Mycotoxin Research最新文献_第5页

Development of a rapid method for determination of Ochratoxin A in grape mash and wine. 开发测定葡萄泥和葡萄酒中赭曲霉毒素 A 的快速方法。

IF 2.6 4区医学

Mycotoxin Research Pub Date : 2024-11-01 Epub Date: 2024-07-21 DOI: 10.1007/s12550-024-00543-4

Efanova Yulia, Pour Nikfardjam Martin

引用次数: 0

Factors influencing fumonisin B₁ contamination in maize: insights from two production regions in Costa Rica. 影响玉米中伏马菌素 B1 污染的因素：哥斯达黎加两个产区的启示。

IF 2.6 4区医学

Mycotoxin Research Pub Date : 2024-11-01 Epub Date: 2024-08-17 DOI: 10.1007/s12550-024-00551-4

Katherine Sánchez-Zúñiga, William Rivera-Méndez, Stefany Campos-Boza, Emanuel Araya-Valverde, Frank Solano-Campos, Maria Vinas

{"title":"Factors influencing fumonisin B1 contamination in maize: insights from two production regions in Costa Rica.","authors":"Katherine Sánchez-Zúñiga, William Rivera-Méndez, Stefany Campos-Boza, Emanuel Araya-Valverde, Frank Solano-Campos, Maria Vinas","doi":"10.1007/s12550-024-00551-4","DOIUrl":"10.1007/s12550-024-00551-4","url":null,"abstract":"Maize (Zea mays L.) is an important cereal crop worldwide. Contaminated maize kernels pose a significant mycotoxin exposure risk for humans in Latin America. Fumonisins, the most prevalent mycotoxin in maize, typically occur during pre-harvest conditions leading to significant economic losses. Various factors, including weather conditions, may influence this contamination. This study aimed to determine the association between fumonisin B1 (FB1) contamination, prevalence of Fusarium verticillioides, weather conditions and kernel quality in the two primary maize production areas in Costa Rica (Brunca and Chorotega). All maize samples (100%) showed FB1 contamination, with higher concentrations in samples from Brunca region, consistent with the presence of F. verticilliodes. Weather conditions appeared to play an important role in this contamination, since Brunca region had the highest mean temperature and relative humidity after maize silking (R1) and the total monthly rainfall in this region was significantly higher during the last two months of maize cultivation (grain-filling and physiological maturity stages R3 to R6). Interestingly, this study found a negative correlation between grain damage and kernel contamination with FB1 and F. verticillioides. The concentration of mineral nutrients in kernels from both regions was largely similar. Most nutrients in kernels exhibited a negative correlation with FB1, particularly nitrogen. Zinc and phosphorus were the only nutrients in kernels showing a positive correlation with FB1 in samples from the Brunca region. The results highlight elevated levels of FB1 contamination in maize and contribute to a better understanding of pre-harvest factors influencing FB1 contamination in tropical conditions.","PeriodicalId":19060,"journal":{"name":"Mycotoxin Research","volume":" ","pages":"641-649"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ochratoxin a levels in Turkish coffee: a probabilistic health risk assessment via Monte Carlo simulation. 土耳其咖啡中的赭曲霉毒素 a 含量：通过蒙特卡罗模拟进行概率健康风险评估。

IF 2.6 4区医学

Mycotoxin Research Pub Date : 2024-11-01 Epub Date: 2024-08-20 DOI: 10.1007/s12550-024-00552-3

Sumeyra Sevim, Arife Macit, Mevlude Kizil

{"title":"Ochratoxin a levels in Turkish coffee: a probabilistic health risk assessment via Monte Carlo simulation.","authors":"Sumeyra Sevim, Arife Macit, Mevlude Kizil","doi":"10.1007/s12550-024-00552-3","DOIUrl":"10.1007/s12550-024-00552-3","url":null,"abstract":"Throughout history, Turkish coffee has been the most widely consumed type of coffee in Turkey. Therefore, the goal of this study was to determine the amount of ochratoxin A (OTA) present in Turkish coffee and to analyze any potential health hazards. A total of 41 Turkish coffees were collected and analyzed for OTA activity using a competitive enzyme immunoassay (ELISA). Furthermore, dietary exposure and health risk assessments for the Turkish population were calculated based on analytical results and coffee consumption data from the Turkish Nutrition and Health Survey 2019 (TNHS-2019) in three age categories (15-18, 19-64, and 65 + years). Nine of the samples contained more than 2.5 μg/kg OTA, with an average of 5.24 μg/kg. The OTA concentration in 3 samples exceeded the permissible maximum limit (5 μg/kg) established by Turkish legislation, and the mean concentration was 8.41 μg/kg. A margin of exposure (MOE) approach was used for risk characterization, considering both non-neoplastic and neoplastic consequences. There were no concerns about health risks because MOEs were more than 10,000 for all categories. Although the levels of OTA analyzed in Turkish coffee did not pose a risk to individuals in the three age categories, emphasis should be placed on minimizing and controlling OTA concentrations in Turkish coffee. Additionally, it is also necessary to consider other food sources that could contribute to OTA exposure.","PeriodicalId":19060,"journal":{"name":"Mycotoxin Research","volume":" ","pages":"651-658"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress on inhibitors and inhibitory mechanisms of mycotoxin biosynthesis. 霉菌毒素生物合成抑制剂和抑制机制的研究进展。

