Multiple Sclerosis Journal最新文献_第8页

Short- and mid-term efficacy of sacral neuromodulation in the treatment of neurogenic overactive bladder in patients with multiple sclerosis. 骶神经调节治疗多发性硬化症患者神经源性膀胱过动症的中短期疗效观察。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-04-01 Epub Date: 2025-03-13 DOI: 10.1177/13524585251323178

Benjamin Carolus, Pierre-Luc Dequirez, Louise Olivier, Samy Hafez, Marie-Aimée Perrouin-Verbe, Benoit Beyronnet, Grégoire Capon, Xavier Biardeau

{"title":"Short- and mid-term efficacy of sacral neuromodulation in the treatment of neurogenic overactive bladder in patients with multiple sclerosis.","authors":"Benjamin Carolus, Pierre-Luc Dequirez, Louise Olivier, Samy Hafez, Marie-Aimée Perrouin-Verbe, Benoit Beyronnet, Grégoire Capon, Xavier Biardeau","doi":"10.1177/13524585251323178","DOIUrl":"10.1177/13524585251323178","url":null,"abstract":"Background: Sacral neuromodulation (SNM) is commonly used in the treatment of overactive bladder, but few studies have evaluated its efficacy in patients with multiple sclerosis (MS).Objectives: To assess the efficacy of SNM in the treatment of neurogenic overactive bladder (nOAB) in patients with MS.Methods: All MS patients that underwent a two-stage SNM to treat nOAB between 2013 and 2023 in four university hospitals were considered eligible. The primary outcome was clinical efficacy, defined as the implantation of an implantable pulse generator (IPG). Secondary outcome included the Patient Global Impression of Improvement (PGI-I), the 3-day bladder diary parameters and the maintenance of efficacy within 5 years.Results: A total of 38 patients were included. The IPG was implanted in 33 patients (87%). The median daily (9.0 to 7.0; p < 0.001) and nocturnal (2.5 to 1.0; p < 0.01) number of micturition/clean self-intermittent catheterization (CISC), the presence of urinary urgency (97% vs 58%; p < 0.01) and urinary incontinence (84% vs 25%, p < 0.001) significantly decreased at the end of the test phase. Efficacy was maintained at 5 years in 46% of cases.Conclusions: In MS patients with nOAB, SNM exhibits clinical efficacy comparable to that observed in the non-neurological population.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"489-496"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward equity in MS care: A roadmap for accessible treatment. 迈向公平的多发性硬化症护理：可及治疗的路线图。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-04-01 Epub Date: 2025-03-17 DOI: 10.1177/13524585251326843

Jorge Correale

引用次数: 0

Severe gastrointestinal adverse reactions including perforation, ulceration, hemorrhage, and obstruction: A fumaric acid ester class new safety risk. 严重的胃肠道不良反应，包括穿孔、溃疡、出血和梗阻：富马酸酯类新的安全风险。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-04-01 Epub Date: 2025-02-11 DOI: 10.1177/13524585251316518

Tiffany Kim, Allen Brinker, David Croteau, Paul R Lee, Laura E Baldassari, Daniela Pimentel-Maldonado, Jessica Stevens, Christine Phipps, Alice Hughes, Erica Lyons, Laura H Finkelstein, Monica A Munoz

{"title":"Severe gastrointestinal adverse reactions including perforation, ulceration, hemorrhage, and obstruction: A fumaric acid ester class new safety risk.","authors":"Tiffany Kim, Allen Brinker, David Croteau, Paul R Lee, Laura E Baldassari, Daniela Pimentel-Maldonado, Jessica Stevens, Christine Phipps, Alice Hughes, Erica Lyons, Laura H Finkelstein, Monica A Munoz","doi":"10.1177/13524585251316518","DOIUrl":"10.1177/13524585251316518","url":null,"abstract":"Background: Although gastrointestinal (GI) adverse reactions (ARs) were commonly observed in registrational clinical trials of fumarate acid ester (FAE) drugs for the treatment of multiple sclerosis, serious GI reactions were uncommon.Objective: The objective of the study is to describe the serious GI ARs that supported the post-market safety labeling change for FAE drugs.Methods: Review of the FDA Adverse Events Reporting System (FAERS) database and published medical literature was conducted to identify cases of serious GI events in patients taking FAE drugs.Results: Forty-nine cases of GI ARs with clinical events of perforation, ulceration, hemorrhage, or obstruction causally associated with FAE drug use were identified. Most cases occurred within 4 months of FAE drug initiation and required hospitalization. Ten of the cases required red blood cell transfusions, nine cases required surgical intervention, and two cases resulted in a fatal outcome.Conclusion: Review of postmarketing reports supported the identification of a class association between FAE drugs and serious GI ARs. As these reactions have implications for prescribing decisions and patient management, a safety labeling change was issued to add serious GI reactions to the Warnings and Precautions section of the prescribing information for FAE drugs.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"578-586"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of optic neuritis among Afro-descendant, a cohort study. 非洲后裔视神经炎的发病率，一项队列研究。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-04-01 Epub Date: 2025-02-18 DOI: 10.1177/13524585251317339

