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Framework for predicting alloreactivity in hematopoietic cell transplants 预测造血细胞移植异体反应的框架
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2024-08-21 DOI: 10.1038/s41587-024-02354-5
{"title":"Framework for predicting alloreactivity in hematopoietic cell transplants","authors":"","doi":"10.1038/s41587-024-02354-5","DOIUrl":"https://doi.org/10.1038/s41587-024-02354-5","url":null,"abstract":"The therapeutic principle of allogeneic hematopoietic cell transplantation, one the most common forms of cancer immunotherapy, is alloreactivity, yet its molecular determinants remain largely unknown. An analytical framework now enables personalized assessment of alloreactivity from whole-exome sequencing of donor–recipient pairs, to help with prognostication of disease relapse and immune-mediated complications.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":null,"pages":null},"PeriodicalIF":46.9,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142013812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small molecules self-organized in an orderly manner to enhance Raman signals 小分子有序自组织，增强拉曼信号
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2024-08-21 DOI: 10.1038/s41587-024-02350-9
{"title":"Small molecules self-organized in an orderly manner to enhance Raman signals","authors":"","doi":"10.1038/s41587-024-02350-9","DOIUrl":"https://doi.org/10.1038/s41587-024-02350-9","url":null,"abstract":"We have discovered an effect, termed stacking-induced intermolecular charge transfer-enhanced Raman scattering (SICTERS), that enhances the Raman signal intensities of small molecules by relying on their self-stacking rather than external substrates. This effect enables the design of substrate-free small-molecule probes for high-resolution, non-invasive transdermal Raman imaging of lymphatic drainage and microvessels.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":null,"pages":null},"PeriodicalIF":46.9,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142013852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-stacked small molecules for ultrasensitive, substrate-free Raman imaging in vivo 用于体内超灵敏、无基底拉曼成像的自堆积小分子
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2024-08-21 DOI: 10.1038/s41587-024-02342-9
Shuai Gao, Yongming Zhang, Kai Cui, Sihang Zhang, Yuanyuan Qiu, Yunhui Liao, Haoze Wang, Sheng Yu, Liyang Ma, Hongzhuan Chen, Minbiao Ji, Xiaohong Fang, Wei Lu, Zeyu Xiao
{"title":"Self-stacked small molecules for ultrasensitive, substrate-free Raman imaging in vivo","authors":"Shuai Gao, Yongming Zhang, Kai Cui, Sihang Zhang, Yuanyuan Qiu, Yunhui Liao, Haoze Wang, Sheng Yu, Liyang Ma, Hongzhuan Chen, Minbiao Ji, Xiaohong Fang, Wei Lu, Zeyu Xiao","doi":"10.1038/s41587-024-02342-9","DOIUrl":"https://doi.org/10.1038/s41587-024-02342-9","url":null,"abstract":"<p>Raman spectroscopy using surface-enhanced Raman scattering (SERS) nanoprobes represents an ultrasensitive and high-precision technique for in vivo imaging. Clinical translation of SERS nanoprobes has been hampered by biosafety concerns about the metal substrates used to enhance Raman signals. We report a set of small molecules with bis-thienyl-substituted benzobisthiadiazole structures that enhance Raman signal through self-stacking rather than external substrates. In our technique, called stacking-induced charge transfer-enhanced Raman scattering (SICTERS), the self-stacked small molecules form an ordered spatial arrangement that enables three-dimensional charge transfer between neighboring molecules. The Raman scattering cross-section of SICTERS nanoprobes is 1350 times higher than that of conventional SERS gold nanoprobes of similar particle size. SICTERS outperforms SERS in terms of in vivo imaging sensitivity, resolution and depth. SICTERS is capable of noninvasive Raman imaging of blood and lymphatic vasculatures, which has not been achieved by SERS. SICTERS represents an alternative technique to enhance Raman scattering for guiding the design of ultrasensitive substrate-free Raman imaging probes.