Multiple Sclerosis Journal最新文献_第6页

Climate change and multiple sclerosis: Clinical challenges and strategies. 气候变化和多发性硬化症：临床挑战和策略。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-05-01 Epub Date: 2025-02-26 DOI: 10.1177/13524585251322664

Alexandra Balshi

引用次数: 0

AI-assisted identification of disability patterns within identical EDSS grades. 人工智能辅助识别相同EDSS等级的残疾模式。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-05-01 Epub Date: 2025-04-18 DOI: 10.1177/13524585251327300

Martina Greselin, Po-Jui Lu, Magdalena Mroczek, Nuria Cerdá-Fuertes, Anastasios Demirtzoglou, Athina Papadopoulou, Jens Kuhle, David Leppert, Sophie Arnould, Manar Aoun, Ludwig Kappos, Cristina Granziera, Marcus D'Souza

{"title":"AI-assisted identification of disability patterns within identical EDSS grades.","authors":"Martina Greselin, Po-Jui Lu, Magdalena Mroczek, Nuria Cerdá-Fuertes, Anastasios Demirtzoglou, Athina Papadopoulou, Jens Kuhle, David Leppert, Sophie Arnould, Manar Aoun, Ludwig Kappos, Cristina Granziera, Marcus D'Souza","doi":"10.1177/13524585251327300","DOIUrl":"10.1177/13524585251327300","url":null,"abstract":"Background: The Neurostatus-Expanded Disability Status Scale (EDSS) is the most frequently used measure of disability in multiple sclerosis (MS) trials. However, EDSS scores ⩾4.5 are mainly based on ambulation and may fail to capture relevant disability patterns in other functional domains.Objective: The objective was to determine how assessments categorized with the same EDSS score may reflect distinct disability patterns.Methods: We analysed 13,103 assessments from 1636 people with secondary progressive MS, from the EXPAND trial. The data set is composed of Functional System scores (FSS) and their corresponding subscores, Ambulation scores and EDSS scores. We performed a descriptive analysis to define the relevant Functional Systems (FS). The subscores were then binarized based on the Neurostatus definition and grouped by respective EDSS scores. Finally, we applied two consecutive machine learning algorithms, to cluster the data. New subscore patterns were then created by aggregating clusters based on their dominant features.Results: The clustering algorithm yielded numerous clusters, grouping assessments with similar patterns. In patients with EDSS ⩾4.0, our approach allowed differentiation into four subscore patterns within the same EDSS score.Conclusion: Applying Artificial Intelligence (AI) to large data sets of high-quality clinical assessments allows for distinguishing among different subscore patterns within identical EDSS scores.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"677-688"},"PeriodicalIF":4.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to the letter: Longitudinal investigation of neuroimaging changes related to memory decline in multiple sclerosis: Testing a mechanistic model. 对来信的回应：多发性硬化症中与记忆力下降相关的神经影像学变化的纵向调查：测试一个机制模型。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-05-01 Epub Date: 2025-03-27 DOI: 10.1177/13524585251324872

Leila Simani, Victoria M Leavitt

引用次数: 0

Treatment effects of cladribine tablets on data-driven patterns of regional grey matter atrophy in multiple sclerosis. 克拉宾片对多发性硬化症局部灰质萎缩数据驱动模式的治疗作用。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-05-01 Epub Date: 2025-02-25 DOI: 10.1177/13524585251314779

Mar Barrantes-Cepas, Samantha Noteboom, Elisa Colato, Marco Battaglini, Maria Pia Sormani, Nicola De Stefano, Martijn D Steenwijk, Ismail Koubiyr, Menno M Schoonheim

{"title":"Treatment effects of cladribine tablets on data-driven patterns of regional grey matter atrophy in multiple sclerosis.","authors":"Mar Barrantes-Cepas, Samantha Noteboom, Elisa Colato, Marco Battaglini, Maria Pia Sormani, Nicola De Stefano, Martijn D Steenwijk, Ismail Koubiyr, Menno M Schoonheim","doi":"10.1177/13524585251314779","DOIUrl":"10.1177/13524585251314779","url":null,"abstract":"Background: Treatment with cladribine tablets (CladT) in relapsing-remitting multiple sclerosis (RRMS) reduced global grey matter (GM) atrophy, but the effects on regional GM are unknown.Objectives: This study aimed to investigate the effect of CladT compared with placebo on magnetic resonance imaging (MRI)-derived patterns of GM atrophy.Methods: We used MRI and clinical data from the CLARITY study, including 393 people with RRMS (CladT (3.5 mg/kg), n = 200 or placebo, n = 193) at baseline, 24, 48 and 96 weeks after treatment initiation. SynthSeg-derived volume changes and GM atrophy patterns derived from source-based morphometry were analysed for group differences over time and associations with disability using mixed-effect models.Results: Deep GM (β = -0.03, p < 0.01), thalamus (β = -0.04, p < 0.01) and the brainstem-thalamus pattern (β = -0.03, p < 0.05) showed higher reduction in the placebo compared with treated group. These regions showed no effect during a predefined pseudo-atrophy period, where global volume loss was worse in the treatment group. Between W24 and W96, Expanded Disability Status Scale (EDSS) scores were associated with lower deep GM volume (β = -0.16, p = 0.001), thalamic volume (β = -0.16, p < 0.001), and the brainstem-thalamus pattern (β = -0.12, p < 0.05).Conclusion: CladT are associated with clinically relevant and slower neurodegeneration in RRMS. Strongest effects were seen in deep GM, thalamus, and brainstem, underlining the importance of regional MRI measures for assessing treatment effects.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"696-705"},"PeriodicalIF":4.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143502628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of gamma-tACS on cognitive impairment in multiple sclerosis: A randomized, double-blind, sham-controlled, pilot study. γ - tacs对多发性硬化症患者认知障碍的影响：一项随机、双盲、假对照的初步研究。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-05-01 Epub Date: 2025-04-26 DOI: 10.1177/13524585251333575

