Neurodegenerative Diseases最新文献_第2页

Active Immunization Targeting Amyloid β for the Treatment of Alzheimer's Disease. 靶向β淀粉样蛋白的主动免疫治疗阿尔茨海默病。

IF 1.9 4区医学

Neurodegenerative Diseases Pub Date : 2025-05-10 DOI: 10.1159/000546287

Olivia Triplett, Nicole Varda, Boris Decourt, Rodrigo Vasconcellos, Marwan N Sabbagh

{"title":"Active Immunization Targeting Amyloid β for the Treatment of Alzheimer's Disease.","authors":"Olivia Triplett, Nicole Varda, Boris Decourt, Rodrigo Vasconcellos, Marwan N Sabbagh","doi":"10.1159/000546287","DOIUrl":"10.1159/000546287","url":null,"abstract":"Background: Alzheimer's disease (AD) is the most prevalent neurodegenerative condition worldwide. It is characterized by the formation of amyloid beta (Aβ) plaques in the brain and by the accumulation of neurofibrillary tangles; the disease is marked by cognitive decline and memory impairment over time. Although cholinesterase inhibitors and <sc>N</sc>-methyl-<sc>D</sc>-aspartate receptor antagonists have been used to relieve symptoms, immunotherapies to treat the disease itself by targeting removal of amyloid are now beginning to be applied clinically. However, methods that allow the control of AD symptoms and that would require only a few clinical follow-ups are often preferred by patients. Thus, active immunization, or vaccination, against Aβ and tau is still being explored as a possible therapeutic intervention.Summary: This review aims to describe ongoing and discontinued immunization trials to treat AD. We conducted a comprehensive review of the literature to analyze the current status of vaccinations for AD. We examined and summarized the studies and clinical trials that explored the efficacy, safety, and challenges associated with this therapeutic approach.Key messages: This review highlights the potential for vaccination development to treat AD, including its efficacy, associated complications, and limitations. Much progress has been made over the past 2 decades, but challenges remain. Immunization is a promising avenue for treating or preventing symptomatic AD, offering potential benefits beyond symptomatic relief. Because challenges such as immunogenicity and safety profiles need to be addressed, further research and development are necessary to meet the growing demand for patient-acceptable, effective AD treatments.","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"1-16"},"PeriodicalIF":1.9,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluid and Waste Clearance in Central Nervous System Health and Diseases. 液体和废物清除在中枢神经系统的健康和疾病。

IF 1.9 4区医学

Neurodegenerative Diseases Pub Date : 2025-05-07 DOI: 10.1159/000546018

Marie-Renee El Kamouh, Stéphanie Lenck, Stéphane Lehericy, Helene Benveniste, Jean-Léon Thomas

{"title":"Fluid and Waste Clearance in Central Nervous System Health and Diseases.","authors":"Marie-Renee El Kamouh, Stéphanie Lenck, Stéphane Lehericy, Helene Benveniste, Jean-Léon Thomas","doi":"10.1159/000546018","DOIUrl":"10.1159/000546018","url":null,"abstract":"Background: In respect to the circulatory system, the central nervous system (CNS) differs from other organs in the body by three main features. First, the CNS is surrounded by a compartment filled with cerebrospinal fluid (CSF). Second, the CNS is devoid of lymphatic vessels, which are found in the dura mater of the meninges. Third, the CNS blood vasculature serves as a scaffold to perivascular spaces allowing CSF to circulate into the CNS parenchyma via the glymphatic system.Summary: This review highlights the contribution of the glymphatic system and meningeal lymphatic vasculature to CNS homeostasis and also recapitulates the alterations of glymphatic-meningeal lymphatic systems that have been associated to neurological disorders, especially neurodegenerative diseases.Key message: We discuss the controversies and limitations in current research, emphasizing the need for cautious interpretation while highlighting the potential of glymphatic and meningeal lymphatic pathways as therapeutic targets in neurological disorders.","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"1-22"},"PeriodicalIF":1.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Amyloid Monoclonal Antibodies for the Treatment of Alzheimer Disease: Intersocietal Recommendations for Their Appropriate Use in Switzerland. 抗淀粉样蛋白单克隆抗体治疗阿尔茨海默病：其在瑞士适当使用的社会间建议。

IF 1.9 4区医学

Neurodegenerative Diseases Pub Date : 2025-04-14 DOI: 10.1159/000545799

Ansgar Felbecker, Olivier Rouaud, Aurelien Lathuiliere, Gilles Allali, Marc Sollberger, Tatjana Meyer-Heim, Andreas U Monsch, Karl-Olof Lövblad, Stefanie Becker, Nadège Barro-Belaygues, Julius Popp, Markus Bürge, Kathrin Lindheimer, Anton Gietl, Hans H Jung, Dan Georgescu, Rafael Meyer, Giovanni B Frisoni

引用次数: 0

Anti-Amyloid Treatments: A Therapeutic Revolution, Ready for Europe. 抗淀粉样蛋白疗法，一场治疗革命，准备在欧洲推出。

