Clinical Immunology & Research最新文献

Therapeutic Apheresis and Immunosuppression in Immunologic Diseases: A Review and Own Observations 免疫性疾病的治疗性分离和免疫抑制:综述和自己的观察

Clinical Immunology & Research Pub Date : 2021-12-30 DOI: 10.33425/2639-8494.1042

R. Bambauer, R. Schiel

引用次数: 3

Serologic Monitoring of the Toxoplasmosis in Pregnant Women in Brazzaville, Congo 刚果布拉柴维尔孕妇弓形虫病血清学监测

Clinical Immunology & Research Pub Date : 2021-12-30 DOI: 10.33425/2639-8494.1039

Fils Landry Mpelle, Sekangue Obili Jery, E. N. Ontsira Ngoyi, Etienne Nguibi, J. B. Mouankie, R. Moyen, S. Kobawila, Gabriel Ahombo

{"title":"Serologic Monitoring of the Toxoplasmosis in Pregnant Women in Brazzaville, Congo","authors":"Fils Landry Mpelle, Sekangue Obili Jery, E. N. Ontsira Ngoyi, Etienne Nguibi, J. B. Mouankie, R. Moyen, S. Kobawila, Gabriel Ahombo","doi":"10.33425/2639-8494.1039","DOIUrl":"https://doi.org/10.33425/2639-8494.1039","url":null,"abstract":"Objectives: The objective of this work was to determine the immune status by researching antitoxoplasmic IgG and IgM. Methods: this is a prospective study from November 4, 2013 to April 4, 2014 carried out at the Exau Kenn medical center laboratory located opposite the Makelekele Base Hospital (I Brazzaville district). A toxoplasmic serology was taken from all pregnant women (first trimester) admitted to the Laboratory as part of a medical follow-up of their pregnancies. Serodiagnosis was performed by the agglutination technique associated with the indirect solid phase immunoenzymatic technique (EIA). Results: Of 139 pregnant women included in our study, 56.12% were immunized and 43.88% unimmunized. The seroprevalence was 69.04%. The percentage of women aged under 20 was 22.22%; and those between 20 and 39 years old was 46.77%; then 31.01% among those over 39 years of age. The risk factors incriminated in toxoplasmic infection for our study were: contact with soil, consumption of raw vegetables, level of hygiene and contact with cats. Conclusion: toxoplasmosis in pregnant women in Brazzaville is a real problem that must be regularly revealed in order to put in place an action plan to identify and evade it.","PeriodicalId":191133,"journal":{"name":"Clinical Immunology & Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134472111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges Experienced by Healthcare Workers on Maternal Tetanus Toxoid Vaccination in Kilimanjaro Region Tanzania 坦桑尼亚乞力马扎罗山地区保健工作者在孕产妇破伤风类毒素疫苗接种方面遇到的挑战

Clinical Immunology & Research Pub Date : 2021-12-30 DOI: 10.33425/2639-8494.1038

S. Laizer, Asia Hemed, Perry M. Cyril, Zuhura Lintu, S. M. Biswaro, B. Mmbaga, A. Msoka

{"title":"Challenges Experienced by Healthcare Workers on Maternal Tetanus Toxoid Vaccination in Kilimanjaro Region Tanzania","authors":"S. Laizer, Asia Hemed, Perry M. Cyril, Zuhura Lintu, S. M. Biswaro, B. Mmbaga, A. Msoka","doi":"10.33425/2639-8494.1038","DOIUrl":"https://doi.org/10.33425/2639-8494.1038","url":null,"abstract":"Background: Healthcare Workers (HCWs) are the first part of call for healthcare enquirers and have a key role in providing appropriate information and evidence-based healthcare recommendations to pregnant and postnatal mothers in order to ensure that they are well informed regarding maternal vaccinations. The World Health Organization (WHO) recommends that five doses are needed in order to acquire lifelong immunity against tetanus. A pregnant mother is considered to be more than 80% protected once she receives at least two doses of the vaccine. This study aimed to identify challenges experienced by the healthcare workers on maternal Tetanus Toxoid (TT) vaccination in Kilimanjaro region, Tanzania. Method: A qualitative approach comprising of In-Depth Interviews (IDIs) and focus group discussion (FGD) was conducted with 10 healthcare workers selected from 10 health facilities in remote villages of Hai district. The healthcare workers were selected purposively based on their availability and convenience; thematic analysis guided the data process. Results: Majority of the Healthcare workers were female, enrolled nurses with college education; their age ranged between 26-59 years with experience of work between 1 to 31 years. Main themes were extracted from the analysis namely: unreliable storage of vaccines, shortage of vaccines, shortage of healthcare workers, behavior of the healthcare workers and spousal influence on maternal vaccinations. Conclusion: The shortage and unreliable storage of TT vaccine has led to mothers missing their required doses, the spousal support and good mother-provider relationship is essential to ensure that the pregnant and post-natal mothers receive all the required doses. The regional and district health officials should ensure constant supply of TT vaccine with the recommended standards of vaccine storage facilities.","PeriodicalId":191133,"journal":{"name":"Clinical Immunology & Research","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122057397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Case Report: Successful Treatment of COVID-19 ARDS with Transcutaneous Vagus Nerve Stimulation 经皮迷走神经刺激成功治疗COVID-19急性呼吸窘迫综合征病例报告

