Nature metabolism最新文献

{"title":"Author Correction: Brain regulation of gastric dysfunction induced by stress","authors":"Wan-Ying Dong,Xia Zhu,Hao-Di Tang,Ji-Ye Huang,Meng-Yu Zhu,Ping-Kai Cheng,Hao Wang,Xi-Yang Wang,Haitao Wang,Yu Mao,Wan Zhao,Yan Zhang,Wen-Juan Tao,Zhi Zhang","doi":"10.1038/s42255-026-01648-z","DOIUrl":"https://doi.org/10.1038/s42255-026-01648-z","url":null,"abstract":"","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"296 1","pages":""},"PeriodicalIF":20.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149090084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arginine inhibits a key innate immune signalling hub","authors":"Quang Nang Truong,Alex R. Trainor,Jay Penney","doi":"10.1038/s42255-026-01638-1","DOIUrl":"https://doi.org/10.1038/s42255-026-01638-1","url":null,"abstract":"","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"3 1","pages":""},"PeriodicalIF":20.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149090082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultraprocessed foods evoke distinct metabolic and neural responses","authors":"","doi":"10.1038/s42255-026-01618-5","DOIUrl":"10.1038/s42255-026-01618-5","url":null,"abstract":"Ultraprocessed foods have been linked with various poor health outcomes. In our study, we characterize acute metabolic responses to these foods and investigate how our brains might encode food value, both nutritional and monetary.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"8 10","pages":"2056-2057"},"PeriodicalIF":27.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic and neural responses to ultraprocessed foods: a randomized, controlled, crossover study","authors":"Zach Hutelin, Monica Ahrens, Mary Elizabeth Baugh, Emmanuel Nartey, Delbert L. Herald III, Alexandra L. Hanlon, Alexandra G. DiFeliceantonio","doi":"10.1038/s42255-026-01619-4","DOIUrl":"10.1038/s42255-026-01619-4","url":null,"abstract":"Dietary patterns worldwide have shifted toward increased consumption of ultraprocessed foods (UPFs), which has been linked to higher disease burden. One proposed mechanism underlying both UPF consumption and metabolic disease is altered post-ingestive responses relative to nutritionally similar foods. Here we report the effects of food processing on post-ingestive metabolism and brain response in a randomized, crossover study involving 57 healthy-weight adults who consumed a nutritionally matched UPF or non-UPF meal. We show that despite being nutritionally similar, UPF meals evoke greater insulinaemic and energetic responses, with attenuated carbohydrate oxidation relative to non-UPF meals. Between-condition differences in peak carbohydrate oxidation are associated with striatal activation in response to food cues. We also find that although subjective food value does not differ between conditions, brain responses correlated with food valuation are positive for non-UPF but negative for UPF in the visual cortex and striatum. Overall, these findings suggest that food processing influences post-ingestive metabolic and neural responses through mechanisms beyond calories and macronutrients alone. In a randomized study in 57 healthy-weight adults, researchers compared nutritionally matched ultraprocessed and non-ultraprocessed meals and found that ultraprocessed foods elicited greater insulin and energy responses, reduced carbohydrate oxidation and altered striatal brain activity linked to food reward despite similar subjective food value.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"8 10","pages":"2152-2164"},"PeriodicalIF":27.