When gut fibroblasts feed epithelial cells to death

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2025-06-26 DOI:10.1038/s42255-025-01315-9

Jong Woo Kim, Byeong Jun Jeong, Eun-Woo Lee

引用次数: 0

Abstract

Epithelial cell death driven by oxidative stress is a hallmark of inflammatory bowel disease (IBD), but the upstream triggers are unclear. A new study reveals that fibroblast-derived lipids enriched with polyunsaturated fatty acids induce epithelial ferroptosis. Genetic or pharmacological inhibition of fibroblast ACSL4 alleviates intestinal inflammation and injury in IBD models.

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当肠成纤维细胞喂养上皮细胞致死时

氧化应激导致的上皮细胞死亡是炎症性肠病（IBD）的一个标志，但上游触发因素尚不清楚。一项新的研究表明，富含多不饱和脂肪酸的成纤维细胞衍生的脂质可诱导上皮性铁下垂。遗传或药理抑制成纤维细胞ACSL4可减轻IBD模型的肠道炎症和损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.