Nature and Science of Sleep最新文献

{"title":"From Model to Bedside: What Kind of OSA Risk Prediction Tools Do We Need More Of? [Response to Letter].","authors":"Botang Guo","doi":"10.2147/NSS.S554173","DOIUrl":"10.2147/NSS.S554173","url":null,"abstract":"","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1805-1806"},"PeriodicalIF":3.4,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12338320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Drug-Induced Sleep Endoscopy with Positive Airway Pressure Titration in the Individualized Treatment of Obstructive Sleep Apnea: A Report of Three Illustrative Cases.","authors":"Pei-Jun Li, Lin-Jing Gong, Zi-Yang Huang, Xiang Zhang, Dan Liu, Zong-An Liang","doi":"10.2147/NSS.S539613","DOIUrl":"10.2147/NSS.S539613","url":null,"abstract":"<p><strong>Purpose: </strong>Drug-induced sleep endoscopy with positive airway pressure titration (DISE-PAPT) can assess the effect of varying positive pressure levels on upper airway collapse in patients with obstructive sleep apnea (OSA) under simulated sleep condition. But it remains unclear whether DISE-PAPT can facilitate the development of personalized therapeutic interventions for OSA and further improve the therapeutic efficacy.</p><p><strong>Patients and methods: </strong>We present three adult patients with severe OSA exhibiting distinct clinical profiles: one case of continuous positive airway pressure (CPAP) treatment failure, one case of intolerance to high CPAP, and one case of psychological resistance to CPAP therapy.</p><p><strong>Results: </strong>According to the DISE-PAPT evaluation findings, CPAP combined with positional therapy was administered in Case 1. CPAP with surgical management was performed in Case 2, resulting in significant therapeutic improvements. Additionally, real-time DISE-PAPT visualization of CPAP-mediated upper airway patency restoration enhanced CPAP adherence in Case 3.</p><p><strong>Conclusion: </strong>The personalized treatment strategies based on the DISE-PAPT technique hold promise for improving the overall therapeutic efficacy and adherence among patients with OSA.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1769-1775"},"PeriodicalIF":3.4,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of Neutrophil-to-Lymphocyte Ratio for Cerebral Infarction in Obstructive Sleep Apnea: A Nomogram-Based Analysis.","authors":"Ziwei Hou, Chen Chen, Hong Liu, Yunpeng Wang, Zongxuan Li","doi":"10.2147/NSS.S536799","DOIUrl":"10.2147/NSS.S536799","url":null,"abstract":"<p><strong>Purpose: </strong>Obstructive sleep apnea (OSA) is associated with cerebral infarction (CIF) through inflammatory pathways. The neutrophil-to-lymphocyte ratio (NLR) serves as an inflammation biomarker, but its relationship with CIF in OSA patients remains unclear.</p><p><strong>Methods: </strong>A total of 188 OSA patients from The Affiliated Cardiovascular Hospital of Shanxi Medical University (January 2022 to December 2023) were included, consisting of 68 patients with CIF (case group) and 120 without CIF (control group). Data on admission, biochemical tests, and clinical characteristics were collected and compared. Multivariate logistic regression and a nomogram model were employed to identify risk factors, evaluated using receiver operating characteristic (ROC) curves, calibration curves and decision curve analysis (DCA).</p><p><strong>Results: </strong>Elevated log-transformed NLR (LnNLR), CRP, age, and reduced albumin levels were independently associated with increased CIF risk. The developed nomogram demonstrated excellent discriminative performance (AUC = 0.9372), superior to LnNLR alone (AUC = 0.665). At the optimal cutoff, the model achieved a sensitivity of 82.35% and specificity of 92.50%. Calibration plots showed good agreement between predicted and observed outcomes, and DCA confirmed the model's potential clinical utility.</p><p><strong>Conclusion: </strong>High NLR can be used as an emerging criterion for evaluating CIF risk in OSA. The nomogram model is capable of estimating CIF risk accurately, providing useful aid to clinical decision-making. The developed nomogram can be implemented in practice as an aid to help healthcare personnel identify high-risk OSA participants who would be offered early intervention in terms of increased monitoring and prophylaxis. External validation in larger, multi-center cohorts is warranted.