Clinical Immunology & Research最新文献

{"title":"Natural Anamorphosis Process","authors":"Alexandros Senarelis Sinaris ND","doi":"10.33425/2639-8494.1024","DOIUrl":"https://doi.org/10.33425/2639-8494.1024","url":null,"abstract":"","PeriodicalId":191133,"journal":{"name":"Clinical Immunology & Research","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133189483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissipative Regulation: A New Approaches To Understanding The Regulatory Mechanisms in The Human Body","authors":"Igor Orzhelskyi, A. Kuznetsov, E.D.G. van Dijk","doi":"10.33425/2639-8494.1029","DOIUrl":"https://doi.org/10.33425/2639-8494.1029","url":null,"abstract":"The functioning of a living body, maintaining the dynamic stability of its homeostasis, is provided by regulatory systems. Traditionally, such systems include the nervous and humoral systems of regulation. The third regulatory system of the body, which provides communication in the body, distance interactions according to the \"informational\" principle, is not considered. For this reason, the understanding of the law of nature – “substance-energyinformation”, uniting the foundations of any matter, is very limited in biology. Therefore, the understanding of rules and postulates of Synergetics, as a science of the self-organization of matter by modern scientists is far from real processes occurring in matter \"here and now.\" This article provides a summary of the basic rules and principles of the interaction of Matter, Energy and Information, which are the basis of the third regulation mechanism in the human body.","PeriodicalId":191133,"journal":{"name":"Clinical Immunology & Research","volume":"163 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125906855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Ferritin, Vitamin D, Total Oxidant and Antioxidant Status in Patients With Behçet's Disease","authors":"G. Toprak, İlhan Sabancilar, N. Ozcan, B. Yokuş","doi":"10.33425/2639-8494.1027","DOIUrl":"https://doi.org/10.33425/2639-8494.1027","url":null,"abstract":"Background & Aim: Behçet's Disease (BD) is a chronic vascular-inflammatory multisystemic disease. Infectious, psychological, genetic and immunological factors are thought to play role in BD. Recent studies have shown that oxidative stress is associated with various diseases. In this study, some oxidative stress parameters were investigated in patients with BD to investigate the relationship of the disease with oxidative stress. Materials & Methods: The study included 35 patients with BD who admitted to the dermatology clinic of Dicle University Hospital and 37 healthy individuals as the control group. Total Oxidant Status (TOS), Total Antioxidant Status (TAS), Paraoxonase (PON-1), Ferritin, Folic Acid (folate) and Vitamin D (D-vit) levels were examined in the serum samples of both groups included in the study. Results: Compared to the control group, serum TOS, ferritin and folate levels were significantly higher in patients with BD, while TAS and D-vit levels were significantly lower (p<0.05). PON-1 level was found lower in BD patients than the control group, but the difference was not statistically significant. Conclusion: High oxidative stress and degraded antioxidant system parameters in patients with BD, may indicate the role of oxidative stress in the pathogenesis of the disease.","PeriodicalId":191133,"journal":{"name":"Clinical Immunology & Research","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116922728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ivermectin and Herd Immunity in SARS COV2 Pandemic from Local Experience to Broader Possibility","authors":"H. Carvallo, R. Hirsch","doi":"10.33425/2639-8494.1030","DOIUrl":"https://doi.org/10.33425/2639-8494.1030","url":null,"abstract":"Immunity can be natural or artificial, and each of them –in turnactive or passive. Artificial active immunity is vaccine-induced (possibly long acting). Active natural immunity is that obtained by becoming ill (it is the longest, the most efficient, but also the most risky, if the disease in question is potentially lethal). When at least 70% of the population reaches immunity, we speak of \"herd immunity\", with which it is assumed that community transmission is reduced to a minimum. We have developed an ivermectin-based treatment for SARS COV2 infection, which has proven to reduce mortality on a 7:1 scale, in moderate and/or critical cases, and to prevent mild cases from progressing to more severe stages –thus staying as out patientsbut, in all of them, humoral immunity was achieved in a reasonable amount. If these procedures were applied on a larger, broader scale, we could achieve herd immunity, without waiting for the vaccines to be developed, and without the hazards their manufacturers haven ́t yet disclaimed.","PeriodicalId":191133,"journal":{"name":"Clinical Immunology & Research","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132302984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profile of Natural Killer (NK) Cells in Simple Malaria in Adults","authors":"Y. Richard, Dassé Séry Romuald, A. Honoré, N’Guéssan Koff, Kouacou Amah Patricia Victorine, Siransy Kouabla Lliliane, Amichia