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Relapsing tumefactive demyelination: time to recognize a distinct demyelinating condition? 复发性肿瘤活动性脱髓鞘：是时候认识一种独特的脱髓鞘病症了吗？
IF 4.8 2区 医学
Multiple Sclerosis Journal Pub Date : 2024-09-08 DOI: 10.1177/13524585241273075
Todd A Hardy, Brian G Weinshenker
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引用次数: 0
Relapsing tumefactive demyelination lesions: A unique, distinct inflammatory brain pathology. 复发性肿瘤活动性脱髓鞘病变：一种独特的、与众不同的脑部炎症病理。
IF 4.8 2区 医学
Multiple Sclerosis Journal Pub Date : 2024-09-08 DOI: 10.1177/13524585241273005
Paola Perini, Marta Gaggiola, Francesca Rinaldi, Paolo Gallo, Marco Puthenparampil
{"title":"Relapsing tumefactive demyelination lesions: A unique, distinct inflammatory brain pathology.","authors":"Paola Perini, Marta Gaggiola, Francesca Rinaldi, Paolo Gallo, Marco Puthenparampil","doi":"10.1177/13524585241273005","DOIUrl":"https://doi.org/10.1177/13524585241273005","url":null,"abstract":"<p><p>We report the case of a patient suffering from biopsy-proven relapsing tumefactive demyelinating lesions (TDLs) of the central nervous system who had five relapses in 16 years. No signs/symptoms suggestive of alternative pathologies emerged during the follow-up. A limited benefit was observed with intravenous (IV) high-dose steroids, while both plasma exchange and IV immunoglobulin G (IgG) administration were ineffective. A long-lasting (9 years) but transient clinical stabilization was obtained with cyclophosphamide. Our case supports the view that recurrent TDL is a relapsing brain inflammation not belonging to multiple sclerosis (MS) or myelin oligodendrocyte glycoprotein (MOG)-/AQP4-associated disorders. TDL concept and clinical features should be revised.</p>","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"13524585241273005"},"PeriodicalIF":4.8,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ECTRIMS 2024 – ePoster ECTRIMS 2024 - 电子海报
IF 5.8 2区 医学
Multiple Sclerosis Journal Pub Date : 2024-09-05 DOI: 10.1177/13524585241269221
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引用次数: 0
ECTRIMS 2024 – Oral Presentations ECTRIMS 2024 - 口头报告
IF 5.8 2区 医学
Multiple Sclerosis Journal Pub Date : 2024-09-05 DOI: 10.1177/13524585241269218
{"title":"ECTRIMS 2024 – Oral Presentations","authors":"","doi":"10.1177/13524585241269218","DOIUrl":"https://doi.org/10.1177/13524585241269218","url":null,"abstract":"","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":"156 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142182865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ECTRIMS 2024 – Poster ECTRIMS 2024 - 海报
IF 5.8 2区 医学
Multiple Sclerosis Journal Pub Date : 2024-09-05 DOI: 10.1177/13524585241269219
{"title":"ECTRIMS 2024 – Poster","authors":"","doi":"10.1177/13524585241269219","DOIUrl":"https://doi.org/10.1177/13524585241269219","url":null,"abstract":"","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":"441 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142223981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monitoring cognitive functioning in MS will trigger anxiety in patients: Yes. 监测多发性硬化症患者的认知功能会引发患者的焦虑：是的。
IF 4.8 2区 医学
Multiple Sclerosis Journal Pub Date : 2024-09-01 Epub Date: 2024-06-16 DOI: 10.1177/13524585241261212
Lauren Krupp, Kimberly A O'Neill
{"title":"Monitoring cognitive functioning in MS will trigger anxiety in patients: Yes.","authors":"Lauren Krupp, Kimberly A O'Neill","doi":"10.1177/13524585241261212","DOIUrl":"10.1177/13524585241261212","url":null,"abstract":"","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1252-1254"},"PeriodicalIF":4.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141331467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progression independent of relapse activity can be predicted by passively acquired tapping speed through a smartphone for 1 month: A prospective study. 通过智能手机在 1 个月内被动获取的敲击速度，可以预测与复发活动无关的病情进展：一项前瞻性研究。
IF 4.8 2区 医学
Multiple Sclerosis Journal Pub Date : 2024-09-01 Epub Date: 2024-09-09 DOI: 10.1177/13524585241272960