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s42255-026-01619-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal obesity imprints methylation marks in oocytes to drive intergenerational metabolic dysfunction","authors":"Longsen Han, Yiqiu Wu, Jiashuo Li, Yujia Chen, Ling Li, Teng Wang, Ming Chen, Shanshan Wang, Congyang Li, Guolian Ding, Jingyu Li, Hongzheng Sun, Zhonghua Shi, Qiang Wang","doi":"10.1038/s42255-026-01617-6","DOIUrl":"10.1038/s42255-026-01617-6","url":null,"abstract":"Maternal obesity predisposes offspring to metabolic disease, yet how oocytes transmit this risk remains unclear. Here, we show that maternal obesity induces locus-specific DNA methylation changes in oocytes to drive intergenerational metabolic dysfunction in a tissue-specific and sex-specific manner. Among these, a subset of metabolic genes, notably Hnf1α, Thra and Pdk4, exhibited persistent intergenerational methylation and transcriptional dysregulation. Although these methylation marks were erased during embryogenesis, H3K36me2 enrichment was retained at the loci, suggesting a potential chromatin-associated cue for methylation re-establishment. Single-CpG analysis identified regulatory landmarks correlating with gene expression, and conserved hypermethylation of HNF1A and THRA was also detected in oocytes from women with obesity. Using methylation-edited mouse models, we further demonstrated that targeted oocyte hypermethylation at Hnf1α enhanced hepatic gluconeogenesis in offspring, whereas Pdk4 hypermethylation impaired glucose tolerance, both in a female-biased manner. Together, our findings provide direct causal evidence that germline methylation at defined loci can programme intergenerational metabolic dysfunction, highlighting the preconception period as a critical window for potential intervention in humans. This study shows that locus-specific DNA methylation changes in oocytes serve as an epigenetic memory linking maternal obesity to intergenerational metabolic dysfunction.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"8 10","pages":"2117-2132"},"PeriodicalIF":27.5,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Senolytics dasatinib and quercetin in metabolic dysfunction-associated steatohepatitis: a proof-of-principle randomized, controlled trial","authors":"Mijra Koning, Artemiy Kovynev, Marcos F. Fondevila, Eliza J. M. Ruhe, Michiel C. Mommersteeg, Christian Ramakers, Barbara A. Hutten, Bart Verwer, Marije Vlug, Teaco Kuiper, Maarten van den Berg, Anne Vrieze, Maurice Bizino, Annewieke van den Beld, Luuk Berk, Thomas Boerlage, Quinten J. J. Augustijn, Willem Pieter Brouwer, Weena J. Chen, Djuna Cahen, Robert Verdonk, Wouter J. de Jonge, Sandjai Ramsoekh, Michail Doukas, Sanne M. M. Vermorgen, Joanne Verheij, Ulrich Beuers, R. B. Takkenberg, Jacques J. G. Bergman, Geert R. A. M. D’Haens, Joost P. H. Drenth, Tamar Tchkonia, Bernd Schnabl, James L. Kirkland, Abraham S. Meijnikman","doi":"10.1038/s42255-026-01643-4","DOIUrl":"https://doi.org/10.1038/s42255-026-01643-4","url":null,"abstract":"Cellular senescence plays an important role in hepatic inflammation and fibrosis1,2,3. However, whether senescence represents a potential therapeutic target in humans with metabolic dysfunction-associated steatohepatitis (MASH) remains unexplored. Here we report the results of a phase-2, double-blind, randomized, placebo-controlled trial of intermittent senolytic therapy with dasatinib plus quercetin (D + Q) in participants with fibrotic MASH. Thirty-one participants (median age 56 years; 76% male; 58% with type 2 diabetes) were randomized (1:1) to receive D + Q (dasatinib 100 mg per day plus quercetin 1,000 mg per day) or placebo for three consecutive days per week over 3 weeks, repeated across three 7-week cycles. The primary endpoint, ≥1 stage fibrosis improvement without MASH worsening on paired liver biopsies, is achieved in 47% of D + Q-treated participants versus 7% with placebo (P = 0.02). MASH resolution occurs more frequently with D + Q than placebo (53% versus 7%; P = 0.02), with a greater reduction in NAFLD Activity Score (−1.43 ± 1.22 versus −0.39 ± 0.77; P = 0.012). Single-nucleus RNA sequencing demonstrates decreased senescence and fibrotic gene signatures and reduced fibrogenic cell populations in the D + Q group. Although adverse events are more frequent in the D + Q group (82% versus 43%), these are all self-limiting. Overall, this proof-of-principle trial supports the need for future trials of senolytic therapy in fibrotic MASH. ClinicalTrials.gov identifier: NCT05506488.