Benoit Bobelna, Quentin Lobjois, Stefana Croitoru, Edmond Jalkh, Eric Ventura, Harold Merle

{"title":"Incidence of optic neuritis among Afro-descendant, a cohort study.","authors":"Benoit Bobelna, Quentin Lobjois, Stefana Croitoru, Edmond Jalkh, Eric Ventura, Harold Merle","doi":"10.1177/13524585251317339","DOIUrl":"10.1177/13524585251317339","url":null,"abstract":"Background: Optic neuritis (ON) is a multifactorial condition with a strong association with ethnicity.Objectives: We conducted a retrospective cohort study in a Caribbean Island, Martinique, French West Indies to assess the incidence and characteristics of ON among an Afro-descendant (AD) population.Methods: We reviewed medical records of all patients presenting ON at the Fort de France University Hospital, Martinique between 2018 and 2022. We analysed clinical, paraclinical, and biological examinations at onset and during follow-up (6 months, 1, 2 and 3 years). ON was confirmed after a neuro-ophthalmological evaluation according to the latest criteria defined in the Lancet, 2022.Results: Overall, 44 patients with a condition suggestive of ON were evaluated, out of which 29 fulfilled the criteria for ON. The overall incidence was 1.61 (95% CI: 1.12-2.08) per 100,000 person-years. The final diagnosis was distributed as follows: neuromyelitis optica spectrum disorder (NMOSD) (10%), myelin oligodendrocyte glycoprotein (MOG) ON (20%), multiple sclerosis (35%), single isolated ON (24%), relapsing isolated ON (7%) and (4%) unclassified diagnosis.Conclusion: This is the first cohort study assessing the incidence of ON and its characteristics among AD. We found a high proportion of severe disease, such as NMOSD and MOG-associated disease.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"529-538"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

We need to engage representative patients' community rather than 'expert patients' to increase impact of research in the era of personalized medicine: Commentary. 我们需要让有代表性的患者社区而不是“专家患者”参与进来，以增加个性化医疗时代研究的影响。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-04-01 Epub Date: 2025-02-11 DOI: 10.1177/13524585251315364

Paola Zaratin

引用次数: 0

Patient-reported outcomes of quality of life before and after autologous hematopoietic stem cell transplantation for multiple sclerosis. 多发性硬化症患者报告的自体造血干细胞移植前后的生活质量结果。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-04-01 Epub Date: 2025-02-17 DOI: 10.1177/13524585251315363

Ann-Christine Mitrache Desaga, Yassine Noui, Thomas Silfverberg, Kristina Carlson, Joachim Burman

{"title":"Patient-reported outcomes of quality of life before and after autologous hematopoietic stem cell transplantation for multiple sclerosis.","authors":"Ann-Christine Mitrache Desaga, Yassine Noui, Thomas Silfverberg, Kristina Carlson, Joachim Burman","doi":"10.1177/13524585251315363","DOIUrl":"10.1177/13524585251315363","url":null,"abstract":"Background: Autologous hematopoietic stem cell transplantation (AHSCT) is a therapeutic intervention for multiple sclerosis (MS) that has gained increased attention in the last decade. The impact of this intervention on the quality of life (QoL) of patients with MS remains unclear.Objective: The aim of this study was to investigate the impact of AHSCT on QoL in patients with MS using Multiple Sclerosis Impact Scale (MSIS-29) scores.Methods: In this observational retrospective cohort study, patients with relapsing-remitting MS treated with AHSCT in Sweden from 2004, when the first transplant was performed, until 31 December 2019, were considered for participation. Anonymized outcome data were extracted from the Swedish MS registry in May 2022.Results: Out of 213 patients assessed for eligibility in the study, 96 were included in the final analysis. After a median follow-up of 5.2 (IQR 3.2-6.8) years, 58% improved, 14% remained unchanged and 28% worsened in the physical domain of the MSIS-29. In the psychological domain, 63% improved, 18% remained unchanged and 19% worsened. Improvements in both domains occurred early, within the first year following intervention.Conclusions: Treatment intervention with AHSCT is associated with a clinically meaningful improvement in QoL.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"455-463"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Migraines, the multiple sclerosis prodrome, and multiple sclerosis susceptibility. 偏头痛，多发性硬化症前驱症状，和多发性硬化症易感性。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-04-01 Epub Date: 2025-02-19 DOI: 10.1177/13524585251318293