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1777-1787"},"PeriodicalIF":3.4,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical and Economic Burden of Idiopathic Hypersomnia: Results from the Real-World Idiopathic Hypersomnia Total Health Model (RHYTHM) Study.","authors":"Ragy Saad, Sarah C Markt, Prasheel Lillaney, Deb A Profant, Douglas S Fuller, Elizabeth M Poole, Trevor Alvord, Patricia Prince, Shaina Desai, Marisa Whalen, Weiyi Ni, Jed Black","doi":"10.2147/NSS.S498432","DOIUrl":"10.2147/NSS.S498432","url":null,"abstract":"<p><strong>Purpose: </strong>Limited research describes the clinical and economic burden of idiopathic hypersomnia. This study compared this burden in individuals with idiopathic hypersomnia against matched controls.</p><p><strong>Patients and methods: </strong>This retrospective cohort study analyzed Merative™ MarketScan^® US claims (12/31/2013-2/29/2020). Individuals were ≥18 years of age and continuously enrolled during a 2-year assessment period. Individuals with idiopathic hypersomnia entered the cohort upon their first idiopathic hypersomnia medical claim; they were matched 1:5 with non-idiopathic hypersomnia controls on age, sex, region, insurance type, and cohort entry date. Odds of comorbid conditions experienced by individuals in either cohort during the 2-year assessment were compared. Healthcare resource utilization (HCRU) was presented as percentages by care setting. Median medical cost per patient per year (PPPY) was the sum of inpatient, outpatient, and emergency costs. <i>P</i>-values were not adjusted for multiplicity.</p><p><strong>Results: </strong>This analysis included 11,412 individuals with idiopathic hypersomnia and 57,058 matched controls. In both cohorts, median age was 45 years and 65% of individuals were female. Compared with matched controls, individuals with idiopathic hypersomnia had 1.6- to 4.4-fold higher odds (all <i>P</i><0.0001) of grouped conditions defined by multilevel Clinical Classifications Software categories, from neoplasms to nervous systems diseases, including sleep-related conditions. Individuals with idiopathic hypersomnia had higher odds of all comorbid conditions evaluated, including sleep-related, cardiovascular and cardiometabolic, and neuropsychiatric conditions, compared with matched controls. Individuals with idiopathic hypersomnia had higher HCRU (outpatient, 100% vs 96.1%; emergency department, 46.6% vs 34.3%; inpatient, 10.2% vs 8.5%, all <i>P</i><0.0001) than matched controls. Median medical costs PPPY were higher for individuals with idiopathic hypersomnia ($4854) than matched controls ($1348).</p><p><strong>Conclusion: </strong>Compared with matched controls, individuals with idiopathic hypersomnia had a higher clinical burden, spanning multiple organ systems, and a higher economic burden. Individuals' clinical profiles may be considered when treating idiopathic hypersomnia and providing holistic care.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1743-1755"},"PeriodicalIF":3.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy Bias and Factors Influencing Polysomnography and Consumer Sleep-Monitoring Device Measuring of Total Sleep Time: A Mixed-Methods Study.","authors":"Jing Yang, Dongmei Xu, Huanhuan Lu, Xuwen Yin, Haiyan Song, Weiwei Zong, Dandan Xu, Xiaohui Lu, Lan Wei, Hong Zhu, Shiyin Zhai, Zejuan Gu","doi":"10.2147/NSS.S537489","DOIUrl":"10.2147/NSS.S537489","url":null,"abstract":"<p><strong>Objective: </strong>The Huawei Band 9 (HWB 9), a consumer sleep-monitoring device with a high market share and a large user base in China, can provide sleep staging parameters and has broad representativeness in sleep monitoring applications. This study aims to compare the accuracy bias of polysomnography (PSG) and consumer sleep-monitoring devices, specifically the HWB 9, in measuring total sleep time (TST) and explore the factors affecting accuracy bias.</p><p><strong>Methods: </strong>This study employed a sequential explanatory mixed-methods design, with quantitative research comprising 108 samples and qualitative research comprising 18 samples. Select hospitalized patients who required polysomnographic monitoring due to their condition from November 2024 to March 2025 were chosen as the research subjects, and who used PSG and HWB 9 for synchronous sleep monitoring throughout the night. Quantitative data analysis was conducted using descriptive statistics, the Wilcoxon test, Bland-Altman plots, univariate analysis, and multiple linear regression analysis. Qualitative content data were analyzed using NVivo 14.0 software.