Multiple Sclerosis Journal最新文献_第5页

The time to include cognition in the multiple sclerosis concept of progression independent from relapse activity is now. 现在是将认知纳入多发性硬化症进展概念的时候了，它与复发活动无关。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-10-01 Epub Date: 2024-08-28 DOI: 10.1177/13524585241264476

Stefano Ziccardi, Maddalena Guandalini, Tom A Fuchs, Massimiliano Calabrese, Ralph Hb Benedict

引用次数: 0

Cytomegalovirus immune responses are associated with lower serum NfL and disability accumulation risk at multiple sclerosis onset. 巨细胞病毒免疫反应与多发性硬化症发病时较低的血清 NfL 和残疾累积风险有关。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-10-01 Epub Date: 2024-09-09 DOI: 10.1177/13524585241274571

Jan D Lünemann, Augusto Sao Avilés, Mar Tintoré, Luciana Midaglia, Nicolás Fissolo, Lucía Gutiérrez, Heinz Wiendl, Xavier Montalban, Manuel Comabella

{"title":"Cytomegalovirus immune responses are associated with lower serum NfL and disability accumulation risk at multiple sclerosis onset.","authors":"Jan D Lünemann, Augusto Sao Avilés, Mar Tintoré, Luciana Midaglia, Nicolás Fissolo, Lucía Gutiérrez, Heinz Wiendl, Xavier Montalban, Manuel Comabella","doi":"10.1177/13524585241274571","DOIUrl":"10.1177/13524585241274571","url":null,"abstract":"Background: Infection by cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) play a prognostic role in multiple sclerosis (MS).Objectives: To explore whether humoral immune responses to HCMV and EBV at disease onset were associated with changes in serum and cerebrospinal fluid (CSF) levels of inflammatory and neurodegeneration biomarkers.Methods: Ninety-eight MS patients with a median follow-up of 20 years were included in the study. The levels of a panel of nine biomarkers were measured in serum (N = 60) and CSF (N = 61) samples of patients at the time of the first demyelinating event.Results: Immune responses to HCMV inversely correlated with serum neurofilament light chain (sNfL) levels (rho = -0.367; p = 0.039). sNfL levels were reduced in patients with high immune responses to HCMV (p = 0.006). Elevated sNfL levels were associated with higher risk of Expanded Disability Status Scale (EDSS) 3.0 (p = 0.016), 4.0 (p = 0.009) and 6.0 (p = 0.003), and with higher risk of developing secondary progressive MS (p = 0.003) and to receive treatment (p = 0.032). Serum soluble CD21 levels were increased in patients with high immune responses to EBV nuclear antigen 1 (p = 0.020).Conclusions: High immune responses to HCMV are associated with limited disease progression and central nervous system (CNS) injury in MS patients. These findings reinforce the protective role of HCMV infection in MS.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1445-1454"},"PeriodicalIF":4.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroaxonal damage in natalizumab-treated MS patients: The role of JCV antibody titres. 纳他珠单抗治疗多发性硬化症患者的神经轴损害：JCV抗体滴度的作用。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-10-01 Epub Date: 2024-06-14 DOI: 10.1177/13524585241260977

Gloria Dalla Costa, Letizia Leocani, Marco Pisa, Tommaso Croese, Vittorio Martinelli, Lucia Moiola, Francesca Sangalli, Bruno Colombo, Aiden Haghikia, Ralf Gold, Roberto Furlan, Giancarlo Comi

引用次数: 0

Mobility trajectories in multiple sclerosis: A comparative study of timed 25-foot walk and a patient-reported outcome measure. 多发性硬化症患者的行动轨迹：25 英尺定时行走与患者报告结果测量的比较研究。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-10-01 Epub Date: 2024-09-05 DOI: 10.1177/13524585241274607

Farren Bs Briggs, Douglas D Gunzler, Deborah M Miller, Daniel Ontaneda, Alessandro S De Nadai

{"title":"Mobility trajectories in multiple sclerosis: A comparative study of timed 25-foot walk and a patient-reported outcome measure.","authors":"Farren Bs Briggs, Douglas D Gunzler, Deborah M Miller, Daniel Ontaneda, Alessandro S De Nadai","doi":"10.1177/13524585241274607","DOIUrl":"10.1177/13524585241274607","url":null,"abstract":"Background: Loss of mobility is common in persons with multiple sclerosis (PwMS), but little is known about this impairment from the patient's perspective.Objective: The aim is to model longitudinal variation in a mobility patient-reported outcome (PRO) and compare trajectories to those observed for Timed 25-Foot Walk (T25FW) in a retrospective cohort.Methods: Latent-class growth analysis was applied to 47,508 measures of Performance Scales© Mobility PRO (PS-Mobility) over ~4 years for 8524 PwMS. For 7347 PwMS, there were 41,988 T25FW measures during this period. Repeated measures correlation and concordance of trajectory assignment were evaluated.Results: At the group level, PS-Mobility and T25FW linearly worsened and repeated-measures correlation was moderate. Eight latent classes with varying shapes that worsened described PS-Mobility variation, compared to six latent classes for T25FW that differed by intercept. The agreement between PS-Mobility and T25FW cluster assignment was modest. A higher proportion of individuals who were Black/African American, older, Medicaid beneficiaries, living in deprived neighborhoods, had longer disease duration, had progressive disease, and ever smokers were assigned to more impaired clusters.Discussion: Cross-sectionally, PS-Mobility and T25FW were highly correlated, but longitudinally correlation was modest to moderate, underscoring the importance of considering both objective and subjective perspectives in evaluating mobility changes in PwMS.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1479-1489"},"PeriodicalIF":4.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating large language models in care, research, and education in multiple sclerosis management. 在多发性硬化症管理的护理、研究和教育中整合大型语言模型。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-10-01 Epub Date: 2024-09-23 DOI: 10.1177/13524585241277376

