Neurodegenerative Diseases最新文献

{"title":"Hearing Loss as a Potentially Modifiable Marker of Dementia Risk: Neurological Evidence, Uncertainty, and Clinical Interpretation.","authors":"Verónica Fuentes-Santamaría, Carmen María Díaz García, Juan Carlos Alvarado","doi":"10.1159/000553216","DOIUrl":"10.1159/000553216","url":null,"abstract":"<p><strong>Background: </strong>Hearing impairment has emerged as a consistently associated and potentially modifiable risk factor for cognitive decline and dementia, including Alzheimer's disease (AD). Epidemiological studies demonstrate an increased dementia risk among individuals with hearing loss, with evidence of dose-response relationships across levels of auditory decline. Despite the robustness of this association, the mechanisms linking auditory dysfunction to cognitive deterioration remain multifactorial and incompletely understood.</p><p><strong>Summary: </strong>By integrating biological, cognitive, and psychosocial perspectives while explicitly addressing persistent uncertainties, this critical narrative review provides a balanced framework for interpreting the relationship between hearing impairment and AD. Current evidence points to several interacting pathways, including sensory deprivation, cortical reorganization, increased cognitive load, and psychosocial consequences like social isolation. Furthermore, emerging research suggests that central auditory processing deficits may represent early functional markers of cortical vulnerability associated with neurodegeneration. Clinically, these insights emphasize the importance of routine hearing assessment in older adults, while observational evidence indicates that hearing rehabilitation, particularly hearing aid use, may be associated with more favorable cognitive outcomes.</p><p><strong>Key messages: </strong>Association vs. causation: hearing loss should be regarded as a robustly associated and potentially modifiable marker of dementia risk rather than a confirmed causal determinant. Neurological implication: from a neurological standpoint, central auditory dysfunction may reflect underlying brain vulnerability in aging rather than acting as a direct causal driver of AD. Clinical outlook: while causal effects of hearing rehabilitation have yet to be firmly established, prioritizing hearing health offers a promising and practical avenue for dementia prevention and clinical practice.</p>","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"1-14"},"PeriodicalIF":4.0,"publicationDate":"2026-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148295855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Incident Dementia in a Cohort of Elders with Essential Tremor: A Prospective, Longitudinal Study.","authors":"Diane S Berry, Stephanie Cosentino, Elan D Louis","doi":"10.1159/000552903","DOIUrl":"10.1159/000552903","url":null,"abstract":"<p><strong>Introduction: </strong>Elders with essential tremor (ET) are at a heightened risk for incident dementia. Although the consequences of this diagnosis are formidable, we know little about what factors elevate the risk of ET-dementia. We analyzed data from a large, prospective, longitudinal study of cognitive status in an ET cohort to examine whether a range of demographic, lifestyle, and clinical variables contribute to dementia risk.</p><p><strong>Methods: </strong>The cognitive status (normal cognition [NC], mild cognitive impairment [MCI], or dementia) of a baseline sample of 350 ET cases (M age = 79.5 years) was tracked for up to 7.5 years (M follow-up = 4.7 years). Cox proportional hazards regressions identified baseline characteristics that predicted the development of dementia.</p><p><strong>Results: </strong>Older age and greater cognitive impairment at baseline (MCI versus NC) each predicted incident dementia, HR > 1.10, p < 0.0001. Diminished functional abilities (HR = 0.39), greater gait impairment (HR = 1.30), lower confidence in one's balance skills (HR = 0.98), and more depressive symptoms at baseline (HR = 1.08) further predicted conversion to dementia, all p < 0.006. Neither continuous nor categorical measures of ET onset age predicted incident ET-dementia.</p><p><strong>Conclusions: </strong>These data represent the most comprehensive assessment to date of risk factors for ET-dementia in terms of number of factors studied and cohort size. At least one of these risk factors - depression - is modifiable and may offer intervention points to reduce risk of dementia. Older age of ET onset, previously viewed as a risk factor, did not predict incident ET-dementia.