发布求助
文献互助 智能选刊 最新文献

Nature biotechnology最新文献

筛选
英文 中文
B cell depletion in autoimmune disease: in vivo CAR-T or T cell engagers? 自身免疫性疾病中的B细胞耗竭：体内CAR-T还是T细胞接合器？
IF 41.7 1区 生物学
Nature biotechnology Pub Date : 2026-03-10 DOI: 10.1038/s41587-026-03069-5
Melanie Senior, Ricardo Grieshaber-Bouyer
{"title":"B cell depletion in autoimmune disease: in vivo CAR-T or T cell engagers?","authors":"Melanie Senior, Ricardo Grieshaber-Bouyer","doi":"10.1038/s41587-026-03069-5","DOIUrl":"10.1038/s41587-026-03069-5","url":null,"abstract":"Deep B cell depletion is delivering transformative clinical results in autoimmune diseases. Dealmakers are wagering on the best tools for the job.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"44 4","pages":"503-509"},"PeriodicalIF":41.7,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147383302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Re-evaluating the site-directed nuclease classification as a regulatory trigger for genome-edited plant products. 重新评估位点导向核酸酶分类作为基因组编辑植物产品的调控触发器。
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2026-03-05 DOI: 10.1038/s41587-026-03028-0
Osman Mewett,John McMurdy,Lieselot Bertho,Ana Atanassova,Naomi Stevens,Scott Huber,Maria Fedorova,Kevin Diehl,Kevin Tianmeng Zhao
{"title":"Re-evaluating the site-directed nuclease classification as a regulatory trigger for genome-edited plant products.","authors":"Osman Mewett,John McMurdy,Lieselot Bertho,Ana Atanassova,Naomi Stevens,Scott Huber,Maria Fedorova,Kevin Diehl,Kevin Tianmeng Zhao","doi":"10.1038/s41587-026-03028-0","DOIUrl":"https://doi.org/10.1038/s41587-026-03028-0","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"47 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147359220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantification and transcriptome profiling reveal abundant, dynamic and translatable dephospho-CoA-capped RNAs 定量和转录组分析揭示了丰富的、动态的和可翻译的去磷酸辅酶a帽rna
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2026-03-04 DOI: 10.1038/s41587-026-03040-4
Hao Hu, Qiyue Zhang, Xuan Ma, Hsu-Feng Chu, Han Wang, Yiwen Guo, Yuze Bai, Qianyu Wang, Zehao Li, Jiayi Zhao, Huiyuan Lin, Chenjiang You, Xing Li, Liang Tong, Xuemei Chen
{"title":"Quantification and transcriptome profiling reveal abundant, dynamic and translatable dephospho-CoA-capped RNAs","authors":"Hao Hu, Qiyue Zhang, Xuan Ma, Hsu-Feng Chu, Han Wang, Yiwen Guo, Yuze Bai, Qianyu Wang, Zehao Li, Jiayi Zhao, Huiyuan Lin, Chenjiang You, Xing Li, Liang Tong, Xuemei Chen","doi":"10.1038/s41587-026-03040-4","DOIUrl":"https://doi.org/10.1038/s41587-026-03040-4","url":null,"abstract":"Cellular metabolites have emerged as noncanonical RNA caps. Despite its early discovery as an RNA cap, the dephospho-CoA (dpCoA) cap remains largely uncharacterized because of a lack of detection technologies. Here we use biochemical and structural analysis to identify Arabidopsis NUDT11 as a specific decapping enzyme toward dpCoA-RNA. Leveraging this specificity, we develop biochemical and transcriptomic methods to quantify and profile dpCoA-RNA across the genome, revealing that dpCoA-RNAs exist across species and exhibit tissue-specific and/or condition-specific variations. In Arabidopsis, dpCoA-RNAs possess distinct transcription start sites and respond more rapidly to high light intensity as compared to 7-methylguanosine (m7G)-capped RNAs. Moreover, Arabidopsis dpCoA-RNAs can reach up to 15% of m7G-capped RNAs in abundance and are associated with translating ribosomes. We further demonstrate that an in vitro transcribed dpCoA-RNA is translated in human cells. This study uncovers a dynamic dpCoA cap that may potentially influence gene expression and establishes a toolkit for future investigations.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"1 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147346840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sharing big data for sustainable agri-food innovation 共享大数据促进可持续农业食品创新。
IF 41.7 1区 生物学
Nature biotechnology Pub Date : 2026-03-03 DOI: 10.1038/s41587-026-03052-0
Erik Alexandersson, Thies Marten Heick, Anna Chailyan, Sisse Marquina-Jongberg, Thomas de Bang, Claus Felby
{"title":"Sharing big data for sustainable agri-food innovation","authors":"Erik Alexandersson, Thies Marten Heick, Anna Chailyan, Sisse Marquina-Jongberg, Thomas de Bang, Claus Felby","doi":"10.1038/s41587-026-03052-0","DOIUrl":"10.1038/s41587-026-03052-0","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"44 4","pages":"514-517"},"PeriodicalIF":41.7,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147346458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishing a commercial solution for extremely rare genetic diseases 为极其罕见的遗传疾病建立商业解决方案。
IF 41.7 1区 生物学
Nature biotechnology Pub Date : 2026-03-02 DOI: 10.1038/s41587-026-03056-w
Stanley T. Crooke, Andrew W. Lo
{"title":"Establishing a commercial solution for extremely rare genetic diseases","authors":"Stanley T. Crooke, Andrew W. Lo","doi":"10.1038/s41587-026-03056-w","DOIUrl":"10.1038/s41587-026-03056-w","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"44 4","pages":"511-513"},"PeriodicalIF":41.7,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147329353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Considerations for the future of in vitro gametogenesis in fertility care 生育护理中体外配子体发生的未来思考。
IF 41.7 1区 生物学
Nature biotechnology Pub Date : 2026-02-26 DOI: 10.1038/s41587-026-03034-2
Hannah L. Landecker, Amander T. Clark
