Neurodegenerative Diseases最新文献

{"title":"Examining the Influence of Task Complexity on Dual-Task Performance in Parkinson's Disease and Healthy Older Adults.","authors":"Sarah Jo Conklin, Elizabeth Barkley, Jonathan Haug, Yi-Fang Chiu, Jason K Longhurst","doi":"10.1159/000550799","DOIUrl":"10.1159/000550799","url":null,"abstract":"<p><p><p>Introduction: People with Parkinson's disease (PwPD) often experience difficulty performing dual-tasks (DTs), negatively impacting mobility, fall risk, and quality of life. The influence of task complexity on DT performance remains unclear. This study examined the effects of gait complexity and cognitive/speaking task on DT effects (DTEs) in PwPD and healthy older adults.</p><p><strong>Methods: </strong>Forty-one PwPD and eleven healthy older adults completed two gait tasks - straight walking (simple) and figure-8 walking with obstacle crossing (complex) - on a pressure-sensitive walkway, paired with four cognitive/speaking tasks: oral trail making, counting, diadochokinetic task, and spontaneous speech. Each combination was performed three times for 20 s. Single-task and DT performance were assessed for gait parameters (step length, step length coefficient of variation) and cognitive/speaking task response rate. Motor DTE (mDTE), cognitive DTE (cogDTE), combined DTE (cDTE), and modified attention allocation index (mAAI) were calculated. A 2 × 5 repeated-measures ANOVA tested effects of gait complexity and cognitive/speaking task on raw gait metrics, and a 2 × 4 ANOVA tested effects on DTE metrics.</p><p><strong>Results: </strong>In PwPD, complex walking resulted in shorter step length and greater step length coefficient of variation compared to simple walking (ps < 0.001), whereas cognitive/speaking task did not affect raw gait metrics. For DTEs, cognitive/speaking task influenced step length-based mDTE, cDTE, and mAAI (ps < 0.05) and step length coefficient of variation-based mAAI (p < 0.05). In healthy older adults, gait complexity led to greater step length coefficient of variation (p < 0.001) while step length was unchanged. Cognitive/speaking task significantly influenced step length-based cogDTE, cDTE, and mAAI, as well as step length coefficient of variation-based cogDTE and mAAI (ps < 0.05). No significant interactions were observed.</p><p><strong>Conclusion: </strong>In PwPD, gait complexity influenced raw gait performance, whereas DTEs were more sensitive to cognitive/speaking task. In healthy older adults, gait complexity primarily affected step length variability, while DTEs were also influenced by cognitive/speaking task. These findings emphasize the value of diverse DT paradigms and the importance of assessing both raw performance and DTEs. Tailoring assessments to include a variety of motor and cognitive challenges may improve sensitivity in evaluating gait and fall risk, supporting more personalized interventions. </p>.</p>","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"131-149"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146086340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Practice Recommendations of the Swiss Society for Neuroradiology: Neuroimaging Standards for Enrollment and Disease Monitoring in Anti-Amyloid Immunotherapies.","authors":"Roland Wiest, Piotr Radojewski, Johanna Maria Lieb, Marios Psychogios, Tammy Lee Smith Benzinger, Ana M Franceschi, Isabel Wanke, Bogdan Draganski, Felix T Kurz, Karl-Olof Lövblad","doi":"10.1159/000549521","DOIUrl":"10.1159/000549521","url":null,"abstract":"<p><p><p>Introduction: The Swiss Society for Neuroradiology (SSNR) has established clinical practice recommendations to guide the use of neuroimaging in the enrollment and treatment monitoring of patients undergoing anti-amyloid immunotherapies for Alzheimer's disease. In Switzerland, anti-amyloid immunotherapy (AAT) has not been approved by Swissmedic ahead of this publication. This paper therefore reflects the existing international standards of care and will be updated after market clearance of AATs in Switzerland. Background and Rationale: Neuroimaging is a key requirement to assess therapeutic responses and manage potential adverse effects, particularly amyloid-related imaging abnormalities (ARIAs). The SSNR recommendations specify the appropriate use of magnetic resonance imaging biomarkers to support therapy inclusion, routine monitoring, and decision-making in case of manifestations of ARIA-E and ARIA-H during treatment. Conclusions: This paper reviews the required imaging protocols and criteria for patient eligibility and discusses the key findings of ARIA-E and ARIA-H. These findings should be detected and interpreted by the practicing radiologist to ensure patient safety. The practice recommendations of the SSNR align with previous published recommendations of the American Society of Neuroradiology. On this basis, we also provide practical recommendations for workflows and candidate selection to continue or discontinue therapy. </p>.