发布求助
文献互助 智能选刊 最新文献

Molecular Cancer最新文献

筛选
英文 中文
Radioresistance and tumor recurrence: cellular plasticity, tolerant niches, and therapeutic opportunities 放射耐药和肿瘤复发：细胞可塑性、耐受壁龛和治疗机会
IF 37.3 1区 医学
Molecular Cancer Pub Date : 2026-10-09 DOI: 10.1186/s12943-026-02806-3
Yi Zhang,Hongshuai Li,Siyao Lv,Lina Peng,Wenjun Meng,Jiamin Guo,Yating Lu,Wu Chen,Wen Yang,Xingchen Peng
{"title":"Radioresistance and tumor recurrence: cellular plasticity, tolerant niches, and therapeutic opportunities","authors":"Yi Zhang,Hongshuai Li,Siyao Lv,Lina Peng,Wenjun Meng,Jiamin Guo,Yating Lu,Wu Chen,Wen Yang,Xingchen Peng","doi":"10.1186/s12943-026-02806-3","DOIUrl":"https://doi.org/10.1186/s12943-026-02806-3","url":null,"abstract":"","PeriodicalId":19000,"journal":{"name":"Molecular Cancer","volume":"9 1","pages":""},"PeriodicalIF":37.3,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149150070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exosomes and cancer immunotherapy resistance: mechanistic circuits, adaptive reprogramming, and therapeutic targetability 外泌体和癌症免疫治疗抵抗：机制回路、适应性重编程和治疗靶向性
IF 37.3 1区 医学
Molecular Cancer Pub Date : 2026-10-08 DOI: 10.1186/s12943-026-02791-7
Xingyao Li,Qiang Zhang,Jia Wang,Jie Zhao,Shijie Cao,Feng Qiu,Jing Zhou,Xueming Dong,Andrea Li-Ann Wong,Lingzhi Wang,Chongyang Shen,Ning Kang,Boon-Cher Goh
{"title":"Exosomes and cancer immunotherapy resistance: mechanistic circuits, adaptive reprogramming, and therapeutic targetability","authors":"Xingyao Li,Qiang Zhang,Jia Wang,Jie Zhao,Shijie Cao,Feng Qiu,Jing Zhou,Xueming Dong,Andrea Li-Ann Wong,Lingzhi Wang,Chongyang Shen,Ning Kang,Boon-Cher Goh","doi":"10.1186/s12943-026-02791-7","DOIUrl":"https://doi.org/10.1186/s12943-026-02791-7","url":null,"abstract":"","PeriodicalId":19000,"journal":{"name":"Molecular Cancer","volume":"62 1","pages":""},"PeriodicalIF":37.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149150069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HSP90 inhibition drives GRP78 relocalization to potentiate CAR-based immunotherapy during tumor evolution HSP90抑制驱动GRP78重新定位，在肿瘤进化过程中增强基于car的免疫治疗
IF 37.3 1区 医学
Molecular Cancer Pub Date : 2026-10-03 DOI: 10.1186/s12943-026-02807-2
Youssef Sabha,Jong Hyun Cho,Xuxiang Zhang,John Haggerty,Alyna Ai,Ailin Mayorga,Sajjan Rajpoot,Chih-hsiung Chen,Joseph J. Bulatowicz,Maeve Byrne,Maria Alejandra Cruz,Anastasia Xynogala,Chang Liu,Fei Chen,William C. Gause,Xuening Wang,Kristy Fu,Luke Fritzky,Yong Qin,Sopio Simonishvili,Zhongren Zhou,Chen Liu,Alexander Lamenze,Zhi Wei,Aimee M. Beaulieu,Raymond B. Birge,Keri E. Lunsford,Dongfang Liu
{"title":"HSP90 inhibition drives GRP78 relocalization to potentiate CAR-based immunotherapy during tumor evolution","authors":"Youssef Sabha,Jong Hyun Cho,Xuxiang Zhang,John Haggerty,Alyna Ai,Ailin Mayorga,Sajjan Rajpoot,Chih-hsiung Chen,Joseph J. Bulatowicz,Maeve Byrne,Maria Alejandra Cruz,Anastasia Xynogala,Chang Liu,Fei Chen,William C. Gause,Xuening Wang,Kristy Fu,Luke Fritzky,Yong Qin,Sopio Simonishvili,Zhongren Zhou,Chen Liu,Alexander Lamenze,Zhi Wei,Aimee M. Beaulieu,Raymond B. Birge,Keri E. Lunsford,Dongfang Liu","doi":"10.1186/s12943-026-02807-2","DOIUrl":"https://doi.org/10.1186/s12943-026-02807-2","url":null,"abstract":"","PeriodicalId":19000,"journal":{"name":"Molecular Cancer","volume":"24 1","pages":""},"PeriodicalIF":37.3,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction Note: Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway 注：环状RNA circNRIP1作为microRNA-149-5p海绵，通过AKT1/mTOR通路促进胃癌进展
