多发性硬化症患者与奥克立珠单抗相关的隐源性组织化肺炎：两份病例报告和全面的文献综述。

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY

Multiple Sclerosis Journal Pub Date : 2024-11-21 DOI:10.1177/13524585241295677

Alessandro Gans, Elena Pinuccia Verrengia, Elisabetta Ricchiuti, Serena Leva, Simona Brajkovic, Daniele Colombo, Antonino Mazzone, Alessandro Prelle

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引用次数: 0

摘要

背景：隐源性组织化肺炎（COP）是一种间质性肺病，病因包括抗CD20抗体。奥克立珠单抗是一种抗 CD20 的人源化单克隆抗体，已被批准用于治疗复发性缓解型或原发性进展型多发性硬化症（MS），目前尚无有关肺毒性的确凿数据：我们描述了两例与多发性硬化症患者使用奥克立珠单抗相关的 COP 病例：我们建议接受奥克立珠单抗治疗的多发性硬化症患者在出现呼吸道症状时考虑 COP。COP的诊断需要通过临床和放射学排除其他诊断，如机会性感染、自身免疫、药物和肿瘤。适当的类固醇治疗具有极佳的临床反应率。

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Ocrelizumab-associated cryptogenic organizing pneumonia in multiple sclerosis: Two case reports and comprehensive literature review.

Background: Cryptogenic organizing pneumonia (COP) is an interstitial lung disease, with causes including anti-CD20 antibodies. Ocrelizumab is a humanized monoclonal antibody against CD20 approved for use in relapsing-remitting or primary progressive multiple sclerosis (MS), with no conclusive data regarding pulmonary toxicity.

Cases: We describe two cases of COP associated with ocrelizumab use in multiple sclerosis patients.

Conclusions: We suggest considering COP whenever respiratory symptoms arise in MS patients receiving ocrelizumab therapy. COP diagnosis requires clinical and radiological exclusion of alternative diagnoses such as opportunistic infections, autoimmunity, drugs, and neoplasms. Appropriate steroid therapy has an excellent clinical response rate.

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来源期刊

Multiple Sclerosis Journal 医学-临床神经学

CiteScore

10.90

自引率

6.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585