Multiple Sclerosis Journal最新文献_第8页

Prioritizing global strategies to cure MS. 确定治疗多发性硬化症全球战略的优先次序。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1177/13524585241272987

Alvaro Cobo-Calvo, Mar Tintore

引用次数: 0

ECTRIMS 2024 Committees. ECTRIMS 2024 委员会。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-09-01 DOI: 10.1177/13524585241269214

引用次数: 0

Aging is associated with reduced inflammatory disease activity independent of disease duration in relapsing multiple sclerosis trial populations. 在复发性多发性硬化症试验人群中，衰老与炎症性疾病活动的减少有关，而与病程无关。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-09-01 Epub Date: 2024-09-08 DOI: 10.1177/13524585241272938

Eline Me Coerver, Sezgi Kaçar, Olga Ciccarelli, Maria P Sormani, Frederik Barkhof, Douglas L Arnold, Menno M Schoonheim, Zoé LE Van Kempen, Jop Mostert, Marcus W Koch, Joep Killestein, Arman Eshaghi, Bernard Mj Uitdehaag, Eva Mm Strijbis

{"title":"Aging is associated with reduced inflammatory disease activity independent of disease duration in relapsing multiple sclerosis trial populations.","authors":"Eline Me Coerver, Sezgi Kaçar, Olga Ciccarelli, Maria P Sormani, Frederik Barkhof, Douglas L Arnold, Menno M Schoonheim, Zoé LE Van Kempen, Jop Mostert, Marcus W Koch, Joep Killestein, Arman Eshaghi, Bernard Mj Uitdehaag, Eva Mm Strijbis","doi":"10.1177/13524585241272938","DOIUrl":"10.1177/13524585241272938","url":null,"abstract":"Background: Higher age is associated with less inflammatory disease activity in relapsing-remitting multiple sclerosis (RRMS). It is unknown whether age itself or disease duration underlies this association.Objectives: This study investigated the effects of age, disease duration, and inflammatory disease activity in people with RRMS.Methods: Individual patient-level data from five large phase III randomized controlled trials (RCTs) was utilized to investigate the association of both age and disease duration with annualized relapse rate (ARR), contrast-enhancing lesions (CELs), and new T2 lesions on magnetic resonance imaging (MRI) at baseline and follow-up.Results: The data set included 5626 participants. Higher age was associated with lower ARRs, lower CEL number on MRI at baseline and follow-up, and lower new T2 lesion numbers at follow-up. This effect was present in all disease duration groups. For example, we found a lower number of new T2 lesions on MRI during follow-up in higher age groups compared to lower age groups, independent of disease duration.Conclusion: Aging in RRMS is associated with a lower risk of inflammatory disease activity, across different disease durations. Age should be taken into account when designing clinical trials and future research should investigate how age should be integrated into personalized predictions of treatment response and risk profiling.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1296-1308"},"PeriodicalIF":4.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered lymphocyte profiles and herpes zoster infections in patients with multiple sclerosis on natalizumab. 使用纳他珠单抗的多发性硬化症患者的淋巴细胞谱改变和带状疱疹感染。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-09-01 Epub Date: 2024-06-16 DOI: 10.1177/13524585241260537

Alexandra Balshi, Nova Manning, John Dempsey, Sachin Kumbar, Ursela Baber, Jacob A Sloane

引用次数: 0

Choroid plexus enlargement correlates with periventricular pathology but not with disease activity in radiologically isolated syndrome. 脉络丛扩大与脑室周围病变相关，但与放射学孤立综合征的疾病活动无关。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-09-01 Epub Date: 2024-09-09 DOI: 10.1177/13524585241272943

Cassandre Landes-Château, Vito Ag Ricigliano, Lydiane Mondot, Eric Thouvenot, Pierre Labauge, Céline Louapre, Hélène Zéphir, Françoise Durand-Dubief, Emmanuelle Le Page, Aksel Siva, Mikael Cohen, Arya Yazdan Panah, Christina J Azevedo, Darin T Okuda, Bruno Stankoff, Christine Lebrun-Frénay

