Neurology Research International最新文献

{"title":"Evaluation of Retinal Structure and Optic Nerve Function Changes in Multiple Sclerosis: Longitudinal Study with 1-Year Follow-Up.","authors":"Riwanti Estiasari,&nbsp;Adisresti Diwyacitta,&nbsp;Muhammad Sidik,&nbsp;Ni Nengah Rida Ariarini,&nbsp;Freddy Sitorus,&nbsp;Saraf Shafa Marwadhani,&nbsp;Kartika Maharani,&nbsp;Darma Imran,&nbsp;Reza Aditya Arpandy,&nbsp;David Pangeran,&nbsp;Manfaluthy Hakim","doi":"10.1155/2021/5573839","DOIUrl":"https://doi.org/10.1155/2021/5573839","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS) is an autoimmune disease characterized by inflammation and demyelination of the central nervous system which often involves the optic nerve even though only 20% of the patients experience optic neuritis (ON).</p><p><strong>Objective: </strong>This study aims to compare the retinal structure and optic nerve function between patients with MS and healthy controls (HCs), evaluate optic nerve alterations in MS over 1-year follow-up, and analyze its correlations with disease duration, number of relapses, degree of disability, and different subtypes.</p><p><strong>Methods: </strong>This is a prospective cohort study involving 58 eyes of MS patients. Optic nerve function was evaluated with best-corrected visual acuity (BCVA), contrast sensitivity, and P100 latency, while the retinal structure was evaluated from the GCIPL and RNFL thickness measured with optical coherence tomography (OCT) and fundus photography.</p><p><strong>Results: </strong>The MS group had lower BCVA (<i>p</i>=0.001), contrast sensitivity (<i>p</i> < 0.001), mean GCIPL thickness (<i>p</i> < 0.001), and mean RNFL thickness (<i>p</i> < 0.001) than HC. At 6 and 12 months of observations, GCIPL and RNFL (nasal quadrant) of MS patients decreased significantly (<i>p</i>=0.007 and <i>p</i>=0.004, respectively). Disease duration and the number of relapses correlated with delayed P100 latency (<i>r</i> = -0.61, <i>p</i> < 0.001 and <i>r</i> = -0.46, <i>p</i>=0.02). GCIPL and RNFL in the SPMS subtype were thinner than in RRMS.</p><p><strong>Conclusions: </strong>The retinal structure and optic nerve function of MS patients are worse than those of normal individuals. GCIPL and RNFL thinning occurs at 6 and 12 months but do not correlate with disease duration, the number of relapses, and degree of disability.</p>","PeriodicalId":19124,"journal":{"name":"Neurology Research International","volume":"2021 ","pages":"5573839"},"PeriodicalIF":1.5,"publicationDate":"2021-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39069242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Ischemic and Hemorrhagic Stroke in Cameroon: A Case-Control Study.","authors":"Jaurès Kamgang,&nbsp;Francklin Tétinou,&nbsp;Yvan Zolo,&nbsp;Chee Yang Tan,&nbsp;Christian Wambo,&nbsp;Emerancienne J N Fongang,&nbsp;Ulrick Sidney Kanmounye","doi":"10.1155/2021/9948990","DOIUrl":"https://doi.org/10.1155/2021/9948990","url":null,"abstract":"<p><strong>Introduction: </strong>Stroke recurrence accounts for a great percentage of catastrophic complications, yet no comprehensive study has analyzed the factors associated with stroke recurrence in Cameroon. We carried out this case-control study to better understand the factors associated with the stroke recurrence in Cameroon.</p><p><strong>Methods: </strong>We collected sociodemographic, clinical, neuroimaging, laboratory, and therapeutic data of eligible patients who consulted the neurology and cardiology department of the Yaounde Central Hospital in Cameroon. We included all patients at least five years removed from their first stroke event who consulted the authors' institution as of January 15, 2019. Wilcoxon signed-rank and Fisher's exact tests were used. Also, a Cox regression model was used to identify confounders.