</p><p><strong>Results: </strong>The statistical analysis showed a significant difference (P < 0.05) between the HWB 9 and PSG in measuring TST. The Bland-Altman plot showed that the measured values deviated from the consistency interval, indicating systematic overestimation bias. The multiple linear regression analysis showed that turning frequency and sleep posture were significant factors affecting measurement bias. Two main themes were found in the qualitative research: sleep habits and environmental factors, and individual differences and psychological perceptions.</p><p><strong>Conclusion: </strong>Considering the significant variations in individuals, data from such devices should be used with caution in clinical practice.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1757-1768"},"PeriodicalIF":3.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Among Obstructive Sleep Apnea, Thyroid Function and Morphology Changes.","authors":"Yushan Xie, Hongli Zhang, Zine Cao, Yanuo Zhou, Chendi Lu, Libo Yin, Simin Zhu, Yonglong Su, Xiaoxin Niu, Lina Ma, Yuqi Yuan, Yitong Zhang, Zitong Wang, Haiqin Liu, Xiaoyong Ren, Yewen Shi","doi":"10.2147/NSS.S507318","DOIUrl":"10.2147/NSS.S507318","url":null,"abstract":"<p><strong>Purpose: </strong>This study unveils the complex interplay among obstructive sleep apnea (OSA), thyroid function, and morphological changes.</p><p><strong>Methods: </strong>Data from 1,102 patients were collected retrospectively from the Department of Otorhinolaryngology-Head and Neck Surgery of the Second Affiliated Hospital of Xi'an Jiaotong University from 2012 to 2023. The patients were divided into severe and non-severe OSA groups according to their polysomnography results. The data were analyzed by sex and age stratification.</p><p><strong>Results: </strong>Serum free triiodothyronine (FT3), total triiodothyronine (TT3), and reverse triiodothyronine (RT3) were higher in severe OSA group in the total population (<i>p</i> < 0.05). Similar trends were observed in male but not in female. FT3 and TT3 are higher in the severe group in the nonelderly population (age < 60) (<i>p</i> < 0.05), and RT3 is higher in the severe group in the elderly population (age ≥ 60) (<i>p</i> < 0.05). In addition, we first reveal that RT3 is associated with the diameter of the left inferior thyroid artery (L-ITA) (r=0.394, <i>p</i> < 0.05) and lowest transcutaneous oxygen saturation at night (lowest SpO₂) (r=-0.269, <i>p</i> < 0.05). The severe OSA group showed larger thyroid volume and isthmus length, as well as the thicker ITA diameter and lower left thyroid lobe resistance index (RI) (all <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Our study demonstrates a significant association between thyroid function/morphology and OSA, with distinct sex- and age-related differences. Reduced RI in severe OSA suggests its clinical utility in assessing vascular health. Increased thyroid volume and isthmus length in severe OSA may reflect ITA-related changes. These findings support our prior observations of rising thyroid hormone levels with OSA progression and highlight the need for sex- and age-stratified analyses. Integrated evaluation of thyroid function and morphology is essential for understanding OSA-thyroid pathophysiology.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1727-1741"},"PeriodicalIF":3.4,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Microbiome Composition Changes During Insomnia Treatment with Lemborexant.","authors":"Seiko Miyata, Kunihiro Iwamoto, Mikako Ito, Ippei Okada, Nao Matsuyama, Akihiro Fujimoto, Yuki Kogo, Hiroshi Nishiwaki, Jun Ueyama, Kinji Ohno, Norio Ozaki","doi":"10.2147/NSS.S526037","DOIUrl":"10.2147/NSS.S526037","url":null,"abstract":"<p><strong>Purpose: </strong>Insomnia is a common disorder worldwide. Growing evidence has revealed that the microbiota-gut-brain axis contributes to the regulation of sleep continuity and duration, both directly and indirectly. Although lemborexant is effective in treating insomnia, its effect on the gut microbiota remains unclear. Here, we investigated the relationship between the gut microbiota and hypnotic use in insomnia.