</p>","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"1-15"},"PeriodicalIF":4.0,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13329797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148205693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Leak: Advanced MRI Assessment of the Blood-Brain Barrier in Neurodegeneration.","authors":"Daniele Botta, Caterina Bernetti, Ioana Hutuca, Jose Federico Ojeda Esparza, Lukas Sveikata, Karl Olof Lovblad, Felix T Kurz","doi":"10.1159/000552173","DOIUrl":"10.1159/000552173","url":null,"abstract":"<p><p><p>Background: The blood-brain barrier (BBB) is a specialized multicellular interface that maintains the central nervous system's tightly regulated microenvironment. BBB disruption is increasingly recognized as a key feature of neurodegeneration, documented across disorders including Alzheimer's disease (AD), Parkinson's disease (PD), and cerebral small vessel disease (cSVD). While the extent to which BBB breakdown is a cause or consequence of neuronal pathology remains unclear, its pronounced presence in disease states suggests a significant contributory role in progression. Summary: This review provides a neuroradiological overview of advanced MRI approaches for assessing BBB integrity in neurodegenerative diseases. The primary quantitative biomarkers discussed are the volume transfer constant (Ktrans) derived from dynamic contrast-enhanced MRI (DCE), reflecting paracellular gadolinium leakage, and the water exchange rate (k_w) from arterial spin labeling (ASL), capturing trans-endothelial water permeability. Disease-specific BBB signatures across AD, PD, and cSVD are systematically described, alongside complementary indirect markers including diffusion MRI, dynamic susceptibility contrast, and vessel architecture imaging. Current technological advances, including ultra-high-field MRI and AI-assisted post-processing, are discussed in relation to their potential to enhance detection sensitivity. With continued technical refinement and standardization, MRI-based BBB metrics are transitioning from research tools into candidate neurovascular biomarkers with growing potential for early diagnosis, treatment monitoring, and longitudinal follow-up. Key Messages: MRI-based BBB imaging represents an emerging neurovascular biomarker under active investigation for future diagnostic and therapeutic applications. DCE and ASL provide complementary BBB metrics (Ktrans, k_w), illuminating distinct and complementary facets of barrier dysfunction. BBB disruption is a key and early feature across AD, PD, and cSVD, with disease-specific regional patterns that may guide patient stratification and therapeutic monitoring. Ultra-high-field MRI and AI-assisted post-processing are advancing BBB imaging sensitivity; however, multicenter standardization and normative validation remain critical prerequisites for clinical translation. </p>.</p>","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"197-212"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13299135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Anti-Amyloid Antibodies Modulate Brain Function in Alzheimer's Disease?","authors":"Lorenzo Pini, Manuela Allegra, Bruno P Imbimbo","doi":"10.1159/000549946","DOIUrl":"10.1159/000549946","url":null,"abstract":"","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"150-155"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12810958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145752088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Utility of Speech and Language Analytics for Screening Alzheimer's Disease.","authors":"Alveena Siddiqui, Thayabaran Kathiresan, Mark Opler, Alex Cohen, Jessica Alber, Peter J Snyder, Adam P Vogel","doi":"10.1159/000552094","DOIUrl":"10.1159/000552094","url":null,"abstract":"<p><p><p>Background: Effective screening and cohort enrichment remain major challenges in clinical trials for Alzheimer's disease (AD), where traditional diagnostic pathways rely on costly, invasive, and time-consuming procedures. Speech and language analysis has emerged as a scalable, low-burden approach for detecting subtle cognitive-linguistic and motor-speech changes that may appear early in the disease course. Summary: This review synthesizes current evidence on acoustic, prosodic, lexical, semantic, and syntactic speech features associated with AD and mild cognitive impairment (MCI) and evaluates their reported utility across a range of elicitation tasks including picture description, verbal fluency, narrative recall, spontaneous speech, and reading. Across studies, machine-learning models trained on speech and language features have reported consistent performance, although results vary substantially depending on task design, feature sets, and cohort characteristics. Task-dependent variability is evident, with picture description and verbal fluency tasks capturing lexical-semantic and timing markers, while narrative and spontaneous speech tasks capture impairments in coherence, information content, and prosody. Hybrid approaches integrating hand-crafted and machine-extracted features have also been explored to improve interpretability and model performance. Speech and language