods: This retrospective study involved patients who received 5 mg ASE, 5 mg OLZ, or 2.5 mg OLZ for 2 days. Daily worst N/V was rated on a scale of 0 (none) to 3 (very much). The primary endpoint was the proportion of patients who had a response, defined as any reduction in N/V score. A complete response (CR) was defined as a score reduction to 0. Secondary endpoints included the proportion of patients with CR and adverse events.Results: Between April 2017 and March 2023, 212 patients were enrolled to receive treatment: 5 mg ASE (n = 34), 5 mg OLZ (n = 102), or 2.5 mg OLZ (n = 76). No significant differences in response rates (52.9% vs. 58.8% vs. 52.6%, p = 0.671) or secondary endpoints were observed between the groups. Patients receiving ASE were more likely to experience oral hypoesthesia (p = 0.004).Conclusion: This preliminary study suggests that ASE may be effective for N/V. Further studies are required to confirm these findings.","PeriodicalId":19137,"journal":{"name":"Neuropsychopharmacology Reports","volume":" ","pages":"158-164"},"PeriodicalIF":2.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10932765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0