Nature Human Behaviour最新文献_第7页

Author Correction: Stable isotope evidence for pre-colonial maize agriculture and animal management in the Bolivian Amazon 作者更正：玻利维亚亚马逊地区殖民前玉米农业和动物管理的稳定同位素证据

IF 21.4 1区心理学

Nature Human Behaviour Pub Date : 2025-01-08 DOI: 10.1038/s41562-025-02101-z

Tiago Hermenegildo, Heiko Prümers, Carla Jaimes Betancourt, Patrick Roberts, Tamsin C. O’Connell

引用次数: 0

Plasma proteomic signatures of social isolation and loneliness associated with morbidity and mortality 与发病率和死亡率相关的社会隔离和孤独的血浆蛋白质组学特征

IF 21.4 1区心理学

Nature Human Behaviour Pub Date : 2025-01-03 DOI: 10.1038/s41562-024-02078-1

Chun Shen, Ruohan Zhang, Jintai Yu, Barbara J. Sahakian, Wei Cheng, Jianfeng Feng

{"title":"Plasma proteomic signatures of social isolation and loneliness associated with morbidity and mortality","authors":"Chun Shen, Ruohan Zhang, Jintai Yu, Barbara J. Sahakian, Wei Cheng, Jianfeng Feng","doi":"10.1038/s41562-024-02078-1","DOIUrl":"10.1038/s41562-024-02078-1","url":null,"abstract":"The biology underlying the connection between social relationships and health is largely unknown. Here, leveraging data from 42,062 participants across 2,920 plasma proteins in the UK Biobank, we characterized the proteomic signatures of social isolation and loneliness through proteome-wide association study and protein co-expression network analysis. Proteins linked to these constructs were implicated in inflammation, antiviral responses and complement systems. More than half of these proteins were prospectively linked to cardiovascular disease, type 2 diabetes, stroke and mortality during a 14 year follow-up. Moreover, Mendelian randomization (MR) analysis suggested causal relationships from loneliness to five proteins, with two proteins (ADM and ASGR1) further supported by colocalization. These MR-identified proteins (GFRA1, ADM, FABP4, TNFRSF10A and ASGR1) exhibited broad associations with other blood biomarkers, as well as volumes in brain regions involved in interoception and emotional and social processes. Finally, the MR-identified proteins partly mediated the relationship between loneliness and cardiovascular diseases, stroke and mortality. The exploration of the peripheral physiology through which social relationships influence morbidity and mortality is timely and has potential implications for public health. Shen et al. characterize protein signatures in the blood associated with social isolation and loneliness, demonstrating how these link social isolation and loneliness to an increased risk of disease and mortality.","PeriodicalId":19074,"journal":{"name":"Nature Human Behaviour","volume":"9 3","pages":"569-583"},"PeriodicalIF":21.4,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41562-024-02078-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene-level analysis reveals the genetic aetiology and therapeutic targets of schizophrenia 基因水平分析揭示了精神分裂症的遗传病因和治疗靶点

IF 21.4 1区心理学

Nature Human Behaviour Pub Date : 2025-01-03 DOI: 10.1038/s41562-024-02091-4

Xinglun Dang, Zhaowei Teng, Yongfeng Yang, Wenqiang Li, Jiewei Liu, Li Hui, Dongsheng Zhou, Daohua Gong, Shan-Shan Dai, Yifan Li, Xingxing Li, Luxian Lv, Yong Zeng, Yonggui Yuan, Xiancang Ma, Zhongchun Liu, Tao Li, Xiong-Jian Luo

