{"title":"People","authors":"","doi":"10.1038/s41587-025-02732-7","DOIUrl":"10.1038/s41587-025-02732-7","url":null,"abstract":"Recent moves of note in and around the biotech and pharma industries.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 7","pages":"1208-1208"},"PeriodicalIF":41.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antibiotic-resistant infections cured by calcium deposition","authors":"Volker Winstel","doi":"10.1038/s41587-025-02755-0","DOIUrl":"https://doi.org/10.1038/s41587-025-02755-0","url":null,"abstract":"A strategy for treating chronic multidrug-resistant staphylococcal infections kills bacteria by encasing them in a calcium shell.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"6 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sadik H. Kassim, Fyodor Urnov, Kiran Musunuru, Ann Lee, Luis Barrera, Pamela Stetkiewicz, Julianne Bruno, Matthew Hewitt, Troy Lister, Harry Malech, Lindsay Gasch, Matt Diver, Nicholas Gertler, Felix Grignon, Audrey Le, Michael Lehmicke, Edwin M. Horwitz, David R. Liu, Josephine Lembong, Vanessa Almendro-Navarro
{"title":"Platform solutions for commercial challenges to expanding patient access and making gene editing sustainable","authors":"Sadik H. Kassim, Fyodor Urnov, Kiran Musunuru, Ann Lee, Luis Barrera, Pamela Stetkiewicz, Julianne Bruno, Matthew Hewitt, Troy Lister, Harry Malech, Lindsay Gasch, Matt Diver, Nicholas Gertler, Felix Grignon, Audrey Le, Michael Lehmicke, Edwin M. Horwitz, David R. Liu, Josephine Lembong, Vanessa Almendro-Navarro","doi":"10.1038/s41587-025-02744-3","DOIUrl":"10.1038/s41587-025-02744-3","url":null,"abstract":"Platform-based approaches for gene-editing therapies could markedly improve development efficiency, reduce costs and increase access for patients with rare diseases. Although gene editing has shown remarkable clinical success for a small number of Mendelian disease indications, broader adoption faces substantial hurdles. We propose strategies to overcome these challenges through modular platforms for nonclinical and chemistry, manufacturing and controls (CMC) data reuse, risk-based manufacturing quality, and streamlined umbrella clinical trials for regulatory efficiency and accelerated approval.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 7","pages":"1047-1049"},"PeriodicalIF":41.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Profiling translated regions in viral genomes at scale","authors":"Iris Marchal","doi":"10.1038/s41587-025-02748-z","DOIUrl":"10.1038/s41587-025-02748-z","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 7","pages":"1054-1054"},"PeriodicalIF":41.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Feng Bao, Li Li, Heinz Hammerlindl, Susan Q. Shen, Sabrina Hammerlindl, Steven J. Altschuler, Lani F. Wu
{"title":"Transitive prediction of small-molecule function through alignment of high-content screening resources","authors":"Feng Bao, Li Li, Heinz Hammerlindl, Susan Q. Shen, Sabrina Hammerlindl, Steven J. Altschuler, Lani F. Wu","doi":"10.1038/s41587-025-02729-2","DOIUrl":"https://doi.org/10.1038/s41587-025-02729-2","url":null,"abstract":"<p>High-content image-based phenotypic screens (HCSs) provide a scalable approach to characterize biological functions of compounds. The widespread adoption of HCS has led to a growing body of available profile datasets. However, study-specific experimental and computational choices lead to profile datasets that cannot be directly combined. A critical, long-standing challenge is how to integrate these rich but currently isolated HCS dataset resources. Here we introduce a contrastive, deep-learning framework that leverages sparse sets of overlapping profiles as fiducials to align heterogeneous HCS profile datasets in a shared latent space. We demonstrate that this alignment facilitates accurate ‘transitive’ predictions, whereby the function of an uncharacterized compound screened in one dataset can be predicted through comparison with characterized compounds already profiled in other datasets. In silico alignment of HCS resources provides a path to unify fast-growing HCS resources and accelerate early drug discovery efforts.</p>","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"22 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}