Molecules最新文献_第8页

Natural Flavonoids from Licorice as Potent Inhibitors of β-Glucuronidase Elucidated Through Computational Studies.

IF 4.2 2区化学

Molecules Pub Date : 2025-03-15 DOI: 10.3390/molecules30061324

Jingli Liu, Yingying Xue, Hao Yan, Jing Zhou, Xu Long, Yuping Tang

{"title":"Natural Flavonoids from Licorice as Potent Inhibitors of β-Glucuronidase Elucidated Through Computational Studies.","authors":"Jingli Liu, Yingying Xue, Hao Yan, Jing Zhou, Xu Long, Yuping Tang","doi":"10.3390/molecules30061324","DOIUrl":"10.3390/molecules30061324","url":null,"abstract":"Gut bacterial β-glucuronidase is an important molecular target in several therapeutic applications. β-glucuronidase inhibitors can effectively alleviate gastrointestinal toxicity caused by certain drugs. Licorice, a traditional Chinese medicine, harmonizes various herbs and mitigates the toxicity of hundreds of herbs. In this study, a comprehensive computational strategy was employed to evaluate four licorice flavonoids (liquiritigenin, isoliquiritigenin, liquiritin, and isoliquiritin) as potential Escherichia coli β-glucuronidase (EcGUS) inhibitors. Density functional theory was used to determine their geometries, thermal parameters, dipole moments, polarizabilities, and molecular electrostatic potentials. The inhibitory mechanisms of these four flavonoids on EcGUS were investigated using molecular docking, molecular dynamics simulations, and free energy calculations. The results show that all four flavonoids stably bind to EcGUS. Moreover, all molecules, except liquiritigenin, are potent and selective inhibitors of EcGUS. Further calculations suggest that isoliquiritin exhibits the strongest binding affinity for EcGUS among the four licorice flavonoids. Thus, isoliquiritin is a promising candidate for the development of EcGUS inhibitors. These findings will aid in designing and developing novel flavonoid-based inhibitors of EcGUS to alleviate gastrointestinal toxicity caused by drugs.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11945163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extraction of Cannabinoids and Terpenes from Hemp Flowers and Leaves (Cannabis sativa L., Futura 75): Chemical Profiling and Evaluation of Anticancer Properties.

IF 4.2 2区化学

Molecules Pub Date : 2025-03-15 DOI: 10.3390/molecules30061325

Monika Haczkiewicz, Marta Świtalska, Jacek Łyczko, Magdalena Pluta, Joanna Wietrzyk, Anna Gliszczyńska

{"title":"Extraction of Cannabinoids and Terpenes from Hemp Flowers and Leaves (Cannabis sativa L., Futura 75): Chemical Profiling and Evaluation of Anticancer Properties.","authors":"Monika Haczkiewicz, Marta Świtalska, Jacek Łyczko, Magdalena Pluta, Joanna Wietrzyk, Anna Gliszczyńska","doi":"10.3390/molecules30061325","DOIUrl":"10.3390/molecules30061325","url":null,"abstract":"This study investigated efficient extraction methods for cannabinoids and terpenes from the above-ground parts of Futura 75, focusing on two techniques: pressurized extraction and magnetic stirrer-assisted extraction. The effects of solvent type, temperature, time, and pressure were evaluated using five organic solvents and two binary solvent systems. Cannabinoid profiles of obtained extracts were analyzed using gas chromatography coupled with mass spectrometry (GC-MS), while terpene profiles were characterized through solid-phase microextraction (SPME) combined with GC-MS. Next, two selected extracts with the highest content of cannabinoid and terpene fractions (Futu1 and Futu2) were tested for antiproliferative activity toward cancer cell lines (MV4-11, AGS, HT-29, MDA-MB-468, MCF-7) and their cytotoxicity was evaluated on non-tumorigenic MCF-10A cells. Extract Futu1 contained 51.57% cannabinoids, 9.8% monoterpenes, and 90.2% sesquiterpenes in the terpene fraction. Futu2 exhibited a higher proportion of monoterpenes in the terpene fraction (19.6% monoterpenes and 80.4% sesquiterpenes) and consisted of 49.49% cannabinoids. Both extracts exhibited higher selectivity for cancer cells over non-tumorigenic cells, with Futu2 demonstrating stronger antiproliferative properties. Interestingly, lower concentrations of extracts and tested free, single cannabinoids stimulated the growth of leukemia (MV4-11) and breast cancer (MDA-MB-468) cell lines while their higher concentrations suppressed proliferation.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11946255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Non-Autonomous Amphoteric Metal Hydroxide Oscillations and Pattern Formation in Hydrogels.