{"title":"Gene-level analysis reveals the genetic aetiology and therapeutic targets of schizophrenia","authors":"Xinglun Dang, Zhaowei Teng, Yongfeng Yang, Wenqiang Li, Jiewei Liu, Li Hui, Dongsheng Zhou, Daohua Gong, Shan-Shan Dai, Yifan Li, Xingxing Li, Luxian Lv, Yong Zeng, Yonggui Yuan, Xiancang Ma, Zhongchun Liu, Tao Li, Xiong-Jian Luo","doi":"10.1038/s41562-024-02091-4","DOIUrl":"10.1038/s41562-024-02091-4","url":null,"abstract":"Genome-wide association studies (GWASs) have reported multiple risk loci for schizophrenia (SCZ). However, the majority of the associations were from populations of European ancestry. Here we conducted a large-scale GWAS in Eastern Asian populations (29,519 cases and 44,392 controls) and identified ten Eastern Asian-specific risk loci, two of which have not been previously reported. A further cross-ancestry GWAS meta-analysis (96,806 cases and 492,818 controls) including populations from diverse ancestries identified 61 previously unreported risk loci. Systematic variant-level analysis, including fine mapping, functional genomics and expression quantitative trait loci, prioritized potential causal variants. Gene-level analyses, including transcriptome-wide association study, proteome-wide association study and Mendelian randomization, nominated the potential causal genes. By integrating evidence from layers of different analyses, we prioritized the most plausible causal genes for SCZ, such as ACE, CNNM2, SNAP91, ABCB9 and GATAD2A. Finally, drug repurposing showed that ACE, CA14, MAPK3 and MAPT are potential therapeutic targets for SCZ. Our study not only showed the power of cross-ancestry GWAS in deciphering the genetic aetiology of SCZ, but also uncovered new genetic risk loci, potential causal variants and genes and therapeutic targets for SCZ. Luo et al. identify schizophrenia risk loci in East Asians and uncover potential causal genes and therapeutic targets through cross-ancestry GWAS, fine mapping and functional genomics, offering insights into the genetic basis of schizophrenia.","PeriodicalId":19074,"journal":{"name":"Nature Human Behaviour","volume":"9 3","pages":"609-624"},"PeriodicalIF":21.4,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distractor-specific control adaptation in multidimensional environments 多维环境中干扰物特异性控制适应

IF 21.4 1区心理学

Nature Human Behaviour Pub Date : 2025-01-03 DOI: 10.1038/s41562-024-02088-z

Davide Gheza, Wouter Kool

{"title":"Distractor-specific control adaptation in multidimensional environments","authors":"Davide Gheza, Wouter Kool","doi":"10.1038/s41562-024-02088-z","DOIUrl":"10.1038/s41562-024-02088-z","url":null,"abstract":"Goal-directed behaviour requires humans to constantly manage and switch between multiple, independent and conflicting sources of information. Conventional cognitive control tasks, however, only feature one task and one source of distraction. Therefore, it is unclear how control is allocated in multidimensional environments. To address this question, we developed a multidimensional task-set interference paradigm, in which people need to manage distraction from three independent dimensions. We use this task to test whether people adapt to previous conflict by enhancing task-relevant information or suppressing task-irrelevant information. Three experiments provided strong evidence for the latter hypothesis. Moreover, control adaptation was highly dimension specific. Conflict from a given dimension only affected processing of that same dimension on subsequent trials, with no evidence for generalization. A new neural network model shows that our results can only be simulated when including multiple independent conflict-detector units. Our results call for an update to classic models of cognitive control and their neurocomputational underpinnings. Gheza and Kool show that, in multidimensional environments, people allocate attention to individual distractors on the basis of their interference with the current task. They develop a neural model that supports these findings and suggest that cognitive control theories need to be revised.","PeriodicalId":19074,"journal":{"name":"Nature Human Behaviour","volume":"9 3","pages":"534-553"},"PeriodicalIF":21.4,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lack of diffusion of popular scientific ideas marks the presence of epistemic ‘bubbles’ 缺乏流行科学思想的传播标志着认知“泡沫”的存在。

IF 21.4 1区心理学

Nature Human Behaviour Pub Date : 2025-01-02 DOI: 10.1038/s41562-024-02042-z

引用次数: 0

Alcohol consumption-related signals identified by multiomics Mendelian randomization 多组学孟德尔随机化识别的酒精消费相关信号

IF 21.4 1区心理学

Nature Human Behaviour Pub Date : 2025-01-02 DOI: 10.1038/s41562-024-02058-5

引用次数: 0

Introducing calorie labels in restaurants in England did not change customer behaviour 在英国的餐馆里引入卡路里标签并没有改变顾客的行为

IF 21.4 1区心理学

Nature Human Behaviour Pub Date : 2025-01-02 DOI: 10.1038/s41562-024-02069-2

引用次数: 0

The US media should rethink coverage of firearm violence 美国媒体应该重新考虑对枪支暴力的报道

IF 21.4 1区心理学

Nature Human Behaviour Pub Date : 2025-01-02 DOI: 10.1038/s41562-024-02095-0

Michelle Degli Esposti, Zainab Hans, Elyse Thulin, Esther L. Hibbs, Rebeccah L. Sokol

