Neurogastroenterology and Motility最新文献

{"title":"Is Endoscopic Pyloric Dilation Beneficial in Gastroparesis? Available Data and Unresolved Issues.","authors":"William L Hasler","doi":"10.1111/nmo.70471","DOIUrl":"https://doi.org/10.1111/nmo.70471","url":null,"abstract":"","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149271188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manometric Parameters of Esophagogastric Junction Competence Are Equivalent Predictors of Gastroesophageal Reflux Disease: A Head-To-Head Comparison.","authors":"Carlo Galdino Riva, Stefano Siboni, Jiurgen Mema, Roberta De Maron, Marco Sozzi, Emanuele Asti","doi":"10.1111/nmo.70477","DOIUrl":"https://doi.org/10.1111/nmo.70477","url":null,"abstract":"<p><strong>Background: </strong>Several high-resolution manometry (HRM) metrics of esophagogastric junction (EGJ) competence exist, but they have never been compared head-to-head in one cohort against a uniform gastroesophageal reflux disease (GERD) definition. We aimed to assess whether any anatomical or pressure metric outperforms the others.</p><p><strong>Methods: </strong>Consecutive patients undergoing endoscopy, HRM, and ambulatory reflux monitoring for suspected GERD between December 2022 and December 2025 were studied. GERD was defined by the Lyon 2.0 criteria. All EGJ metrics were recalculated de novo by a single blinded reader. Paired AUC differences were tested with the DeLong method and interpreted against a pre-specified equivalence margin of ΔAUC 0.05.</p><p><strong>Results: </strong>Of 429 patients (48.3% male; median age 52 years), 212 (49.4%) had GERD. Every metric differed between groups (all p < 0.001) and correlated weakly to moderately with acid exposure time and mean nocturnal baseline impedance. Among anatomical metrics, EGJ morphology (2017 Consensus) had the highest AUC (0.714); LES intra-abdominal length, hiatal hernia, and Akimoto morphology were equivalent (95% CI of ΔAUC within ±0.05), whereas LES total length performed worse (ΔAUC 0.095, 95% CI 0.034-0.155). Among pressure metrics, EGJ-CI at IGP + 2 mmHg had the highest AUC (0.692), and six of seven comparators were equivalent. Comparisons between hiatal hernia sizing methods and for LESPI were inconclusive.</p><p><strong>Conclusions: </strong>Anatomical and pressure HRM metrics of EGJ competence are equivalent within a 0.05 AUC margin and all provide only moderate discrimination for GERD. None can be preferred on diagnostic grounds, so the simplest and fastest to calculate may reasonably be chosen.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149271199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Mechanism of Medicated Thread Moxibustion of Zhuang Medicine in Diabetic Gastroparesis Rats Based on the Enteric Nervous System.","authors":"Hui Xu, Yujun He, Yu Wu, Zibin Wang, Fangzhi Zhang, Yushan Fan","doi":"10.1111/nmo.70418","DOIUrl":"10.1111/nmo.70418","url":null,"abstract":"<p><strong>Background: </strong>Diabetic gastroparesis (DGP) is a common complication of diabetes mellitus, for which Western medicine treatments are associated with adverse effects and limitations. Enteric nervous system (ENS) injury is a core mechanism underlying this condition. Although Medicated Thread Moxibustion of Zhuang Medicine shows significant therapeutic efficacy, the specific mechanism by which it regulates the ENS to improve DGP remains unclear.</p><p><strong>Methods: </strong>A DGP rat model was established by intraperitoneal injection of streptozotocin (STZ) (60 mg/kg). The experimental animals were divided into five groups: control group, model group, mosapride citrate group, non-meridian and non-acupoint group, and Yangming meridian acupoint group. The Yangming meridian acupoint group received Medicated Thread Moxibustion of Zhuang Medicine at bilateral ST21, ST30, ST36, and ST40. Blood glucose, body weight, gastric emptying rate, and small intestinal propulsion rate were measured in each group. Hematoxylin-eosin (HE) staining was used to observe the histomorphology of the antrum and duodenum. Western blotting, immunofluorescence, and immunohistochemistry were performed to detect markers of enteric neurons (PGP9.5, ChAT, and neuronal nitric oxide synthase [nNOS]) and enteric glial cells (EGCs) (S100β, glial fibrillary acidic protein [GFAP], and Glial-cell line-derived neurotrophic factor [GDNF]).