Gina Ferrazzano, Davide Maccarrone, Andrea Guerra, Angelo Collura, Federica Satriano, Mariangela Fratino, Fabrizio Ievolella, Daniele Belvisi, Maria Pia Amato, Diego Centonze, Marta Altieri, Antonella Conte, Giorgio Leodori

{"title":"The effects of gamma-tACS on cognitive impairment in multiple sclerosis: A randomized, double-blind, sham-controlled, pilot study.","authors":"Gina Ferrazzano, Davide Maccarrone, Andrea Guerra, Angelo Collura, Federica Satriano, Mariangela Fratino, Fabrizio Ievolella, Daniele Belvisi, Maria Pia Amato, Diego Centonze, Marta Altieri, Antonella Conte, Giorgio Leodori","doi":"10.1177/13524585251333575","DOIUrl":"10.1177/13524585251333575","url":null,"abstract":"Background: Multiple sclerosis (MS) often causes impairment in working memory (WM), information processing speed (IPS), and verbal memory (VM). These deficits are linked to disrupted neural oscillatory activity. Transcranial alternating current stimulation (tACS), which modulates cortical oscillations, may hold promise for treating cognitive impairment in MS.Objectives: To evaluate online and offline effects of gamma (γ)-tACS on WM, IPS, and VM while assessing changes in brain rhythms using electroencephalography (EEG).Methods: Thirty-six MS patients with single-domain impairment in WM (12), IPS (13), or VM (11) underwent γ-tACS and sham-tACS over the left dorsolateral prefrontal cortex (DLPFC) (WM, IPS) or precuneus (VM). Cognitive performance was assessed pre-tACS (T0), during (T1), and post-tACS (T2) using the Digit Span Backward (DSBW) for WM, Symbol Digit Modalities Test (SDMT) for IPS, and Rey Auditory Verbal Learning Test (RAVLT) for VM. EEG was recorded at T0 and T2 to analyze local power spectral density and local-to-global connectivity.Results: DSBW, SDMT, and RAVLT scores transiently improved during γ-tACS and not during sham. IPS-impaired patients showed a reduction in spectral power across all frequency bands, at the stimulation site, post-DLPFC γ-tACS.Conclusion: γ-tACS briefly improves WM, IPS, and VM in MS patients, warranting further trials of this non-invasive intervention.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"728-739"},"PeriodicalIF":4.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ocrelizumab-associated cryptogenic organizing pneumonia in multiple sclerosis: Two case reports and comprehensive literature review. 多发性硬化症患者与奥克立珠单抗相关的隐源性组织化肺炎：两份病例报告和全面的文献综述。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-05-01 Epub Date: 2024-11-21 DOI: 10.1177/13524585241295677

Alessandro Gans, Elena Pinuccia Verrengia, Elisabetta Ricchiuti, Serena Leva, Simona Brajkovic, Daniele Colombo, Antonino Mazzone, Alessandro Prelle

引用次数: 0

The relationship between cladribine and reduced regional grey matter volume loss in people with relapsing-remitting multiple sclerosis. 克拉德滨与复发缓解型多发性硬化症患者减少区域性灰质体积损失的关系

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-05-01 Epub Date: 2025-05-03 DOI: 10.1177/13524585251338772

Davide Maccarrone, Ferran Prados, Olga Ciccarelli

引用次数: 0

Positive impact of cladribine tablets on reducing brain atrophy in patients with relapsing-remitting multiple sclerosis: A longitudinal study. 克拉西宾片对减少复发缓解型多发性硬化症患者脑萎缩的积极影响：一项纵向研究。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-05-01 Epub Date: 2025-01-27 DOI: 10.1177/13524585251313749