引用次数: 0

Polygenic prediction of occupational status GWAS elucidates genetic and environmental interplay in intergenerational transmission, careers and health in UK Biobank GWAS阐明了遗传和环境在代际传递、职业和健康方面的相互作用

IF 21.4 1区心理学

Nature Human Behaviour Pub Date : 2024-12-23 DOI: 10.1038/s41562-024-02076-3

Evelina T. Akimova, Tobias Wolfram, Xuejie Ding, Felix C. Tropf, Melinda C. Mills

{"title":"Polygenic prediction of occupational status GWAS elucidates genetic and environmental interplay in intergenerational transmission, careers and health in UK Biobank","authors":"Evelina T. Akimova, Tobias Wolfram, Xuejie Ding, Felix C. Tropf, Melinda C. Mills","doi":"10.1038/s41562-024-02076-3","DOIUrl":"10.1038/s41562-024-02076-3","url":null,"abstract":"Socioeconomic status (SES) impacts health and life-course outcomes. This genome-wide association study (GWAS) of sociologically informed occupational status measures (ISEI, SIOPS, CAMSIS) using the UK Biobank (N = 273,157) identified 106 independent single-nucleotide polymorphisms of which 8 are novel to the study of SES. Genetic correlations with educational attainment (rg = 0.96–0.97) and income (rg = 0.81–0.91) point to a common genetic factor for SES. We observed a 54–57% reduction in within-family predictions compared with population-based predictions, attributed to indirect parental effects (22–27% attenuation) and assortative mating (21–27%) following our calculations. Using polygenic scores from population predictions of 5–10% (incremental R2 = 0.023–0.097 across different approaches and occupational status measures), we showed that (1) cognitive and non-cognitive traits, including scholastic and occupational motivation and aspiration, link polygenic scores to occupational status and (2) 62% of the intergenerational transmission of occupational status cannot be ascribed to genetic inheritance of common variants but other factors such as family environments. Finally, links between genetics, occupation, career trajectory and health are interrelated with parental occupational status. This genome-wide association study of occupational status in UK Biobank identified 106 genetic variants. Results highlight the role of family environment, childhood educational and occupational aspirations, and links to health.","PeriodicalId":19074,"journal":{"name":"Nature Human Behaviour","volume":"9 2","pages":"391-405"},"PeriodicalIF":21.4,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41562-024-02076-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142874432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behaviour-based dependency networks between places shape urban economic resilience 地方之间基于行为的依赖网络塑造了城市的经济弹性

IF 21.4 1区心理学

Nature Human Behaviour Pub Date : 2024-12-23 DOI: 10.1038/s41562-024-02072-7

Takahiro Yabe, Bernardo García Bulle Bueno, Morgan R. Frank, Alex Pentland, Esteban Moro

{"title":"Behaviour-based dependency networks between places shape urban economic resilience","authors":"Takahiro Yabe, Bernardo García Bulle Bueno, Morgan R. Frank, Alex Pentland, Esteban Moro","doi":"10.1038/s41562-024-02072-7","DOIUrl":"10.1038/s41562-024-02072-7","url":null,"abstract":"Disruptions, such as closures of businesses during pandemics, not only affect businesses and amenities directly but also influence how people move, spreading the impact to other businesses and increasing the overall economic shock. However, it is unclear how much businesses depend on each other during disruptions. Leveraging human mobility data and same-day visits in five US cities, we quantify dependencies between points of interest encompassing businesses, stores and amenities. We find that dependency networks computed from human mobility exhibit significantly higher rates of long-distance connections and biases towards specific pairs of point-of-interest categories. We show that using behaviour-based dependency relationships improves the predictability of business resilience during shocks by around 40% compared with distance-based models, and that neglecting behaviour-based dependencies can lead to underestimation of the spatial cascades of disruptions. Our findings underscore the importance of measuring complex relationships in patterns of human mobility to foster urban economic resilience to shocks. Yabe and colleagues use human mobility data to identify dependencies in visitation patterns between places in cities, with unexpected prevalence at long-distance connections. Leveraging this network enhances the accuracy of predicting business resilience during shocks.","PeriodicalId":19074,"journal":{"name":"Nature Human Behaviour","volume":"9 3","pages":"496-506"},"PeriodicalIF":21.4,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41562-024-02072-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142874429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0