{"title":"Choroid plexus enlargement correlates with periventricular pathology but not with disease activity in radiologically isolated syndrome.","authors":"Cassandre Landes-Château, Vito Ag Ricigliano, Lydiane Mondot, Eric Thouvenot, Pierre Labauge, Céline Louapre, Hélène Zéphir, Françoise Durand-Dubief, Emmanuelle Le Page, Aksel Siva, Mikael Cohen, Arya Yazdan Panah, Christina J Azevedo, Darin T Okuda, Bruno Stankoff, Christine Lebrun-Frénay","doi":"10.1177/13524585241272943","DOIUrl":"10.1177/13524585241272943","url":null,"abstract":"Background: Choroid plexus (ChP) enlargement is an emerging radiological biomarker in multiple sclerosis (MS).Objectives: This study aims to assess ChP volume in a large cohort of patients with radiologically isolated syndrome (RIS) versus healthy controls (HC) and explore its relationship with other brain volumes, disease activity, and biological markers.Methods: RIS individuals were included retrospectively and compared with HC. ChPs were automatically segmented using an in-house automated algorithm and manually corrected.Results: A total of 124 patients fulfilled the 2023 RIS criteria, and 55 HCs were included. We confirmed that ChPs are enlarged in RIS versus HC (mean (±SD) normalized ChP volume: 17.24 (±4.95) and 11.61 (±3.58), respectively, p < 0.001). Larger ChPs were associated with more periventricular lesions (ρ = 0.26; r2 = 0.27; p = 0.005 for the correlation with lesion volume, and ρ = 0.2; r2 = 0.21; p = 0.002 for the correlation with lesion number) and lower thalamic volume (ρ = -0.38; r2 = 0.44; p < 0.001), but not with lesions in other brain regions. Conversely, ChP volume did not correlate with biological markers. No significant difference in ChP volume was observed between subjects who presented or did not have a clinical event or between those with or without imaging disease activity.Conclusions: This study provides evidence that ChP volume is higher in RIS and is associated with measures reflecting periventricular pathology but does not correlate with biological, radiological, or clinical markers of disease activity.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1278-1289"},"PeriodicalIF":4.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From discovery to replication: Power and definitions matter for multiple sclerosis severity. 从发现到复制：权力和定义对多发性硬化症的严重程度很重要。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-09-01 Epub Date: 2024-07-26 DOI: 10.1177/13524585241265021

Pernilla Stridh, Jesse Huang, Ingrid Kockum

引用次数: 0

Phonemic processing is below expectations and linked to word-finding difficulty in multiple sclerosis. 音位处理能力低于预期，与多发性硬化症患者的找词困难有关。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-09-01 Epub Date: 2024-08-05 DOI: 10.1177/13524585241259648

Emily Dvorak, Sarah Levy, Jordyn R Anderson, James F Sumowski

{"title":"Phonemic processing is below expectations and linked to word-finding difficulty in multiple sclerosis.","authors":"Emily Dvorak, Sarah Levy, Jordyn R Anderson, James F Sumowski","doi":"10.1177/13524585241259648","DOIUrl":"10.1177/13524585241259648","url":null,"abstract":"Background: Word-finding difficulty is prevalent but poorly understood in persons with relapsing-remitting multiple sclerosis (RRMS).Objective: The objective was to investigate our hypothesis that phonological processing ability is below expectations and related to word-finding difficulty in patients with RRMS.Method: Data were analyzed from patients with RRMS (n = 50) on patient-reported word-finding difficulty (PR-WFD) and objective performance on Wechsler Individual Achievement Test, Fourth Edition (WIAT-4) Phonemic Proficiency (PP; analysis of phonemes within words), Word Reading (WR; proxy of premorbid literacy and verbal ability), and Sentence Repetition (SR; auditory processing of word-level information).Results: Performance (mean (95% confidence interval)) was reliably lower than normative expectations for PP (-0.41 (-0.69, -0.13)) but not for WR (0.02 (-0.21, 0.25)) or SR (0.08 (-0.15, 0.31). Within-subjects performance was worse on PP than on both WR (t(49) = 4.00, p < 0.001, d = 0.47) and SR (t(49) =3.76, p < 0.001, d = 0.54). Worse PR-WFD was specifically related to lower PP (F2,47 = 6.24, p = 0.004, η2 = 0.21); worse PP performance at PR-WFD Often (n = 13; -1.16 (-1.49, -0.83)) than Sometimes (n = 17; -0.14 (-0.68, 0.41)) or Rarely (n = 20; -0.16 (-0.58, 0.27). PR-WFD was unrelated to WR or SR (ps > 0.25).Conclusion: Phonological processing was below expectations and specifically linked to word-finding difficulty in RRMS. Findings are consistent with early disease-related cortical changes within the posterior superior temporal/supramarginal region. Results inform our developing model of multiple sclerosis-related word-finding difficulty.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1374-1378"},"PeriodicalIF":4.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neighborhood disadvantage, race, and clinical outcomes in neuromyelitis optica spectrum disorder. 神经脊髓炎视谱系障碍患者的邻里劣势、种族和临床结果。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-09-01 Epub Date: 2024-08-06 DOI: 10.1177/13524585241267231