Vinicius A Schoeps, Jessica B Smith, Annette Langer-Gould

{"title":"Migraines, the multiple sclerosis prodrome, and multiple sclerosis susceptibility.","authors":"Vinicius A Schoeps, Jessica B Smith, Annette Langer-Gould","doi":"10.1177/13524585251318293","DOIUrl":"10.1177/13524585251318293","url":null,"abstract":"Background: Multiple studies identified an association between migraines and multiple sclerosis (MS).Objective: To investigate whether migraines increase MS risk or are part of the MS prodrome.Methods: Incident MS cases and matched controls completed structured interviews that included a detailed headache and MS history. Participants were classified as having migraines if they fulfilled the third edition of the International Classification of Headache Disorders criteria. The association between migraine onset concurrent with or before the first MS symptom/index date was estimated using multivariable logistic regression.Results: Among the 591 MS cases (70.6% females, 42.0% White), 21.2% developed migraines concurrent with or before the onset of MS compared to 18.7% of the 651 controls (70.4% females, 42.1% White, adjusted odds ratio (aOR) = 1.15, 95% confidence interval (CI) = 0.87-1.53). Migraine onset was more likely to occur either concurrently or 1 year before MS symptom onset/index date among MS cases (n = 18, 14.4%) than controls (n = 8, 6.6%; aOR = 2.52, 95% CI = 1.08-5.86, p = 0.032). However, not when restricted to only those with migraine onset before MS onset.Conclusion: Migraine was associated with an increased odds of MS only when co-occurrence was considered. These findings imply that migraines are part of the constellation of MS onset symptoms rather than a risk factor for or prodromal symptom of MS.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"539-547"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterizing gait in people with multiple sclerosis using digital data from smartphone sensors: A proposed framework. 使用智能手机传感器的数字数据表征多发性硬化症患者的步态：一个拟议的框架。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-04-01 Epub Date: 2025-02-18 DOI: 10.1177/13524585251316242

Angelos Karatsidis, Lorenza Angelini, Matthew Scaramozza, Emmanuel Bartholome, Susanne P Clinch, Changyu Shen, Michael Lindemann, Claudia Mazzà, Alf Scotland, Johan van Beek, Shibeshih Belachew, Licinio Craveiro

{"title":"Characterizing gait in people with multiple sclerosis using digital data from smartphone sensors: A proposed framework.","authors":"Angelos Karatsidis, Lorenza Angelini, Matthew Scaramozza, Emmanuel Bartholome, Susanne P Clinch, Changyu Shen, Michael Lindemann, Claudia Mazzà, Alf Scotland, Johan van Beek, Shibeshih Belachew, Licinio Craveiro","doi":"10.1177/13524585251316242","DOIUrl":"10.1177/13524585251316242","url":null,"abstract":"Background: Mobility assessment is essential for monitoring disease progression in people with multiple sclerosis (PwMS). Technologies such as wearable sensors show potential for this purpose, but consensus is needed to optimize collection and interpretation of digital measures in PwMS.Objective: To propose a framework for measuring and interpreting key aspects of impaired gait in PwMS using a smartphone worn at the waist level.Methods: The framework was developed on the basis of clinical understanding and knowledge of sensor signal processing, supported by a systematic literature review (SLR). The SLR targeted articles published after 2011 that measured gait characteristics in PwMS. Findings were used to propose standardized definitions for complementary gait domains and define digital measures that should be captured for each domain.Results: The resulting framework for PwMS recommends definitions for pace, rhythm, stability, symmetry, variability, smoothness, complexity and fatigability gait domains. For each domain, a set of digital measures is described with respect to their interpretability and associated caveats.Conclusion: This framework provides recommendations for measuring complex gait patterns in PwMS using widely available technology. This work promotes the use of standardized gait domain definitions and harmonized descriptions of associated digital measures, paving the way for future validation efforts.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"512-528"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Communication deficits in multiple sclerosis: Interactions with cognitive dysfunction and their impact on employment status. 多发性硬化症的沟通缺陷：与认知功能障碍的相互作用及其对就业状况的影响。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-04-01 Epub Date: 2025-03-20 DOI: 10.1177/13524585251328556

