Molecules最新文献_第8页

Synthesis and Biological Screening of Structurally Modified Phaeosphaeride Analogues. 结构修饰的磷化物类似物的合成及生物学筛选。

IF 4.2 2区化学

Molecules Pub Date : 2025-04-30 DOI: 10.3390/molecules30092016

Konstantinos Rantzios, Oraia-Eirini Chatzimentor, George Leonidis, Jorgo Giuliani, Ioanna Sigala, Vasiliki Sarli

{"title":"Synthesis and Biological Screening of Structurally Modified Phaeosphaeride Analogues.","authors":"Konstantinos Rantzios, Oraia-Eirini Chatzimentor, George Leonidis, Jorgo Giuliani, Ioanna Sigala, Vasiliki Sarli","doi":"10.3390/molecules30092016","DOIUrl":"10.3390/molecules30092016","url":null,"abstract":"Phaeosphaeride A and its analogues have been extensively explored for their potential pharmacological applications, particularly in the development of anticancer agents. In this study, the synthesis of structurally modified phaeosphaeride analogues is reported. The structures of the synthesized analogues bearing the tetrahydro- and hexahydro-2H-furo[3,2-b]pyran-2-one and hexahydropyrano[3,2-b]pyrrol-2(1H)-one moieties were assessed and the new compounds were evaluated for their antiproliferative activity against two cancer cell lines. Despite successful synthesis and structural modification, the majority of the phaeosphaeride analogues exhibited limited bioactivity. Structure-activity relationship studies suggested that specific modifications did not enhance anticancer potency. The hydroxy groups and the alkyl moiety in cyclic or non-cyclic phaeosphaeride analogues contribute to the activity, as shown by the activity of compounds 24 and 25. The presence of double bonds and oxygen or nitrogen heteroatoms in furopyranones or pyranopyrrolones 9, 28, 29 and 33a, does not significantly impact cytotoxic activity. These findings highlight the challenges in optimizing phaeosphaerides for anticancer applications and provide insights into future structural modifications to improve their therapeutic potential. Moreover, our studies open a synthetic route for the development of new phaeosphaeride analogues.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Selective MAP3K1 Inhibitor Facilitates Discovery of NPM1 as a Member of the Network. 选择性MAP3K1抑制剂促进NPM1作为网络成员的发现。

IF 4.2 2区化学

Molecules Pub Date : 2025-04-30 DOI: 10.3390/molecules30092001

Lidia Boghean, Sarbjit Singh, Kiran K Mangalaparthi, Smitha Kizhake, Lelisse Umeta, Donn Wishka, Paul Grothaus, Akhilesh Pandey, Amarnath Natarajan

引用次数: 0

Early-Stage Pancreatic Cancer Diagnosis: Serum Biomarkers and the Potential for Aptamer-Based Biosensors. 早期胰腺癌诊断：血清生物标志物和基于适配体的生物传感器的潜力。

IF 4.2 2区化学

Molecules Pub Date : 2025-04-30 DOI: 10.3390/molecules30092012

Weisi He, Jingyu Cui, Xue-Yan Wang, Ryan H P Siu, Julian A Tanner

{"title":"Early-Stage Pancreatic Cancer Diagnosis: Serum Biomarkers and the Potential for Aptamer-Based Biosensors.","authors":"Weisi He, Jingyu Cui, Xue-Yan Wang, Ryan H P Siu, Julian A Tanner","doi":"10.3390/molecules30092012","DOIUrl":"10.3390/molecules30092012","url":null,"abstract":"Pancreatic cancer has a high mortality rate, and both the incidence and mortality are continuing to increase in many countries globally. The poor prognosis of pancreatic cancer is in part due to the challenges in early diagnosis. Improving early-stage pancreatic cancer diagnosis would improve survival outcomes. Aptamer-based biosensors provide an alternative technological approach for the analysis of serum biomarkers with several potential advantages. This review summarizes the major pancreatic cancer serum biomarkers, as well as discusses recent progress in biomarker exploration and aptasensor development. Here, we review both established and novel serum biomarkers identified recently, emphasizing their potential for early-stage pancreatic cancer diagnosis. We also propose strategies for further expanding multiplex biomarker panels beyond the established CA19-9 biomarker to enhance diagnostic performance. We discuss technological advancements in aptamer-based sensors for pancreatic cancer-related biomarkers over the last decade. Optical and electrochemical sensors are highlighted as two primary modalities in aptasensor design, each offering unique advantages. Finally, we propose steps towards clinical application using aptamer-based sensors with multiplexed biomarker detection for improved pancreatic cancer diagnostics.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Enzymatic Acylation on the Stability and Antioxidant Properties of Cyanidin-3-O-Glucoside in Both Aqueous and Lipid Systems. 酶促酰化对花青素-3- o -葡萄糖苷在水体系和脂体系中的稳定性和抗氧化性能的影响。

