发布求助
文献互助 智能选刊 最新文献

Nature biotechnology最新文献

筛选
英文 中文
Biotech financing: divide and reset 生物技术融资：划分与重置
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2025-06-16 DOI: 10.1038/s41587-025-02723-8
{"title":"Biotech financing: divide and reset","authors":"","doi":"10.1038/s41587-025-02723-8","DOIUrl":"https://doi.org/10.1038/s41587-025-02723-8","url":null,"abstract":"Today’s uniquely challenging biotech climate may result in a more resilient sector.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"23 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FDA says GM pigs safe to eat FDA称转基因猪可以安全食用
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2025-06-16 DOI: 10.1038/s41587-025-02716-7
{"title":"FDA says GM pigs safe to eat","authors":"","doi":"10.1038/s41587-025-02716-7","DOIUrl":"https://doi.org/10.1038/s41587-025-02716-7","url":null,"abstract":"<p>Pigs genetically modified to resist a devastating virus are now approved for human consumption in the United States. British animal genetics company Genus, based in Basingstoke, announced in April that the US Food and Drug Administration (FDA) had approved its gene-edited pigs after a lengthy review through the agency’s Investigational New Drug regulatory pathway.</p>","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"92 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biotech news from around the world 来自世界各地的生物技术新闻
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2025-06-16 DOI: 10.1038/s41587-025-02714-9
{"title":"Biotech news from around the world","authors":"","doi":"10.1038/s41587-025-02714-9","DOIUrl":"https://doi.org/10.1038/s41587-025-02714-9","url":null,"abstract":"<p>A new law proposed by the Federal Council would ease restrictions on plants developed through new genomic techniques such as CRISPR. Currently in Switzerland, such plants are treated similarly to those developed through conventional genetic engineering, including an ongoing moratorium on cultivation. If passed, the Breeding Technologies Act would enact a risk-based authorization system that reflects the potential of new breeding technologies and the need for appropriate safeguards.</p>","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organoids Organoids
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2025-06-16 DOI: 10.1038/s41587-025-02698-6
{"title":"Organoids","authors":"","doi":"10.1038/s41587-025-02698-6","DOIUrl":"https://doi.org/10.1038/s41587-025-02698-6","url":null,"abstract":"Recent patents relating to the production, culture and use of organoids.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"229 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infant receives the first customized CRISPR therapy 婴儿接受首个定制的CRISPR治疗
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2025-06-16 DOI: 10.1038/s41587-025-02719-4
Iris Marchal
{"title":"Infant receives the first customized CRISPR therapy","authors":"Iris Marchal","doi":"10.1038/s41587-025-02719-4","DOIUrl":"https://doi.org/10.1038/s41587-025-02719-4","url":null,"abstract":"<p>Base and prime editors promise to correct nearly all known pathogenic variants, but their therapeutic development is restricted to a handful of recurrent mutations owing to the high cost of bringing gene therapies to market. Writing in the <i>New England Journal of Medicine</i>, Musunuru et al. report on the rapid development of a customized base-editing therapy, provided to an infant born with a rare disease and delivered in vivo to hepatocytes through lipid nanoparticles.</p><p>The patient, who was diagnosed with a rare metabolic disease of the urea cycle known as carbamoyl phosphate synthetase 1 (CPS1) deficiency that prevents the proper breakdown of protein from food, received the first dose of base-editing therapy at just seven months of age. Within two months, the authors developed a cell line harboring two <i>CPS1</i> variants identified in the patient’s genome and screened various adenine base editors with guide RNAs tiling one of those <i>CPS1</i> variants. They selected the most efficient and precise base editor, called k-abe. Five months after birth, they assessed the in vivo efficiency of k-abe in a patient-specific mouse model, showing up to 42% whole-liver corrective editing. Safety studies in nonhuman primates and analyses of off-target editing in hepatocytes cleared the way for regulatory approval.</p>","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"35 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
England poised to green-light precision breeding 英国准备为精准育种开绿灯
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2025-06-16 DOI: 10.1038/s41587-025-02715-8
{"title":"England poised to green-light precision breeding","authors":"","doi":"10.1038/s41587-025-02715-8","DOIUrl":"https://doi.org/10.1038/s41587-025-02715-8","url":null,"abstract":"<p>The UK government is close to approving rules for precision-bred plants in England. In May, Parliament published draft legislation that will enable a new regulatory system, as set out in the Genetic Technology (Precision Breeding) Act 2023.</p>","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"10 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
People 人
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2025-06-16 DOI: 10.1038/s41587-025-02703-y
{"title":"People","authors":"","doi":"10.1038/s41587-025-02703-y","DOIUrl":"https://doi.org/10.1038/s41587-025-02703-y","url":null,"abstract":"Recent moves of note in and around the biotech and pharma industries.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"598 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thinking about a move from academia to industry? Look before you leap 想从学术界转到工业界吗？三思而后行
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2025-06-16 DOI: 10.1038/s41587-025-02700-1
William N. Hait
{"title":"Thinking about a move from academia to industry? Look before you leap","authors":"William N. Hait","doi":"10.1038/s41587-025-02700-1","DOIUrl":"https://doi.org/10.1038/s41587-025-02700-1","url":null,"abstract":"To those considering a change in careers from academia to the pharmaceutical industry, here are the keys to a successful transition.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"10 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Limitations of cell embedding metrics assessed using drifting islands 用漂流岛评估细胞嵌入指标的局限性
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2025-06-11 DOI: 10.1038/s41587-025-02702-z
Hanchen Wang, Jure Leskovec, Aviv Regev
{"title":"Limitations of cell embedding metrics assessed using drifting islands","authors":"Hanchen Wang, Jure Leskovec, Aviv Regev","doi":"10.1038/s41587-025-02702-z","DOIUrl":"https://doi.org/10.1038/s41587-025-02702-z","url":null,"abstract":"<p>Biological studies rely on embeddings of single-cell profiles but assessing the quality of these embeddings is challenging. Here we show that current evaluation metrics are incomplete by training a three-layer perceptron, Islander. Islander outperforms all leading embedding methods on a diverse set of cell atlases but it distorts biological structures, limiting its use for biological discovery. We then present a new metric, scGraph, to help flag such distortions.</p>","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"14 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Individualized mRNA cancer vaccines make strides 个体化mRNA癌症疫苗取得进展
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2025-06-10 DOI: 10.1038/s41587-025-02708-7
{"title":"Individualized mRNA cancer vaccines make strides","authors":"","doi":"10.1038/s41587-025-02708-7","DOIUrl":"https://doi.org/10.1038/s41587-025-02708-7","url":null,"abstract":"The first cancer vaccines matched to a person’s unique tumor neoantigens are forging ahead, with expectations running high as the field awaits results from the first pivotal trial.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"2 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144252046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信