IF 2.6 4区医学

Mycotoxin Research Pub Date : 2024-11-01 Epub Date: 2024-08-21 DOI: 10.1007/s12550-024-00553-2

Mengjie Li, Honghua Li

引用次数: 0

Identification of mycotoxins in yogurt samples using an optimized QuEChERS extraction and UHPLC-MS/MS detection. 利用优化的 QuEChERS 萃取和超高效液相色谱-质谱/质谱检测技术鉴定酸奶样品中的霉菌毒素。

IF 2.6 4区医学

Mycotoxin Research Pub Date : 2024-11-01 Epub Date: 2024-07-17 DOI: 10.1007/s12550-024-00547-0

Inés Rodríguez-Cañás, Jesús M González-Jartín, Rebeca Alvariño, Amparo Alfonso, Mercedes R Vieytes, Luis M Botana

{"title":"Identification of mycotoxins in yogurt samples using an optimized QuEChERS extraction and UHPLC-MS/MS detection.","authors":"Inés Rodríguez-Cañás, Jesús M González-Jartín, Rebeca Alvariño, Amparo Alfonso, Mercedes R Vieytes, Luis M Botana","doi":"10.1007/s12550-024-00547-0","DOIUrl":"10.1007/s12550-024-00547-0","url":null,"abstract":"Yogurt, a milk-derived product, is susceptible to mycotoxin contamination. While various methods have been developed for the analysis of dairy products, only a few have been specifically validated for yogurt. In addition, these methods are primarily focus on detecting aflatoxins and zearalenone. This study aimed to conduct a preliminary investigation into the presence of regulated, emerging, and modified mycotoxins in natural and oat yogurts available in the Spanish market. For this, a QuEChERS-based extraction method was optimized and then validated to detect and quantify 32 mycotoxins using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The method was in-house validated for the analysis of natural and oat yogurt in terms of linearity, matrix effect, sensitivity, accuracy, and precision. Satisfactory performance characteristics were achieved; for most of the analytes, LOQs were lower than 2 ng/g, and recoveries ranged from 60 to 110% with a precision, expressed as the relative standard deviation of the recovery, lower than 15%. Subsequently, the validated method was applied to analyze commercial yogurt samples, revealing a notable incidence of beauvericin and enniatins, with some analogues found in up to 100% of the samples. Alternariol methyl ether was also frequently found, appearing in 50% of the samples. Additionally, the study identified regulated toxins such as fumonisins, ochratoxin A , and HT-2 toxin. These results provide new incidence data in yogurt, raising concerns about potential health risks for consumers.","PeriodicalId":19060,"journal":{"name":"Mycotoxin Research","volume":" ","pages":"569-579"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aflatoxin B1-associated oxidative stress along with toxicopathological and immunological alterations is efficiently counteracted by dietary supplementation of distillery yeast sludge in broilers. 在肉鸡日粮中添加酒厂酵母污泥可有效抵消黄曲霉毒素 B1 导致的氧化应激以及毒性病理和免疫学改变。

IF 2.6 4区医学

Mycotoxin Research Pub Date : 2024-11-01 Epub Date: 2024-07-29 DOI: 10.1007/s12550-024-00549-y

Aisha Khatoon, Muhammad Zargham Khan, Zain Ul Abidin, Muhammad Kashif Saleemi, Halis Oguz, Shafia Tehseen Gul, Rao Zahid Abbas, Ashiq Ali, Sheraz Ahmad Bhatti