IF 4.2 2区化学

Molecules Pub Date : 2025-03-15 DOI: 10.3390/molecules30061323

Norbert Német, Hugh Shearer Lawson, Masaki Itatani, Federico Rossi, Nobuhiko J Suematsu, Hiroyuki Kitahata, István Lagzi

{"title":"A Non-Autonomous Amphoteric Metal Hydroxide Oscillations and Pattern Formation in Hydrogels.","authors":"Norbert Német, Hugh Shearer Lawson, Masaki Itatani, Federico Rossi, Nobuhiko J Suematsu, Hiroyuki Kitahata, István Lagzi","doi":"10.3390/molecules30061323","DOIUrl":"10.3390/molecules30061323","url":null,"abstract":"Oscillations in animate and inanimate systems are ubiquitous phenomena driven by sophisticated chemical reaction networks. Non-autonomous chemical oscillators have been designed to mimic oscillatory behavior using programmable syringe pumps. Here, we investigated the non-autonomous oscillations, pattern formation, and front propagation of amphoteric hydroxide (aluminum (III), zinc (II), tin (II), and lead (II)) precipitates under controlled pH conditions. A continuous stirred-tank reactor with modulated inflows of acidic and alkaline solutions generated pH oscillations, leading to periodic precipitation and dissolution of metal hydroxides in time. The generated turbidity oscillations exhibited ion-specific patterns, enabling their characterization through quantitative parameters such as peak width (W) and asymmetry (As). The study of mixed metal cationic systems showed that turbidity patterns contained signatures of both hydroxides due to the formation of mixed hydroxides and oxyhydroxides. The reaction-diffusion setup in solid hydrogel columns produced spatial precipitation patterns depending on metal cations and their concentrations. Additionally, in the case of tin (II), a propagating precipitation front was observed in a thin precipitation layer. These findings provide new insights into precipitation pattern formation and open avenues for metal ion identification and further exploration of complex reaction-diffusion systems.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11944573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analytical Strategies for Green Extraction, Characterization, and Bioactive Evaluation of Polyphenols, Tocopherols, Carotenoids, and Fatty Acids in Agri-Food Bio-Residues.

IF 4.2 2区化学

Molecules Pub Date : 2025-03-15 DOI: 10.3390/molecules30061326

David Vicente-Zurdo, Esther Gómez-Mejía, Sonia Morante-Zarcero, Noelia Rosales-Conrado, Isabel Sierra

{"title":"Analytical Strategies for Green Extraction, Characterization, and Bioactive Evaluation of Polyphenols, Tocopherols, Carotenoids, and Fatty Acids in Agri-Food Bio-Residues.","authors":"David Vicente-Zurdo, Esther Gómez-Mejía, Sonia Morante-Zarcero, Noelia Rosales-Conrado, Isabel Sierra","doi":"10.3390/molecules30061326","DOIUrl":"10.3390/molecules30061326","url":null,"abstract":"Recent advancements in analytical strategies have enabled the efficient extraction and characterization of bioactive compounds from agri-food bio-residues, emphasizing green chemistry and circular economy principles. This review highlights the valorization of several agri-food bio-residues for the extraction of high-value-added bioactive compounds, particularly polyphenols, tocopherols, carotenoids, and fatty acids, as a biorefinery approach. To this end, the adoption of environmentally friendly extraction technologies is essential to improve performance, reduce energy consumption, and minimize costs. This study therefore examines emerging methodologies such as supercritical fluid extraction, pressurized liquid extraction, pulsed electric fields, and matrix solid-phase dispersion, highlighting their advantages and limitations. Additionally, the chemical characterization of these bioactive compounds is explored through spectrophotometric and high-resolution chromatographic techniques, crucial for their accurate identification and quantification. This is complemented by an analysis of bioactivity assays evaluating antioxidant, antimicrobial, anticancer, neuroprotective, and anti-inflammatory properties, with a focus on their applications in the food, pharmaceutical, and cosmetic industries. However, the analytical control of toxic compounds, such as alkaloids, in these bio-residues is undoubtedly needed. Ultimately, this approach not only promotes sustainability but also contributes to the development of eco-friendly solutions in various industries.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11944699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aromatic Herbs as a Source of Bioactive Compounds: An Overview of Their Antioxidant Capacity, Antimicrobial Activity, and Major Applications.