IF 4.2 2区化学

Molecules Pub Date : 2025-04-30 DOI: 10.3390/molecules30092015

Ziwei Ye, Mingyun Liu, Jingmei Lyu, Han Rong, Lujing Gan

{"title":"Influence of Enzymatic Acylation on the Stability and Antioxidant Properties of Cyanidin-3-O-Glucoside in Both Aqueous and Lipid Systems.","authors":"Ziwei Ye, Mingyun Liu, Jingmei Lyu, Han Rong, Lujing Gan","doi":"10.3390/molecules30092015","DOIUrl":"10.3390/molecules30092015","url":null,"abstract":"Cyanidin-3-O-glucoside (C3G) was used as a substrate for enzymatic acylation, and different compounds (methyl n-octanoate and methyl salicylate) were selected as acyl donors. Structural analysis (UV-Vis, FTIR, and HPLC) revealed the successful integration of methyl ester compounds into the structural units of C3G. The thermostability and photostability of acylated C3Gs, particularly those with methyl salicylate as the acyl donor, exhibited significant improvements. The molecular geometries of the different anthocyanins were optimized using computational chemistry, and energy level calculations were performed by using Density Functional Theory (DFT) to identify the antioxidant active site. Then, the antioxidant properties of C3G and acylated C3Gs (O-C3G and S-C3G) were studied in both aqueous and lipid systems. In aqueous systems, acylated C3Gs exhibited higher antioxidant properties than C3G in DPPH radical scavenging and hydroxyl radical scavenging assays, with cyanidin-3-O-glucoside salicyl acyl product (S-C3G) demonstrating the highest activity. However, the antioxidant properties varied in lipid systems. In lipid systems, acylated C3Gs displayed better antioxidant properties than C3G in POV and TBARS assays, with cyanidin-3-O-glucoside n-octanoate acid acyl product (O-C3G) showing better antioxidant properties compared to that in aqueous systems.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silver Nanoparticles (AgNPs) as Potential Antiviral Agents: Synthesis, Biophysical Properties, Safety, Challenges and Future Directions─Update Review. 银纳米粒子（AgNPs）作为潜在的抗病毒药物：合成、生物物理性质、安全性、挑战和未来方向─最新综述

IF 4.2 2区化学

Molecules Pub Date : 2025-04-30 DOI: 10.3390/molecules30092004

Abhinav Sati, Tanvi N Ranade, Suraj N Mali, Haya Khader Ahmad Yasin, Nehal Samdani, Nikil Navnath Satpute, Susmita Yadav, Amit P Pratap

{"title":"Silver Nanoparticles (AgNPs) as Potential Antiviral Agents: Synthesis, Biophysical Properties, Safety, Challenges and Future Directions─Update Review.","authors":"Abhinav Sati, Tanvi N Ranade, Suraj N Mali, Haya Khader Ahmad Yasin, Nehal Samdani, Nikil Navnath Satpute, Susmita Yadav, Amit P Pratap","doi":"10.3390/molecules30092004","DOIUrl":"10.3390/molecules30092004","url":null,"abstract":"AgNPs have gained significant attention due to their unique physicochemical properties, making them valuable across a range of fields including medicine, textiles, and household products. With their strong antimicrobial and antiviral properties, AgNPs have shown promise in treating infections, particularly in wound care management. This review explores the mechanisms underlying the antiviral activities of AgNPs, as well as the methods used for their synthesis, which include physical, chemical, and biological approaches. The review also addresses the potential limitations of AgNPs, including their cytotoxicity to humans and the environment. The interaction between AgNPs and microorganisms, particularly viruses, varies based on synthesis methods and particle morphology. As viral infections, including resistant strains, present major global health challenges, there is a growing need for alternative antiviral therapies. Metal nanoparticles like AgNPs offer potential advantages over conventional antiviral drugs due to their broad target range, which reduces the likelihood of resistance development. This review highlights AgNPs' effectiveness against a variety of viruses, such as HIV, hepatitis B, and respiratory syncytial virus, and discusses their potential for use in novel antiviral treatments. The review also examines AgNPs' toxicity, offering insights into their future therapeutic roles.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comprehensive Review of the Phenolic Compounds in Dracocephalum Genus (Lamiaceae) Related to Traditional Uses of the Species and Their Biological Activities. 龙头草属（Lamiaceae）中酚类化合物的研究进展及其生物活性。

