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IF 41.7 1区 生物学
Nature biotechnology Pub Date : 2025-07-15 DOI: 10.1038/s41587-025-02732-7
{"title":"People","authors":"","doi":"10.1038/s41587-025-02732-7","DOIUrl":"10.1038/s41587-025-02732-7","url":null,"abstract":"Recent moves of note in and around the biotech and pharma industries.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 7","pages":"1208-1208"},"PeriodicalIF":41.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibiotic-resistant infections cured by calcium deposition 用钙沉积治疗耐抗生素感染
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2025-07-15 DOI: 10.1038/s41587-025-02755-0
Volker Winstel
{"title":"Antibiotic-resistant infections cured by calcium deposition","authors":"Volker Winstel","doi":"10.1038/s41587-025-02755-0","DOIUrl":"https://doi.org/10.1038/s41587-025-02755-0","url":null,"abstract":"A strategy for treating chronic multidrug-resistant staphylococcal infections kills bacteria by encasing them in a calcium shell.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"6 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FDA approves first-in-class HIV prevention shot 美国食品和药物管理局批准了首例艾滋病预防疫苗
IF 41.7 1区 生物学
Nature biotechnology Pub Date : 2025-07-15 DOI: 10.1038/s41587-025-02756-z
{"title":"FDA approves first-in-class HIV prevention shot","authors":"","doi":"10.1038/s41587-025-02756-z","DOIUrl":"10.1038/s41587-025-02756-z","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 7","pages":"1024-1024"},"PeriodicalIF":41.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ocean-grown bioplastics Ocean-grown生物塑料
IF 41.7 1区 生物学
Nature biotechnology Pub Date : 2025-07-15 DOI: 10.1038/s41587-025-02746-1
Claire Turrell
{"title":"Ocean-grown bioplastics","authors":"Claire Turrell","doi":"10.1038/s41587-025-02746-1","DOIUrl":"10.1038/s41587-025-02746-1","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 7","pages":"1027-1027"},"PeriodicalIF":41.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Platform solutions for commercial challenges to expanding patient access and making gene editing sustainable 应对商业挑战的平台解决方案,以扩大患者获取和使基因编辑可持续发展
IF 41.7 1区 生物学
Nature biotechnology Pub Date : 2025-07-15 DOI: 10.1038/s41587-025-02744-3
Sadik H. Kassim, Fyodor Urnov, Kiran Musunuru, Ann Lee, Luis Barrera, Pamela Stetkiewicz, Julianne Bruno, Matthew Hewitt, Troy Lister, Harry Malech, Lindsay Gasch, Matt Diver, Nicholas Gertler, Felix Grignon, Audrey Le, Michael Lehmicke, Edwin M. Horwitz, David R. Liu, Josephine Lembong, Vanessa Almendro-Navarro
{"title":"Platform solutions for commercial challenges to expanding patient access and making gene editing sustainable","authors":"Sadik H. Kassim, Fyodor Urnov, Kiran Musunuru, Ann Lee, Luis Barrera, Pamela Stetkiewicz, Julianne Bruno, Matthew Hewitt, Troy Lister, Harry Malech, Lindsay Gasch, Matt Diver, Nicholas Gertler, Felix Grignon, Audrey Le, Michael Lehmicke, Edwin M. Horwitz, David R. Liu, Josephine Lembong, Vanessa Almendro-Navarro","doi":"10.1038/s41587-025-02744-3","DOIUrl":"10.1038/s41587-025-02744-3","url":null,"abstract":"Platform-based approaches for gene-editing therapies could markedly improve development efficiency, reduce costs and increase access for patients with rare diseases. Although gene editing has shown remarkable clinical success for a small number of Mendelian disease indications, broader adoption faces substantial hurdles. We propose strategies to overcome these challenges through modular platforms for nonclinical and chemistry, manufacturing and controls (CMC) data reuse, risk-based manufacturing quality, and streamlined umbrella clinical trials for regulatory efficiency and accelerated approval.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 7","pages":"1047-1049"},"PeriodicalIF":41.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Profiling translated regions in viral genomes at scale 大规模分析病毒基因组的翻译区域
IF 41.7 1区 生物学
Nature biotechnology Pub Date : 2025-07-15 DOI: 10.1038/s41587-025-02748-z
Iris Marchal
{"title":"Profiling translated regions in viral genomes at scale","authors":"Iris Marchal","doi":"10.1038/s41587-025-02748-z","DOIUrl":"10.1038/s41587-025-02748-z","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 7","pages":"1054-1054"},"PeriodicalIF":41.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mast cells drive Blueprint mega-deal 肥大细胞驱动Blueprint的巨额交易
IF 41.7 1区 生物学
Nature biotechnology Pub Date : 2025-07-15 DOI: 10.1038/s41587-025-02750-5
{"title":"Mast cells drive Blueprint mega-deal","authors":"","doi":"10.1038/s41587-025-02750-5","DOIUrl":"10.1038/s41587-025-02750-5","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 7","pages":"1021-1021"},"PeriodicalIF":41.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eli Lilly in $650M pact to boost muscle 礼来(Eli Lilly)达成6.5亿美元的协议,以增强肌肉
IF 41.7 1区 生物学
Nature biotechnology Pub Date : 2025-07-15 DOI: 10.1038/s41587-025-02753-2
{"title":"Eli Lilly in $650M pact to boost muscle","authors":"","doi":"10.1038/s41587-025-02753-2","DOIUrl":"10.1038/s41587-025-02753-2","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 7","pages":"1025-1025"},"PeriodicalIF":41.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computationally designed enzymes show potent catalytic activity 计算设计的酶显示出强大的催化活性
IF 41.7 1区 生物学
Nature biotechnology Pub Date : 2025-07-15 DOI: 10.1038/s41587-025-02751-4
Iris Marchal
{"title":"Computationally designed enzymes show potent catalytic activity","authors":"Iris Marchal","doi":"10.1038/s41587-025-02751-4","DOIUrl":"10.1038/s41587-025-02751-4","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 7","pages":"1054-1054"},"PeriodicalIF":41.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transitive prediction of small-molecule function through alignment of high-content screening resources 高含量筛选资源比对小分子功能的传递预测
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2025-07-11 DOI: 10.1038/s41587-025-02729-2
Feng Bao, Li Li, Heinz Hammerlindl, Susan Q. Shen, Sabrina Hammerlindl, Steven J. Altschuler, Lani F. Wu
{"title":"Transitive prediction of small-molecule function through alignment of high-content screening resources","authors":"Feng Bao, Li Li, Heinz Hammerlindl, Susan Q. Shen, Sabrina Hammerlindl, Steven J. Altschuler, Lani F. Wu","doi":"10.1038/s41587-025-02729-2","DOIUrl":"https://doi.org/10.1038/s41587-025-02729-2","url":null,"abstract":"<p>High-content image-based phenotypic screens (HCSs) provide a scalable approach to characterize biological functions of compounds. The widespread adoption of HCS has led to a growing body of available profile datasets. However, study-specific experimental and computational choices lead to profile datasets that cannot be directly combined. A critical, long-standing challenge is how to integrate these rich but currently isolated HCS dataset resources. Here we introduce a contrastive, deep-learning framework that leverages sparse sets of overlapping profiles as fiducials to align heterogeneous HCS profile datasets in a shared latent space. We demonstrate that this alignment facilitates accurate ‘transitive’ predictions, whereby the function of an uncharacterized compound screened in one dataset can be predicted through comparison with characterized compounds already profiled in other datasets. In silico alignment of HCS resources provides a path to unify fast-growing HCS resources and accelerate early drug discovery efforts.</p>","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"22 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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