IF 1.9 4区医学

Neurodegenerative Diseases Pub Date : 2025-04-14 DOI: 10.1159/000545800

Paolo Salvioni Chiabotti, Giulia Bommarito, Patrik Michel, Beatrice Pizzarotti, Fabrizio Piazza, Federica Agosta, Ralf J Jox, Simon Wieser, Philippe Ryvlin, Giovanni B Frisoni, Bruno Dubois, Olivier Rouaud, Gilles Allali

引用次数: 0

Sex Differences for Social Determinants Associated with Lewy Body Dementia Onset and Diagnosis. 路易体痴呆发病和诊断相关社会决定因素的性别差异。

IF 1.9 4区医学

Neurodegenerative Diseases Pub Date : 2025-01-01 Epub Date: 2025-02-18 DOI: 10.1159/000544772

Ece Bayram, Kathryn A Wyman-Chick, Reilly Costello, Hamidreza Ghodsi, Charlotte S Rivera, Lisa Solomon, Joseph P M Kane, Irene Litvan

{"title":"Sex Differences for Social Determinants Associated with Lewy Body Dementia Onset and Diagnosis.","authors":"Ece Bayram, Kathryn A Wyman-Chick, Reilly Costello, Hamidreza Ghodsi, Charlotte S Rivera, Lisa Solomon, Joseph P M Kane, Irene Litvan","doi":"10.1159/000544772","DOIUrl":"10.1159/000544772","url":null,"abstract":"Introduction: Multiple studies report sex and gender differences in Lewy body dementia (LBD); however, there is a paucity of research investigating social determinants associated with LBD.Methods: Participants with LBD (51 females, 79 males) and controls with similar age (64 females, 60 males) completed remote surveys assessing various social and demographic variables, and age at LBD onset for LBD group. Sex-stratified comparisons for LBD and control groups, and comparisons of females and males with LBD were done for social determinants. Sex differences for onset age were further analyzed with linear models adjusting for significantly differing social variables between the sexes.Results: LBD group had lower years of education, income, subjective social status than controls, with larger differences for males than females (p < 0.05 for all). Higher percentage of females with LBD was living alone (p = 0.016) and not married/partnered (p = 0.002) compared to males with LBD. Adjusting for social variables that differed between the sexes, females were younger at cognitive impairment onset (p = 0.037) and diagnosis (p = 0.032). For the overall cohort, being ethnoracial minoritized, sexual and gender minoritized, and having lower education quality were associated with younger age at symptom onset (p < 0.049 for all). For females, lower childhood subjective social status (p = 0.037), and for males, being ethnoracial minoritized (p < 0.001) and lower years of education (p = 0.031) were associated with younger age at diagnosis.Conclusion: Social determinants, even during childhood, can impact the LBD onset differently for females and males. Interactions between biological and social factors need to be investigated further with inclusive and diverse cohorts in LBD.","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"1-13"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum. 勘误表。

IF 1.9 4区医学

Neurodegenerative Diseases Pub Date : 2025-01-01 Epub Date: 2025-05-12 DOI: 10.1159/000545725

引用次数: 0

Anti-Amyloid Drugs for Alzheimer's Disease: Considering the Role of Depression. 抗淀粉样蛋白药物治疗阿尔茨海默病：考虑抑郁症的作用。

IF 1.9 4区医学

Neurodegenerative Diseases Pub Date : 2025-01-01 Epub Date: 2024-12-06 DOI: 10.1159/000541783

Beatriz Pozuelo Moyano, Leonardo Zullo, Olivier Rouaud, Pierre Vandel, Armin von Gunten, Gilles Allali

引用次数: 0

Locus Coeruleus Sexual Dimorphism and Its Impact on Cognitive Impairment and Cortical Atrophy in Alzheimer's Disease. 蓝斑性别二态性及其对阿尔茨海默病认知障碍和皮质萎缩的影响。

IF 1.9 4区医学

Neurodegenerative Diseases Pub Date : 2025-01-01 Epub Date: 2025-03-03 DOI: 10.1159/000544882

Alessandro Galgani, Francesco Lombardo, Francesca Frijia, Marco Scotto, Gloria Tognoni, Nicola Pavese, Filippo Sean Giorgi

{"title":"Locus Coeruleus Sexual Dimorphism and Its Impact on Cognitive Impairment and Cortical Atrophy in Alzheimer's Disease.","authors":"Alessandro Galgani, Francesco Lombardo, Francesca Frijia, Marco Scotto, Gloria Tognoni, Nicola Pavese, Filippo Sean Giorgi","doi":"10.1159/000544882","DOIUrl":"10.1159/000544882","url":null,"abstract":"Introduction: Experimental data suggest sexual dimorphism in the Locus Coeruleus (LC), with females exhibiting higher neuronal count and noradrenergic activity. In Alzheimer's disease (AD), progressive LC dysfunction may contribute early to pathogenesis, and female sex is a key risk factor for AD. This study aimed to investigate if such sex differences exist in humans and whether they influence the relationship between LC degeneration and AD features, such as cortical atrophy and cognitive decline.Methods: Fifty-three healthy controls (HCs), 70 mild cognitive impaired (MCI) participants, and 29 Alzheimer's disease demented (ADD) patients underwent high-field brain MRI with LC-sensitive sequences following detailed neuropsychological and neurological assessments. LC integrity was measured using the LC contrast ratio (LCCR) parameter based on a previously published template approach.Results: Within the HC and MCI groups, females showed higher LCCR values than males. A significant sex effect was observed in the relationship between LC integrity and cortical volume in the frontotemporal cortices, with males showing a stronger association.Conclusion: LC structure and function may differ between sexes, influencing AD pathophysiology through distinct mechanisms. While this sexual dimorphism may have a minor role, it should be considered in clinical investigations and drug development research.","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"53-66"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Differences in Progression of Neurodegeneration: The Age, Gene/Environment Susceptibility-Reykjavik Study. 神经变性进展的性别差异：AGES-Reykjavik研究。

