Neurodegenerative Diseases最新文献_第4页

Abstracts: 31st Edition Société Francophone Posture Équilibre et Locomotion (SOFPEL), Bordeaux, France, December 4-5, 2025. 摘要：第31届societansuise Francophone Posture Équilibre et Locomotion (SOFPEL)，法国波尔多，2025年12月4-5日。

IF 4 4区医学

Neurodegenerative Diseases Pub Date : 2025-01-01 Epub Date: 2025-12-03 DOI: 10.1159/000549168

引用次数: 0

Sex Differences for Social Determinants Associated with Lewy Body Dementia Onset and Diagnosis. 路易体痴呆发病和诊断相关社会决定因素的性别差异。

IF 2.6 4区医学

Neurodegenerative Diseases Pub Date : 2025-01-01 Epub Date: 2025-02-18 DOI: 10.1159/000544772

Ece Bayram, Kathryn A Wyman-Chick, Reilly Costello, Hamidreza Ghodsi, Charlotte S Rivera, Lisa Solomon, Joseph P M Kane, Irene Litvan

{"title":"Sex Differences for Social Determinants Associated with Lewy Body Dementia Onset and Diagnosis.","authors":"Ece Bayram, Kathryn A Wyman-Chick, Reilly Costello, Hamidreza Ghodsi, Charlotte S Rivera, Lisa Solomon, Joseph P M Kane, Irene Litvan","doi":"10.1159/000544772","DOIUrl":"10.1159/000544772","url":null,"abstract":"Introduction: Multiple studies report sex and gender differences in Lewy body dementia (LBD); however, there is a paucity of research investigating social determinants associated with LBD.Methods: Participants with LBD (51 females, 79 males) and controls with similar age (64 females, 60 males) completed remote surveys assessing various social and demographic variables, and age at LBD onset for LBD group. Sex-stratified comparisons for LBD and control groups, and comparisons of females and males with LBD were done for social determinants. Sex differences for onset age were further analyzed with linear models adjusting for significantly differing social variables between the sexes.Results: LBD group had lower years of education, income, subjective social status than controls, with larger differences for males than females (p < 0.05 for all). Higher percentage of females with LBD was living alone (p = 0.016) and not married/partnered (p = 0.002) compared to males with LBD. Adjusting for social variables that differed between the sexes, females were younger at cognitive impairment onset (p = 0.037) and diagnosis (p = 0.032). For the overall cohort, being ethnoracial minoritized, sexual and gender minoritized, and having lower education quality were associated with younger age at symptom onset (p < 0.049 for all). For females, lower childhood subjective social status (p = 0.037), and for males, being ethnoracial minoritized (p < 0.001) and lower years of education (p = 0.031) were associated with younger age at diagnosis.Conclusion: Social determinants, even during childhood, can impact the LBD onset differently for females and males. Interactions between biological and social factors need to be investigated further with inclusive and diverse cohorts in LBD.","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"1-13"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum. 勘误表。

IF 2.6 4区医学

Neurodegenerative Diseases Pub Date : 2025-01-01 Epub Date: 2025-05-12 DOI: 10.1159/000545725

引用次数: 0

Anti-Amyloid Drugs for Alzheimer's Disease: Considering the Role of Depression. 抗淀粉样蛋白药物治疗阿尔茨海默病：考虑抑郁症的作用。

IF 1.9 4区医学

Neurodegenerative Diseases Pub Date : 2025-01-01 Epub Date: 2024-12-06 DOI: 10.1159/000541783

Beatriz Pozuelo Moyano, Leonardo Zullo, Olivier Rouaud, Pierre Vandel, Armin von Gunten, Gilles Allali

引用次数: 0

Locus Coeruleus Sexual Dimorphism and Its Impact on Cognitive Impairment and Cortical Atrophy in Alzheimer's Disease. 蓝斑性别二态性及其对阿尔茨海默病认知障碍和皮质萎缩的影响。

IF 2.6 4区医学

Neurodegenerative Diseases Pub Date : 2025-01-01 Epub Date: 2025-03-03 DOI: 10.1159/000544882

