发布求助
文献互助 智能选刊 最新文献

Nature biotechnology最新文献

筛选
英文 中文
Comprehensive taxonomic identification of microbial species in metagenomic data using SingleM and Sandpiper 利用SingleM和矶鹞对宏基因组数据中的微生物种类进行综合分类鉴定
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2025-07-16 DOI: 10.1038/s41587-025-02738-1
Ben J. Woodcroft, Samuel T. N. Aroney, Rossen Zhao, Mitchell Cunningham, Joshua A. M. Mitchell, Rizky Nurdiansyah, Linda Blackall, Gene W. Tyson
{"title":"Comprehensive taxonomic identification of microbial species in metagenomic data using SingleM and Sandpiper","authors":"Ben J. Woodcroft, Samuel T. N. Aroney, Rossen Zhao, Mitchell Cunningham, Joshua A. M. Mitchell, Rizky Nurdiansyah, Linda Blackall, Gene W. Tyson","doi":"10.1038/s41587-025-02738-1","DOIUrl":"https://doi.org/10.1038/s41587-025-02738-1","url":null,"abstract":"<p>Determining the taxonomy and relative abundance of microorganisms in metagenomic data remains technically challenging. Here we present ‘SingleM’, which estimates community composition using conserved regions within universal marker genes. By accurately incorporating species lacking genomic representation, we show that unknown species dominate in most environmental microbial communities. Our website ‘Sandpiper’ collates microbial community profiles from 248,559 publicly available metagenomes.</p>","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"669 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144639831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical trials gain intelligence 临床试验获得智慧
IF 41.7 1区 生物学
Nature biotechnology Pub Date : 2025-07-15 DOI: 10.1038/s41587-025-02754-1
{"title":"Clinical trials gain intelligence","authors":"","doi":"10.1038/s41587-025-02754-1","DOIUrl":"10.1038/s41587-025-02754-1","url":null,"abstract":"As governments around the world begin to embrace artificial intelligence in healthcare, clinical trials are entering a new phase — faster, smarter and more inclusive. With regulatory momentum building to adapt new technologies, artificial intelligence is no longer just a promise for the future but a powerful tool reshaping how trials are designed, conducted and analyzed today.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 7","pages":"1017-1018"},"PeriodicalIF":41.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41587-025-02754-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biotech news from around the world 来自世界各地的生物技术新闻
IF 41.7 1区 生物学
Nature biotechnology Pub Date : 2025-07-15 DOI: 10.1038/s41587-025-02749-y
{"title":"Biotech news from around the world","authors":"","doi":"10.1038/s41587-025-02749-y","DOIUrl":"10.1038/s41587-025-02749-y","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 7","pages":"1026-1026"},"PeriodicalIF":41.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new impact framework for investors in life sciences bridges financial returns and patient outcomes 为生命科学投资者提供的一个新的影响框架将财务回报与患者结果联系起来
IF 41.7 1区 生物学
Nature biotechnology Pub Date : 2025-07-15 DOI: 10.1038/s41587-025-02726-5
Philip Brainin
{"title":"A new impact framework for investors in life sciences bridges financial returns and patient outcomes","authors":"Philip Brainin","doi":"10.1038/s41587-025-02726-5","DOIUrl":"10.1038/s41587-025-02726-5","url":null,"abstract":"A new model for quantifying the impact of capital investments in life science interventions could help investors, policymakers and healthcare stakeholders to assess, monitor and optimize the societal impact of their investments.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 7","pages":"1041-1046"},"PeriodicalIF":41.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The strength and importance of government-funded patents for approved drugs 政府资助的药物专利的力量和重要性
IF 41.7 1区 生物学
Nature biotechnology Pub Date : 2025-07-15 DOI: 10.1038/s41587-025-02724-7
Sarah M. E. Gabriele, Matthew J. Martin, Aaron S. Kesselheim, S. Sean Tu
{"title":"The strength and importance of government-funded patents for approved drugs","authors":"Sarah M. E. Gabriele,&nbsp;Matthew J. Martin,&nbsp;Aaron S. Kesselheim,&nbsp;S. Sean Tu","doi":"10.1038/s41587-025-02724-7","DOIUrl":"10.1038/s41587-025-02724-7","url":null,"abstract":"Understanding the strength and importance of US government-sponsored patents can help to limit high drug prices as well as constitute a justification to enact reasonable pricing clauses and exercise march-in rights.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 7","pages":"1050-1052"},"PeriodicalIF":41.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vascular organoids recover blood flow in vivo 类血管器官在体内恢复血液流动