IF 1.9 4区医学

Neurodegenerative Diseases Pub Date : 2025-01-01 Epub Date: 2025-03-13 DOI: 10.1159/000545184

Emma L Twait, Vilmundur Gudnason, Lenore J Launer, Lotte Gerritsen, Mirjam I Geerlings

{"title":"Sex Differences in Progression of Neurodegeneration: The Age, Gene/Environment Susceptibility-Reykjavik Study.","authors":"Emma L Twait, Vilmundur Gudnason, Lenore J Launer, Lotte Gerritsen, Mirjam I Geerlings","doi":"10.1159/000545184","DOIUrl":"10.1159/000545184","url":null,"abstract":"Introduction: Advancing age is associated with global brain atrophy. Cross-sectional studies have found sex differences in neuroanatomy; however, longitudinal studies assessing sex differences in neurodegeneration are currently scarce. The effects of age and sex on brain atrophy may not be uniform across the whole brain and may partially explain the sex differences observed in dementia. The current study aimed to examine sex differences in longitudinal atrophy patterns in gray and white matter regions in older adults.Methods: The study sample included 1,480 individuals from the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, a population-based cohort study, that underwent two magnetic resonance imaging scans within an average of 5 years between assessments. Individuals were also followed-up for incident dementia diagnosis. Linear regression models were used to assess sex differences between mean differences in gray and white matter regions, correcting for age, education, baseline intracranial volume, baseline regional volumes, hypertension, body mass index, and apolipoprotein (APOE) e4 allele status.Results: Men showed increased longitudinal atrophy in the total gray matter, as well as in the parietal cortex, cingulate cortex, caudate nucleus, brainstem, left cerebellum, precentral gyrus, putamen, globus pallidus, and orbitofrontal cortex. Whereas women exhibited greater atrophy over time in total white matter, but not in specific regions. No moderation was found between sex differences in incident dementia regarding atrophy patterns.Conclusions: While men show larger gray matter volumes cross-sectionally, their rates of atrophy over time are steeper compared to women. Sex differences in brain atrophy seem to be specifically detrimental in men in regions related to executive functioning, motor control, and emotion processing.","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"67-75"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alzheimer's Disease, β-Amyloid Peptides, and Ubiquitin-Proteasome System: Nutritherapeutic Insights. 阿尔茨海默病，β-淀粉样肽和泛素-蛋白酶体系统：营养治疗的见解。

IF 1.9 4区医学

Neurodegenerative Diseases Pub Date : 2025-01-01 Epub Date: 2025-03-25 DOI: 10.1159/000545170

Philippe Yves Rémy Simon, Renaud David

{"title":"Alzheimer's Disease, β-Amyloid Peptides, and Ubiquitin-Proteasome System: Nutritherapeutic Insights.","authors":"Philippe Yves Rémy Simon, Renaud David","doi":"10.1159/000545170","DOIUrl":"10.1159/000545170","url":null,"abstract":"Background: Alzheimer's disease - an age-related neurodegenerative disorder leading to progressive cognitive impairment - is characterized by an intracerebral accumulation of soluble β-amyloid (Aβ) oligomers, followed by the appearance of abnormally ubiquitinylated neurofibrillary tangles - a process associated with a chronic inflammation. The systematic presence of ubiquitinylated inclusions reflects a decrease in the proteasome activity due to (and contributing to) the presence of Aβ oligomers - a central dysfunction in the etiology of the disease.Summary: The involvement of the ubiquitin-proteasome system opens new therapeutic perspectives for both prevention and treatment. In particular, the potential for synergistic strategies combining diet-derived proteasome activators, immunoproteasome inhibitors, and modulators of Aβ peptide aggregation to prevent, delay or even reverse disease progression over time is currently arousing growing interest.Key messages: From that perspective, and in light of the recent advances in the understanding of the key molecular and cellular mechanisms underlying Alzheimer's disease pathogenesis, the present review highlights the mechanisms of action and the preventive and therapeutic potential of some diet-derived bioactive compounds and other natural substances of interest. This article is a translated, updated, and expanded version of an article originally published in French in Médecine/Sciences, August/September 2023 (<ext-link ext-link-type=\"doi\" xlink:href=\"https://doi.org/10.1051/medsci/2023094\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">https://doi.org/10.1051/medsci/2023094</ext-link>).","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"76-87"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0