IF 37.3 1区 医学
Molecular Cancer Pub Date : 2026-10-01 DOI: 10.1186/s12943-026-02804-5
Xing Zhang,Sen Wang,Haixiao Wang,Jiacheng Cao,Xiaoxu Huang,Zheng Chen,Penghui Xu,Guangli Sun,Jianghao Xu,Jialun Lv,Zekuan Xu
{"title":"Retraction Note: Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway","authors":"Xing Zhang,Sen Wang,Haixiao Wang,Jiacheng Cao,Xiaoxu Huang,Zheng Chen,Penghui Xu,Guangli Sun,Jianghao Xu,Jialun Lv,Zekuan Xu","doi":"10.1186/s12943-026-02804-5","DOIUrl":"https://doi.org/10.1186/s12943-026-02804-5","url":null,"abstract":"","PeriodicalId":19000,"journal":{"name":"Molecular Cancer","volume":"1 1","pages":""},"PeriodicalIF":37.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heterogeneity of cancer-associated fibroblasts in tumor metastasis: mechanisms and precision therapeutic strategies 肿瘤转移中癌症相关成纤维细胞的异质性：机制和精确治疗策略
IF 37.3 1区 医学
Molecular Cancer Pub Date : 2026-10-01 DOI: 10.1186/s12943-026-02805-4
Yue Li,Yuhan Chen,Xueting Shen,Jinwei Lou,Luyao Zhang,Jian Qin,Yuqin Pan,Shukui Wang
{"title":"Heterogeneity of cancer-associated fibroblasts in tumor metastasis: mechanisms and precision therapeutic strategies","authors":"Yue Li,Yuhan Chen,Xueting Shen,Jinwei Lou,Luyao Zhang,Jian Qin,Yuqin Pan,Shukui Wang","doi":"10.1186/s12943-026-02805-4","DOIUrl":"https://doi.org/10.1186/s12943-026-02805-4","url":null,"abstract":"","PeriodicalId":19000,"journal":{"name":"Molecular Cancer","volume":"11 1","pages":""},"PeriodicalIF":37.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PIAS1 circRNA-translated novel protein inhibits NF-κB signaling pathway by promoting the nuclear translocation of TAB2 and impedes pyroptosis in colon cancer PIAS1 circrna翻译的新蛋白通过促进TAB2核易位抑制NF-κB信号通路，阻碍结肠癌细胞焦亡
IF 37.3 1区 医学
Molecular Cancer Pub Date : 2026-09-30 DOI: 10.1186/s12943-026-02803-6
Meng-Yue Wang,Shui-Ming Wang,Xin Zang,Cheng-Yan Liu,Cheng-Mei Xiao,Hui Hou,Xi Wu,Yu Wang,Ling-Yi Kong,Yuan-Zheng Xia
{"title":"PIAS1 circRNA-translated novel protein inhibits NF-κB signaling pathway by promoting the nuclear translocation of TAB2 and impedes pyroptosis in colon cancer","authors":"Meng-Yue Wang,Shui-Ming Wang,Xin Zang,Cheng-Yan Liu,Cheng-Mei Xiao,Hui Hou,Xi Wu,Yu Wang,Ling-Yi Kong,Yuan-Zheng Xia","doi":"10.1186/s12943-026-02803-6","DOIUrl":"https://doi.org/10.1186/s12943-026-02803-6","url":null,"abstract":"","PeriodicalId":19000,"journal":{"name":"Molecular Cancer","volume":"8 1","pages":""},"PeriodicalIF":37.3,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149092160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient-derived organoids for modeling therapy tolerance, persistence, and resistance in cancer 患者来源的类器官用于模拟癌症的治疗耐受性、持久性和耐药性
IF 37.3 1区 医学
Molecular Cancer Pub Date : 2026-09-22 DOI: 10.1186/s12943-026-02800-9
Kenji Harada,Naoya Sakamoto,Shoichi Ukai,Shumpei Ishikawa
{"title":"Patient-derived organoids for modeling therapy tolerance, persistence, and resistance in cancer","authors":"Kenji Harada,Naoya Sakamoto,Shoichi Ukai,Shumpei Ishikawa","doi":"10.1186/s12943-026-02800-9","DOIUrl":"https://doi.org/10.1186/s12943-026-02800-9","url":null,"abstract":"","PeriodicalId":19000,"journal":{"name":"Molecular Cancer","volume":"15 1","pages":""},"PeriodicalIF":37.3,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting ADAR1 reprograms cold tumors to hot and enhances immunotherapy in bladder cancer 靶向ADAR1将冷肿瘤重编程为热肿瘤，增强膀胱癌的免疫治疗