</p><p><strong>Results: </strong>Following treatment with Medicated Thread Moxibustion of Zhuang Medicine at the Yangming meridian acupoints, DGP rats exhibited reduced blood glucose levels, restored body weight, increased gastric emptying rate and small intestinal propulsion rate, and ameliorated pathological damage in the gastric antrum and duodenum. Moreover, the expression levels of PGP9.5, ChAT, nNOS, S100β, GFAP, and GDNF were elevated. In addition, the glucose-lowering effect of this therapy was superior to that of mosapride citrate.</p><p><strong>Conclusion: </strong>Medicated Thread Moxibustion of Zhuang Medicine at the Yangming meridian acupoints effectively restores gastrointestinal motility in DGP rats by upregulating the expression of marker proteins of enteric neurons and EGCs, thereby ameliorating the morphological damage to both cell types.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 9","pages":"e70418"},"PeriodicalIF":3.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subtypes of Enteric Neurons in Hirschsprung Disease: A Comparison of Fully Ganglionic and Transitional Zone.","authors":"C Nebeling, M Lee-Theilen, E Gradhand, F Friedmacher, U Rolle, Y Braun","doi":"10.1111/nmo.70444","DOIUrl":"10.1111/nmo.70444","url":null,"abstract":"<p><strong>Background: </strong>Hirschsprung disease (HD) is characterized by aganglionosis of the distal bowel and an adjacent transitional zone with structural abnormalities of the enteric nervous system (ENS). While previous studies have focused primarily on neuronal density, it remains unclear whether the neurochemical composition of enteric neurons differs between transitional and fully ganglionic bowel. This study therefore aimed to characterize neuronal subtype composition in these regions of HD specimens.</p><p><strong>Methods: </strong>Colonic specimens resected during pullthrough surgery from pediatric HD patients were analyzed. Chromogenic immunohistochemistry and multiplex fluorescent immunohistochemistry (HuC/D, nNOS, ChAT) were performed and analyzed across myenteric and submucosal plexuses. Digital image analysis (QuPath) enabled automated cell detection and subtype classification. Cell counts were normalized per segment length for density analysis. Neuronal subtype composition was analyzed by paired testing and complementary Bayesian Dirichlet-multinomial regression modeling.</p><p><strong>Key results: </strong>HuC/D-, nNOS-, and ChAT-positive neurons were identified in both transitional and fully ganglionic bowel, with only minor differences in neuronal density. Paired analysis and Bayesian Dirichlet-multinomial modeling of neuronal subtype proportions indicated that the relative composition of major neurochemical neuronal subtypes was largely preserved between transitional and fully ganglionic bowel. Although expected differences in subtype distribution were observed between enteric plexuses, no consistent zone-specific alterations were identified.</p><p><strong>Conclusions & inferences: </strong>Neurochemical subtype composition of enteric neurons is largely preserved between transitional and fully ganglionic bowel in HD. Within the limitations of this study, we did not detect major differences in neuronal subtype composition between transitional and fully ganglionic bowel that could explain persistent postoperative bowel dysfunction.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 9","pages":"e70444"},"PeriodicalIF":3.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Definition of Clinically Meaningful Thresholds for the Brief Esophageal Dysphagia Questionnaire and Eckardt Score: A Multicenter Psychometric Study.","authors":"Eugenia Morales, Esteban Glasinovic, José María Remes-Troche, Karla García-Zermeño, Juan Pablo García Marmolejo, Albis Hani, Andrés Ardila-Hani, Andrés Ditaranto, Joaquin Agotegaray, Claudio Bilder, Hugo Monrroy, Paula Rey, José Ignacio Gran, Jordi Serra, Luis G Alcalá-González, Claudia Barber-Caselles, Dustin A Carlson, Daniel Cisternas","doi":"10.1111/nmo.70431","DOIUrl":"10.1111/nmo.70431","url":null,"abstract":"<p><strong>Background: </strong>The Brief Esophageal Dysphagia Questionnaire (BEDQ) and Eckardt score (ES) are the most used patient-reported outcomes (PROs) for dysphagia. However, their patient-centered cutoffs, minimal important difference (MID), and test-retest reliability have not been established. We aimed to address these gaps and evaluate BEDQ treatment responsiveness.