</p><p><strong>Participants and methods: </strong>We enrolled 29 adults with insomnia and performed sleep electroencephalography and stool analyses at baseline and after 4 and 12 weeks of open-label lemborexant treatment. Changes in gut microbiota were analyzed using 16S rRNA sequencing and metabolite analysis was performed to assess short-chain fatty acids (SCFAs).</p><p><strong>Results: </strong>Beta diversity (Jaccard dissimilarity) and Firmicutes/Bacteroidetes ratio significantly increased after administration of lemborexant for 12 weeks (p < 0.05). Seven genera were significantly different (p < 0.05). Among these, <i>Tannerellaceae Parabacteroides</i> decreased significantly after 12 weeks of lemborexant treatment (p = 0.013), even after correcting for false discovery rates. <i>Akkermansia</i> was strongly negatively correlated with sleep efficiency (r = -0.754, p = 0.0003). <i>Allisonella</i> showed opposite correlations with latency to persistent sleep and sleep efficiency after 12 weeks of lemborexant treatment (r = 0.523, p = 0.018, r = -0.516, p = 0.020, respectively). There were no significant differences in SCFAs during the treatment period.</p><p><strong>Conclusion: </strong>Our findings suggest that prolonged lemborexant treatment in individuals with insomnia may induce notable shifts in gut microbiota composition, including a significant reduction in <i>Parabacteroides</i> underscoring the potential interaction between hypnotic use and gut microbial balance.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1709-1726"},"PeriodicalIF":3.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restless Legs Syndrome Patients with Early Onset Disease or a Relevant Family History Associated with Pramipexole Ineffectiveness but Not Pregabalin.","authors":"Miaofa Ying, Tiantian Wang, Ting Zhang, Ziyang Zhai, Lisan Zhang","doi":"10.2147/NSS.S532626","DOIUrl":"10.2147/NSS.S532626","url":null,"abstract":"<p><strong>Background: </strong>Restless legs syndrome (RLS) is a complex condition characterized by significant heterogeneity. Factors that affect medication efficacy remain unclear; different RLS subtypes may respond differently to various drugs.</p><p><strong>Objective: </strong>To identify factors associated with the ineffectiveness of pramipexole and pregabalin in patients with various subtypes of RLS.</p><p><strong>Methods: </strong>This retrospective nested case-control study enrolled 257 RLS patients prescribed pramipexole or pregabalin between March 2019 and April 2024 at the sleep center of Sir Run Run Shaw Hospital. All patients completed a semi-structured questionnaire, underwent polysomnography and laboratory evaluations, and participated in a telephone survey. To represent iron-storage status, one principal component score that included five indicators of peripheral iron metabolism was extracted by principal component analysis. Treatment effectiveness was assessed using the Clinical Global Impression-Improvement (CGI-I) scale, with scores of 1-3 indicating effective treatment and higher scores reflecting ineffective treatment. Multivariate logistic regression was employed to assess the risk factors (or RLS subtypes) of medication ineffectiveness.</p><p><strong>Results: </strong>Of patients treated with pramipexole, 42.7% (70/164) reported poor outcomes. Early onset RLS (OR = 5.076; 95% CI, 1.836-14.033) and relevant family history (OR = 4.537; 95% CI, 1.556-13.437) increased pramipexole ineffectiveness risk. Among pregabalin users, 34.4% (32/93) reported ineffectiveness, which was associated with hemoglobin levels (OR = 1.039; 95% CI, 1.001-1.079).</p><p><strong>Conclusion: </strong>These findings suggest that RLS patients with familial or early-onset characteristics may represent a distinct subtype that responds preferentially to α2δ ligands over dopamine agonists, supporting personalized treatment approaches based on clinical phenotyping.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1695-1708"},"PeriodicalIF":3.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Restriction and Weekend Sleep Compensation Relate to Eating Behavior in School-Aged Children.","authors":"Rodrigo Chamorro, Marcelo Garrido-González, Mariolly Gutierrez, José L Santos, Gerardo Weisstaub","doi":"10.2147/NSS.S509636","DOIUrl":"10.2147/NSS.S509636","url":null,"abstract":"<p><strong>Purpose: </strong>Several studies showed that shortened sleep duration and subsequent sleep debt are related to obesity risk in children. We evaluated the association between habitual sleep restriction and eating behavior in school-aged children with and without obesity.