Nature metabolism最新文献_第2页

GLP-2 attenuates antipsychotics’ adverse metabolic effects

IF 20.8 1区医学

Nature metabolism Pub Date : 2025-03-20 DOI: 10.1038/s42255-025-01248-3

Sandra Pereira, Margaret K. Hahn

引用次数: 0

GLP-2 prevents antipsychotics-induced metabolic dysfunction in mice

IF 20.8 1区医学

Nature metabolism Pub Date : 2025-03-20 DOI: 10.1038/s42255-025-01252-7

Yanmin Peng, Chenzhang Feng, Shiyu Peng, Ying Wang, Qian Zhang, Zhuolei Jiao, Huateng Cao, Shajin Huang, Peihuang Tian, Xiujia Sun, Xiaohong Xu, Yu Fu, Ji Hu, Zhe Zhang

{"title":"GLP-2 prevents antipsychotics-induced metabolic dysfunction in mice","authors":"Yanmin Peng, Chenzhang Feng, Shiyu Peng, Ying Wang, Qian Zhang, Zhuolei Jiao, Huateng Cao, Shajin Huang, Peihuang Tian, Xiujia Sun, Xiaohong Xu, Yu Fu, Ji Hu, Zhe Zhang","doi":"10.1038/s42255-025-01252-7","DOIUrl":"https://doi.org/10.1038/s42255-025-01252-7","url":null,"abstract":"Antipsychotic drugs have severe metabolic side effects. Acute use can induce hypothermia, while chronic use often leads to weight gain and associated disorders. However, no treatment is currently available for drug-induced hypothermia, and weight control measures lack evidence for long-term effectiveness. Here we demonstrate that a glucagon-like peptide 2 analogue, teduglutide, effectively prevents olanzapine-induced hypothermia and weight gain, and restores glucose tolerance and insulin sensitivity in mice. Mechanistically, olanzapine suppresses prodynorphin-expressing neurons in the ventromedial hypothalamus (VMHPdyn neurons) via serotonin receptor 2C, while teduglutide activates the same neuron population. Selective ablation of VMHPdyn neurons mimics olanzapine-induced side effects. More importantly, chemogenetic activation of VMHPdyn neurons abolishes olanzapine-induced hypothermia and excessive weight gain, although the psychotropic effects remain intact. Together, our data show that VMHPdyn neurons are the crucial mediator of antipsychotic-induced metabolic dysfunction and glucagon-like peptide 2 receptor agonism may be an effective target to mitigate both acute and chronic side effects.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"8 1","pages":""},"PeriodicalIF":20.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Glycolytic neutrophils accrued in the spleen compromise anti-tumour T cell immunity in breast cancer.

IF 18.9 1区医学

Nature metabolism Pub Date : 2025-03-18 DOI: 10.1038/s42255-025-01279-w

Yu Wang, Muhan Xu, Jian Sun, Xiaoxiao Li, Huazheng Shi, Xuefeng Wang, Benming Liu, Tao Zhang, Xu Jiang, Liangyu Lin, Qing Li, Yin Huang, Yong Liang, Mingyuan Hu, Fanjun Zheng, Fengyu Zhang, Jian Sun, Yufang Shi, Ying Wang

引用次数: 0

AI-driven framework to map the brain metabolome in three dimensions

IF 20.8 1区医学

Nature metabolism Pub Date : 2025-03-18 DOI: 10.1038/s42255-025-01242-9

Xin Ma, Cameron J. Shedlock, Terrymar Medina, Roberto A. Ribas, Harrison A. Clarke, Tara R. Hawkinson, Praveen K. Dande, Hari K. R. Golamari, Lei Wu, Borhane EC. Ziani, Sara N. Burke, Matthew E. Merritt, Craig W. Vander Kooi, Matthew S. Gentry, Nirbhay N. Yadav, Li Chen, Ramon C. Sun