</p><p><strong>Results: </strong>We recruited 100 patients; seven out of ten patients had hypertension, while six out of 10 had a sedentary lifestyle. Half of the patients consumed alcohol regularly, while one patient out of five had diabetes. Most patients presented with their first stroke event, and a quarter had a stroke recurrence. Stroke recurrence was associated with right handedness (OR = 0.23, 95% CI = 0.16-0.33), congestive heart failure (OR = 3.45, 95% CI = 1.16-10.28), gout (OR = 4.34, 95% CI = 1.09-18.09), dysarthria (OR = 4.34, 95% CI = 1.30-14.54), and facial palsy (OR = 3.96, 95% CII = 1.49 - 10.51), as well as modifiable factors such as elevated abdominal circumference (<i>P</i> < 0.01), systolic blood pressure (<i>P</i> < 0.01), blood glucose level (<i>P</i>I <I 0.01), LDL cholesterol (<i>P</i> < 0.01), and triglyceride levels (<i>P</i> < 0.01). The mulitvariable regression model only identified laterality (<i>B</i> = -1.48, <i>P</i> = 0.04) as a statistically significant explanatory varibale for stroke recurrence.</p><p><strong>Conclusion: </strong>We mapped the landscape of recurrent strokes in Cameroon. There is a need to evaluate the causes of suboptimal drug adherence rates and both the role and adherence to nonpharmacologic interventions.</p>","PeriodicalId":19124,"journal":{"name":"Neurology Research International","volume":"2021 ","pages":"9948990"},"PeriodicalIF":1.5,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39081942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Stroke in Asian Patients with Sickle Cell Anemia: A Systematic Review and Meta-Analysis.","authors":"Sandip Kuikel,&nbsp;Robin Rauniyar,&nbsp;Sanjeev Kharel,&nbsp;Anil Bist,&nbsp;Subarna Giri,&nbsp;Sahil Thapaliya,&nbsp;Sunanda Paudel","doi":"10.1155/2021/9961610","DOIUrl":"https://doi.org/10.1155/2021/9961610","url":null,"abstract":"<p><p>Sickle cell anemia (SCA) is an inherited autosomal recessive disease. It is caused due to point mutation that substitutes glutamate with valine at the sixth amino acid position of the beta chain of hemoglobin molecules leading to the sickling of the red blood cells and decreased structural deformability. Silent cerebral infarcts are the most common neurological complication of SCA, while overt stroke comprises substantial burden in patients with SCA. This meta-analysis aimed to find the pooled prevalence of overt stroke in SCA patients and discuss the importance of screening them. PubMed, Embase, and Google Scholar were the electronic databases used to search the studies. A total of 765 articles were retrieved upon detailed searching in the abovementioned databases. After a series of removing duplicate articles, title and abstract screening, and full-text review, 20 articles were found eligible and included in the study. The total number of participants from all the included studies was 3,956, and pooled prevalence of stroke in patients with sickle cell anemia in Asia was found to be 5% (95% CI: 4%, 6%) with a range from 1 to 41%. Stroke occurrence in sickle cell anemia patients is an emergency complication that needs immediate intervention and management. Because of the high prevalence of stroke in patients with sickle cell anemia, clinicians should focus on its prevention and treatment strategies.</p>","PeriodicalId":19124,"journal":{"name":"Neurology Research International","volume":"2021 ","pages":"9961610"},"PeriodicalIF":1.5,"publicationDate":"2021-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39250310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Evaluation and Treatment of Patients with Postconcussion Syndrome.","authors":"Vijay Renga","doi":"10.1155/2021/5567695","DOIUrl":"https://doi.org/10.1155/2021/5567695","url":null,"abstract":"<p><p>Postconcussion syndrome (PCS) is a complex set of symptoms occurring in a small percentage of patients following concussion. The condition is characterized by headaches, dizziness, cognitive difficulties, somatosensory issues, and a variety of other symptoms with varying durations. There is a lack of objective markers and standard treatment protocols. With the complexity created by premorbid conditions, psychosomatic issues, secondary gains, and litigations, providers often find themselves in a tough situation in the care of these patients. This article combines literature review and clinical insights with a focus on the underlying pathophysiology of PCS to provide a roadmap for evaluating and treating this condition.