非洲后裔视神经炎的发病率,一项队列研究。

IF 5 2区 医学 Q1 CLINICAL NEUROLOGY
Multiple Sclerosis Journal Pub Date : 2025-04-01 Epub Date: 2025-02-18 DOI:10.1177/13524585251317339
Benoit Bobelna, Quentin Lobjois, Stefana Croitoru, Edmond Jalkh, Eric Ventura, Harold Merle
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引用次数: 0

摘要

背景:视神经炎(ON)是一种多因素疾病,与种族密切相关。目的:我们在加勒比岛、马提尼克岛、法属西印度群岛进行了一项回顾性队列研究,以评估非洲后裔(AD)人群中ON的发病率和特征。方法:我们回顾了2018年至2022年在马提尼克岛法兰西堡大学医院就诊的所有ON患者的病历。我们分析了发病时和随访期间(6个月、1年、2年和3年)的临床、临床旁和生物学检查。根据《柳叶刀》(Lancet) 2022年最新定义的标准,经神经眼科评估后确诊为ON。结果:总体而言,44例提示ON的患者进行了评估,其中29例符合ON的标准。总发病率为每10万人年1.61例(95% CI: 1.12-2.08)。最终诊断分布如下:视神经脊髓炎频谱障碍(NMOSD)(10%),髓鞘少突胶质细胞糖蛋白(MOG) ON(20%),多发性硬化症(35%),单一分离ON(24%),复发分离ON(7%)和未分类诊断(4%)。结论:这是第一个评估AD患者ON发病率及其特征的队列研究。我们发现严重疾病的比例很高,如NMOSD和mog相关疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Incidence of optic neuritis among Afro-descendant, a cohort study.

Background: Optic neuritis (ON) is a multifactorial condition with a strong association with ethnicity.

Objectives: We conducted a retrospective cohort study in a Caribbean Island, Martinique, French West Indies to assess the incidence and characteristics of ON among an Afro-descendant (AD) population.

Methods: We reviewed medical records of all patients presenting ON at the Fort de France University Hospital, Martinique between 2018 and 2022. We analysed clinical, paraclinical, and biological examinations at onset and during follow-up (6 months, 1, 2 and 3 years). ON was confirmed after a neuro-ophthalmological evaluation according to the latest criteria defined in the Lancet, 2022.

Results: Overall, 44 patients with a condition suggestive of ON were evaluated, out of which 29 fulfilled the criteria for ON. The overall incidence was 1.61 (95% CI: 1.12-2.08) per 100,000 person-years. The final diagnosis was distributed as follows: neuromyelitis optica spectrum disorder (NMOSD) (10%), myelin oligodendrocyte glycoprotein (MOG) ON (20%), multiple sclerosis (35%), single isolated ON (24%), relapsing isolated ON (7%) and (4%) unclassified diagnosis.

Conclusion: This is the first cohort study assessing the incidence of ON and its characteristics among AD. We found a high proportion of severe disease, such as NMOSD and MOG-associated disease.

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来源期刊
Multiple Sclerosis Journal
Multiple Sclerosis Journal 医学-临床神经学
CiteScore
10.90
自引率
6.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585
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