IF 4.2 2区化学

Molecules Pub Date : 2025-04-30 DOI: 10.3390/molecules30092017

Izabela Weremczuk-Jeżyna, Izabela Grzegorczyk-Karolak

{"title":"A Comprehensive Review of the Phenolic Compounds in Dracocephalum Genus (Lamiaceae) Related to Traditional Uses of the Species and Their Biological Activities.","authors":"Izabela Weremczuk-Jeżyna, Izabela Grzegorczyk-Karolak","doi":"10.3390/molecules30092017","DOIUrl":"10.3390/molecules30092017","url":null,"abstract":"The genus Dracocephalum (family Lamiaceae) comprises approximately 70 species, many of which have been traditionally used in various ethnomedical systems. The plants exhibit a broad distribution across steppe, semi-deserts, deserts, and alpine zones of temperate Eurasia, with isolated endemic species occurring in North America and North Africa. The traditional medicinal uses of the Dracocephalum species encompass the treatment of respiratory diseases, colds and fever, gastrointestinal disorders, liver and gallbladder ailments, musculoskeletal conditions, cardiovascular diseases, diabetes, gynecological and urological disorders, as well as ailments of the ears, throat, mouth, and eyes, as well as various dermatological conditions. The plants are rich sources of polyphenolic compounds, including flavonoids and phenolic acids, which contribute to their diverse pharmacological activities. The flavonoid profile of the Dracocephalum species is dominated by luteolin and apigenin derivatives, supplemented by mono-, di-, tri-, tetra-, and pentamethoxylated flavones. The predominant phenolic acids are chlorogenic acid, coumaric acid, rosmarinic acid, and their derivatives. Other phenolic compounds have also been identified in the genus: anthocyanins, lignans, phenylethanoids, phenylacetamide glycosides, flavonoid alkaloids, gingerols, coumarins, furanocoumarins, and cyanogenic glucosides. Despite growing scientific interest in this genus, a comprehensive review of its polyphenolic constituents, their structures, and associated biological activities remains lacking. To bridge this gap, this review presents an analysis of the polyphenolic profile of the Dracocephalum species, their ethnomedicinal uses, and the latest findings on their biological potential.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peas (Pisum sativum subsp. arvense Asch) and Beans (Vicia faba var. minor) as Source of Quality Plant Proteins. 豌豆（豌豆）蚕豆（Vicia faba var. minor）作为优质植物蛋白的来源。