</p>","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"77-88"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145505901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compensation of Postural Control in Demyelinating Neuropathies: Better Visual Integration in Charcot-Marie-Tooth Type 1A than in Chronic Inflammatory Demyelinating Polyradiculoneuropathy.","authors":"Loïc Dupont, Arnaud Delval, Luc Defebvre, Jean-Baptiste Davion, Cédrick T Bonnet, Céline Tard","doi":"10.1159/000547256","DOIUrl":"10.1159/000547256","url":null,"abstract":"<p><strong>Introduction: </strong>Demyelinating neuropathies, such as chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and Charcot-Marie-Tooth type 1A (CMT1A), significantly impair postural control. While both conditions affect sensory integration, differences in compensatory mechanisms remain poorly understood. This study aimed to explore how visual, proprioceptive, and cognitive perturbations influence postural stability in CIDP and CMT1A patients.</p><p><strong>Methods: </strong>A single-center, prospective study was conducted with 25 CIDP and 24 CMT1A patients. Posturographic recordings were used to assess postural stability under standard conditions and during visual tracking, proprioceptive perturbation (Achilles tendon vibration), and cognitive dual-tasking (DT) (backward counting). Center of pressure parameters, including area, velocity, and body sway, were analyzed to evaluate postural control.</p><p><strong>Results: </strong>CMT1A patients demonstrated improved postural stability during visual tracking tasks, suggesting better visual integration and long-term compensatory adaptations. In contrast, CIDP patients showed greater postural instability and reliance on static visual cues. Both groups experienced increased postural sway during proprioceptive and cognitive perturbations, with no significant differences between them in DT performance.</p><p><strong>Conclusion: </strong>The study highlights distinct postural control mechanisms in CIDP and CMT1A patients. CMT1A patients exhibit better adaptation to visual disturbances, while CIDP patients struggle with visual integration and rely more on static visual cues. This difference reflects the progressive nature of CMT1A, which may facilitate better development of compensatory strategies over time. These findings underscore the need for personalized rehabilitation approaches, focusing on visual integration for CIDP patients and reinforcing compensatory mechanisms in CMT1A patients to enhance balance and reduce fall risk.</p>","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"26-37"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum.","authors":"","doi":"10.1159/000548756","DOIUrl":"10.1159/000548756","url":null,"abstract":"<p><p>In the article \"Compensation of Postural Control in Demyelinating Neuropathies: Better Visual Integration in Charcot-Marie-Tooth Type 1A than in Chronic Inflammatory Demyelinating Polyradiculoneuropathy\" [Neurodegener Dis. 2025; https://doi.org/10.1159/000547256] by Dupont et al., a wrong copyright license was displayed. It was corrected to a CC-BY 4.0 license. The section title was also corrected to Research Article.The original online article has been updated to reflect this.</p>","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"75"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145636594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Societal Gender Norms and Their Influence on Late Life Cognition.","authors":"Shana D Stites, Carolyn Kuz, Kimberly Halberstadter, Valerie Humphreys, Katheryn A Q Cousins, Dawn Mechanic-Hamilton","doi":"10.1159/000547115","DOIUrl":"10.1159/000547115","url":null,"abstract":"<p><strong>Introduction: </strong>This study assesses the influence of normative gender effects on cognitive outcomes of cognitively unimpaired older adults. The results help to understand how sex/gender identity operates as a structural determinant of AD outcomes and informs future research that is more inclusive of gender-diverse identities.