IF 4.2 2区化学

Molecules Pub Date : 2025-03-14 DOI: 10.3390/molecules30061304

Leontina Grigore-Gurgu, Loredana Dumitrașcu, Iuliana Aprodu

{"title":"Aromatic Herbs as a Source of Bioactive Compounds: An Overview of Their Antioxidant Capacity, Antimicrobial Activity, and Major Applications.","authors":"Leontina Grigore-Gurgu, Loredana Dumitrașcu, Iuliana Aprodu","doi":"10.3390/molecules30061304","DOIUrl":"10.3390/molecules30061304","url":null,"abstract":"Many aromatic herbs are conventionally used for flavoring various foods, but receive wide attention because of the variety of health-related properties. The aromatic herbs can be used either fresh or as dried powders and in the form of extracts, essential oils, or purified metabolites. In this review, the main functional properties, in terms of antioxidant and antimicrobial properties, and the applications of some of the commonly used aromatic herbs from the Lamiaceae family, are discussed. Herbs like oregano, rosemary, sage, thyme, summer savory, marjoram, and basil possess high levels of bioactive phytochemicals. They are particularly rich in phenolic acids, flavones, phenolic diterpenes, and flavanones, with various beneficial effects. The phytochemical profile of aromatic plants is highly influenced by genetic factors, environmental conditions, and their interaction. In cases of the extracts and essential oils, the extraction method has a strong effect on the final composition of the herb products. Most of the applications of these aromatic herbs are related to their antioxidant, antimicrobial, and flavoring properties. In particular, aromatic herb extracts and essential oils have multiple applications in fields like food, feed, pharmaceutical, cosmetics, biopesticides, and textile industries.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11944975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visible-Light-Mediated Synthesis of Anomeric S-Aryl Glycosides via Electron Donor-Acceptor Complex Using Thianthrenium Salts.

IF 4.2 2区化学

Molecules Pub Date : 2025-03-14 DOI: 10.3390/molecules30061315

Zhuoyi Zhou, Yufeng Zhang, Zhiqiang Yu, Yuping Liu, Zhen Wang, Qingju Zhang, Liming Wang

引用次数: 0

Luminescent Manganese(II) Iminophosphorane Derivatives.

IF 4.2 2区化学

Molecules Pub Date : 2025-03-14 DOI: 10.3390/molecules30061319

Domenico Piccolo, Jesús Castro, Daniele Rosa-Gastaldo, Marco Bortoluzzi

{"title":"Luminescent Manganese(II) Iminophosphorane Derivatives.","authors":"Domenico Piccolo, Jesús Castro, Daniele Rosa-Gastaldo, Marco Bortoluzzi","doi":"10.3390/molecules30061319","DOIUrl":"10.3390/molecules30061319","url":null,"abstract":"The reaction between the iminophosphorane ligand N-phenyl-1,1,1-triphenylphosphanimine (NPh=PPh3) and anhydrous manganese(II) halides allowed the isolation of complexes with the general formula [MnX2(NPh=PPh3)2] (X = Cl, Br, I). The compounds showed luminescence in the green region attributed to the 4T1(4G)→6A1(6S) transition of the metal centre in the tetrahedral field, which was superimposed in the cases of X = Cl and X = Br on weak ligand-centred fluorescence. The emission and excitation spectra were compared with those of the free ligand and of the related zinc(II) bromo-complex. DFT calculations on the free ligand and on the manganese(II) bromo-complex helped to rationalise the experimental data. The protonation of NPh=PPh3 led to the formation of the iminium cation [NHPh=PPh3]+, which was used as a building block for the synthesis of organic-inorganic hybrids with the general formula [NHPh=PPh3]2[MnX4] (X = Cl, Br, I). The crystal structure of [NHPh=PPh3]2[MnBr4] was determined by means of X-ray diffraction. Green photoluminescence associated with the metal-centred transition was also observed for the organic-inorganic hybrids, with higher quantum yields with respect to the neutral [MnX2(NPh=PPh3)2] complexes. In the case of X = I, luminescence from the cation was superimposed on that from the tetraiodomanganate anion upon excitation of the compound with near-UV light.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11945198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing Cancer Treatment and Diagnosis: A Review on Photodynamic Therapy Using OLED Technology.

IF 4.2 2区化学

Molecules Pub Date : 2025-03-14 DOI: 10.3390/molecules30061305

Rajesh Kumar Tiwari, Rajesh Mishra, Sanjay Kumar Sharma, Nakshathra Prabhu, Mangey Ram Nagar, Saulius Grigalevicius