IF 4.2 2区化学

Molecules Pub Date : 2025-04-30 DOI: 10.3390/molecules30092009

Abebaw Tiruneh, Paweł Ptaszek, Daniel Żmudziński, Tomasz Tarko

{"title":"Peas (Pisum sativum subsp. arvense Asch) and Beans (Vicia faba var. minor) as Source of Quality Plant Proteins.","authors":"Abebaw Tiruneh, Paweł Ptaszek, Daniel Żmudziński, Tomasz Tarko","doi":"10.3390/molecules30092009","DOIUrl":"10.3390/molecules30092009","url":null,"abstract":"The demand for plant-based proteins has grown significantly due to their sustainability and lower environmental impact compared to animal proteins. Shifting from animal-based to plant-based diets, particularly those incorporating protein-rich legumes like beans and peas, can substantially reduce the climate footprint of food production. Underutilized legumes, which are often critical in resource-poor regions, hold immense potential for enhancing food security, nutrition, and agricultural development. Despite their importance, information about these legumes remains limited and region-specific. The shift towards plant proteins is further driven by the growing popularity of vegetarian and vegan diets, alongside mounting concerns over the environmental impacts of livestock farming. Consequently, plant proteins are increasingly favored over their animal-based counterparts in the food industry. Scientists are now exploring novel plant protein sources and developing superior-quality proteins with enhanced functional and nutritional characteristics using cutting-edge technologies. While traditional plant protein sources like wheat and soy present challenges such as allergenicity, pulses like peas, beans, chickpeas, and lentils are gaining prominence due to their agronomic and nutritional advantages. It is anticipated that ongoing research will address the existing knowledge gaps regarding the nutritional and health benefits of fodder seeds such as field bean and field pea seeds, broadening their application across diverse food industries. In this context, the present review focuses on the potential of field bean and field pea as valuable sources of food and functional ingredients. Despite their benefits, current knowledge about these crops is limited to specific geographic areas where they hold cultural or local significance.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation, Digestion, and Storage of Microencapsulated Nervonic Acid-Enriched Structured Phosphatidylcholine. 微囊化富神经酸结构磷脂酰胆碱的制备、消化和储存。

IF 4.2 2区化学

Molecules Pub Date : 2025-04-30 DOI: 10.3390/molecules30092007

Xun Ang, Hong Chen, Jiqian Xiang, Fang Wei, Siew Young Quek

{"title":"Preparation, Digestion, and Storage of Microencapsulated Nervonic Acid-Enriched Structured Phosphatidylcholine.","authors":"Xun Ang, Hong Chen, Jiqian Xiang, Fang Wei, Siew Young Quek","doi":"10.3390/molecules30092007","DOIUrl":"10.3390/molecules30092007","url":null,"abstract":"This study focuses on the encapsulation of nervonic acid-enriched structured phospholipid (NA-enriched SPL) by analysing its physical and chemical properties. Wall materials for encapsulation were initially screened, with whey protein isolate and maltodextrin exhibiting the most favourable characteristics. Optimisation of encapsulation parameters determined that a core-to-wall ratio of 1:3 provided the highest physical stability. Encapsulated samples underwent in vitro digestion, where MC-FD exhibited the highest digestibility (79.54%), followed by CV-E (72.1%) and NA-enriched SPL (29.82%). Storage stability was assessed over 90 days at 4 °C, 25 °C, and 45 °C by monitoring particle size, zeta potential, polydispersity index, microscopy, fatty acid composition, and primary and secondary lipid oxidation. MC-FD demonstrated superior stability, maintaining its physical and chemical properties, particularly at 4 °C. In contrast, CV-E showed the lowest physical stability, with significant changes in appearance and increased particle size at elevated temperatures (25 °C and 45 °C).","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTED: Godugu et al. Nanoformulated Ajwa (Phoenix Dactylifera) Bioactive Compounds Improve the Safety of Doxorubicin Without Compromising Its Anticancer Efficacy in Breast Cancer. Molecules 2020, 25, 2597. 撤稿：Godugu et al。纳米配方Ajwa （Phoenix Dactylifera）生物活性化合物提高了阿霉素的安全性，同时又不影响其对乳腺癌的抗癌功效。分子化学，2020,25,2597。

IF 4.2 2区化学

Molecules Pub Date : 2025-04-30 DOI: 10.3390/molecules30091996

Kavitha Godugu, Ali H El-Far, Soad Al Jaouni, Shaker A Mousa

引用次数: 0

RETRACTED: Block et al. Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies. Molecules 2017, 22, 2081. 缩回：Block等。大蒜（Allium sativum）中有机硫化合物的氟化类似物：合成、化学和抗血管生成和抗血栓研究。分子学报，2017,22,2081。

IF 4.2 2区化学

Molecules Pub Date : 2025-04-30 DOI: 10.3390/molecules30092005

Eric Block, Benjamin Bechand, Sivaji Gundala, Abith Vattekkatte, Kai Wang, Shaymaa S Mousa, Kavitha Godugu, Murat Yalcin, Shaker A Mousa

引用次数: 0