</p><p><strong>Methods: </strong>We analyze data from 216 adults aged 65 and older who completed survey questions from the Aging Gender Index (AGI), which pertain to often gendered experiences of American men and women, which relate to education, employment experiences, and relationship characteristics. The participants also completed cognitive testing. We conducted bivariate and multivariable analyses, which statistically adjusted for age, education, and race.</p><p><strong>Results: </strong>In multivariable analyses, being full time employed or partially retired rather than full time retired or part time employed is associated with lower memory and learning scores (β = -0.29 95% CI: -0.56 to -0.01). Fewer years out of the workforce to raise children was associated with higher language scores (β = 0.14, 95% CI: 0.03 to 0.25). While not being a veteran versus being a veteran was associated with lower language scores (β = -0.27, 95% CI: -0.51 to -0.02).</p><p><strong>Conclusions: </strong>The results of this study show how workforce and other economic experiences, which tend to vary by gender, may associate with some cognitive outcomes. Research is warranted to replicate the findings and build upon this method of inquiry.</p>","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"15-25"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in Phenomenology of Behavioral and Psychological Symptoms of Dementia.","authors":"Samira Choudhury, Sarah Colman, Li Chu, Simon Jonathan Cheshire Davies, Peter Derkach, Sarah Elmi, Corinne E Fischer, Philip Gerretsen, Ariel Graff-Guerrero, Maria Hussain, Zahinoor Ismail, Shehroz S Khan, Donna Kim, Linda Krisman, Rola Moghabghab, Benoit H Mulsant, Vasavan Nair, Bruce G Pollock, Soham Rej, Aviva Rostas, David Streiner, Lisa Van Bussel, Tarek K Rajji, Sanjeev Kumar, Amer M Burhan","doi":"10.1159/000548713","DOIUrl":"10.1159/000548713","url":null,"abstract":"<p><strong>Introduction: </strong>Behavioral and psychological symptoms in dementia (BPSD) are highly prevalent in patients with Alzheimer's dementia (AD). We examined sex differences in the frequency and severity of BPSD in patients with AD living in long-term care homes or admitted to inpatient psychiatric units.</p><p><strong>Methods: </strong>Data were obtained from the Standardizing Care for Neuropsychiatric Symptoms and Quality of Life in Dementia (StaN) study (ClinicalTrials.gov/NCT03672201). BPSD were assessed using the Neuropsychiatric Inventory-Clinician rating scale (NPI-C), and symptom clusters were clustered as follows: (1) psychosis (hallucinations and delusions), (2) emotional distress cluster A (depression and anxiety), (3) emotional distress cluster B (depression, anxiety, and apathy), and (4) agitation (agitation, aggression, irritability, aberrant motor behavior, and aberrant vocalizations). Sex differences in frequency and severity of individual BPSD and clusters were compared using chi-square and Mann-Whitney U tests and generalized linear models while controlling for age and place of residence.</p><p><strong>Results: </strong>Females had higher frequency (males = 21.7% vs. females = 42.9%, χ2 = 8.83, N = 174, p = 0.003) and greater severity of delusions (mean [SD] males = 51.87 [44.15], mean [SD] females = 67.93 [70.53], U = 2,924, N = 174, p = 0.002). Males had higher frequency (males = 51.8% vs. females = 27.5%, χ2 = 10.80, N = 174, p = 0.001) and greater severity of sleep disorders (mean [SD] males = 2.94 [4.21], mean [SD] females = 1.76 [3.92], U = 2,885.50, N = 174, p = 0.002). After controlling for age and residence, sex differences remained significant for delusions (Wald χ2 = 3.97, N = 176, p = 0.046), but not for sleep disorders. There were no sex differences in the frequency or severity of any BPSD clusters.</p><p><strong>Conclusions: </strong>We observed sex differences in the frequency and severity of specific BPSD. Future studies should aim to understand potential mechanisms underlying these differences and to study their relevance in screening, and for individualized sex-specific management of BPSD.</p>","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"64-74"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Alzheimer's Disease Progression Using a Radiomics Approach: The Hippocampal-Amygdala Border in FDG-Positron Emission Tomography Scans.","authors":"Ramin Rasi, Albert Guvenis","doi":"10.1159/000550231","DOIUrl":"10.1159/000550231","url":null,"abstract":"<p><p><p>Introduction: This study introduces a novel and simple radiomics approach to identify highly sensitive and interpretable imaging biomarkers for tracking Alzheimer's disease (AD) progression using FDG-positron emission tomography (PET) imaging. Our unique focus is on a custom-defined hippocampal-amygdala border region. We hypothesize that this specific small, anatomically and biologically critical, yet underexplored interface region can effectively capture subtle, early stage metabolic deterioration indicative of AD progression.