analytics may support digital prescreening, cohort enrichment, and quality-assurance monitoring within clinical trials; however, their application depends on methodological considerations and validation across diverse settings. Key Messages: Despite encouraging findings, several methodological challenges persist, including interindividual variability, limited dataset sizes, differences in recording conditions, and limitations in automatic speech recognition performance in cognitively impaired populations. Continued development of standardized protocols, disorder-adapted speech models, and multimodal analytic pipelines is needed to support clinical translation. Collectively, current evidence suggests that speech and language features represent candidate digital markers that may improve screening efficiency and support clinical trial enrichment in AD, although further validation is required to establish their reliability and generalizability. </p>.</p>","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"184-196"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13299133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Impairment Is Associated with Disrupted Motor Planning in Older Adults.","authors":"Gabriel Poirier, Charalambos Papaxanthis, Lucie Lordon, Yannick Béjot, Patrick Manckoundia, France Mourey, Jeremie Gaveau","doi":"10.1159/000552691","DOIUrl":"10.1159/000552691","url":null,"abstract":"<p><p><p>Introduction: Neurocognitive disorders (NCD) are frequently accompanied by motor impairments that may precede overt cognitive decline. However, most motor markers remain coarse and do not disentangle global motor deterioration from disruptions of specific motor control processes. Motor planning, a process relying on both motor and cognitive resources, may be particularly vulnerable to cognitive impairment yet has rarely been investigated using process-specific motor control frameworks.</p><p><strong>Methods: </strong>We assessed motor planning abilities in 57 older adults, including cognitively impaired (CI; n = 27) and healthy adult (HA; n = 30) participants. Using a gravity-related motor planning paradigm, participants performed vertical arm movements requiring different interactions with gravitational torque. Directional asymmetries in movement kinematics were used as a process-specific proxy of motor planning. Movement smoothness was quantified using jerk-based measures as a complementary index of global motor execution. Movement duration was carefully controlled across groups and directions, and age effects were accounted for in the analyses.</p><p><strong>Results: </strong>Movement duration did not differ between groups. Compared with HA participants, the CI group exhibited reduced directional asymmetries, indicating altered motor planning. Within the CI group, the magnitude of directional asymmetries was positively correlated with cognitive status, as assessed by the Mini-Mental State Examination. In contrast, although movement smoothness was globally reduced in CI participants, jerk-based measures were not associated with cognitive status after controlling for age and movement duration.</p><p><strong>Conclusion: </strong>These findings suggest that cognitive impairment in older adults is specifically associated with a disruption of motor planning processes rather than a uniform degradation of motor execution. By dissociating global motor deterioration from planning-related decompensation, this study highlights the value of process-specific motor control measures for understanding sensorimotor alterations in NCD and their potential relevance for early detection. </p>.</p>","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"173-183"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13363112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147988425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Many Steps to Reach Steady State of Postural Stability, Progression Velocity, and Step Length during Gait Initiation? Effects of Ageing and Parkinson's Disease.","authors":"Arnaud Simonet, Arnaud Delafontaine, Paul Fourcade, Eric Yiou","doi":"10.1159/000547017","DOIUrl":"10.1159/000547017","url":null,"abstract":"<p><strong>Introduction: </strong>This study examined how many steps are required to reach a steady state of postural stability, progression velocity, and step length during gait initiation in healthy young adults, healthy elderly adults, and patients with Parkinson's disease (PD).</p><p><strong>Methods: </strong>Healthy young adults (n = 10), healthy elderly adults (n = 11), and PD patients (n = 12) had to initiate gait and walk straight at spontaneous and maximal velocity to the end of an 11-m long room. Mean values and variability of biomechanical indicators of postural stability (\"margin of stability\" [MoS], \"braking index\" [BI]), progression velocity (peak anteroposterior centre-of-mass velocity), and step length were computed along five successive steps using a markerless motion capture system.