</p>","PeriodicalId":19124,"journal":{"name":"Neurology Research International","volume":"2021 ","pages":"5567695"},"PeriodicalIF":1.5,"publicationDate":"2021-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39045737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening of Cognitive Impairment in Patients with Multiple Sclerosis: A Cross-Sectional Study in Georgia.","authors":"Nazibrola Botchorishvili,&nbsp;Nino Shiukashvili,&nbsp;Nina Mikeladze,&nbsp;Ann Dzagnidze,&nbsp;Nino Mikava,&nbsp;Maia Tighashvili,&nbsp;Marina Janelidze","doi":"10.1155/2021/5591078","DOIUrl":"https://doi.org/10.1155/2021/5591078","url":null,"abstract":"<p><p>Cognitive impairment (CI) is a common symptom of multiple sclerosis (MS), with a significant negative impact on the occupational and social functioning of patients. This study aimed to estimate the prevalence and characteristics of CI among MS patients in Georgia. Sixty-eight patients with MS attending a neurology outpatient clinic in Tbilisi, Georgia, were enrolled in the study. Cognitive status was evaluated using two screening tools: the Brief International Cognitive Assessment for MS and the Montreal Cognitive Assessment. The overall prevalence of CI in our MS patients was 47%. We found negative associations between cognitive test results and patients' age, disability status, and depression. Lower education, higher scores on the Expanded Disability Status Scale, and the progressive course of MS were the main predictors of CI in the logistic regression analysis. This is the first study in Georgia to evaluate CI in patients with MS. The prevalence of CI in our study was comparable with those reported in other countries; however, we found greater impairment of the executive system compared to other cognitive domains. In our study, patients who were on continuous DMT showed significantly better performance on the cognitive tests used, indicating possible favorable effect of immunomodulatory drugs on cognition.</p>","PeriodicalId":19124,"journal":{"name":"Neurology Research International","volume":"2021 ","pages":"5591078"},"PeriodicalIF":1.5,"publicationDate":"2021-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39239109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Paraclinical Screening for Celiac Disease in Children with Intractable Epilepsy.","authors":"Golnaz Ghazizadeh Esslami,&nbsp;Bahar Allahverdi,&nbsp;Reza Shervin Badv,&nbsp;Morteza Heidari,&nbsp;Nahid Khosroshahi,&nbsp;Hosein Shabani-Mirzaee,&nbsp;Kambiz Eftekhari","doi":"10.1155/2021/1639745","DOIUrl":"https://doi.org/10.1155/2021/1639745","url":null,"abstract":"<p><strong>Background: </strong>Celiac disease is the inflammatory entropy caused by hypersensitivity to gluten, which occurs in susceptible individuals. Some studies have suggested a link between celiac disease and epilepsy in children. Our aim was to screen for clinical and paraclinical features of celiac disease in children with intractable epilepsy.</p><p><strong>Methods: </strong>This was a cross-sectional study. Children aged 2 to 18 years with refractory epilepsy that referred to the pediatric neurology clinic within one year (2018-2019) were enrolled. Demographic and clinical characteristics of patients, especially clinical manifestations of celiac disease, were recorded in a questionnaire. A venous blood sample was sent to determine the total IgA, anti-tTG (IgA), and anti-endomysial antibody (IgA). Endoscopy was performed in cases where the celiac serological test was positive.</p><p><strong>Results: </strong>Seventy children with idiopathic drug-resistant epilepsy (44 boys) were evaluated. The height-for-age index was 49.2% and the weight-for-age index was 38.2% less than normal. Constipation (48.6%), anorexia (25.7%), and abdominal pain (21.4%) were the most common gastrointestinal symptoms. Celiac serological tests were negative in all children. Therefore, endoscopy and bowel biopsy were not performed in any case.</p><p><strong>Conclusion: </strong>Celiac disease was not found in any patient with intractable epilepsy. Gastrointestinal symptoms and growth disorders in this group may be related to the underlying disease or medications and not to celiac disease.