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"16 1","pages":""},"PeriodicalIF":20.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRMhub: a scalable data-processing framework for large-scale targeted metabolomics","authors":"Bo Burla, Guo Shou Teo, Peter Imre Benke, Zinan Lu, Sock Hwee Tan, Shanshan Ji, Jeongah Oh, Pei Yen Lim,  Vaitheeswari, Liang Gao, Amaury Cazenave-Gassiot, Kavita Venkataraman, E Shyong Tai, Federico Torta, Markus Rene Wenk, Mark Yan Yee Chan, Hyungwon Choi","doi":"10.1038/s42255-026-01629-2","DOIUrl":"10.1038/s42255-026-01629-2","url":null,"abstract":"","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"8 10","pages":"2042-2044"},"PeriodicalIF":27.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149081546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Size-dependent plastic exposure disrupts macrophage function and tissue-specific metabolism","authors":"Nikola Makdissi, Maria Francesca Viola, Lisa Maria Steinheuer, Nelli Blank-Stein, Ronja Kardinal, Fabrizio Musacchio, Eliana Franco Taveras, Virginia Aliprandi, Katharina Sieckmann, Akram Abdulkadyrov, Marina L. Mayer, Marie-Louise Diefenbach-Wilke, Diana Fink, Hannes Beckert, Stefan Böhmdorfer, Quentin Deveuve, Frederike J. Graelmann, Katharina Mauel, Nele Kronau, Jake Thomas, David Bejarano, Andreas Schlitzer, Sandra Högler, Mohamed H. Yaghmour, Joerg Heeren, Christoph Thiele, Lukas Kenner, Felix Meissner, Falk Nimmerjahn, Martin Fuhrmann, Dagmar Wachten, Kevin Thurley, Elvira Mass","doi":"10.1038/s42255-026-01615-8","DOIUrl":"10.1038/s42255-026-01615-8","url":null,"abstract":"Plastic pollution is an emerging yet understudied environmental risk to the immune system. Once ingested, microplastic and nanoplastic particles (MNPs) can translocate from the gut to internal organs1–3, with macrophages serving as primary targets4. Kupffer cells (KCs), the liver-resident macrophages, have a central role in immune surveillance and metabolism5, yet their response to MNPs remains unclear. Here we identify KCs as the primary hepatic reservoir for MNPs in young male mice. Chronic plastic exposure over 12 weeks alters their transcriptional profile, impairs phagocytic function and is associated with metabolic dysregulation of hepatocytes. Microplastics, but not nanoplastics, reduce KC-mediated clearance of circulating cells. Under diet-induced obesity, microplastics exacerbate hepatic lipid accumulation, while nanoplastics alter systemic glucose metabolism and energy expenditure. These findings demonstrate that chronic MNP exposure disrupts macrophage function in a size-dependent manner, with subsequent distinct consequences for liver and systemic metabolism. This study reports that chronic exposure to microplastic and nanoplastic particles differentially affects Kupffer cells, which impairs their function and has consequences on both liver and systemic metabolism.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"8 10","pages":"2084-2101"},"PeriodicalIF":27.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s42255-026-01615-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149081554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-chain fatty acids and blood pressure","authors":"Rikeish R. Muralitharan,Francine Z. Marques","doi":"10.1038/s42255-026-01641-6","DOIUrl":"https://doi.org/10.1038/s42255-026-01641-6","url":null,"abstract":"","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"35 1","pages":""},"PeriodicalIF":20.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis","authors":"Abigail Strefeler,Zakery N. Baker,Sylvain Chollet,Mads M. Foged,Rachel M. Guerra,Julijana Ivanisevic,Hector Gallart-Ayala,David J. Pagliarini,Alexis A. Jourdain","doi":"10.1038/s42255-026-01645-2","DOIUrl":"https://doi.org/10.1038/s42255-026-01645-2","url":null,"abstract":"","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"55 1","pages":""},"PeriodicalIF":20.8,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149021151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}