Clinical Immunology & Research Pub Date : 2021-12-30 DOI: 10.33425/2639-8494.1040

Patrick Do, Ivan Evlogiev

{"title":"Case Report: Successful Treatment of COVID-19 ARDS with Transcutaneous Vagus Nerve Stimulation","authors":"Patrick Do, Ivan Evlogiev","doi":"10.33425/2639-8494.1040","DOIUrl":"https://doi.org/10.33425/2639-8494.1040","url":null,"abstract":"We report two individuals who successfully recovered from COVID-19-induced ARDS after being treated with transcutaneous auricular vagus nerve stimulation (taVNS). In the first case, taVNS was started after eleven hospital days of continual deterioration despite mechanical ventilation along with supportive therapy of steroids, antibiotics, and immunoglobulins. On the twelfth day of hospitalization, taVNS was begun four times daily, resulting in sudden improvement in oxygenation. There was a concomitant reduction of c-reactive protein from 109.6 μg/mL to 10 μg/mL. After nine days of taVNS therapy, the patient's improved respiratory function improved enough that she was able to be extubated. No additional treatments had been added or changed during this time. After twenty-seven days of hospitalization, the patient was discharged to home without supplemental oxygen. The second case involves taVNS therapy in the home setting. After nineteen days of progressive deterioration, the patient's oxygen saturation declined to 90% on room air before taVNS treatment was instituted. After tens days of taVNS treatment three times daily, his oxygen saturation had climbed to 97%, and by day 25 of VNS therapy, the patient felt he was fully recovered. taVNS is capable of improving regulation of the inflammatory response in other clinical conditions such as autoimmune disorders in humans and septic shock in animal models. We suggest that transcutaneous auricular vagus nerve stimulation is potent enough to improve the clinical course of COVID-19 associated ARDS because of its potential to minimize the clinical deterioration associated with the immunological surge known as the cytokine storm. taVNS is a safe and potentially efficacious treatment for COVID-19 ARDS.","PeriodicalId":191133,"journal":{"name":"Clinical Immunology & Research","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122600157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How Nanotherapy Fails SARS-CoV-2: The BI(G)MED Experience 纳米疗法如何治疗SARS-CoV-2: BI(G)MED经验

Clinical Immunology & Research Pub Date : 2021-12-30 DOI: 10.33425/2639-8494.1041

G. Gilbert, Bahi-Jaber Narges

引用次数: 0

The HIV Patient and their Antibody Response to SARS-CoV-2 Infection HIV患者及其对SARS-CoV-2感染的抗体反应

Clinical Immunology & Research Pub Date : 2021-12-30 DOI: 10.33425/2639-8494.1037

R. Stout, S. Rigatti

引用次数: 0

Antibiotic Susceptibility Profile of Salmonella spp and Shigella spp Isolated from Commercial Frozen Chicken Sold in three Markets within Awka Metropolis 奥卡市3个市场商品冷冻鸡肉中沙门氏菌和志贺氏菌的抗生素敏感性分析

Clinical Immunology & Research Pub Date : 2021-12-30 DOI: 10.33425/2639-8494.1036

Muna F. Okoli, M. Ugwu, Kene C. Ezejiegu, U. Morikwe

{"title":"Antibiotic Susceptibility Profile of Salmonella spp and Shigella spp Isolated from Commercial Frozen Chicken Sold in three Markets within Awka Metropolis","authors":"Muna F. Okoli, M. Ugwu, Kene C. Ezejiegu, U. Morikwe","doi":"10.33425/2639-8494.1036","DOIUrl":"https://doi.org/10.33425/2639-8494.1036","url":null,"abstract":"Background: Contamination of chicken meat by bacteria contributes to the increasing incidence of food –borne infections in humans. This study was aimed at providing data on the antibiotic susceptibility profile of Salmonella and Shigella species from frozen chicken sold within the Awka metropolis. Methodology: A total of 100 frozen chicken samples were obtained from different markets within the Awka metropolis. Smear samples were gotten from each chicken sample using sterile swab stick. Salmonella and Shigella samples were isolated after culturing the samples with Salmonella –Shigella agar and pure isolates identified morphologically, by Gram and biochemical characteristics. Antibiotic susceptibility test was performed using the disc diffusion method as recommended by CSLI. Isolates that showed resistance to any of the third-generation cephalosporin used were further subjected to the Double Disk Synergy Tests (DDST). Results: Of the 100 samples, 25 Shigella spp and 51 isolates of Salmonella were isolated. All Salmonella and Shigella isolates were resistant to the β-latam antibiotics. A 100% of the shigella isolates were resistant to all generation cephalospoin used. The bacterial spps were however, sensitive to nitrofurantoin and ciprofloxacin. Conclusion: This study has shown that frozen chicken serves as sources/ reservoir for bacterial infections. The isolates were resistant to the cephalosporins but sensitive to ciprofloxacin and nitrofurantoin.","PeriodicalId":191133,"journal":{"name":"Clinical Immunology & Research","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126442334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Assessment of Attitudes towards People Living with HIV/Aids in North Central Nigeria 尼日利亚中北部对艾滋病毒/艾滋病感染者的态度评估