Hernan Inojosa, Isabel Voigt, Judith Wenk, Dyke Ferber, Isabella Wiest, Dario Antweiler, Eva Weicken, Stephen Gilbert, Jakob Nikolas Kather, Katja Akgün, Tjalf Ziemssen

{"title":"Integrating large language models in care, research, and education in multiple sclerosis management.","authors":"Hernan Inojosa, Isabel Voigt, Judith Wenk, Dyke Ferber, Isabella Wiest, Dario Antweiler, Eva Weicken, Stephen Gilbert, Jakob Nikolas Kather, Katja Akgün, Tjalf Ziemssen","doi":"10.1177/13524585241277376","DOIUrl":"10.1177/13524585241277376","url":null,"abstract":"Use of techniques derived from generative artificial intelligence (AI), specifically large language models (LLMs), offer a transformative potential on the management of multiple sclerosis (MS). Recent LLMs have exhibited remarkable skills in producing and understanding human-like texts. The integration of AI in imaging applications and the deployment of foundation models for the classification and prognosis of disease course, including disability progression and even therapy response, have received considerable attention. However, the use of LLMs within the context of MS remains relatively underexplored. LLMs have the potential to support several activities related to MS management. Clinical decision support systems could help selecting proper disease-modifying therapies; AI-based tools could leverage unstructured real-world data for research or virtual tutors may provide adaptive education materials for neurologists and people with MS in the foreseeable future. In this focused review, we explore practical applications of LLMs across the continuum of MS management as an initial scope for future analyses, reflecting on regulatory hurdles and the indispensable role of human supervision.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1392-1401"},"PeriodicalIF":4.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Misdiagnosis and underdiagnosis of multiple sclerosis: A systematic review and meta-analysis. 多发性硬化症的误诊和漏诊：系统回顾和荟萃分析。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-10-01 Epub Date: 2024-09-08 DOI: 10.1177/13524585241274527

Wolfgang Emanuel Zürrer, Amelia Elaine Cannon, Dariya Ilchenko, María Inés Gaitán, Tobias Granberg, Fredrik Piehl, Andrew J Solomon, Benjamin Victor Ineichen

{"title":"Misdiagnosis and underdiagnosis of multiple sclerosis: A systematic review and meta-analysis.","authors":"Wolfgang Emanuel Zürrer, Amelia Elaine Cannon, Dariya Ilchenko, María Inés Gaitán, Tobias Granberg, Fredrik Piehl, Andrew J Solomon, Benjamin Victor Ineichen","doi":"10.1177/13524585241274527","DOIUrl":"10.1177/13524585241274527","url":null,"abstract":"Background: Diagnostic errors in multiple sclerosis (MS) impact patients and healthcare systems.Objectives: This study aimed to determine the prevalence of MS misdiagnosis and underdiagnosis, time delay in reaching a correct diagnosis and potential impact of sex.Methods: Systematic review and meta-analysis on MS diagnostic errors.Results: Out of 3910 studies, we included 62 for a qualitative synthesis and 24 for meta-analyses. Frequency of misdiagnosis (incorrect assignment of an MS diagnosis) ranged from 5% to 41%, with a pooled proportion based on six studies of 15% (95% CI: 9%-26%, n = 1621). The delay to rectify a misdiagnosis ranged from 0.3 to 15.9 years. Conversely, underdiagnosis (unrecognized diagnosis of MS) ranged from 3% to 58%, with a pooled proportion in four studies of 36% (95% CI: 20%-55%, n = 728). Pooling seven studies comprising 2851 individuals suggested a diagnostic delay to establish a correct MS diagnosis of 17.3 months (95% CI: 11.9-22.7) in patients underdiagnosed. In a meta-analysis of five studies, women were 2.1 times more likely to be misdiagnosed with MS compared to men (odds ratio, 95% CI: 1.53-2.86).Conclusion: This study provides summary-level evidence for the high prevalence of MS misdiagnosis and underdiagnosis. Future studies are needed to understand the causes of these diagnostic challenges in MS care.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1409-1422"},"PeriodicalIF":4.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between ethnicity and multiple sclerosis characteristics in the United Kingdom: A UK MS Register study. 英国种族与多发性硬化症特征之间的关系：英国多发性硬化症登记研究。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-10-01 Epub Date: 2024-09-20 DOI: 10.1177/13524585241277018