</p><p><strong>Methods: </strong>This prospective multicenter study was conducted in tertiary centers in Spain and Latin America and enrolled adults referred for high-resolution manometry. Three cohorts were derived: the cutoff cohort (subsequently subdivided into a derivation and a validation cohort), the test-retest cohort (consecutive subsample re-administered PROs), and the treatment responsiveness cohort (patients treated for achalasia). Self-perceived severity was evaluated using a 5-point Likert Patient Global Impression of Severity (PGIS) scale and applied as PGIS < 2 (No/Mild symptoms (NMSS)) and ≥ 2.</p><p><strong>Results: </strong>The cutoff cohort included 571 patients, subdivided into derivation (397) and validation (174) cohorts. A BEDQ cutoff of < 9 and ES < 4 optimally predicted NMSS. The validation cohort and bootstrapping confirmed the stability of these cutoffs. MID was 5 points for BEDQ and 1 point for ES, consistent across cohorts. BEDQ showed excellent test-retest reliability (intraclass correlation coefficient = 0.97), significantly higher than ES (0.85). Both PROs showed statistically significant reductions following treatment (p < 0.001 for both), with standardized response means of 2.14 and 1.98 for BEDQ and ES, respectively.</p><p><strong>Conclusions: </strong>BEDQ < 9 and ES < 4 are clinically meaningful thresholds for identifying patients with NMSS. Changes exceeding 5 points for BEDQ and 1 point for ES represent clinically meaningful differences. BEDQ demonstrates superior psychometric properties compared to ES.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 9","pages":"e70431"},"PeriodicalIF":3.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13558786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal Pain Sensitization Connected With Upper but Not Lower Abdominal Pain in Adults With Gastroparesis.","authors":"Helen Burton-Murray, Emily P Mitchell, Laura A Miriel, Henry P Parkman, Irene Sarosiek, Baha Moshiree, Madhusudan Grover, Gianrico Farrugia, Bruno P Chumpitazi, Robert J Shulman, Geoffrey A Preidis, Thomas L Abell, William L Hasler, Robert R Edwards, Pankaj J Pasricha, Braden Kuo","doi":"10.1111/nmo.70443","DOIUrl":"10.1111/nmo.70443","url":null,"abstract":"<p><strong>Introduction: </strong>Although pain is recognized as an important symptom in gastroparesis, it has not been well studied and characterized. Quantitative sensory testing (QST) is a psychophysical method that has the potential to provide a measure of pain processing, as well as insight into pain pathophysiology and the prediction of response to specific therapies. We aimed to characterize somatic QST in a well-characterized cohort of patients with gastroparesis.</p><p><strong>Methods: </strong>Adults with scintigraphically defined gastroparesis underwent abdominal QST with assessment of mechanical pain: pain sensitivity (thresholds and tolerance) and pain facilitation (temporal summation). The Patient Assessment of Upper GI Symptoms (PAGI-SYM) upper and lower abdominal pain scales were used.</p><p><strong>Results: </strong>QST was performed on 264 participants (87% female; age = 18-78 years). In both the upper and lower abdomen, smaller pain thresholds and lower pain tolerance were significantly associated with greater PAGI-SYM upper abdominal pain severity (b's = 0.07-0.15; p's = 0.007-0.02), but not lower abdominal pain severity. Scores on the PAGI-SYM upper and lower abdominal pain scales were moderately correlated (r = 0.48, p < 0.0001). No significant associations were found for temporal summation.