{"title":"AI-driven framework to map the brain metabolome in three dimensions","authors":"Xin Ma, Cameron J. Shedlock, Terrymar Medina, Roberto A. Ribas, Harrison A. Clarke, Tara R. Hawkinson, Praveen K. Dande, Hari K. R. Golamari, Lei Wu, Borhane EC. Ziani, Sara N. Burke, Matthew E. Merritt, Craig W. Vander Kooi, Matthew S. Gentry, Nirbhay N. Yadav, Li Chen, Ramon C. Sun","doi":"10.1038/s42255-025-01242-9","DOIUrl":"https://doi.org/10.1038/s42255-025-01242-9","url":null,"abstract":"High-resolution spatial imaging is transforming our understanding of foundational biology. Spatial metabolomics is an emerging field that enables the dissection of the complex metabolic landscape and heterogeneity from a thin tissue section. Currently, spatial metabolism highlights the remarkable complexity in two-dimensional (2D) space and is poised to be extended into the three-dimensional (3D) world of biology. Here we introduce MetaVision3D, a pipeline driven by computer vision, a branch of artificial intelligence focusing on image workflow, for the transformation of serial 2D MALDI mass spectrometry imaging sections into a high-resolution 3D spatial metabolome. Our framework uses advanced algorithms for image registration, normalization and interpolation to enable the integration of serial 2D tissue sections, thereby generating a comprehensive 3D model of unique diverse metabolites across host tissues at submesoscale. As a proof of principle, MetaVision3D was utilized to generate the mouse brain 3D metabolome atlas of normal and diseased animals (available at https://metavision3d.rc.ufl.edu) as an interactive online database and web server to further advance brain metabolism and related research.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"6 1","pages":""},"PeriodicalIF":20.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143641100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research

IF 18.9 1区医学

Nature metabolism Pub Date : 2025-03-17 DOI: 10.1038/s42255-025-01237-6

Shaunak Deota, Julie S. Pendergast, Ullas Kolthur-Seetharam, Karyn A. Esser, Frédéric Gachon, Gad Asher, Charna Dibner, Salvador Aznar Benitah, Carolina Escobar, Deborah M. Muoio, Eric Erquan Zhang, Gökhan S. Hotamışlıgil, Joseph Bass, Joseph S. Takahashi, Joshua D. Rabinowitz, Katja A. Lamia, Rafael de Cabo, Shingo Kajimura, Valter D. Longo, Ying Xu, Mitchell A. Lazar, Eric Verdin, Juleen R. Zierath, Johan Auwerx, Daniel J. Drucker, Satchidananda Panda

{"title":"The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research","authors":"Shaunak Deota, Julie S. Pendergast, Ullas Kolthur-Seetharam, Karyn A. Esser, Frédéric Gachon, Gad Asher, Charna Dibner, Salvador Aznar Benitah, Carolina Escobar, Deborah M. Muoio, Eric Erquan Zhang, Gökhan S. Hotamışlıgil, Joseph Bass, Joseph S. Takahashi, Joshua D. Rabinowitz, Katja A. Lamia, Rafael de Cabo, Shingo Kajimura, Valter D. Longo, Ying Xu, Mitchell A. Lazar, Eric Verdin, Juleen R. Zierath, Johan Auwerx, Daniel J. Drucker, Satchidananda Panda","doi":"10.1038/s42255-025-01237-6","DOIUrl":"10.1038/s42255-025-01237-6","url":null,"abstract":"The constant expansion of the field of metabolic research has led to more nuanced and sophisticated understanding of the complex mechanisms that underlie metabolic functions and diseases. Collaborations with scientists of various fields such as neuroscience, immunology and drug discovery have further enhanced the ability to probe the role of metabolism in physiological processes. However, many behaviours, endocrine and biochemical processes, and the expression of genes, proteins and metabolites have daily ~24-h biological rhythms and thus peak only at specific times of the day. This daily variation can lead to incorrect interpretations, lack of reproducibility across laboratories and challenges in translating preclinical studies to humans. In this Review, we discuss the biological, environmental and experimental factors affecting circadian rhythms in rodents, which can in turn alter their metabolic pathways and the outcomes of experiments. We recommend that these variables be duly considered and suggest best practices for designing, analysing and reporting metabolic experiments in a circadian context. This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental factors affecting circadian rhythms in metabolic studies in rodents.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"7 3","pages":"454-468"},"PeriodicalIF":18.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s42255-025-01237-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SIRT5 slows skeletal muscle ageing by alleviating inflammation

