{"title":"Metabolic Messengers: oestradiol","authors":"Andrea L. Hevener, Stephanie M. Correa","doi":"10.1038/s42255-025-01317-7","DOIUrl":null,"url":null,"abstract":"<p>Oestradiol (E2), a steroid hormone derived from cholesterol, has long been recognized for its central role in female reproduction and pathobiology of menopause. However, accumulating evidence underscores a critical role for E2 in the regulation of systemic metabolism in both women and men. The metabolic actions of E2 are predominantly mediated by oestrogen receptor α (encoded by <i>ESR1</i>), a nuclear receptor with heritable expression patterns and tissue-specific transcript levels highly correlated with indices of metabolic health in both sexes. Here we provide an overview of the cell-specific actions of E2 and its receptors (α and β) in modulating key metabolic pathways. We contextualize these mechanistic preclinical studies with epidemiological data linking the menopausal transition to a marked rise of metabolic disease risk and provide evidence that E2 replacement mitigates this risk by preserving metabolic health.</p>","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"45 1","pages":""},"PeriodicalIF":18.9000,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s42255-025-01317-7","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Oestradiol (E2), a steroid hormone derived from cholesterol, has long been recognized for its central role in female reproduction and pathobiology of menopause. However, accumulating evidence underscores a critical role for E2 in the regulation of systemic metabolism in both women and men. The metabolic actions of E2 are predominantly mediated by oestrogen receptor α (encoded by ESR1), a nuclear receptor with heritable expression patterns and tissue-specific transcript levels highly correlated with indices of metabolic health in both sexes. Here we provide an overview of the cell-specific actions of E2 and its receptors (α and β) in modulating key metabolic pathways. We contextualize these mechanistic preclinical studies with epidemiological data linking the menopausal transition to a marked rise of metabolic disease risk and provide evidence that E2 replacement mitigates this risk by preserving metabolic health.
期刊介绍：
Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.
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