</p><p><strong>Conclusions: </strong>Our findings suggest self-reported upper abdominal pain severity correlated with both lower and upper abdominal mechanical pain sensitivity-possibly reflecting secondary sensitization of the abdominal wall, due to viscerosomatic convergence in upper abdominal somatic segments. Lower abdominal pain severity association with only upper (but not lower) abdominal QST may be due to cross-organ sensitization. Further investigations are needed to test the clinical utility of abdominal QST in gastric sensorimotor disorders.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov: NCT01696747.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 9","pages":"e70443"},"PeriodicalIF":3.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13693293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tardive Dyskinesia in Patients Receiving Continuous Versus Intermittent Oral Metoclopramide: A Retrospective Real World Study.","authors":"Pierantonio Russo, Ramaa Nathan, Michael Camilleri","doi":"10.1111/nmo.70422","DOIUrl":"10.1111/nmo.70422","url":null,"abstract":"<p><strong>Background: </strong>Tardive dyskinesia (TD) is an often irreversible movement disorder associated with prolonged exposure to dopamine receptor antagonists such as metoclopramide (MCP). This study evaluates the prevalence and timing of TD in patients receiving continuous versus intermittent MCP.</p><p><strong>Methods: </strong>A retrospective analysis was conducted using Symphony Health Solutions data from July 2018 to June 2024, covering over 307 million U.S.</p><p><strong>Patients: </strong>Two cohorts were analyzed: (1) all patients with ≥ 2 MCP prescriptions (Cohort A), and (2) patients with a gastroparesis diagnosis (ICD10 K31.84) prior to ≥ 2 MCP prescriptions (Cohort B). TD prevalence was evaluated based on ≥ 1 or ≥ 2 ICD-10 G24.01 claims within 12 months after initial MCP prescription. MCP exposure was classified as continuous (Proportion of days covered (PDC) > = 1) or intermittent (PDC < 1).</p><p><strong>Results: </strong>TD prevalence was higher in patients receiving continuous MCP across both cohorts. In Cohort A (N = 1,360,196), TD prevalence was 0.25% (continuous) vs. 0.18% (intermittent) for ≥ 1 claim, and 0.13% vs. 0.09% for ≥ 2 claims. In the cohort with gastroparesis (N = 125,279), TD prevalence was 0.77% (continuous) vs. 0.55% (intermittent) for ≥ 1 claim, and 0.43% vs. 0.25% for ≥ 2 claims. Median time to TD diagnosis was shorter for continuous users: 567 vs. 758 days in Cohort A and 490 vs. 573 days in Cohort B. All group differences were statistically significant (p < 0.005).</p><p><strong>Conclusions: </strong>Continuous MCP dosing was associated with higher TD prevalence and earlier onset. Intermittent dosing, despite longer cumulative exposure, was associated with lower TD risk. These findings suggest that intermittent regimens may offer a safer MCP therapeutic strategy.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 9","pages":"e70422"},"PeriodicalIF":3.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscularis EGR1 Deficiency Impairs M2 Macrophage Polarization and Disrupts Gastric Motility in Diabetic Gastroparesis.","authors":"Ni Xie, Guanhao Su, Ying Wu, Kui Peng, Zhu Mei, Wei Chen, Kai Xu, Baiwen Li","doi":"10.1111/nmo.70439","DOIUrl":"10.1111/nmo.70439","url":null,"abstract":"<p><strong>Background: </strong>Diabetic gastroparesis (DGP) is characterized by delayed gastric emptying and limited mechanism-based therapies. Pyloric dysfunction has been associated with loss of interstitial cells of Cajal (ICC) and altered muscularis macrophage polarization. This study examined whether early growth response 1 (EGR1) links macrophage polarization to ICC integrity in DGP.</p><p><strong>Methods: </strong>Human full-thickness gastric body transcriptomic data (GSE115601) were analyzed using differential expression and exploratory machine learning, with validation in single-cell RNA sequencing data (GSE252126) and clinical pyloric muscularis biopsies. A streptozotocin-induced DGP rat model was used to test local pyloric adeno-associated virus 9 (AAV9)-mediated EGR1 restoration. Macrophage and primary ICC experiments included EGR1 knockdown, thioredoxin 2 (TXN2) rescue, mitochondrial respiration analysis, cytokine profiling, C-C motif chemokine ligand 5 (CCL5) neutralization, and C-C chemokine receptor 5 (CCR5) blockade.