</p>","PeriodicalId":19124,"journal":{"name":"Neurology Research International","volume":"2021 ","pages":"1639745"},"PeriodicalIF":1.5,"publicationDate":"2021-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38964224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypnotic Effect of <i>A</i>. <i>absinthium</i> Hydroalcoholic Extract in Pentobarbital-Treated Mice.","authors":"Hassan Rakhshandeh, Amirhossein Heidari, Ali Mohammad Pourbagher-Shahri, Roghayeh Rashidi, Fatemeh Forouzanfar","doi":"10.1155/2021/5521019","DOIUrl":"10.1155/2021/5521019","url":null,"abstract":"<p><strong>Background: </strong>Current drugs used in the management of insomnia are associated with side effects. The use of medicinal herbs for insomnia treatment has recently been suggested.</p><p><strong>Objective: </strong>The present study aimed to determine the hypnotic activity of the hydroalcoholic extract of <i>Artemisia absinthium (A</i>. <i>absinthium)</i> in mice.</p><p><strong>Method: </strong>The toxicity of <i>A</i>. <i>absinthium</i> extract is assessed by their lethal dose 50% (LD50), and cytotoxicity evaluation was also done with PC12 cell lines by MTT assay. <i>A</i>. <i>absinthium</i> extract (25, 50, 100, and 200 mg/kg) and 3 fractions (<i>n</i>-butanol fraction (NBF), ethyl acetate fraction (EAF), and aqueous fraction (AQF)) were administered intraperitoneally30 minutes before 30 mg/kg pentobarbital intraperitoneal injection; after that, the sleeping time and sleep latency were recorded.</p><p><strong>Results: </strong>The LD50 value was 2.4 g/kg. The extracts tested showed no negative effect on the proliferation of PC12 cells. <i>A</i>. <i>absinthium</i> extract increased the duration of pentobarbital-induced sleep at doses of 100 and 200 mg/kg (<i>P</i> < 0.01-<i>P</i> < 0.001). Similarly, AQF, EAF, and NBF at 200 mg/kg could increase sleep duration (<i>P</i> < 0.05). The sleep latency was decreased by <i>A</i>. <i>absinthium</i> extract at doses of 100 and 200 mg/kg (<i>P</i> < 0.05-<i>P</i> < 0.01), AQF (<i>P</i> < 0.05), and EAF (<i>P</i> < 0.05). Besides, flumazenil reversed the hypnotic effect of <i>A</i>. <i>absinthium</i> extract (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong><i>A</i>. <i>absinthium</i> extract probably demonstrated sleep-enhancing effects by regulating GABAergic system.</p>","PeriodicalId":19124,"journal":{"name":"Neurology Research International","volume":"2021 ","pages":"5521019"},"PeriodicalIF":1.5,"publicationDate":"2021-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38964225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction Score for Cervical Spine Fracture in Patients with Traumatic Neck Injury.","authors":"Natsinee Athinartrattanapong,&nbsp;Chaiyaporn Yuksen,&nbsp;Sittichok Leela-Amornsin,&nbsp;Chetsadakon Jenpanitpong,&nbsp;Sirote Wongwaisayawan,&nbsp;Pittavat Leelapattana","doi":"10.1155/2021/6658679","DOIUrl":"https://doi.org/10.1155/2021/6658679","url":null,"abstract":"<p><strong>Background: </strong>Cervical spine fracture is approximately 2%-5%. Diagnostic imaging in developing countries has several limitations. A computed tomography scan is not available 24 hours and not cost-effective. This study aims to develop a clinical tool to identify patients who must undergo a computed tomography scan to evaluate cervical spine fracture in a noncomputed tomography scan available hospital.</p><p><strong>Methods: </strong>The study was a diagnostic prediction rule. A retrospective cross-sectional study was conducted between August 1, 2016, and December 31, 2018, at the emergency department. This study included all patients aged over 16 years who had suspected cervical spine injury and underwent a computed tomography scan at the emergency department. The predictive model and prediction scores were developed via multivariable logistic regression analysis.</p><p><strong>Results: </strong>375 patients met the criteria. 29 (7.73%) presented with cervical spine fracture on computed tomography scan and 346 did not. Five independent factors (i.e., high-risk mechanism of injury, paraparesis, paresthesia, limited range of motion of the neck, and associated chest or facial injury) were considered good predictors of C-spine fracture. The clinical prediction score for C-spine fracture was developed by dividing the patients into three probability groups (low, 0; moderate, 1-5; and high, 6-11), and the accuracy was 82.52%. In patients with a score of 1-5, the positive likelihood ratio for C-spine fracture was 1.46. Meanwhile, those with a score of 6-11 had an LR+ of 7.16.