Christos Bakirtzis, Nefeli Dimitriou, Theodoros Moysiadis, Sarah El-Wahsh, Athina Andravizou, Elli Nteli, Marina-Kleopatra Boziki, Grigorios Nasios, Lambros Messinis, Nikolaos Grigoriadis

{"title":"Communication deficits in multiple sclerosis: Interactions with cognitive dysfunction and their impact on employment status.","authors":"Christos Bakirtzis, Nefeli Dimitriou, Theodoros Moysiadis, Sarah El-Wahsh, Athina Andravizou, Elli Nteli, Marina-Kleopatra Boziki, Grigorios Nasios, Lambros Messinis, Nikolaos Grigoriadis","doi":"10.1177/13524585251328556","DOIUrl":"10.1177/13524585251328556","url":null,"abstract":"Background: People living with multiple sclerosis (PwMS) are at risk of experiencing communication difficulties that can limit their vocational outcomes.Objective: To investigate clinical and cognitive variables that may contribute to communication restrictions in PwMS, and to evaluate how these factors affect vocational status.Methods: In this cross-sectional study, 502 PwMS underwent clinical and cognitive assessment tasks and were administered self-reported measures assessing fatigue and mood. The communication and language assessment questionnaire for persons with multiple sclerosis (CLAMS) was also administered.Results: Performance in information processing speed (p < 0.001), the presence of dysarthria (p < 0.001) and levels of self-reported fatigue (p < 0.001) were independent predictors of communication difficulties. Higher levels of communication difficulties were associated with a higher risk of unemployment and allowance (area under the receiver operating characteristic curve 0.649, p < 0.001 and 0.749, p < 0.001, respectively).Conclusion: Cognitive deficits, high levels of fatigue and the presence of dysarthria may independently contribute to communication difficulties in PwMS regardless of disease type or disability levels. These factors are associated with poorer vocational outcomes, highlighting the need for targeted interventions to support effective communication and improve employment prospects for this population.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"587-594"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic and lipid alterations in multiple sclerosis linked to disease severity. 多发性硬化症的代谢和脂质改变与疾病严重程度相关

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-04-01 Epub Date: 2025-03-27 DOI: 10.1177/13524585251325468

Rezvan Noroozi, Hui-Hsin Tsai, Ketian Yu, Paola Bronson, Karunakar Samuel, Kien Trinh, Ru Wei, Ellen Tsai, Farren Bs Briggs, Pavan Bhargava, Kathryn C Fitzgerald

{"title":"Metabolic and lipid alterations in multiple sclerosis linked to disease severity.","authors":"Rezvan Noroozi, Hui-Hsin Tsai, Ketian Yu, Paola Bronson, Karunakar Samuel, Kien Trinh, Ru Wei, Ellen Tsai, Farren Bs Briggs, Pavan Bhargava, Kathryn C Fitzgerald","doi":"10.1177/13524585251325468","DOIUrl":"10.1177/13524585251325468","url":null,"abstract":"Background: The circulating metabolome incorporates multiple levels of biological interactions and is an emerging field for biomarker discovery. However, few studies have linked metabolite levels with quantitative neurologic function assessments in people with multiple sclerosis (pwMS).Objectives: We quantified metabolomic differences between pwMS and healthy controls (HCs) and assessed the association of metabolites with disease severity.Methods: We profiled 517 metabolites using liquid chromatography-mass spectrometry (Biocrates Inc.) for participants from the MS Partners Advancing Technology and Health Solutions (MS PATHS). We conducted a multicenter cross-sectional study and applied linear regression to assess the association between metabolites and neurological function measures in multiple sclerosis (MS), including walking speed, manual dexterity, and processing speed.Results: Among 1010 participants (837 MS; 71.2% relapsing-remitting MS; 173 HC; mean age: 44.5 (standard deviation (SD): 11.4); 73.9% female; 12.7% non-white), pwMS showed decreased levels of phosphatidylcholines (PCs) and different amino acids (AAs) but increased triglycerides (TGs). Metabolites showed an association with worse neurologic function; for instance, a 1-SD decrease in PC aa C36:6 was associated with 21.36% (95% confidence interval (CI): 11.07-30.46; p = 1.35E-04) slower walking speed.Conclusions: This large study identified lipid alterations linked to MS severity. Future longitudinal studies will evaluate if these metabolite levels predict MS outcomes.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"433-443"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0