IF 41.7 1区 生物学
Nature biotechnology Pub Date : 2025-07-15 DOI: 10.1038/s41587-025-02747-0
Iris Marchal
{"title":"Vascular organoids recover blood flow in vivo","authors":"Iris Marchal","doi":"10.1038/s41587-025-02747-0","DOIUrl":"10.1038/s41587-025-02747-0","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 7","pages":"1054-1054"},"PeriodicalIF":41.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
De-extinction: debate continues around tech to ‘resurrect’ lost species 反灭绝：围绕技术“复活”灭绝物种的争论仍在继续
IF 41.7 1区 生物学
Nature biotechnology Pub Date : 2025-07-15 DOI: 10.1038/s41587-025-02745-2
Michael Eisenstein
{"title":"De-extinction: debate continues around tech to ‘resurrect’ lost species","authors":"Michael Eisenstein","doi":"10.1038/s41587-025-02745-2","DOIUrl":"10.1038/s41587-025-02745-2","url":null,"abstract":"Experts disagree about the extent to which hybrids based on dire wolves reflect the original extinct species, and the broader role of de-extinction technologies in ecosystem restoration.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 7","pages":"1023-1026"},"PeriodicalIF":41.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiopharmaceuticals 放射性药物
IF 41.7 1区 生物学
Nature biotechnology Pub Date : 2025-07-15 DOI: 10.1038/s41587-025-02728-3
{"title":"Radiopharmaceuticals","authors":"","doi":"10.1038/s41587-025-02728-3","DOIUrl":"10.1038/s41587-025-02728-3","url":null,"abstract":"Recent patents relating to radiopharmaceutical compositions, preparation methods and delivery systems.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 7","pages":"1053-1053"},"PeriodicalIF":41.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovation to investment: how to build your first life sciences pitch deck 从创新到投资：如何建立你的第一个生命科学推介平台
IF 41.7 1区 生物学
Nature biotechnology Pub Date : 2025-07-15 DOI: 10.1038/s41587-025-02730-9
Katherine E. Reuther, Darren Cooke, Mark Kessel
{"title":"Innovation to investment: how to build your first life sciences pitch deck","authors":"Katherine E. Reuther,&nbsp;Darren Cooke,&nbsp;Mark Kessel","doi":"10.1038/s41587-025-02730-9","DOIUrl":"10.1038/s41587-025-02730-9","url":null,"abstract":"A strong pitch deck can help make a good first impression, establish credibility and build the confidence to secure the support and financial resources needed for eventual commercial success.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 7","pages":"1204-1207"},"PeriodicalIF":41.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inducing bacterial calcification for systematic treatment and immunomodulation against methicillin-resistant Staphylococcus aureus 诱导细菌钙化对耐甲氧西林金黄色葡萄球菌的系统治疗和免疫调节
IF 46.9 1区 生物学
Nature biotechnology Pub Date : 2025-07-15 DOI: 10.1038/s41587-025-02736-3
Wanying Zhang, Liang Liu, Qingyan Zhang, Huidan Lu, Anyao Li, Yuqiao Huang, Wenting Zhang, Hanhui Li, Xiaoyan Lu, Xinliang Ming, Ze Yang, Hao Shou, Yilin Wang, Jingyan Xia, Feng Xu, Ben Wang
{"title":"Inducing bacterial calcification for systematic treatment and immunomodulation against methicillin-resistant Staphylococcus aureus","authors":"Wanying Zhang, Liang Liu, Qingyan Zhang, Huidan Lu, Anyao Li, Yuqiao Huang, Wenting Zhang, Hanhui Li, Xiaoyan Lu, Xinliang Ming, Ze Yang, Hao Shou, Yilin Wang, Jingyan Xia, Feng Xu, Ben Wang","doi":"10.1038/s41587-025-02736-3","DOIUrl":"https://doi.org/10.1038/s41587-025-02736-3","url":null,"abstract":"<p>Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) has become one of the deadliest bacteria globally due to antibiotic resistance. In this study, we crosslinked antigen-binding fragments of monoclonal antibodies against the wall-teichoic acid of <i>S. aureus</i> with polysialic acid to form an antibody‒PSA conjugate, which can effectively target and induce calcification on the surface of MRSA. This process eliminates bacteria by hindering the energy metabolism and multiple essential metabolic pathways of MRSA. We found that bacterial calcification leads to increased expression of calprotectin, S100A8/S100A9, in macrophages and monocytes in vivo and can stimulate the activation of macrophages to an inflammatory state, thereby promoting bacterial eradication as an immunomodulator. Systemic administration of the antibody‒PSA conjugate demonstrates high efficacy and safety for treating chronic lung infections and chronic osteomyelitis caused by MRSA in mice. This study offers a promising therapy for treating drug-resistant bacteria and related refractory pathogenic infections.</p>","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"45 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信