</p><p><strong>Results: </strong>The results showed that the number of steps required to reach steady state walking depended on the experimental variable. For the progression velocity, the step length and the BI, two steps were required. For the MoS, one step was required. PD patients and healthy participants used different strategies to reach steady state of BI, which may expose the former to a high risk of instability in the first step. Interestingly, mean BI and variability of PD patients returned to normal following this first step.</p><p><strong>Conclusion: </strong>These findings suggest that rehabilitation programs aiming to improve walking in PD patients at an early stage of the disease (stage 2 on the Hoen and Year scale) may specifically target the first step.</p>","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"1-14"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailored Dementia Care across Seven Swiss Memory Clinics: The CareMENS Model Improves Patients' Mood and Quality of Life.","authors":"Benedetta Leidi-Maimone, Sophie Bugnon, Mélanie Bieler-Aeschlimann, Margaux Fumasoli, Alessa Hausmann, Delphine Frochaux, Mélanie Genetti Gatfield, Alexia Deslex-Maspero, Léa Massy, Marie-Louise Montandon, Gabriella Schuler-Gyürüsi, Beatriz Pozuelo Moyano, Estelle Fetida, Julien Sauser, Daniel Damian, Jean-François Démonet, Olivier Rouaud, Gilles Allali, Andrea Brioschi Guevara","doi":"10.1159/000547932","DOIUrl":"10.1159/000547932","url":null,"abstract":"<p><strong>Introduction: </strong>Dementia is a growing global health concern, requiring a comprehensive approach to care. The CareMENS model is a non-pharmacological intervention designed to ensure continuity of care for individuals at the early stages of cognitive decline (CDR ≤1) or those with subjective cognitive complaints. It combines tailored neuropsychological, speech and language, and physical therapies with community-based leisure activities to sustain cognitive and physical function, promote social engagement and enhance overall patient well-being. A care manager - a new role introduced within Swiss memory clinics implementing the model - provides personalized and ongoing support.</p><p><strong>Methods: </strong>This observational study was conducted across seven memory clinics in Western Switzerland between September 2020 and January 2024. It evaluated the acceptability and impact of the CareMENS model of care through the following outcomes: anxiety and depression symptoms (HADS), functional autonomy (DAD-6), global cognition (MoCA), and quality of life (WHOQOL). Pre-post analyses were performed in 184 patients (median age: 74 years old; 53.3% women) assessed at baseline (T0) and, on average, 324.2 days later (T1). Changes over time were evaluated using a linear mixed-effects model. A retrospective standard care group (N = 165) of patients aged ≥50 years (median age: 74 years old; 53.9% women) and with a dementia severity score (CDR) ≤1 was included for comparison of HADS, DAD-6, and MoCA outcomes.</p><p><strong>Results: </strong>The CareMENS model was successfully implemented into routine clinical practices of the participating memory clinics. Compared to standard care, the CareMENS intervention was associated with greater improvements in HADS-depression overall scores (-0.853, 95% CI = -1.441 to -0.265; p = 0.005) and in HADS-anxiety scores among patients with high baseline anxiety (-1.134, 95% CI = -2.134 to -0.133; p = 0.027). No significant between-groups differences were found in MoCA (0.361, 95% CI = -0.32 to 1.04; p = 0.299) and DAD-6 scores (0.892, 95% CI = -3.5 to 5.28; p = 0.69). Following the intervention, we observed positive within-group changes in the WHOQOL mean total score (+2.67, 95% CI = 1.31 to 4.02; p < 0.001) and particularly in the social participation subdomain (+6.1, 95% CI = 3.82 to 8.32; p < 0.001).</p><p><strong>Discussion: </strong>These findings indicate that the CareMENS model of care can be effectively implemented into clinical settings. It showed a significant reduction in mood symptoms and suggested positive benefits for quality of life. Integrating care management models into memory clinics may enhance patient outcomes and represents a promising direction for the evolution of current memory clinic practice.</p>","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"48-63"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Radiomics-Based Analysis of Functional Dopaminergic Scintigraphic Imaging for the Diagnosis of Dementia with Lewy Bodies.","authors":"Jérémy Perriraz, Daniel Abler, Paolo Salvioni Chiabotti, Caroline Hall, Noemie Lejay, George K Kurian, Thomas Vetterli, Olivier Rouaud, Marie Nicod Lalonde, Niklaus Schaefer, Gilles Allali, Adrien Depeursinge, John O Prior, Mario Jreige","doi":"10.1159/000547261","DOIUrl":"10.1159/000547261","url":null,"abstract":"<p><strong>Introduction: </strong>Radiomics features, a technique based on quantitative image analysis, can be used to capture tissue and lesion characteristics, such as heterogeneity and shape. Using functional dopaminergic scintigraphy, we aimed to study the value of radiomics features in predicting the diagnosis of dementia with Lewy bodies (DLB).