</p><p><strong>Patients and methods: </strong>In 131 school-aged children (mean [±SD] age 10.2 ± 2.0 years), we assessed eating behavior through the Child Eating Behavior Questionnaire (CEBQ). Actigraphic recordings measured sleep patterns for 4 consecutive days, including a weekend day. CEBQ scores were calculated in sleep-restricted children (having a nighttime sleep duration <8 hours) during week and weekend days and compared for those with (n = 67) and without obesity (n = 64). CEBQ scores were also compared between children with and without sleep compensation (a weekend catch-up in sleep duration ≥1 hour compared to weekdays' sleep duration).</p><p><strong>Results: </strong>The mean sleep duration was 8.0 ± 1.3 h, and about 70% of children slept less than the daily sleep recommendation. Children having sleep restriction had higher scores in the four CEBQ pro-ingestion dimensions (all <i>P</i><0.021) as well as lower \"satiety responsiveness\" but higher \"emotional undereating\" scores (both <i>P</i><0.049). No differences in CEBQ were found in the normal-weight group when comparing children with or without sleep restriction. In the group with obesity, however, those sleep-restricted showed lower ratings in \"slowness of eating\" (<i>P</i><0.015), \"satiety responsiveness\", and \"food fussiness\" (both <i>P</i><0.035) compared to non-restricted, particularly during weekend days. Finally, children showing no sleep compensation on weekend days had higher pro-ingestion (all <i>P</i><0.020) and lower anti-ingestion scores (all <i>P</i><0.041).</p><p><strong>Conclusion: </strong>Sleep duration was lower than the recommended sleep in this sample of school-aged children. Sleep restriction was associated with enhanced pro-ingestion eating behavior scores and reduced anti-ingestion scores. Sleep compensation appears to have a positive effect on eating behavior scores.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1671-1681"},"PeriodicalIF":3.4,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived Stress Mediates the Relationship Between Childhood Trauma and Onset of Bruxism Among Adolescents.","authors":"Lei-Lei Wang, Shuang-Jiang Zhou, Hong-Juan Li, Jiu-Ju Li, Meng Qi, Jing Zhao, Yun-Long Tan, Jing-Xu Chen","doi":"10.2147/NSS.S531172","DOIUrl":"10.2147/NSS.S531172","url":null,"abstract":"<p><strong>Purpose: </strong>Bruxism is relatively common among adolescents; however, the psychological factors affecting its occurrence remain unclear. This study explored the incidence of bruxism in adolescents, and the role of childhood trauma and perceived stress in the occurrence of bruxism.</p><p><strong>Patients and methods: </strong>This was an online cross-sectional survey of 7794 adolescents aged 12-18 years, with 6780 adolescents meeting the inclusion criteria. We used the Adverse Childhood Experiences Questionnaire (ACEQ) to assess childhood trauma experiences, the Perceived Stress Scale (PSS) to evaluate stress in adolescents, and three items to assess bruxism. The chi-square test was used for demographic data and <i>t</i>-test was used for continuous variables. A mediation analysis was used to explore the mechanism of childhood trauma as it relates to bruxism.</p><p><strong>Results: </strong>Our research shows that about 21.6% of sampled adolescents had bruxism. Being in adolescents, childhood trauma, and high levels of perceived stress were risk factors for bruxism, and good academic performance was a protective factor against bruxism. Adolescents with bruxism had higher levels of childhood trauma and perceived stress. Perceived stress levels played a mediating role in the relationship between childhood trauma and the development of bruxism.</p><p><strong>Conclusion: </strong>Bruxism is common in adolescents, and its occurrence is related to childhood trauma and perceived stress levels. Childhood trauma mediates bruxism through perceived stress levels. Attention should be paid to the childhood trauma experiences and perceived stress levels of adolescents with bruxism, and timely interventions should be provided that are conducive to reducing the occurrence of bruxism.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1683-1694"},"PeriodicalIF":3.4,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}