Clinical Immunology & Research Pub Date : 2021-06-30 DOI: 10.33425/2639-8494.1031

Chiwa Musa Dalah

引用次数: 0

Women Who Have Sex with Women’s Attitudes and Willingness to Participate in Future Female Same Sex Public Health Research: Opportunity for Disease Prevention and Control in Tanzania 与妇女发生性行为的妇女参与未来女性同性公共卫生研究的态度和意愿:坦桑尼亚疾病预防和控制的机会

Clinical Immunology & Research Pub Date : 2021-06-30 DOI: 10.33425/2639-8494.1034

S. Kamazima, H. Saronga, Saidah S. Bakar, Jackline V. Mbishi

{"title":"Women Who Have Sex with Women’s Attitudes and Willingness to Participate in Future Female Same Sex Public Health Research: Opportunity for Disease Prevention and Control in Tanzania","authors":"S. Kamazima, H. Saronga, Saidah S. Bakar, Jackline V. Mbishi","doi":"10.33425/2639-8494.1034","DOIUrl":"https://doi.org/10.33425/2639-8494.1034","url":null,"abstract":"Recruitment of acceptable number of participants in a (public) health research with ‘hard to reach’/‘hidden’ populations is an old global problem, mostly challenging public health researchers in resource limited countries like Tanzania. Violence, stigma, criminalization of behaviors practiced by these groups, and potential participants’ suspicion toward the research and the researchers, further limit willingness to voluntarily participate. We conducted a cross-sectional descriptive and retrospective qualitative formative study with women who have sex with women in Dar-es-Salaam City region, Tanzania. The aim, among other objectives, was to understand women who have sex with women’s attitudes and willingness to participate in future female same sex public health research targeting this group. Findings indicate that all women we studied expressed willingness to participate in future health research targeting issues around female same sex relationships in the Tanzania context; an opportunity for (public) health professionals to prevent and control diseases in the country. To attain this goal, we recommend tailoring research protocols’ content, communication messages, and recruitment tactics to recognize, appreciate, and embrace the specific characteristics, backgrounds, and concerns of women who have sex with women in Tanzania.","PeriodicalId":191133,"journal":{"name":"Clinical Immunology & Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121711592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Factors Associated with Hepatitis B Virus (HBV) Infection among The University students in Dhaka, Bangladesh 孟加拉国达卡大学生乙型肝炎病毒(HBV)感染相关因素

Clinical Immunology & Research Pub Date : 2020-12-28 DOI: 10.33425/2639-8494.1025

Moazzem Hossain, Ariful Hoque, K. Yoshimura

{"title":"Factors Associated with Hepatitis B Virus (HBV) Infection among The University students in Dhaka, Bangladesh","authors":"Moazzem Hossain, Ariful Hoque, K. Yoshimura","doi":"10.33425/2639-8494.1025","DOIUrl":"https://doi.org/10.33425/2639-8494.1025","url":null,"abstract":"Background and Objectives: University students are the major blood donors in Dhaka city. There is no HBV immunization policy for university students in Bangladesh, and the virus can be transmited during blood transfusion if blood is not adequately screened. This study was conducted to determine the prevalence of HBV infection, vaccination status of HBV, and to determine risk factors for HBV infection among University students in Bangladesh. Methods: The cross-sectional study was conducted among 614 randomly selected students of four Universities in Dhaka from July 2018 to November 2018 on behalf of Thalassaemia hospital and Institute, a project of IACIB during the screening of Thalassaemia carriers among the students. Student’s demographic information was collected by using a questionnaire. Blood samples were collected to screen HBsAg along with Thalassaemia carriers. SPSS version 20 was used for data analysis. Results: During the study we found 5% HBV infection and 19.2% vaccination coverage for HBV. HBV infection was higher (8.9%) among graduate students (p=0.031), 22.5% among married students (p=0.001). Students having an HBV vaccine, not having sexual contact, and not having a history of surgery were less likely to have HBV infection with odds ratios (95% CI) of 9.396 (1.038-85.022), 48.268 (13.511-172.436) and 14.407 (3.86353.732) respectively. Conclusion: Absence of HBV vaccination, unsafe sexual contact and history of previous surgery are the major cause of HBV infection among university students. Students should be aware of HBV infection, and appropriate screening, as well as vaccination programs, should be launched in the universities of Bangladesh.","PeriodicalId":191133,"journal":{"name":"Clinical Immunology & Research","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116353526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0