Juan Luis Chico-Garcia, Raquel Sainz Amo, Enric Monreal, Susana Sainz de la Maza, Fernando Rodriguez Jorge, Jaime Masjuan, Lucienne Costa-Frossard, Luisa María Villar
{"title":"Progression independent of relapse activity can be predicted by passively acquired tapping speed through a smartphone for 1 month: A prospective study.","authors":"Juan Luis Chico-Garcia, Raquel Sainz Amo, Enric Monreal, Susana Sainz de la Maza, Fernando Rodriguez Jorge, Jaime Masjuan, Lucienne Costa-Frossard, Luisa María Villar","doi":"10.1177/13524585241272960","DOIUrl":"10.1177/13524585241272960","url":null,"abstract":"<p><strong>Background: </strong>Tapping speed (TS) correlates with baseline disability scales in people with multiple sclerosis (pwMS).</p><p><strong>Objective: </strong>The study aimed to address if progression independent of relapse activity (PIRA) could be predicted by first-month measurement of TS.</p><p><strong>Methods: </strong>Prospective study including pwMS in one referral MS center. Consecutive patients were included and keys/second (Keys/s) were passively measured each day using an in-house smartphone application for 1 month. Median, mean, and maximum keys/s were obtained. Multivariate logistic regression models (including keys/s, age, sex, and baseline disability scores) were obtained for prediction of a PIRA event after 1 year.</p><p><strong>Results: </strong>Overall, 59 patients were included in the final analysis (64.4% women, median age of 44.5 years). However, 10 patients presented a PIRA event, without differences regarding baseline characteristics between PIRA and no-PIRA groups. PIRA group presented lower median keys/s (2 vs 4 keys/s, <i>p</i> = 0.002) and mean keys/s (2.8 vs 4.6, <i>p</i> = 0.008), while maximum keys/s were similar (<i>p</i> = 0.32). A median ⩽ 3 keys/s was independently associated with PIRA (aOR = 16.8, <i>p</i> = 0.03), as did a mean ⩽ 3.7 keys/s (aOR = 17, <i>p</i> = 0.02). These differences were not detected regarding other variables analyzed.</p><p><strong>Conclusion: </strong>Low median or mean keys/s obtained during initial month of assessment were indicative of a PIRA event within the next year.</p>","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1341-1349"},"PeriodicalIF":4.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The refined Pathways to Cures Research Roadmap for multiple sclerosis cures. 完善的多发性硬化症治疗研究路线图。
IF 4.8 2区 医学
Multiple Sclerosis Journal Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.1177/13524585241266483
Bruce F Bebo, Brenda L Banwell, Caroline C Whitacre, Timothy Coetzee, Ulrik Dalgas, Phillip L De Jager, Anne-Katrin Proebstel, V Wee Yong, Etty N Benveniste, Alan J Thompson
{"title":"The refined Pathways to Cures Research Roadmap for multiple sclerosis cures.","authors":"Bruce F Bebo, Brenda L Banwell, Caroline C Whitacre, Timothy Coetzee, Ulrik Dalgas, Phillip L De Jager, Anne-Katrin Proebstel, V Wee Yong, Etty N Benveniste, Alan J Thompson","doi":"10.1177/13524585241266483","DOIUrl":"10.1177/13524585241266483","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis is a chronic immune-mediated disease of the central nervous system affecting nearly 3 million people worldwide. Although much progress has been made in the understanding and treatment of MS, cures remain elusive.</p><p><strong>Objectives: </strong>To accelerate the development of cures for MS by updating the Pathways to Cures Research Roadmap based on a contemporary understanding of disease. The refined Roadmap will help to promote research in scientific areas with great potential to reveal insights leading to cures and inspire greater coordination of global resources.</p><p><strong>Methods: </strong>Refinements to the Roadmap were achieved during a Global Summit that included close to 200 academic and industry scientists, health care providers, policy makers, funders, and people with MS from 15 countries.