</p><p><strong>Methods: </strong>We leveraged 18F-FDG-PET scans from 513 participants across the AD spectrum (control normal [CN], mild cognitive impairment [MCI], AD) from the Alzheimer's Disease Neuroimaging Initiative database. Building on the established involvement of the hippocampus, amygdala, and entorhinal cortex, we innovatively defined the hippocampal-amygdala connecting region using a distance transform approach to specifically capture the metabolic interplay between these vital structures. A rigorous radiomics pipeline was then applied, involving systematic evaluation of eight feature selection techniques combined with six classification models to identify the most effective predictive framework.</p><p><strong>Results: </strong>Our findings demonstrate the high discriminatory power of the hippocampal-amygdala border region for AD diagnosis and monitoring of disease progression. A concise set of radiomic features derived from this single, novel region of interest (ROI) exhibited high predictive accuracy across various diagnostic distinctions: two features (specifically, shape MeshVolume Right and gldm SmallDependenceLowGrayLevelEmphasis left) distinguished AD from CN with ROC AUC = 0.914; two distinct features predicted MCI from AD with ROC AUC = 0.796; and two other features (shape LeastAxisLength left and glszm LargeAreaEmphasis left) differentiated CN from MCI with ROC AUC = 0.691. Crucially, the mean values of these identified features consistently demonstrated statistically significant incremental deterioration (p < 0.05) across consecutive AD stages (CN to MCI, MCI to AD), underscoring their sensitivity to disease progression.</p><p><strong>Conclusion: </strong>This study establishes the clinical potential of radiomics in providing highly sensitive and interpretable biomarkers for monitoring AD progression, specifically by targeting the novel, biologically informed hippocampal-amygdala border ROI on FDG-PET. By identifying distinct, parsimonious sets of robust radiomic features for different disease stages, our approach offers an efficient, noninvasive, and clinically translatable tool that balances diagnostic power with interpretability, paving the way for its integration into existing clinical workflows for AD. </p>.</p>","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"101-117"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characterization of Probable Dementia with Lewy Bodies Based on the Initial Clinical Presentation in a Latin American Low- and Middle-Income Country.","authors":"Nilton Custodio, Marco Malaga, Diego Bustamante-Paytan, José Huilca-Flores, Katherine Agüero, Graciet Verastegui, Pamela Bartolo, Daniela Bendezu, Zadith Yauri, Rosa Montesinos","doi":"10.1159/000550415","DOIUrl":"10.1159/000550415","url":null,"abstract":"<p><p><p>Introduction: Dementia with Lewy bodies (DLBs) is a distinct form of dementia characterized by the accumulation of alpha-synuclein in the brain. Early presentations are often heterogeneous, and the impact of this variability on disease progression remains poorly understood. This study explored the initial clinical presentation of DLB among Peruvian patients and its influence on the clinical course.</p><p><strong>Methods: </strong>We conducted a retrospective study of patients diagnosed with DLB and Alzheimer's disease (AD) using standard clinical criteria. Cognitive function was assessed using Mini-Mental State Examination (MMSE), INECO Frontal Screening, and Uniform Data Set (UDS). We classified DLB patients based on their initial symptoms (hallucinations or parkinsonism) and compared their clinical and neuropsychological characteristics. Statistical analyses (ANOVA, chi-squared, Wilcoxon tests, and multivariate linear regression) were used to evaluate group differences and examine how initial symptoms influenced disease progression and cognitive decline.