{"title":"Aflatoxin B1-associated oxidative stress along with toxicopathological and immunological alterations is efficiently counteracted by dietary supplementation of distillery yeast sludge in broilers.","authors":"Aisha Khatoon, Muhammad Zargham Khan, Zain Ul Abidin, Muhammad Kashif Saleemi, Halis Oguz, Shafia Tehseen Gul, Rao Zahid Abbas, Ashiq Ali, Sheraz Ahmad Bhatti","doi":"10.1007/s12550-024-00549-y","DOIUrl":"10.1007/s12550-024-00549-y","url":null,"abstract":"Aflatoxin B1 (AFB1) is among the most potent genotoxic and carcinogenic mycotoxins and is a major source of distress for the growing poultry sector. On the other hand, distillery yeast sludge or distillery sludge (DS) is a byproduct of molasses-based industries. It is often treated as a waste despite containing abundant nutrients particularly protein, basic amino acids, and vitamins along with other macro and micronutrients. This study was designed to investigate the oxidative stress and immunological alterations induced by AFB1 and their amelioration by dietary supplementation with DS. For this purpose, 360 newly hatched broiler chicks were randomly divided into twelve groups (30 birds each) and fed different combinations of AFB1 (100, 200, or 600 µg/kg) and DS (5 or 10 g/kg) for 42 days. The parameters under consideration were body weight, feed conversion ratio (FCR), relative organ weights, histopathological examination of different visceral organs, total antioxidant capacity, antibody response to intravenous injection of sheep red blood cells, in situ lymphoproliferative response to phytohemagglutinin-P, and phagocytic potential through a carbon clearance assay system. The results of this study established that DS supplementation ameliorated AFB1-associated oxidative stress and ameliorated toxicopathological and immunological anomalies in groups given AFB1 at 100 µg/kg and 200 µg/kg; however, little to no relief was observed in birds fed AFB1 at 600 µg/kg. The determination of the actual ratio of the AFB1 to the DS for substantiating the ameliorating effects requires further investigation.","PeriodicalId":19060,"journal":{"name":"Mycotoxin Research","volume":" ","pages":"615-629"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reactions of citrinin with amino compounds modelling thermal food processing 食品热加工模型中柠檬素与氨基化合物的反应

IF 3 4区医学

Mycotoxin Research Pub Date : 2024-09-19 DOI: 10.1007/s12550-024-00557-y

Lea Brückner, Benedikt Cramer, Hans-Ulrich Humpf

引用次数: 0

First evidence on the occurrence of multi-mycotoxins and dietary risk exposure to AFB1 along the cassava value chain in Uganda 关于乌干达木薯价值链中出现多种霉菌毒素和膳食中暴露于 AFB1 风险的初步证据

IF 3 4区医学

Mycotoxin Research Pub Date : 2024-09-17 DOI: 10.1007/s12550-024-00556-z

Elias Oyesigye, Carla Cervini, Abimbola Oluwakayode, George Mahuku, Angel Medina

{"title":"First evidence on the occurrence of multi-mycotoxins and dietary risk exposure to AFB1 along the cassava value chain in Uganda","authors":"Elias Oyesigye, Carla Cervini, Abimbola Oluwakayode, George Mahuku, Angel Medina","doi":"10.1007/s12550-024-00556-z","DOIUrl":"https://doi.org/10.1007/s12550-024-00556-z","url":null,"abstract":"This study investigated the occurrence and distribution of multiple mycotoxins (aflatoxin B1, B2, G1, G2, fumonisins B1, B2, ochratoxin A (OTA), deoxynivalenol (DON), zearalenone (ZEN), and citrinin (CIT)) in cassava products and as assessed the potential risk of aflatoxin B1 (AFB1) exposure among cassava consumers. A total of 192 samples of cassava products (96 flour and 96 chips, each with 48 samples from farmer and 48 from wholesaler) were analysed using LC/MS–MS. All positive samples irrespective of their origin (flour or chips) exhibited AFB1 levels exceeding the EU regulatory threshold of 5 µg/kg. The sum of fumonisins (FB1 + FB2), ZEN, and DON were significantly (P < 0.05) higher in cassava flour (14.3 µg/kg; 3.71 µg/kg; 25.1 µg/kg) compared to chips (6.54 µg/kg; 1.25 µg/kg; 0.25 µg/kg), respectively. Aflatoxins G2 was not detected in any of 192 samples. Cassava flour samples from farmers exhibited significantly (P < 0.05) higher mean concentrations of AFB1 (27.1 µg/kg), total aflatoxins (78.2 µg/kg), and ochratoxin A (79.6 µg/kg) in contrast to wholesalers, whose mean levels were notably lower at 8.91, 5.79 µg/kg, and 2.44 µg/kg, respectively, pointing the likely critical source of mycotoxin contamination. Cassava consumers in Northern Uganda are at a higher risk, with an estimated 2.06 cancer cases per 100,000 individuals per year compared to those in Eastern Uganda at 0.25. This study underscores the urgent need for interventions to manage aflatoxins in cassava flour, particularly at farm level in Northern Uganda. It accentuates a shift market to household-level sampling and the need for analytical methods targeting multiple mycotoxins.","PeriodicalId":19060,"journal":{"name":"Mycotoxin Research","volume":"32 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142262214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-tumor activity of beauvericin: focus on intracellular signaling pathways 蒲公英的抗肿瘤活性：关注细胞内信号通路