</p><p><strong>Results: </strong>The refined Roadmap describes three pathways that target opportunities for generating scientific insights leading to cures. Recommendations for accelerating research progress include, lowering barriers for global data sharing, enhancing collaboration and coordination among research supporters, committing to sustained funding, considering implications for implementation, engaging PwMS and committing to diversity, equity, and inclusion in the global MS movement.</p><p><strong>Conclusion: </strong>The refined roadmap provides a strategic framework for tackling the complexities of MS and advancing prevention strategies, effective treatments, and cures.</p>","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1242-1251"},"PeriodicalIF":4.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11451078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142109627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Telomere length as a biomarker in multiple sclerosis. 作为多发性硬化症生物标志物的端粒长度。
IF 4.8 2区 医学
Multiple Sclerosis Journal Pub Date : 2024-09-01 Epub Date: 2024-09-09 DOI: 10.1177/13524585241273054
Maria Agustina Piedrabuena, Jorge Correale, Mauricio Franco Farez, Sofia Rodríguez Murúa, Carlos Martínez Canyazo, Marcela Fiol, Mariano Marrodan, Maria Celica Ysrraelit
{"title":"Telomere length as a biomarker in multiple sclerosis.","authors":"Maria Agustina Piedrabuena, Jorge Correale, Mauricio Franco Farez, Sofia Rodríguez Murúa, Carlos Martínez Canyazo, Marcela Fiol, Mariano Marrodan, Maria Celica Ysrraelit","doi":"10.1177/13524585241273054","DOIUrl":"10.1177/13524585241273054","url":null,"abstract":"<p><strong>Background: </strong>Leukocyte telomere length (LTL) shortens with age and may be related to multiple sclerosis (MS).</p><p><strong>Objective: </strong>We hypothesize that chronologically young people with MS (pwMS) with short LTL behave similarly to older MS subjects.</p><p><strong>Methods: </strong>Prospective 2-year study including two cohorts of young (18-35 years) and elderly (⩾50 years) pwMS with similar disease duration. Physical and cognitive evaluation, 3 T brain magnetic resonance imaging (MRI) and retinal nerve fiber layer (RNFL) measurement by optical coherence tomography were performed. LTL was measured by quantitative polymerase chain reaction assay.</p><p><strong>Results: </strong>Around 105 patients were included, 57 young and 48 elderly. LTL was shorter in older patients (0.61 versus 0.57, <i>p</i> = 0.0081) and in males (female, 0.60; male, 0.59; <i>p</i> = 0.01335). For every 10-year increase in age, LTL was 0.02 U shorter. In elderly, LTL correlated with disease duration (<i>p</i> = 0.05), smoking (<i>p</i> = 0.03), Expanded Disability Status Scale (EDSS; <i>p</i> = 0.004), 9HPT (<i>p</i> = 0.00007), high-efficacy therapies (<i>p</i> = 0.001), brain lesion volume (BLV) (<i>p</i> = 0.011), and number of T2 lesions (<i>p</i> = 0.01). In young patients, LTL did not correlate with clinical or radiological variables. For every 0.1 U shorter LTL, gray matter volume decreased 1.75 cm<sup>3</sup> and white matter volume 1.78 cm<sup>3</sup>.</p><p><strong>Conclusion: </strong>LTL correlated with disability and BLV in elderly. Besides LTL shortening, other variables should be considered as mechanisms of neurodegeneration that might be involved in aging pwMS.</p>","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1258-1267"},"PeriodicalIF":4.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monitoring cognitive functioning in multiple sclerosis will trigger anxiety in patients: Commentary. 监测多发性硬化症患者的认知功能会引发患者焦虑：评论。
IF 4.8 2区 医学
Multiple Sclerosis Journal Pub Date : 2024-09-01 Epub Date: 2024-06-16 DOI: 10.1177/13524585241261200
Sarah A Morrow, Laura Hancock
{"title":"Monitoring cognitive functioning in multiple sclerosis will trigger anxiety in patients: Commentary.","authors":"Sarah A Morrow, Laura Hancock","doi":"10.1177/13524585241261200","DOIUrl":"10.1177/13524585241261200","url":null,"abstract":"","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1256-1257"},"PeriodicalIF":4.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11437696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141331468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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