J R Abbatemarco, A Aboseif, C Swetlik, J Widmar, T Harvey, A Kunchok, J O'Mahony, D M Miller, D S Conway

{"title":"Neighborhood disadvantage, race, and clinical outcomes in neuromyelitis optica spectrum disorder.","authors":"J R Abbatemarco, A Aboseif, C Swetlik, J Widmar, T Harvey, A Kunchok, J O'Mahony, D M Miller, D S Conway","doi":"10.1177/13524585241267231","DOIUrl":"10.1177/13524585241267231","url":null,"abstract":"Background: Little is known about the relationship between neighborhood disadvantage and neuromyelitis optica spectrum disorder (NMOSD) outcomes.Objective: The objective is to determine the impact of neighborhood disadvantage on time from symptom onset to diagnosis and annualized relapse rate (ARR).Methods: Neighborhood disadvantage were captured with the Area Deprivation Index (ADI), a validated measure of neighborhood-level disadvantage. Negative binomial regression models assessed the impact of ADI on diagnostic delay (⩾3 months between symptom onset and diagnosis) and ARR.Results: A total of 158 NMOSD patients were identified, a majority of whom were White (56.3%) and female (89.9%) with a mean age of 46 years at diagnosis. The ADI did not significantly affect odds of diagnostic delay (odds ratio (OR) = 0.99, p = 0.26). In univariable models, the ADI was not significantly associated with ARR (OR = 1.004, p = 0.29), but non-White race (OR = 1.541, p = 0.02) and time on immunosuppressive therapies (ISTs; OR = 0.994, p = 0.03) were. White patients used IST for an average of 81% of the follow-up period, compared to an average of 65% for non-White patients (p < 0.01).Conclusion: No significant relationship between neighborhood-level disadvantage and diagnostic delay or ARR in NMOSD patients was observed. Non-White patients had a higher ARR, which may be related to less IST use.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1322-1330"},"PeriodicalIF":4.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of health care use and a possible prodrome before the first attack in NMOSD and MOGAD. 对 NMOSD 和 MOGAD 首次发作前使用医疗保健和可能的前驱症状的调查。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-09-01 Epub Date: 2024-09-05 DOI: 10.1177/13524585241272939

Dalia L Rotstein, Mark S Freedman, Andrea Konig, Liesly Lee, Jin Luo, Colleen Maxwell, Sarah A Morrow, Helen Tremlett, Manav V Vyas, Ruth Ann Marrie