</p><p><strong>Results: </strong>Forty-six patients with probable DLB between June 2018 and May 2023 were included. The median time from symptom onset to diagnosis was 5 years. Cognitive symptoms were the most frequent initial presentation, followed by motor and behavioral signs. No significant clinical or neuropsychological differences were found between presentation subgroups at evaluation. Compared to AD patients, those with DLB scored higher on cognitive measures (MMSE, Rowland Universal Dementia Assessment Scale) and behavioral symptoms (Neuropsychiatric Inventory). Neuropsychological testing revealed DLB patients had more pronounced deficits in visuospatial and executive functions than those with AD.</p><p><strong>Conclusion: </strong>In our cohort, patients in the cognitive-onset group reached the threshold for dementia more rapidly. However, the initial presenting symptoms did not result in worse severity across specific cognitive or behavioral domains. </p>.</p>","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"118-130"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12890269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145960084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial Emotion Recognition Deficits and Electroencephalogram Alterations in Mild Behavioral Impairment.","authors":"YongSoo Shim, Eun-Ye Lim","doi":"10.1159/000551440","DOIUrl":"10.1159/000551440","url":null,"abstract":"<p><p><p>Introduction: Mild behavioral impairment (MBI) is a late-life neurobehavioral syndrome associated with increased risk of incident cognitive decline and dementia. Facial emotion recognition (FER), a core component of social cognition, is impaired across neurodegenerative disorders, yet its association with MBI remains underexplored. We examined cognitive/socio-emotional profiles and resting-state electroencephalogram (EEG) in individuals with MBI.</p><p><strong>Methods: </strong>A total of 120 older adults with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) were classified into MBI (n = 57) and non-MBI (n = 63) using the MBI Checklist. Participants underwent comprehensive clinical and neuropsychological evaluation and neuropsychological assessments including Mini-Mental State Examination (MMSE) and the Korean Facial Affect Battery (K-FAB subtests 1-5). Resting-state EEG was analyzed using an automated platform to derive sensor-level spectral power and source-level connectivity measures. Group comparisons used appropriate tests; K-FAB analyses were adjusted for age, education, MMSE, and Geriatric Depression Scale (GDS).</p><p><strong>Results: </strong>The MBI group showed greater functional impairment (higher CDR-SOB, p = 0.019) and higher depressive symptom severity (GDS, p = 0.004), with a trend toward fewer years of education (p = 0.090). Neuropsychological domain scores were broadly comparable, although the MBI group showed a trend toward lower frontal executive composite performance after covariate adjustment (p = 0.076). On K-FAB, the MBI group demonstrated significantly poorer affect selection performance (FAB4; adjusted p = 0.031), with additional trend-level differences in affect naming (FAB3; adjusted p = 0.084) and in negative emotion recognition (fear and sadness). Resting-state EEG findings indicated elevated Beta1-3 and gamma absolute power in the MBI group across multiple scalp regions (p < 0.05), as well as frequency-specific source connectivity differences, including widespread delta band hyperconnectivity, relatively stronger Alpha1 connectivity in the non-MBI group, and increased Beta1 connectivity within fronto-parietal and fronto-temporal circuits in the MBI group.</p><p><strong>Conclusion: </strong>In this clinic-based SCD/MCI cohort, MBI was associated with greater functional impairment and depressive symptom burden, selective FER deficits - particularly in affect selection - and distinct resting-state EEG spectral and connectivity patterns. These findings suggest that socio-emotional measures and EEG markers may provide complementary information for characterizing neurobehavioral alterations associated with MBI, although interpretations should remain cautious given the cross-sectional design and methodological constraints of automated EEG analyses. </p>.</p>","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"157-172"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13193690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147458681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgement to Reviewers.","authors":"","doi":"10.1159/000549123","DOIUrl":"https://doi.org/10.1159/000549123","url":null,"abstract":"","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"1"},"PeriodicalIF":2.6,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145505968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}