Alessandro Galgani, Francesco Lombardo, Francesca Frijia, Marco Scotto, Gloria Tognoni, Nicola Pavese, Filippo Sean Giorgi

{"title":"Locus Coeruleus Sexual Dimorphism and Its Impact on Cognitive Impairment and Cortical Atrophy in Alzheimer's Disease.","authors":"Alessandro Galgani, Francesco Lombardo, Francesca Frijia, Marco Scotto, Gloria Tognoni, Nicola Pavese, Filippo Sean Giorgi","doi":"10.1159/000544882","DOIUrl":"10.1159/000544882","url":null,"abstract":"Introduction: Experimental data suggest sexual dimorphism in the Locus Coeruleus (LC), with females exhibiting higher neuronal count and noradrenergic activity. In Alzheimer's disease (AD), progressive LC dysfunction may contribute early to pathogenesis, and female sex is a key risk factor for AD. This study aimed to investigate if such sex differences exist in humans and whether they influence the relationship between LC degeneration and AD features, such as cortical atrophy and cognitive decline.Methods: Fifty-three healthy controls (HCs), 70 mild cognitive impaired (MCI) participants, and 29 Alzheimer's disease demented (ADD) patients underwent high-field brain MRI with LC-sensitive sequences following detailed neuropsychological and neurological assessments. LC integrity was measured using the LC contrast ratio (LCCR) parameter based on a previously published template approach.Results: Within the HC and MCI groups, females showed higher LCCR values than males. A significant sex effect was observed in the relationship between LC integrity and cortical volume in the frontotemporal cortices, with males showing a stronger association.Conclusion: LC structure and function may differ between sexes, influencing AD pathophysiology through distinct mechanisms. While this sexual dimorphism may have a minor role, it should be considered in clinical investigations and drug development research.","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"53-66"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Amyloid Monoclonal Antibodies for the Treatment of Alzheimer Disease: Intersocietal Recommendations for Their Appropriate Use in Switzerland. 抗淀粉样蛋白单克隆抗体治疗阿尔茨海默病：其在瑞士适当使用的社会间建议。

IF 2.6 4区医学

Neurodegenerative Diseases Pub Date : 2025-01-01 Epub Date: 2025-04-14 DOI: 10.1159/000545799

Ansgar Felbecker, Ansgar Felbecker, Olivier Rouaud, Aurelien Lathuiliere, Gilles Allali, Marc Sollberger, Tatjana Meyer-Heim, Andreas U Monsch, Karl-Olof Lövblad, Stefanie Becker, Nadège Barro-Belaygues, Julius Popp, Markus Bürge, Kathrin Lindheimer, Anton Gietl, Hans H Jung, Dan Georgescu, Rafael Meyer, Giovanni B Frisoni

引用次数: 0

Erratum. 勘误表。

IF 2.6 4区医学

Neurodegenerative Diseases Pub Date : 2025-01-01 Epub Date: 2025-11-05 DOI: 10.1159/000548749

引用次数: 0

Sclerostin: A Potential Link between Osteoporosis and Alzheimer's Disease. 骨质疏松症和阿尔茨海默病之间的潜在联系。

IF 2.6 4区医学

Neurodegenerative Diseases Pub Date : 2025-01-01 Epub Date: 2025-06-23 DOI: 10.1159/000547072

Ziyang Guo, Qian Xu, Kexin Zhang, Yujie Ma, Sufang Sheng, Dongqing Jing, Xiaodong Sun, Chengxia Kan, Xinjun Yu