Benjamin M Jacobs, Luisa Schalk, Emily Tregaskis-Daniels, Pooja Tank, Sadid Hoque, Michelle Peter, Katherine Tuite-Dalton, James Witts, Riley Bove, Ruth Dobson

{"title":"The relationship between ethnicity and multiple sclerosis characteristics in the United Kingdom: A UK MS Register study.","authors":"Benjamin M Jacobs, Luisa Schalk, Emily Tregaskis-Daniels, Pooja Tank, Sadid Hoque, Michelle Peter, Katherine Tuite-Dalton, James Witts, Riley Bove, Ruth Dobson","doi":"10.1177/13524585241277018","DOIUrl":"10.1177/13524585241277018","url":null,"abstract":"Background: Previous studies have suggested differences in multiple sclerosis (MS) severity according to ethnicity.Methods: Data were obtained from the UK MS Register, a prospective longitudinal cohort study of persons with MS. We examined the association between self-reported ethnic background and age at onset, symptom of onset and a variety of participant-reported severity measures. We used adjusted multivariable linear regression models to explore the association between ethnicity and impact of MS, and Cox proportional hazards models to assess disability progression.Results: We analysed data from 17,314 people with MS, including participants from self-reported Black (n = 157) or South Asian (n = 230) ethnic backgrounds. Age at MS onset and diagnosis was lower in those of South Asian (median 30.0) and Black (median 33.0) ethnicity compared with White ethnicity (median 35.0). In participants with online MS severity measures available, we found no statistically significant evidence for an association between ethnic background and physical disability in MS in both cross-sectional and longitudinal analyses.Conclusion: We found no association between ethnic background and MS severity in a large, diverse UK cohort. These findings suggest that other factors, such as socioeconomic status and structural inequalities, may explain previous findings.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1544-1555"},"PeriodicalIF":4.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11520257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The kappa free light chains index is an accurate diagnostic biomarker for paediatric multiple sclerosis. 卡帕游离轻链指数是儿科多发性硬化症的准确诊断生物标志物。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-10-01 Epub Date: 2024-09-08 DOI: 10.1177/13524585241274034

Aurélie Sarthou, Pascale Chrétien, Laetitia Giorgi, Andrada Chiron, Carole Leroy, Philippe Horellou, Roman Krzysiek, Kumaran Deiva, Salima Hacein-Bey-Abina

{"title":"The kappa free light chains index is an accurate diagnostic biomarker for paediatric multiple sclerosis.","authors":"Aurélie Sarthou, Pascale Chrétien, Laetitia Giorgi, Andrada Chiron, Carole Leroy, Philippe Horellou, Roman Krzysiek, Kumaran Deiva, Salima Hacein-Bey-Abina","doi":"10.1177/13524585241274034","DOIUrl":"10.1177/13524585241274034","url":null,"abstract":"Background: Multiple sclerosis (MS) may occur before the age of 18. Differentiation between paediatric MS (PedMS) and other demyelinating syndromes (ODSs) is challenging. In adult with MS, the kappa free light chain (KFLC) index has proven to be a reliable marker of intrathecal Ig synthesis.Objective: To assess the diagnostic value of the KFLC index in a cohort of patients with paediatric-onset, inflammatory disorders of the CNS.Methods: We included 73 patients and divided them into four groups: PedMS (n = 16), ODS (n = 17), encephalitis and/or inflammatory epilepsy (EE, n = 15), and controls without inflammatory CNS diseases (n = 25). The KFLC index was calculated and compared with the results of the oligoclonal bands determination.Results: The KFLC index was higher in the PedMS group (median (interquartile range (IQR)): 150.9 (41.02-310.6)) than in the ODS (3.37 (2.22-8.11)), the EE (5.53 (2.31-25.81)) and the control group (3.41 (2.27-5.08)), respectively. The best KFLC index cut-off for differentiating between patients with PedMS and controls was 6.83 (sensitivity: 100%; specificity: 92%). A KFLC index over 93.77 indicated that the patient is very likely to have PedMS (sensitivity: 68%; specificity: 100%).Conclusion: The KFLC index is a reliable tool for the diagnosis of MS in a paediatric population.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1436-1444"},"PeriodicalIF":4.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple sclerosis and cancer: Navigating a dual diagnosis. 多发性硬化症和癌症：驾驭双重诊断。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-09-30 DOI: 10.1177/13524585241274523

Cassie Nesbitt, Anneke Van Der Walt, Helmut Butzkueven, Bianca Devitt, Vilija G Jokubaitis

引用次数: 0

Uveitis: A snapshot in the MOG antibody spectrum. 葡萄膜炎MOG 抗体谱的一个缩影。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-09-29 DOI: 10.1177/13524585241285173

Claudia Fabiani, Gian Marco Tosi, Valentina Damato, Monica Ulivelli, Alessandra Rufa, Alfonso Cerase, Nicola De Stefano, Rosa Cortese

引用次数: 0