Abaa Florence, H. Sansan, Tariam Djibangar Agnès, A. A. U. Aniela, B. Aboubacar, Zao Ouléon Léa, Yapi Ivan Alexia Dechy","doi":"10.33425/2639-8494.1021","DOIUrl":"https://doi.org/10.33425/2639-8494.1021","url":null,"abstract":"Justification: In the problematic of protection against severe forms of malaria, premunition has often been mentioned as a protective factor acquired in adults at the cost of multiple infections for several years. Exploration of the cellular component of anti-parasite immunity in uncomplicated malaria will provide comparisons of evidence that, despite relative protection, 2 to 3% of adults living in the endemic zone are victims of severe malaria. Main objective: The objective was to evaluate the role of the innate cellular response in susceptibility to uncomplicated malaria in subjects older than 15 years. Patients and Methods: It was a prospective study with descriptive and analytical purpose that took place at Koumassi General Hospital for simple malaria patients and the NBTC for witnesses. All blood samples were analyzed in the Immunology and Hematology Laboratory of CHU de Cocody. It included 50 patients (25 patients with malaria and 25 witnesses) of both sexes, over a 3-month period. The samples carried were processed in the said-laboratory. Results: The average age of our patients was 35 years. The mean of NK cells were 45 cells/mm3 in patients and 154.64 cells/ mm3 in witness persons. The risk of not seeing a simple malaria when the number of NK cells is high was 9.03. The PPV was 88.88% and the NPV was 62.6%. The mean parasitemia in patients was 1840 trophozoites/μL. The influence of NK cells on parasitemia was undetermined with a PPV at 1% and a NPV at 39.13%. Conclusion: Susceptibility to simple malaria is a multifactorial phenomenon in which the immune response plays a central role. The evolution towards this clinical state will have to be studied with all the other cellular actors to better appreciate the role of NK cells during its evolution.","PeriodicalId":191133,"journal":{"name":"Clinical Immunology & Research","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122668935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of Antibiotic Resistance in Uncomplicated Urinary Tract Infection in Children and Effectiveness of Immunoprophylaxis","authors":"Stoieva T.V, Gruzievskyi O.A","doi":"10.33425/2639-8494.1022","DOIUrl":"https://doi.org/10.33425/2639-8494.1022","url":null,"abstract":"Background: The relapsing course of urinary tract infections (UTI) is an important issue. Repeated courses of antibiotics contribute to selection of multi-resistant microorganisms. Obviously, a new way of prevention, such as vaccination, has to be introduced. Objectives: The purpose of this study was to evaluate the effectiveness of oral vaccination with a complex of frozen lyophilized microorganisms — Escherichia coli, Enterococcus faecalis, Proteus mirabilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Propionibacterium acnes for the prevention of recurrent UTI in children. Methods: The study involved 30 children aged 7 to 16 years with an uncomplicated course of UTI and a frequency of 3 or more episodes per year. The study found that pathogens of uncomplicated UTI were E. coli (66.7%), Enterobacter aer., Enterococcus faecalis, Enterococcus spp., Proteus mirabilis, Proteus vulgaris, S. hominis, Streptococcus haemolyticus. Several pathogens were observed in 10% of patients, the presence of polymycrobial microflora correlated with the frequency of UTI (χ2 = 3.84, p<0.05). The resistance of microflora to antibiotics decreased in the following order: aminoglycosides (4%), carbapenems (9%), cephalosporins (9%), fluoroquinolones (13%), protected penicillins (17%), macrolides (22%), penicillins (26%). Results: Evaluation of the oral vaccination effectiveness after 6 months showed a decrease of UTI rate (before vaccination: 3.55 (95% CI 2.91–4.18); after: 0.93 (95% 0.57–1.29) and also reduction of urinary syndrome signs (bacteriuria and leukocyturia). Side effects were not registered and 2/3 patients showed an improvement of their condition. Conclusion: So, a multi-component vaccine can be a safe, effective alternative in prevention of UTI in children.","PeriodicalId":191133,"journal":{"name":"Clinical Immunology & Research","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131886279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposal of Artificial Pandemics by Infectious Attenuated Live Influenza Vaccines to Save the World from Dangerous Wild Type New Influenza Pandemics –Operation Backfire-","authors":"Y. Hayakawa","doi":"10.33425/2639-8494.1017","DOIUrl":"https://doi.org/10.33425/2639-8494.1017","url":null,"abstract":"Background: Fears of a global pandemic are mounting as experts have warned at the annual World Economic Forum in Davos 2018. They claim there will be ‘no way to stop’ a killer disease from claiming millions of lives. New pandemic is feared to appear in the world. Especially H7N9 is the most plausible and feared candidates. H5N1 is also a dangerous candidate. Spanish influenza pandemic killed 50 million to 100million people in the world. Total population at that time was 2.2 milliyard. Present