Nature biotechnology最新文献_第5页

Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research 通过生物技术实现下一代厌氧培养，推进功能性微生物组研究

IF 46.9 1区生物学

Nature biotechnology Pub Date : 2025-04-29 DOI: 10.1038/s41587-025-02660-6

Thomas Clavel, Franziska Faber, Mathieu Groussin, Dirk Haller, Jörg Overmann, Charlie Pauvert, Mathilde Poyet, Joel Selkrig, Bärbel Stecher, Athanasios Typas, Maria J. G. T. Vehreschild, Alexander J. Westermann, David Wylensek, Lisa Maier

{"title":"Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research","authors":"Thomas Clavel, Franziska Faber, Mathieu Groussin, Dirk Haller, Jörg Overmann, Charlie Pauvert, Mathilde Poyet, Joel Selkrig, Bärbel Stecher, Athanasios Typas, Maria J. G. T. Vehreschild, Alexander J. Westermann, David Wylensek, Lisa Maier","doi":"10.1038/s41587-025-02660-6","DOIUrl":"https://doi.org/10.1038/s41587-025-02660-6","url":null,"abstract":"Microbiomes are complex communities of microorganisms that are essential for biochemical processes on Earth and for the health of humans, animals and plants. Many environmental and host-associated microbiomes are dominated by anaerobic microbes, some of which cannot tolerate oxygen. Anaerobic microbial communities have been extensively studied over the last 20 years using molecular techniques, especially next-generation sequencing. However, there is a renewed interest in microbial cultivation because isolates provide the basis for understanding the taxonomic and functional units of biodiversity, elucidating novel biochemical pathways and the mechanisms underlying microbe–microbe and microbe–host interactions and opening new avenues for biotechnological and clinical applications. In this Perspective, we present areas of research and applications that will benefit from advancement in anaerobic microbial cultivation. We highlight key technical and infrastructural hurdles associated with the development and deployment of sophisticated cultivation workflows. Improving the performance of cultivation techniques will set new trends in functional microbiome research in the coming years.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"222 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials 膜透性海藻糖6-磷酸前体喷雾在田间试验中提高小麦产量

IF 46.9 1区生物学

Nature biotechnology Pub Date : 2025-04-29 DOI: 10.1038/s41587-025-02611-1

Cara A. Griffiths, Xiaochao Xue, Javier A. Miret, Fernando Salvagiotti, Liana G. Acevedo-Siaca, Jacinta Gimeno, Matthew P. Reynolds, Kirsty L. Hassall, Kirstie Halsey, Swati Puranik, Maria Oszvald, Smita Kurup, Benjamin G. Davis, Matthew J. Paul

{"title":"Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials","authors":"Cara A. Griffiths, Xiaochao Xue, Javier A. Miret, Fernando Salvagiotti, Liana G. Acevedo-Siaca, Jacinta Gimeno, Matthew P. Reynolds, Kirsty L. Hassall, Kirstie Halsey, Swati Puranik, Maria Oszvald, Smita Kurup, Benjamin G. Davis, Matthew J. Paul","doi":"10.1038/s41587-025-02611-1","DOIUrl":"https://doi.org/10.1038/s41587-025-02611-1","url":null,"abstract":"Trehalose 6-phosphate (T6P) is an endogenous sugar signal in plants that promotes growth, yet it cannot be introduced directly into crops or fully genetically controlled. Here we show that wheat yields were improved using a timed microdose of a plant-permeable, sunlight-activated T6P signaling precursor, DMNB-T6P, under a variety of agricultural conditions. Under both well-watered and water-stressed conditions over 4 years, DMNB-T6P stimulated yield of three elite varieties. Yield increases were an order of magnitude larger than average annual genetic gains of breeding programs and occurred without additional water or fertilizer. Mechanistic analyses reveal that these benefits arise from increased CO2 fixation and linear electron flow (‘source’) as well as from increased starchy endosperm volume, enhanced grain sieve tube development and upregulation of genes for starch, amino acid and protein synthesis (‘sink’). These data demonstrate a step-change, scalable technology with net benefit to the environment that could provide sustainable yield improvements of diverse staple cereal crops.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"66 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental monitoring from the air with hyperspectral reporters 用高光谱报告器从空中进行环境监测

IF 46.9 1区生物学

Nature biotechnology Pub Date : 2025-04-29 DOI: 10.1038/s41587-025-02668-y

Maxwell Z. Wilson

引用次数: 0

Application of a sunlight-switched sugar signal increases wheat yield in the field 应用日光开关糖信号可提高田间小麦产量

IF 46.9 1区生物学

Nature biotechnology Pub Date : 2025-04-29 DOI: 10.1038/s41587-025-02667-z

引用次数: 0

Precision neuroscience 精密神经科学

IF 46.9 1区生物学

Nature biotechnology Pub Date : 2025-04-28 DOI: 10.1038/s41587-025-02673-1

引用次数: 0

Chemigenetic kinase biosensors illuminate cell signaling networks 化学遗传激酶生物传感器照亮细胞信号网络

IF 46.9 1区生物学

Nature biotechnology Pub Date : 2025-04-28 DOI: 10.1038/s41587-025-02672-2

Katarina Nemec, Vikas D. Trivedi, M. Madan Babu

引用次数: 0

A call for built-in biosecurity safeguards for generative AI tools 呼吁为生成式人工智能工具提供内置生物安全保障