</p><p><strong>Results: </strong>EGR1 was downregulated in DGP gastric body samples and subsequently validated in human pyloric muscularis biopsies, with enrichment in macrophages, particularly M2 macrophages. EGR1 loss reduced TXN2 transcription and mitochondrial oxidative phosphorylation (OXPHOS), impaired M2 polarization, and increased macrophage CCL5 secretion. Conditioned medium from EGR1-deficient macrophages induced Ca²⁺ dysregulation, NLR family pyrin domain containing 3 (NLRP3) activation, and ICC marker loss; these effects were attenuated by CCL5 neutralization or CCR5 blockade. Local AAV9-EGR1 restoration increased M2 macrophage and ICC marker expression, improved gastric emptying, and regularized pyloric slow waves without improving systemic glucose control.</p><p><strong>Conclusions: </strong>Muscularis EGR1 deficiency may promote DGP by disrupting TXN2-dependent macrophage OXPHOS and triggering CCL5/CCR5/NLRP3-mediated ICC injury. Local EGR1 restoration improved gastric motility and may represent a therapeutic strategy.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 9","pages":"e70439"},"PeriodicalIF":3.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13578571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ameliorating Effects and Autonomic Mechanisms of Transcutaneous Auricular Vagus Nerve Stimulation on Abdominal Pain in Patients With Functional Dyspepsia and Irritable Bowel Syndrome.","authors":"Xiaomeng Sun, Qi Lin, Yuemei Xu, Pingping Hu, Peijing Rong, Jieyun Yin, Lin Lin, Jiande D Z Chen","doi":"10.1111/nmo.70224","DOIUrl":"10.1111/nmo.70224","url":null,"abstract":"<p><strong>Background: </strong>Patients with functional dyspepsia (FD) and irritable bowel syndrome (IBS) often experience abdominal pain and reduced quality of life and need effective treatments. This exploratory study aimed to evaluate whether transcutaneous auricular vagus nerve stimulation (taVNS) could improve abdominal pain and quality of life in patients with FD and IBS, and whether the effects were mediated via the autonomic mechanisms.</p><p><strong>Methods: </strong>A total of 64 patients with abdominal pain (43 FD and 21 IBS) with a pain score of 3 out of 10 or higher were randomized to receive 2 weeks of taVNS or sham-taVNS treatment. The primary outcome was numeric rating scale (NRS) for abdominal pain. The dyspeptic symptom scales (DSS), IBS symptom severity scale score (IBS-SSS), anxiety and depression scores, and the SF36 quality of life scale were assessed before and after the treatment. The electrocardiogram was also recorded for the assessment of autonomic function at baseline and after the treatment.</p><p><strong>Key results: </strong>(1) taVNS reduced the abdominal pain score (p < 0.001 for both FD and IBS), the frequency of abdominal pain (p < 0.001 for both FD and IBS), and overall symptom scores in both FD patients and IBS patients (p < 0.001 for FD and IBS). There was no significant difference in the effect of taVNS on abdominal pain between FD and IBS patients. (2) taVNS improved quality of life compared with baseline in both FD and IBS patients. (3) taVNS decreased anxiety (p < 0.001) and depression (p < 0.001). (4) taVNS increased vagal activity. At the end of the taVNS treatment, the vagal activity was negatively correlated with the pain score (r = -0.491, p = 0.004).</p><p><strong>Conclusions: </strong>Non-invasive taVNS improves abdominal pain, quality of life, and anxiety and depression in patients with FD and patients with IBS, possibly attributed to the enhancement of vagal activity.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registry: ChiCTR2400085697.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 9","pages":"e70224"},"PeriodicalIF":3.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13535475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wireless Patch System, a \"Holter Monitor\" for the Stomach: Next Steps in Identifying Gastric Phenotypes or Just Too Much Noise?","authors":"Daniel Martin Simadibrata, Anthony Lembo","doi":"10.1111/nmo.70440","DOIUrl":"10.1111/nmo.70440","url":null,"abstract":"","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 9","pages":"e70440"},"PeriodicalIF":3.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148970466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}