{"title":"Sclerostin: A Potential Link between Osteoporosis and Alzheimer's Disease.","authors":"Ziyang Guo, Qian Xu, Kexin Zhang, Yujie Ma, Sufang Sheng, Dongqing Jing, Xiaodong Sun, Chengxia Kan, Xinjun Yu","doi":"10.1159/000547072","DOIUrl":"10.1159/000547072","url":null,"abstract":"Background: Osteoporosis and Alzheimer's disease (AD) are age-related disorders with shared risk factors such as aging, oxidative stress, and neuroinflammation. Sclerostin, a glycoprotein secreted by osteocytes, inhibits Wnt/β-catenin signaling, leading to suppressed bone formation and increased resorption in osteoporosis. Recent findings reveal sclerostin is also expressed in the brain, where it may disrupt synaptic function and contribute to AD progression. Romosozumab, an anti-sclerostin monoclonal antibody approved for osteoporosis, is being explored for potential use in AD, though its ability to cross the blood-brain barrier remains a challenge.Summary: This review highlights the emerging connection between osteoporosis and AD, focusing on sclerostin as a shared molecular mediator. Understanding this link may open new avenues for dual-purpose therapies targeting sclerostin, with the potential to benefit both bone and brain health. Further studies are needed to clarify the causal mechanisms and therapeutic implications.Key messages: This review highlights sclerostin as a key molecular link between osteoporosis and AD, supporting the emerging concept of a bone-brain axis. Anti-sclerostin therapies like romosozumab may offer benefits beyond bone health, with potential in neurodegenerative disease treatment. Sclerostin may drive AD pathology by disrupting Wnt/β-catenin signaling and promoting β-amyloid and tau abnormalities.","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"218-226"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The 31st Annual Congress of the Société Francophone Posture Équilibre et Locomotion (SOFPEL), Bordeaux. 第31届社会<s:1>法语国家姿势Équilibre与运动（SOFPEL）年会，波尔多。

IF 2.6 4区医学

Neurodegenerative Diseases Pub Date : 2025-01-01 Epub Date: 2025-12-02 DOI: 10.1159/000548913

Jean-René Cazalets

引用次数: 0

Sex Differences in Progression of Neurodegeneration: The Age, Gene/Environment Susceptibility-Reykjavik Study. 神经变性进展的性别差异：AGES-Reykjavik研究。

IF 2.6 4区医学

Neurodegenerative Diseases Pub Date : 2025-01-01 Epub Date: 2025-03-13 DOI: 10.1159/000545184

Emma L Twait, Vilmundur Gudnason, Lenore J Launer, Lotte Gerritsen, Mirjam I Geerlings

{"title":"Sex Differences in Progression of Neurodegeneration: The Age, Gene/Environment Susceptibility-Reykjavik Study.","authors":"Emma L Twait, Vilmundur Gudnason, Lenore J Launer, Lotte Gerritsen, Mirjam I Geerlings","doi":"10.1159/000545184","DOIUrl":"10.1159/000545184","url":null,"abstract":"Introduction: Advancing age is associated with global brain atrophy. Cross-sectional studies have found sex differences in neuroanatomy; however, longitudinal studies assessing sex differences in neurodegeneration are currently scarce. The effects of age and sex on brain atrophy may not be uniform across the whole brain and may partially explain the sex differences observed in dementia. The current study aimed to examine sex differences in longitudinal atrophy patterns in gray and white matter regions in older adults.Methods: The study sample included 1,480 individuals from the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, a population-based cohort study, that underwent two magnetic resonance imaging scans within an average of 5 years between assessments. Individuals were also followed-up for incident dementia diagnosis. Linear regression models were used to assess sex differences between mean differences in gray and white matter regions, correcting for age, education, baseline intracranial volume, baseline regional volumes, hypertension, body mass index, and apolipoprotein (APOE) e4 allele status.Results: Men showed increased longitudinal atrophy in the total gray matter, as well as in the parietal cortex, cingulate cortex, caudate nucleus, brainstem, left cerebellum, precentral gyrus, putamen, globus pallidus, and orbitofrontal cortex. Whereas women exhibited greater atrophy over time in total white matter, but not in specific regions. No moderation was found between sex differences in incident dementia regarding atrophy patterns.Conclusions: While men show larger gray matter volumes cross-sectionally, their rates of atrophy over time are steeper compared to women. Sex differences in brain atrophy seem to be specifically detrimental in men in regions related to executive functioning, motor control, and emotion processing.","PeriodicalId":19115,"journal":{"name":"Neurodegenerative Diseases","volume":" ","pages":"67-75"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0