IF 18.9 1区医学

Nature metabolism Pub Date : 2025-03-14 DOI: 10.1038/s42255-025-01228-7

Vera Gorbunova, Andrei Seluanov

引用次数: 0

SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1

IF 18.9 1区医学

Nature metabolism Pub Date : 2025-03-14 DOI: 10.1038/s42255-025-01235-8

Qian Zhao, Ying Jing, Xiaoyu Jiang, Xin Zhang, Feifei Liu, Haoyan Huang, Zhihua Zhang, Haijun Wang, Shuhui Sun, Shuai Ma, Weiqi Zhang, Yang Yu, Xiaobing Fu, Guoguang Zhao, Jing Qu, Si Wang, Guang-Hui Liu

{"title":"SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1","authors":"Qian Zhao, Ying Jing, Xiaoyu Jiang, Xin Zhang, Feifei Liu, Haoyan Huang, Zhihua Zhang, Haijun Wang, Shuhui Sun, Shuai Ma, Weiqi Zhang, Yang Yu, Xiaobing Fu, Guoguang Zhao, Jing Qu, Si Wang, Guang-Hui Liu","doi":"10.1038/s42255-025-01235-8","DOIUrl":"10.1038/s42255-025-01235-8","url":null,"abstract":"Ageing-induced skeletal muscle deterioration contributes to sarcopenia and frailty, adversely impacting the quality of life in the elderly. However, the molecular mechanisms behind primate skeletal muscle ageing remain largely unexplored. Here, we show that SIRT5 expression is reduced in aged primate skeletal muscles from both genders. SIRT5 deficiency in human myotubes hastens cellular senescence and intensifies inflammation. Mechanistically, we demonstrate that TBK1 is a natural substrate for SIRT5. SIRT5 desuccinylates TBK1 at lysine 137, which leads to TBK1 dephosphorylation and the suppression of the downstream inflammatory pathway. Using SIRT5 lentiviral vectors for skeletal muscle gene therapy in male mice enhances physical performance and alleviates age-related muscle dysfunction. This study sheds light on the molecular underpinnings of skeletal muscle ageing and presents the SIRT5–TBK1 pathway as a promising target for combating age-related skeletal muscle degeneration. SIRT5 protects against primate skeletal muscle ageing through TBK1 desuccinylation, which inhibits the downstream inflammatory and senescent phenotypes.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"7 3","pages":"556-573"},"PeriodicalIF":18.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cyclic metabolic switching theory of intermittent fasting

IF 20.8 1区医学

Nature metabolism Pub Date : 2025-03-14 DOI: 10.1038/s42255-025-01254-5

Mark P. Mattson

引用次数: 0

Human gut microbial aromatic amino acid and related metabolites prevent obesity through intestinal immune control

IF 20.8 1区医学

Nature metabolism Pub Date : 2025-03-14 DOI: 10.1038/s42255-025-01246-5

Zengliang Jiang, Liuqing He, Diyin Li, Laibao Zhuo, Lingjun Chen, Rui-Qi Shi, Jianhua Luo, Yuhui Feng, Yuhui Liang, Danyang Li, Xiao Congmei, Yuanqing Fu, Yu-ming Chen, Ju-Sheng Zheng, Liang Tao

引用次数: 0

More protein in ultra-processed foods: no shortcut to eating less

IF 20.8 1区医学

Nature metabolism Pub Date : 2025-03-13 DOI: 10.1038/s42255-025-01258-1

Rikard Landberg, Therese Karlsson

引用次数: 0