IF 46.9 1区生物学

Nature biotechnology Pub Date : 2025-04-28 DOI: 10.1038/s41587-025-02650-8

Mengdi Wang, Zaixi Zhang, Amrit Singh Bedi, Alvaro Velasquez, Stephanie Guerra, Sheng Lin-Gibson, Le Cong, Yuanhao Qu, Souradip Chakraborty, Megan Blewett, Jian Ma, Eric Xing, George Church

{"title":"A call for built-in biosecurity safeguards for generative AI tools","authors":"Mengdi Wang, Zaixi Zhang, Amrit Singh Bedi, Alvaro Velasquez, Stephanie Guerra, Sheng Lin-Gibson, Le Cong, Yuanhao Qu, Souradip Chakraborty, Megan Blewett, Jian Ma, Eric Xing, George Church","doi":"10.1038/s41587-025-02650-8","DOIUrl":"https://doi.org/10.1038/s41587-025-02650-8","url":null,"abstract":"Generative AI is changing biotechnology research, and accelerating drug discovery, protein design and synthetic biology. It also enhances biomedical imaging, personalized medicine and laboratory automation, which enables faster and more efficient scientific advancements. However, these breakthroughs have also raised biosecurity concerns, which has prompted policy and community discussions1,2,3,4.The power of generative AI lies in its ability to generalize from known data to the unknown. Deep generative models can predict novel biological molecules that might not resemble existing genome sequences or proteins. This capability introduces dual-use risks and serious biosecurity threats — such models could potentially bypass the established safety screening mechanisms used by nucleic acid synthesis providers5, which presently rely on database matching to identify sequences of concerns6. AI-driven tools could be misused to engineer pathogens, toxins or destabilizing biomolecules, and AI science agents could amplify risks by automating experimental designs7.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"1 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Agnostic viral detection at single-cell resolution reveals novel viruses 以单细胞分辨率进行不可知病毒检测，揭示新型病毒

IF 46.9 1区生物学

Nature biotechnology Pub Date : 2025-04-24 DOI: 10.1038/s41587-025-02638-4

引用次数: 0

Author Correction: Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion 作者更正：利用 Cas9-胞苷脱氨酶融合技术在水稻、小麦和玉米中进行精确碱基编辑

IF 46.9 1区生物学

Nature biotechnology Pub Date : 2025-04-24 DOI: 10.1038/s41587-025-02671-3

Yuan Zong, Yanpeng Wang, Chao Li, Rui Zhang, Kunling Chen, Yidong Ran, Jin-Long Qiu, Daowen Wang, Caixia Gao

引用次数: 0

Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein 通过靶向细胞表面 RNA 结合蛋白治疗急性髓性白血病模型

IF 46.9 1区生物学

Nature biotechnology Pub Date : 2025-04-23 DOI: 10.1038/s41587-025-02648-2

Benson M. George, Maria Eleftheriou, Eliza Yankova, Jonathan Perr, Peiyuan Chai, Gianluca Nestola, Karim Almahayni, Siân Evans, Aristi Damaskou, Helena Hemberger, Charlotta G. Lebedenko, Justyna Rak, Qi Yu, Ece Bapcum, James Russell, Jaana Bagri, Regan F. Volk, Malte Spiekermann, Richard M. Stone, George Giotopoulos, Brian J. P. Huntly, Joanna Baxter, Fernando Camargo, Jie Liu, Balyn W. Zaro, George S. Vassiliou, Leonhard Möckl, Jorge de la Rosa, Ryan A. Flynn, Konstantinos Tzelepis

{"title":"Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein","authors":"Benson M. George, Maria Eleftheriou, Eliza Yankova, Jonathan Perr, Peiyuan Chai, Gianluca Nestola, Karim Almahayni, Siân Evans, Aristi Damaskou, Helena Hemberger, Charlotta G. Lebedenko, Justyna Rak, Qi Yu, Ece Bapcum, James Russell, Jaana Bagri, Regan F. Volk, Malte Spiekermann, Richard M. Stone, George Giotopoulos, Brian J. P. Huntly, Joanna Baxter, Fernando Camargo, Jie Liu, Balyn W. Zaro, George S. Vassiliou, Leonhard Möckl, Jorge de la Rosa, Ryan A. Flynn, Konstantinos Tzelepis","doi":"10.1038/s41587-025-02648-2","DOIUrl":"https://doi.org/10.1038/s41587-025-02648-2","url":null,"abstract":"Immunotherapies for acute myeloid leukemia (AML) and other cancers are limited by a lack of tumor-specific targets. Here we discover that RNA-binding proteins and glycosylated RNAs (glycoRNAs) form precisely organized nanodomains on cancer cell surfaces. We characterize nucleophosmin (NPM1) as an abundant cell surface protein (csNPM1) on a variety of tumor types. With a focus on AML, we observe csNPM1 on blasts and leukemic stem cells but not on normal hematopoietic stem cells. We develop a monoclonal antibody to target csNPM1, which exhibits robust anti-tumor activity in multiple syngeneic and xenograft models of AML, including patient-derived xenografts, without observable toxicity. We find that csNPM1 is expressed in a mutation-agnostic manner on primary AML cells and may therefore offer a general strategy for detecting and treating AML. Surface profiling and in vivo work also demonstrate csNPM1 as a target on solid tumors. Our data suggest that csNPM1 and its neighboring glycoRNA–cell surface RNA-binding protein (csRBP) clusters may serve as an alternative antigen class for therapeutic targeting or cell identification.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"69 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0