IF 37.3 1区 医学
Molecular Cancer Pub Date : 2026-09-22 DOI: 10.1186/s12943-026-02778-4
Kexin Bai,Juntao Zhuang,Hao Yu,Jiancheng Lv,Yuhan Chen,Linjing Jiang,Kai Li,Haiwei Yang,Qiang Lu,Xiao Yang
{"title":"Targeting ADAR1 reprograms cold tumors to hot and enhances immunotherapy in bladder cancer","authors":"Kexin Bai,Juntao Zhuang,Hao Yu,Jiancheng Lv,Yuhan Chen,Linjing Jiang,Kai Li,Haiwei Yang,Qiang Lu,Xiao Yang","doi":"10.1186/s12943-026-02778-4","DOIUrl":"https://doi.org/10.1186/s12943-026-02778-4","url":null,"abstract":"","PeriodicalId":19000,"journal":{"name":"Molecular Cancer","volume":"2 1","pages":""},"PeriodicalIF":37.3,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dysfunction of CD58 in tumor immune evasion: from mechanistic regulation to therapeutic resistance CD58在肿瘤免疫逃避中的功能障碍：从机制调节到治疗抵抗
IF 37.3 1区 医学
Molecular Cancer Pub Date : 2026-09-22 DOI: 10.1186/s12943-026-02797-1
Pengfei Guo,Ming Yi,Yu Gan,Guo Chen,Qi Liang,Wei Li
{"title":"Dysfunction of CD58 in tumor immune evasion: from mechanistic regulation to therapeutic resistance","authors":"Pengfei Guo,Ming Yi,Yu Gan,Guo Chen,Qi Liang,Wei Li","doi":"10.1186/s12943-026-02797-1","DOIUrl":"https://doi.org/10.1186/s12943-026-02797-1","url":null,"abstract":"Abstract CD58, the primary ligand of the co-stimulatory receptor CD2, plays a crucial role in the formation of the immunological synapse (IS) and the initiation of antitumor immunity involving T cells and natural killer (NK) cells. Aberrant CD58 expression, resulting from genomic inactivation, epigenetic silencing, transcriptional repression, and post-translational modifications, disrupts the architecture of the IS, impairs T and NK cell activation and effector functions, and promotes an immunosuppressive microenvironment. Consequently, restoring CD58 expression or function has emerged as a promising therapeutic strategy, with approaches such as epigenetic drugs to reverse CD58 silencing, engineered T cells to restore CD2 co-stimulation, and neutralizing agents targeting soluble CD58. In this review, we summarize the current understanding of how CD58 expression is regulated across multiple dimensions and how its dysfunction drives immune evasion and therapy resistance. We also explore the therapeutic potential of targeting the CD58-CD2 axis in cancer treatment, aiming to provide novel theoretical insights and innovative strategies to advance cancer immunotherapy.","PeriodicalId":19000,"journal":{"name":"Molecular Cancer","volume":"874 1","pages":""},"PeriodicalIF":37.3,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149022457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interconnected death: crosstalk among ferroptosis, cuproptosis, and pyroptosis in cancer 相互关联的死亡：癌症中铁下垂、铜下垂和焦下垂之间的串扰
IF 37.3 1区 医学
Molecular Cancer Pub Date : 2026-09-22 DOI: 10.1186/s12943-026-02799-z
Yixuan Liu,Jiachen Liu,Dianjie Zeng,Leyi Chen,Chenming Wei,Xiaorui Qiu,Liangmin Fu,Zebin Deng
{"title":"Interconnected death: crosstalk among ferroptosis, cuproptosis, and pyroptosis in cancer","authors":"Yixuan Liu,Jiachen Liu,Dianjie Zeng,Leyi Chen,Chenming Wei,Xiaorui Qiu,Liangmin Fu,Zebin Deng","doi":"10.1186/s12943-026-02799-z","DOIUrl":"https://doi.org/10.1186/s12943-026-02799-z","url":null,"abstract":"","PeriodicalId":19000,"journal":{"name":"Molecular Cancer","volume":"1 1","pages":""},"PeriodicalIF":37.3,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书