</p><p><strong>Conclusion: </strong>In a noncomputed tomography scan available hospital, traumatic spine injuries patients with a clinical prediction score ≥1 were associated with cervical spine fracture and should undergo computed tomography scan to evaluate C-spine fracture.</p>","PeriodicalId":19124,"journal":{"name":"Neurology Research International","volume":"2021 ","pages":"6658679"},"PeriodicalIF":1.5,"publicationDate":"2021-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25558800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Human-Centered Robotics: Towards an Automated Process for Neurorehabilitation.","authors":"Meenakshi Devi Parre,&nbsp;B Sujatha","doi":"10.1155/2021/6690715","DOIUrl":"https://doi.org/10.1155/2021/6690715","url":null,"abstract":"<p><p>The global requirement of patient rehabilitation has surged with time due to the growing number of accidents, injuries, age-related issues, and other aspects. Parallelly, the cost of treatment and patient care also increased in a manifold. Moreover, constant monitoring and support for the patients having physical disabilities have become an ongoing challenge to the medical system. Robotics-based neurorehabilitation has reduced the human error while assisting such patients, precisely interpreting the signals, and communicating to the patient. Gradual precise application and improvement of the technology with time yielded a novel direction for patient care and support. The interdisciplinary contribution of many advanced technical branches allowed us to develop robotics-based assistance with high precision for the upper limb and the lower limb impairments. The present review summarizes the generation and background of robotic implementation for patient support, progress, present status, and future requirements.</p>","PeriodicalId":19124,"journal":{"name":"Neurology Research International","volume":"2021 ","pages":"6690715"},"PeriodicalIF":1.5,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25351260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Properties of Preference-Based Measures for Economic Evaluation in Amyotrophic Lateral Sclerosis: A Systematic Review.","authors":"Nicole Peters,&nbsp;Vanina Dal Bello-Haas,&nbsp;Tara Packham,&nbsp;Ava Mehdipour,&nbsp;Ayse Kuspinar","doi":"10.1155/2021/6681554","DOIUrl":"https://doi.org/10.1155/2021/6681554","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this review was to synthesize the psychometric properties of generic preference-based measures (PBMs) of health-related quality of life (HRQL) in Amyotrophic Lateral Sclerosis (ALS).</p><p><strong>Methods: </strong>A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Four databases were searched from inception to April 2019: OVID Medline, Embase, PsycINFO, and CINAHL. Studies were included if (1) the sample represented individuals with ALS, (2) a generic PBM was utilized and reported on, and (3) information on the psychometric property of a generic PBM was provided.</p><p><strong>Results: </strong>Ninety-one articles were screened, and 39 full-text articles were reviewed. Seven full-text articles were included in this review. The mean age of participants ranged from 58.1 to 63.8 years, and mean time since diagnosis ranged from 20.5 to 44.6 months. Two generic PBMs were found, the EQ-5D-3L (<i>n</i> = 6) and the Quality of Well-Being Self-Administered (QWB-SA) scale (<i>n</i> = 1). Convergent validity of the EQ-5D-3L was large against a global scale of self-perceived health (<i>r</i> = 0.60) and small to large against ALS specific HRQL measures (<i>r</i> = 0.19 to 0.75). For the QWB-SA scale, correlations were small against a generic measure (<i>r</i> = 0.21) and large against ALS specific measures (<i>r</i> = 0.55). The EQ-5D-3L discriminated across different disease severity; however, floor effects were reported.</p><p><strong>Conclusion: </strong>This review highlights the need for more rigorously designed studies to assess the psychometric properties of generic PBMs in ALS and the development of an ALS specific PBM that adequately reflects the health concerns of individuals with ALS.</p>","PeriodicalId":19124,"journal":{"name":"Neurology Research International","volume":"2021 ","pages":"6681554"},"PeriodicalIF":1.5,"publicationDate":"2021-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25360325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}