</p>","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":null,"pages":null},"PeriodicalIF":46.9,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142013813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic identification of minor histocompatibility antigens predicts outcomes of allogeneic hematopoietic cell transplantation 系统鉴定次要组织相容性抗原可预测异基因造血细胞移植的结果
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2024-08-21 DOI: 10.1038/s41587-024-02348-3
Nicoletta Cieri, Nidhi Hookeri, Kari Stromhaug, Liang Li, Julia Keating, Paula Díaz-Fernández, Valle Gómez-García de Soria, Jonathan Stevens, Raphael Kfuri-Rubens, Yiren Shao, Kameron A. Kooshesh, Kaila Powell, Helen Ji, Gabrielle M. Hernandez, Jennifer Abelin, Susan Klaeger, Cleo Forman, Karl R. Clauser, Siranush Sarkizova, David A. Braun, Livius Penter, Haesook T. Kim, William J. Lane, Giacomo Oliveira, Leslie S. Kean, Shuqiang Li, Kenneth J. Livak, Steven A. Carr, Derin B. Keskin, Cecilia Muñoz-Calleja, Vincent T. Ho, Jerome Ritz, Robert J. Soiffer, Donna Neuberg, Chip Stewart, Gad Getz, Catherine J. Wu
{"title":"Systematic identification of minor histocompatibility antigens predicts outcomes of allogeneic hematopoietic cell transplantation","authors":"Nicoletta Cieri, Nidhi Hookeri, Kari Stromhaug, Liang Li, Julia Keating, Paula Díaz-Fernández, Valle Gómez-García de Soria, Jonathan Stevens, Raphael Kfuri-Rubens, Yiren Shao, Kameron A. Kooshesh, Kaila Powell, Helen Ji, Gabrielle M. Hernandez, Jennifer Abelin, Susan Klaeger, Cleo Forman, Karl R. Clauser, Siranush Sarkizova, David A. Braun, Livius Penter, Haesook T. Kim, William J. Lane, Giacomo Oliveira, Leslie S. Kean, Shuqiang Li, Kenneth J. Livak, Steven A. Carr, Derin B. Keskin, Cecilia Muñoz-Calleja, Vincent T. Ho, Jerome Ritz, Robert J. Soiffer, Donna Neuberg, Chip Stewart, Gad Getz, Catherine J. Wu","doi":"10.1038/s41587-024-02348-3","DOIUrl":"https://doi.org/10.1038/s41587-024-02348-3","url":null,"abstract":"<p>T cell alloreactivity against minor histocompatibility antigens (mHAgs)—polymorphic peptides resulting from donor–recipient (D–R) disparity at sites of genetic polymorphisms—is at the core of the therapeutic effect of allogeneic hematopoietic cell transplantation (allo-HCT). Despite the crucial role of mHAgs in graft-versus-leukemia (GvL) and graft-versus-host disease (GvHD) reactions, it remains challenging to consistently link patient-specific mHAg repertoires to clinical outcomes. Here we devise an analytic framework to systematically identify mHAgs, including their detection on HLA class I ligandomes and functional verification of their immunogenicity. The method relies on the integration of polymorphism detection by whole-exome sequencing of germline DNA from D–R pairs with organ-specific transcriptional- and proteome-level expression. Application of this pipeline to 220 HLA-matched allo-HCT D–R pairs demonstrated that total and organ-specific mHAg load could independently predict the occurrence of acute GvHD and chronic pulmonary GvHD, respectively, and defined promising GvL targets, confirmed in a validation cohort of 58 D–R pairs, for the prevention or treatment of post-transplant disease recurrence.</p>","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":null,"pages":null},"PeriodicalIF":46.9,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142013814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editor’s pick: Cargo Therapeutics 编辑推荐Cargo Therapeutics
IF 33.1 1区 生物学
Nature biotechnology Pub Date : 2024-08-19 DOI: 10.1038/s41587-024-02358-1
Ken Garber