IF 3 4区医学

Mycotoxin Research Pub Date : 2024-09-17 DOI: 10.1007/s12550-024-00561-2

Ruoxuan Liu, Jie Ouyang, Liming Li

{"title":"Anti-tumor activity of beauvericin: focus on intracellular signaling pathways","authors":"Ruoxuan Liu, Jie Ouyang, Liming Li","doi":"10.1007/s12550-024-00561-2","DOIUrl":"https://doi.org/10.1007/s12550-024-00561-2","url":null,"abstract":"Beauvericin, a Fusarium mycotoxin commonly found in feeds, particularly cereals worldwide, exhibits a wide array of biofunction. It exhibits anticancer characteristics in addition to its antiviral, antifungal and antibacterial capabilities against gram-positive and gram-negative microorganisms. The mechanism underlying most of beauvericin’s properties lies in its ionophoric activity. By facilitating calcium (Ca2+) flow from the extracellular space as well as its release from intracellular reservoirs, beauvericin increases intracellular free Ca2+. This elevation in Ca2+ levels leads to detrimental effects on mitochondria and oxidative stress, ultimately resulting in apoptosis and cell death. Studies on various cancer cell lines have shown that beauvericin induces apoptosis upon exposure. Moreover, besides its cytotoxic effects, beauvericin also inhibits cancer growth and progression by exerting anti-angiogenic and anti-migratory effects on cancer cells. Additionally, beauvericin possesses immunomodulatory properties, albeit less explored. Recent research indicates its potential to enhance the maturation and activation of dendritic cells (DCs) and T cells, both directly through its interaction with Toll-like receptor 4 (TLR4) and indirectly by increasing intracellular Ca2+ levels. Hence, beauvericin could serve as an adjuvant in chemoimmunotherapy regimens to enhance treatment outcomes. Given these diverse properties, beauvericin emerges as an intriguing candidate for developing effective cancer treatments. This review explores the cellular signaling pathways involved in its anticancer effects.","PeriodicalId":19060,"journal":{"name":"Mycotoxin Research","volume":"5 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142262215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mycotoxin management: exploring natural solutions for mycotoxin prevention and detoxification in food and feed 霉菌毒素管理：探索食品和饲料中霉菌毒素预防和解毒的天然解决方案

IF 3 4区医学

Mycotoxin Research Pub Date : 2024-09-14 DOI: 10.1007/s12550-024-00562-1

Epole Ngolle Ntungwe, Angéle N. Tchana, Wilfred Angie Abia

{"title":"Mycotoxin management: exploring natural solutions for mycotoxin prevention and detoxification in food and feed","authors":"Epole Ngolle Ntungwe, Angéle N. Tchana, Wilfred Angie Abia","doi":"10.1007/s12550-024-00562-1","DOIUrl":"https://doi.org/10.1007/s12550-024-00562-1","url":null,"abstract":"Mycotoxins, secondary metabolites produced by various fungi, pose a significant threat to food and feed safety worldwide due to their toxic effects on human and animal health. Traditional methods of mycotoxin management often involve chemical treatments, which may raise concerns about residual toxicity and environmental impact. In recent years, there has been growing interest in exploring natural alternatives for preventing mycotoxin contamination and detoxification. This review provides an overview of the current research on the use of natural products for mitigating mycotoxin risks in food and feed. It encompasses a wide range of natural sources, including plant-derived compounds, microbial agents, and enzymatic control. The mechanisms underlying the efficacy of these natural products in inhibiting mycotoxin synthesis, adsorbing mycotoxins, or enhancing detoxification processes are discussed. Challenges and future directions in the development and application of natural products for mycotoxin management are also addressed. Overall, this review highlights the promising role of natural products as sustainable and eco-friendly alternatives for combating mycotoxin contamination in the food and feed supply chain.","PeriodicalId":19060,"journal":{"name":"Mycotoxin Research","volume":"40 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142262042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0