{"title":"Considerations for the future of in vitro gametogenesis in fertility care","authors":"Hannah L. Landecker, Amander T. Clark","doi":"10.1038/s41587-026-03034-2","DOIUrl":"10.1038/s41587-026-03034-2","url":null,"abstract":"The potential use of in vitro gametogenesis (IVG) as a reproductive technology could redefine parentage, including the possibility of bipaternal parentage, raising hopes for those who have infertility or desire reproductive autonomy. However, IVG is not yet feasible for human reproduction, and substantial hurdles must be overcome if it is to become a clinical reality. This Comment outlines the major technical limitations of IVG and argues for public engagement in shaping the future directions of IVG research.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"44 4","pages":"518-520"},"PeriodicalIF":41.7,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147308310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highly mutagenic continuous evolution in E. coli using a Φ29-based orthogonal replication system 利用Φ29-based正交复制系统在大肠杆菌中进行高度诱变的连续进化
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2026-02-24 DOI: 10.1038/s41587-025-02944-x
Fabian B. H. Rehm, Kim C. Liu, Rongzhen Tian, Jason W. Chin
{"title":"Highly mutagenic continuous evolution in E. coli using a Φ29-based orthogonal replication system","authors":"Fabian B. H. Rehm, Kim C. Liu, Rongzhen Tian, Jason W. Chin","doi":"10.1038/s41587-025-02944-x","DOIUrl":"https://doi.org/10.1038/s41587-025-02944-x","url":null,"abstract":"Organisms that permit hypermutation of target genes without off-target mutagenesis of the host genome enable the accelerated, continuous evolution of genes for new or enhanced functions. We develop and optimize an orthogonal DNA replication system in <jats:italic>Escherichia</jats:italic> <jats:italic>coli</jats:italic> that uses components from bacteriophage Φ29. The minimal system requires just two Φ29 genes to maintain the replicon and replicons can be efficiently engineered in vivo. We generate a highly mutagenic Φ29 DNA polymerase that introduces mutations at a frequency approaching 10 <jats:sup>−4</jats:sup> per base per generation (one mutation in a 1-kb gene every ten generations). Our system is stable for hundreds of generations and enables the continuous, accelerated evolution of new gene functions. We demonstrate the rapid evolution of a tetracycline resistance gene to confer resistance to tigecycline at higher levels than achieved with previously reported systems. We further evolve a 1,000-fold increase in β-lactamase activity for a third-generation cephalosporin in just 3 days.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"1 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147279660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Agentic AI and the rise of in silico team science in biomedical research 人工智能和生物医学研究中硅团队科学的兴起
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2026-02-24 DOI: 10.1038/s41587-026-03035-1
Binglan Li, Anil Kumar Saini, Jose Guadalupe Hernandez, Jason H. Moore
{"title":"Agentic AI and the rise of in silico team science in biomedical research","authors":"Binglan Li, Anil Kumar Saini, Jose Guadalupe Hernandez, Jason H. Moore","doi":"10.1038/s41587-026-03035-1","DOIUrl":"https://doi.org/10.1038/s41587-026-03035-1","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"346 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147279663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transposable elements in the dark genome 暗基因组中的转座因子。
IF 41.7 1区 生物学
Nature biotechnology Pub Date : 2026-02-23 DOI: 10.1038/s41587-026-03012-8
Iris Marchal
{"title":"Transposable elements in the dark genome","authors":"Iris Marchal","doi":"10.1038/s41587-026-03012-8","DOIUrl":"10.1038/s41587-026-03012-8","url":null,"abstract":"Transposable elements (TEs), such as retrotransposons and endogenous retroviruses, are increasingly recognized for their important roles in genome function and impact on disease development. Residing mostly in the ‘dark genome’ — the part of the genome that does not encode proteins — TEs have long been difficult to study because of their repetitive nature. Recent technological advances are helping researchers overcome this issue, allowing them to identify how TEs contribute to disease development and discover novel targets for therapeutics. Despite this progress, the field still faces challenges. How can we translate this growing understanding of the dark genome into therapeutics? We asked experts in the field for their thoughts.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"44 4","pages":"525-528"},"PeriodicalIF":41.7,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR scHiCAR在复杂组织中转录组、表观基因组和3D基因组的三峰单细胞谱分析
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2026-02-19 DOI: 10.1038/s41587-026-03013-7
Xiaolin Wei, Yueyuan Xu, Dongchan Yang, Kyukwang Kim, Lizhi Yi, Wenzhe Luo, Xin Lin, Yu Xiang, Ashley B. Williams, Xiaotao Wang, Sweta Srivas, Christabel Tan, Kan Zhang, Wei Li, Yang Eric Li, Feng Yue, Z. Josh Huang, Inkyung Jung, Yarui Diao
{"title":"Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR","authors":"Xiaolin Wei, Yueyuan Xu, Dongchan Yang, Kyukwang Kim, Lizhi Yi, Wenzhe Luo, Xin Lin, Yu Xiang, Ashley B. Williams, Xiaotao Wang, Sweta Srivas, Christabel Tan, Kan Zhang, Wei Li, Yang Eric Li, Feng Yue, Z. Josh Huang, Inkyung Jung, Yarui Diao","doi":"10.1038/s41587-026-03013-7","DOIUrl":"https://doi.org/10.1038/s41587-026-03013-7","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"1 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146223031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书