{"title":"Investigation of health care use and a possible prodrome before the first attack in NMOSD and MOGAD.","authors":"Dalia L Rotstein, Mark S Freedman, Andrea Konig, Liesly Lee, Jin Luo, Colleen Maxwell, Sarah A Morrow, Helen Tremlett, Manav V Vyas, Ruth Ann Marrie","doi":"10.1177/13524585241272939","DOIUrl":"10.1177/13524585241272939","url":null,"abstract":"Background: Prodromal phases are well recognized in many inflammatory and neurodegenerative diseases, including multiple sclerosis. We evaluated the possibility of a prodrome in aquaporin-4 antibody positive (AQP4+) neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) using health administrative data.Methods: We investigated individuals with AQP4 + NMOSD and MOGAD, confirmed by medical chart review, in Ontario, Canada. Each NMOSD and MOGAD participant was matched 1:5 to general population controls by sex, birth year, immigrant status, and region. Total outpatient visits and hospitalizations were compared in the 5 years preceding the incident attack in multivariable negative binomial models.Results: We identified 96 people with AQP4 + NMOSD, matched to 479 controls, and 61 people with MOGAD, matched to 303 controls. In the 5 years preceding the incident attack, health care use was elevated for outpatient visits and hospitalizations for the NMOSD cohort (adjusted rate ratio (aRR): 1.47; 95% confidence interval (CI): 1.25-1.73; aRR: 1.67; 95% CI: 1.19-2.36, respectively) but not for MOGAD. Rate ratios steadily increased in NMOSD for outpatient visits in the 2 years preceding the incident attack.Conclusion: Our findings support a prodromal phase preceding clinical onset of AQP4 + NMOSD. Earlier recognition and management of NMOSD patients may be possible.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1331-1340"},"PeriodicalIF":4.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis. 中央静脉征与寡克隆带对多发性硬化症的诊断效果。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-09-01 Epub Date: 2024-09-05 DOI: 10.1177/13524585241271988

Karlo Toljan, Lynn Daboul, Praneeta Raza, Melissa L Martin, Quy Cao, Carly M O'Donnell, Paulo Rodrigues, John Derbyshire, Christina J Azevedo, Amit Bar-Or, Eduardo Caverzasi, Peter A Calabresi, Bruce Ac Cree, Leorah Freeman, Roland G Henry, Erin E Longbrake, Jiwon Oh, Nico Papinutto, Daniel Pelletier, Rohini D Samudralwar, Matthew K Schindler, Elias S Sotirchos, Nancy L Sicotte, Andrew J Solomon, Russell T Shinohara, Daniel S Reich, Pascal Sati, Daniel Ontaneda

{"title":"Diagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis.","authors":"Karlo Toljan, Lynn Daboul, Praneeta Raza, Melissa L Martin, Quy Cao, Carly M O'Donnell, Paulo Rodrigues, John Derbyshire, Christina J Azevedo, Amit Bar-Or, Eduardo Caverzasi, Peter A Calabresi, Bruce Ac Cree, Leorah Freeman, Roland G Henry, Erin E Longbrake, Jiwon Oh, Nico Papinutto, Daniel Pelletier, Rohini D Samudralwar, Matthew K Schindler, Elias S Sotirchos, Nancy L Sicotte, Andrew J Solomon, Russell T Shinohara, Daniel S Reich, Pascal Sati, Daniel Ontaneda","doi":"10.1177/13524585241271988","DOIUrl":"10.1177/13524585241271988","url":null,"abstract":"Background: Cerebrospinal fluid (CSF) oligoclonal bands (OCB) are a diagnostic biomarker in multiple sclerosis (MS). The central vein sign (CVS) is an imaging biomarker for MS that may improve diagnostic accuracy.Objectives: The objective of the study is to examine the diagnostic performance of simplified CVS methods in comparison to OCB in participants with clinical or radiological suspicion for MS.Methods: Participants from the CentrAl Vein Sign in MS (CAVS-MS) pilot study with CSF testing were included. Select-3 and Select-6 (counting up to three or six CVS+ lesions per scan) were rated on post-gadolinium FLAIR* images. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value for Select-3, Select-6, OCB, and combinations thereof were calculated for MS diagnosis at baseline and at 12 months.Results: Of 53 participants, 25 were OCB+. At baseline, sensitivity for MS diagnosis was 0.75 for OCB, 0.83 for Select-3, and 0.71 for Select-6. Specificity for MS diagnosis was 0.76 for OCB, 0.48 for Select-3, and 0.86 for Select-6. At 12 months, PPV for MS diagnosis was 0.95 for Select-6 and 1.00 for Select-6 with OCB+ status.Discussion: Results suggest similar diagnostic performance of simplified CVS methods and OCB. Ongoing studies will refine whether CVS could be used in replacement or in conjunction with OCB.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1268-1277"},"PeriodicalIF":4.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11421977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0