population is 7.4 milliyard. Dr. Nabarro D, one of the most senior public health experts at the World Health Organization (WHO) told the BBC that the \"range of deaths could be anything between five and 150 million\". Ordinary vaccine is too costly for many people in developing countries. And vaccines are not available in early stages of pandemic. Methods: Ferret has same nature to influenza with man. It has human-like α2-6 linked sialosides, while birds α 2-3. Ferret nasal mucosa is carcinized using carcinogen for easiness of incubation. Bird influenza virus is attenuated by reverse genetics. The virus is marked by green fluorescent protein. This attenuated virus is sprayed to many cultured cancer cell specimen incubated. In some specimen attenuated virus will mutated to increase in cancer cells, checked by green fluorescence. Then the virus is tested to infect ferret and then human volunteers without serious symptom. Virus with strongest virus titer to infect ferret is selected as seed virus of infectious attenuated live vaccine. The seed virus will be increased in incubated cancer cells all over the world and sprayed to vulnerable people and inevitable necessitated persons for basic life of citizens, e.g., soldiers, students, people in slums, medical staffs, and people engaged in lifeline. Drones may be used to enhance infection, spraying in slums thin capsules including the live vaccine. Thin capsules are melted at human nasal mucous membrane. Thus basic immunity is gained by many people against dangerous virus. Remarks: Highly virulent influenza virus kills cancer cells of ferret. So this system cannot be used for producing biological weapons and can be used only for peaceful purposes. Infectious attenuated live influenza vaccine for H7N9 should now be prepared. Artificial pandemics of dangerous viruses as H7N9, H5N1 etc., are to be created serially with few years interval. Artificial pandemic should be initiated before wild type pandemic starts. One reason is to avoid reassortment (mixture) of virus RNA and another is to avoid clinical and social confusion. It should not overlap with influenza season. The number of victims seems to be less than 300 thousands in the world. As the live vaccine is less virulent than A/H1N1. Cooperation of many people, researchers, companies, institutes, organizations, nations, and especially International Cooperation seem to be necessary to achieve -Operation Backfiresuccessfully. Conclusion: A novel method is proposed to s","PeriodicalId":191133,"journal":{"name":"Clinical Immunology & Research","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114857100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic TNF-α Reduction by Blocking IgE-mediated Cellular Activation in Inflammatory Bowel Disease","authors":"Rachael E. Hamilton Ba, S. Vikram, F. Farraye, J. Connor, L. Ganley-Leal","doi":"10.33425/2639-8494.1019","DOIUrl":"https://doi.org/10.33425/2639-8494.1019","url":null,"abstract":"","PeriodicalId":191133,"journal":{"name":"Clinical Immunology & Research","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134341084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccination against Pneumococcus and Influenza in Old Age: Evidence- Based Geriatrics","authors":"Jimenez Carmen, Mondragón-Cervantes Martha Ivón, De la Cruz-Pérez Cristy Noemí, Padilla-Sánchez Mónica Lizeth, Franco-Navarro Alfonso, L. David, D. Alberto","doi":"10.33425/2639-8494.1020","DOIUrl":"https://doi.org/10.33425/2639-8494.1020","url":null,"abstract":"Populations around the world are rapidly ageing. Ageing presents a diminished function of the immune system which is known as immunosenescence; therefore, the elderly develop a greater susceptibility to infections such as influenza and pneumococcal pneumonia. Vaccines schemes are one of the most cost-effective strategies because they offer a cheap alternative of preventing morbidity and mortality. Demographic aging demands the improvement in elderly care in order to prevent geriatric syndromes, which affect not only dependency but also quality of life. Negative outcomes like disability could be related to an increased mortality and a decreased likelihood of influenza and pneumococcal vaccination in older people. The establishment of the culture of primary prevention in health directed to the population of older adults, through the strategy of vaccination in old age is one of the great challenges of geriatric medicine and public health worldwide. The aim of this manuscript is to present a detailed description of the current scientific evidence of vaccination against pneumococcus and influenza in older adults.","PeriodicalId":191133,"journal":{"name":"Clinical Immunology & Research","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133942961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Pathogenic Bacteria Associated with the Nigerian’s Currency","authors":"Ademokoya A.A","doi":"10.33425/2639-8494.1018","DOIUrl":"https://doi.org/10.33425/2639-8494.1018","url":null,"abstract":"","PeriodicalId":191133,"journal":{"name":"Clinical Immunology & Research","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122736394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}