Anat Achiron, Yehuda Warszawer, Yael Nissan, Ariel Kerpel, Chen Hoffmann, Gil Harari, David Magalashvili, Sigal Tal

{"title":"Positive impact of cladribine tablets on reducing brain atrophy in patients with relapsing-remitting multiple sclerosis: A longitudinal study.","authors":"Anat Achiron, Yehuda Warszawer, Yael Nissan, Ariel Kerpel, Chen Hoffmann, Gil Harari, David Magalashvili, Sigal Tal","doi":"10.1177/13524585251313749","DOIUrl":"10.1177/13524585251313749","url":null,"abstract":"Background: Measuring brain volume changes over time is an objective and dependable surrogate marker for the pathological processes that damage the brain in relapsing-remitting multiple sclerosis (RRMS). These measures are particularly valuable for monitoring the long-term impact of immunomodulatory treatments such as cladribine.Objectives: To evaluate the long-term impact of oral cladribine treatment on brain volume loss in patients with RRMS.Methods: This real-world study processed magnetic resonance imaging (MRI) scans using FreeSurfer's recon-all-clinical pipeline leveraging SynthSeg for brain segmentation. Piecewise linear regression was used to analyze brain atrophy changes over 4.5 years before and after cladribine treatment and estimate the time breakpoint of atrophy rate change.Results: A total of 448 MRI exams from 102 RRMS patients were analyzed. Before the initiation of cladribine treatment, brain atrophy rates were significantly steep with an α1 slope between -1.27 and -0.62 for the Thalamus, DGM, Subcortical GM, Cerebral WM, and BP. Over 2 years after treatment, breakpoints marked a shift in atrophy rates, with post-breakpoint slopes (α2) becoming non-significant, reflecting stabilization of brain atrophy.Conclusions: Cladribine treatment in highly active RRMS patients protects the brain from atrophy, with stabilization occurring over 2 years after initiation. The extended observation period highlights its sustained benefits compared with shorter clinical trials.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"689-695"},"PeriodicalIF":4.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eculizumab treatment during pregnancy in a patient with AQP4-IgG-seropositive NMOSD: A case report. 妊娠期依曲单抗治疗aqp4 - igg血清阳性NMOSD患者：1例报告

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-04-01 Epub Date: 2025-01-22 DOI: 10.1177/13524585241283648

Guerra Tommaso, Paolicelli Damiano, Iaffaldano Pietro

引用次数: 0

Long-term acceptability of MSReactor digital cognitive monitoring among people living with multiple sclerosis. MSReactor数字认知监测在多发性硬化症患者中的长期可接受性

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-04-01 DOI: 10.1177/13524585251329035

Daniel Merlo, Johnson Ja, Yi Chao Foong, Chao Zhu, Melissa Gresle, Tomas Kalincik, Jeannette Lechner-Scott, Trevor Kilpatrick, Michael Barnett, Bruce Taylor, Katherine Buzzard, David Darby, Helmut Butzkueven, Anneke van der Walt

{"title":"Long-term acceptability of MSReactor digital cognitive monitoring among people living with multiple sclerosis.","authors":"Daniel Merlo, Johnson Ja, Yi Chao Foong, Chao Zhu, Melissa Gresle, Tomas Kalincik, Jeannette Lechner-Scott, Trevor Kilpatrick, Michael Barnett, Bruce Taylor, Katherine Buzzard, David Darby, Helmut Butzkueven, Anneke van der Walt","doi":"10.1177/13524585251329035","DOIUrl":"10.1177/13524585251329035","url":null,"abstract":"Background: Monitoring of cognition in multiple sclerosis (MS) is critical. Traditional cognitive testing is resource intensive and insensitive to subtle changes. Digital tests could address this need; however, their long-term usability remains unexplored.Objectives: To determine the long-term acceptability and feasibility of digital cognitive measures in MS.Methods: Participants with relapsing or secondary progressive MS were prospectively enrolled. MSReactor, a web-based test evaluating processing speed, attention and working memory, was performed 6-monthly for up to 36 months. Patient acceptability, anxiety, depression and quality of life were collected concurrently. Correlations between test acceptability, psychosocial measures, physical disability and cognition were analysed using Spearman's correlation.Results: This study included participants with complete data at 12 (n = 601), 24 (n = 280) and 36 (n = 317) months. Attrition after 12 months was low (3.5%). Acceptability of MSReactor was high, although interest and enjoyment decreased slightly. Minor correlations were observed between reduced acceptability and increased anxiety, depression and disability and lower quality of life.Conclusion: Long-term cognitive monitoring was highly acceptable. We identified characteristics, such as increased anxiety, that were associated with reduced acceptability. Patients with these characteristics may benefit from support to maintain monitoring. These findings underscore the potential for integrating such tools into MS care.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"595-606"},"PeriodicalIF":4.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0