{"title":"Advancing Cancer Treatment and Diagnosis: A Review on Photodynamic Therapy Using OLED Technology.","authors":"Rajesh Kumar Tiwari, Rajesh Mishra, Sanjay Kumar Sharma, Nakshathra Prabhu, Mangey Ram Nagar, Saulius Grigalevicius","doi":"10.3390/molecules30061305","DOIUrl":"10.3390/molecules30061305","url":null,"abstract":"Photodynamic therapy (PDT) is an innovative and non-invasive approach to treating apparent tumours with minimal toxicity. PDT has a long-standing application in antitumor treatment utilizing various photosensitizers (PSs) for different tumours. Historically, light has served as a therapeutic tool in many diseases. PDT involves a dual treatment process in which light energy and PSs are combined to ablate tumour cells following light activation. In general, PDT exhibits reduced side effects and toxicity compared to chemotherapy and radiotherapy, as it spares the extracellular matrix, facilitating excellent tissue healing and minimizing scarring. In addition, PSs can serve in diagnostic roles in tumour identification, termed photodynamic diagnosis (PDD). Advancements in flexible light sources that produce uniform illumination could significantly enhance the consistency of light delivery. This review outlines the clinical applications of OLEDs in PDT for cancer, addressing both diagnostic and therapeutic methods. Furthermore, we will explore various tumour cases using PDT with OLEDs. In particular, antimicrobial PDT targets antibiotic-resistant strains in diabetic foot ulcers, while metronomic PDT promotes cancer cell apoptosis through prolonged, low-intensity light exposure. Our emphasis is on PDT employing organic light-emitting diodes (OLEDs). Furthermore, the combination of PDT with NIR-OLEDs is examined for its potential to enhance tumour-targeting effectiveness, possibly exceeding the results of standalone treatments.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11946556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial Peptide Databases as the Guiding Resource in New Antimicrobial Agent Identification via Computational Methods.

IF 4.2 2区化学

Molecules Pub Date : 2025-03-14 DOI: 10.3390/molecules30061318

Bogdan Marczak, Aleksandra Bocian, Andrzej Łyskowski

{"title":"Antimicrobial Peptide Databases as the Guiding Resource in New Antimicrobial Agent Identification via Computational Methods.","authors":"Bogdan Marczak, Aleksandra Bocian, Andrzej Łyskowski","doi":"10.3390/molecules30061318","DOIUrl":"10.3390/molecules30061318","url":null,"abstract":"In light of the growing interest in antimicrobial peptides (AMPs) as potential alternatives to traditional antibiotics, proteomic research has increasingly focused on this area. Addressing this significant scientific need, we undertook an initiative to review and analyze the available databases containing information on AMPs. These databases play a pivotal role as a foundation for most AMP-related studies, enabling not only the identification of new compounds, but also a deeper understanding of their properties and therapeutic potential. As part of this study, we evaluated the quality of information within selected AMP databases, considering their accessibility, content, and research potential. The initial step of the analysis involved a comparison of the per-database and cross-database peptide sequences. A diamond, high-throughput protein alignment program was used to compare the degree of sequence similarity among peptides across the individual databases. The redundancy of the data was also evaluated. Collected information was used for an in silico evaluation of the selected species' venom proteomes in order to identify putative antimicrobial peptide candidates. An example candidate was further evaluated via a combination of structural analysis based on the computed homology based structural model, the in silico digestion of the source protein, and the antimicrobial potential.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11944441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Advances in the Use of Mushrooms as Therapeutics for Lung Cancer: A Review.

IF 4.2 2区化学

Molecules Pub Date : 2025-03-14 DOI: 10.3390/molecules30061322

Edward Thato Khunoana, Sanah Malomile Nkadimeng

{"title":"Current Advances in the Use of Mushrooms as Therapeutics for Lung Cancer: A Review.","authors":"Edward Thato Khunoana, Sanah Malomile Nkadimeng","doi":"10.3390/molecules30061322","DOIUrl":"10.3390/molecules30061322","url":null,"abstract":"Medicinal mushrooms have become increasingly important in the pharmaceutical industry because they contain a wealth of bioactive compounds and offer various nutritional benefits. These qualities also contribute to their widespread use in cooking. Global mycologists have suggested that a deeper understanding of mushrooms can aid in treating a variety of cancers at different stages. The excellent anticancer potential of fungi has inevitably attracted the attention of researchers, given the ever-increasing number of cases of lung cancer. Thus, the purpose of this review was to compile and synthesize the existing scientific literature about the potential of mushroom extracts particularly towards lung cancer prevention. A comprehensive literature search was conducted in electronic databases to identify relevant studies for the review. We found that 26 distinct kinds of mushrooms, prepared in over 10 different solvents, were used to make extracts that decreased the viability of different types of lung cancer cells (A549, NCI-H460, 3LL, H1264 cells etc.). We also examined a range of experimental models, including cell cultures (in vitro), mouse models (in vivo), as well as case studies and randomized controlled trials. The investigated mushrooms' effective mechanisms included: a reduction in the growth of cancer cells; an imbalanced percentage of cells in different phases of the cell cycle; an increase in autophagy and phagocytosis; an enhanced immune response; and the induction of cell apoptosis through the upregulation of pro-apoptotic factors and the downregulation of anti-apoptotic genes. Considering that mushrooms are consumed as a daily supplement, their potent pro-apoptotic properties and high antiproliferative efficacy are advantageous and could provide a model for further studies in this field as well as novel drug therapies and cancer treatments.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11944945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0