</p><p><strong>Materials and methods: </strong>We retrospectively analyzed 74 patients (29 F and 45 M, mean age 71.6 ± 9.2) investigated in the Leenaards Memory Center (Lausanne University Hospital) for DLB who underwent quantitative I-123-ioflupane single positron emission computed tomography (SPECT)/CT (DaTscan). All scanned examinations had xSPECT reconstruction, allowing standard uptake value (SUV) quantification. We segmented the right and left striatum using a 3D Slicer and performed radiomics feature extraction and analysis using the QuantImage v2 platform. The dataset was divided into training (80%) and test (20%) sets, and various classification algorithms were used to predict the definitive clinical diagnosis of DLB using xSPECT and/or clinical features. Receiver operating characteristic (ROC) curve analysis was performed to characterize the performance of the obtained models.</p><p><strong>Results: </strong>Thirty-three of 74 patients (45%) were diagnosed with DLB. The xSPECT radiomics models showing the highest diagnostic performance were developed based on nine non-correlated features from both striatal regions and a support vector classifier (SVC) algorithm. The xSPECT radiomics models demonstrated superior performance compared to models based on SUV intensity features alone (p = 0.001) or clinical features alone (p = 0.001), with area under the ROC curve (AUC) values of 0.932 (0.920-0.944), 0.856 (0.840-0.875), and 0.793 (0.770-0.815), respectively. The combined model, incorporating both clinical and xSPECT features, achieved the highest overall performance with a sensitivity of 100% (95% confidence interval: 100-100), specificity of 89.7% (87.6-91.4), and an AUC of 0.956 (0.945-0.964).</p><p><strong>Conclusion: </strong>The radiomics model based on quantitative I-123-ioflupane xSPECT/CT showed high diagnostic accuracy in predicting the diagnosis of DLB using diverse features derived from striatal analysis. This tool may improve the diagnostic accuracy of I-123-ioflupane, which is of major importance for DLB diagnosis.</p>","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"38-47"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Foam Rolling after Task-Oriented Circuit Training on Gait, Balance, and Range of Motion in Parkinson's Disease: A Randomised Controlled Trial.","authors":"Kutay Kaşlı, Mert Doğan, Cemil Özal, Yahya Doğan, Muhammed Kılınç, Sibel Aksu Yıldırım","doi":"10.1159/000550230","DOIUrl":"10.1159/000550230","url":null,"abstract":"<p><p><p>Introduction: Task-oriented circuit training (TOCT) is known to improve balance and gait in people with Parkinson's disease. This study aimed to examine whether post-TOCT myofascial release with foam roller (FR) could extend this effect by improving gait parameters, balance performance, and joint range of motion (ROM) in Parkinson's disease (PD).</p><p><strong>Methods: </strong>The study was conducted in the neurological rehabilitation unit and involved 36 participants with PD who were randomised into an intervention group (IG, n = 18) and a sham group (SG, n = 18). Both groups received TOCT for 3 days and 8 weeks. After exercise, myofascial release was applied to the neck, trunk, and lumbar region using three sets of 60-s FR in both groups. Participants' spatiotemporal gait parameters, balance, cervical, trunk, and ankle dorsiflexion ROM, motor symptoms, stability limits, functional mobility, quality of life, and goal attainment level were assessed before and after the procedure.</p><p><strong>Results: </strong>Compared with the SG, gait speed, balance, stability limits, dynamic sitting balance, and trunk control improved in the IG; neck, trunk, and ankle ROM increased; and motor symptom severity decreased (p < 0.05). There was no statistically significant difference in quality of life and goal attainment scores between groups (p > 0.05).</p><p><strong>Conclusion: </strong>FR is an effective method of supporting TOCT to improve gait speed, balance, and ROM in PD. Our findings support the inclusion of myofascial release in PD rehabilitation programmes.</p><p><strong>Clinical trial number: </strong>NCT05900934 (<ext-link ext-link-type=\"uri\" xlink:href=\"http://ClinicalTrials.gov\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">ClinicalTrials.gov</ext-link>). </p>.</p>","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"89-100"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12880828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}