{"title":"Editor’s pick: Cargo Therapeutics","authors":"Ken Garber","doi":"10.1038/s41587-024-02358-1","DOIUrl":"10.1038/s41587-024-02358-1","url":null,"abstract":"Each year, Nature Biotechnology highlights companies that have received sizeable early-stage funding in the previous year. A rescued chimeric antigen receptor from Cargo Therapeutics for hard-to-treat lymphomas shows promise in patients while a trispecific advances toward human testing.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":null,"pages":null},"PeriodicalIF":33.1,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41587-024-02358-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142002742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biotech news from around the world 来自世界各地的生物技术新闻。
IF 33.1 1区 生物学
Nature biotechnology Pub Date : 2024-08-14 DOI: 10.1038/s41587-024-02362-5
{"title":"Biotech news from around the world","authors":"","doi":"10.1038/s41587-024-02362-5","DOIUrl":"10.1038/s41587-024-02362-5","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":null,"pages":null},"PeriodicalIF":33.1,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving the predictive power of mouse models 提高小鼠模型的预测能力。
IF 33.1 1区 生物学
Nature biotechnology Pub Date : 2024-08-14 DOI: 10.1038/s41587-024-02349-2
Martin Pera, Andy Greene, Lon Cardon, Gregory W. Carter, Elissa J. Chesler, Gary Churchill, Vivek Kumar, Cathleen Lutz, Steven Munger, Steve Murray, Kristen O’Connell, Laura Reinholdt, Nadia A. Rosenthal
{"title":"Improving the predictive power of mouse models","authors":"Martin Pera,&nbsp;Andy Greene,&nbsp;Lon Cardon,&nbsp;Gregory W. Carter,&nbsp;Elissa J. Chesler,&nbsp;Gary Churchill,&nbsp;Vivek Kumar,&nbsp;Cathleen Lutz,&nbsp;Steven Munger,&nbsp;Steve Murray,&nbsp;Kristen O’Connell,&nbsp;Laura Reinholdt,&nbsp;Nadia A. Rosenthal","doi":"10.1038/s41587-024-02349-2","DOIUrl":"10.1038/s41587-024-02349-2","url":null,"abstract":"Comparative studies that integrate genetically diverse mouse models and in vitro cell-based assays will accelerate drug discovery for precision medicine.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":null,"pages":null},"PeriodicalIF":33.1,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spanish tortillas go vegan 西班牙玉米饼素食化
IF 33.1 1区 生物学
Nature biotechnology Pub Date : 2024-08-14 DOI: 10.1038/s41587-024-02366-1
Monica Hoyos Flight
{"title":"Spanish tortillas go vegan","authors":"Monica Hoyos Flight","doi":"10.1038/s41587-024-02366-1","DOIUrl":"10.1038/s41587-024-02366-1","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":null,"pages":null},"PeriodicalIF":33.1,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The patentability and bioethics of molecular de-extinction 分子灭绝的专利性和生物伦理学。
IF 33.1 1区 生物学
Nature biotechnology Pub Date : 2024-08-14 DOI: 10.1038/s41587-024-02332-x
Andrew W. Torrance, Cesar de la Fuente-Nunez
{"title":"The patentability and bioethics of molecular de-extinction","authors":"Andrew W. Torrance,&nbsp;Cesar de la Fuente-Nunez","doi":"10.1038/s41587-024-02332-x","DOIUrl":"10.1038/s41587-024-02332-x","url":null,"abstract":"The resurrection of strings of extinct molecules raises intriguing questions of patentability and bioethical considerations in an emerging area of patent law.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":null,"pages":null},"PeriodicalIF":33.1,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbes: next-generation fertilizers 微生物：下一代肥料。
IF 33.1 1区 生物学
Nature biotechnology Pub Date : 2024-08-14 DOI: 10.1038/s41587-024-02368-z
{"title":"Microbes: next-generation fertilizers","authors":"","doi":"10.1038/s41587-024-02368-z","DOIUrl":"10.1038/s41587-024-02368-z","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":null,"pages":null},"PeriodicalIF":33.1,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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