Nature reviews. Chemistry最新文献_第6页

Spatiotemporal analysis of reactive oxygen species using specific activity-based sensing fluorescent imaging probes 基于特定活性的传感荧光成像探针对活性氧的时空分析。

IF 51.7 1区化学

Nature reviews. Chemistry Pub Date : 2026-06-03 DOI: 10.1038/s41570-026-00836-5

Xin Wang, Alexander K. Hurben, Yuantao Mao, Qi Ding, Wen Zhang, Ping Li, Tony D. James, Christopher J. Chang, Bo Tang

{"title":"Spatiotemporal analysis of reactive oxygen species using specific activity-based sensing fluorescent imaging probes","authors":"Xin Wang, Alexander K. Hurben, Yuantao Mao, Qi Ding, Wen Zhang, Ping Li, Tony D. James, Christopher J. Chang, Bo Tang","doi":"10.1038/s41570-026-00836-5","DOIUrl":"10.1038/s41570-026-00836-5","url":null,"abstract":"Oxidative stress, driven by reactive oxygen species (ROS), is implicated in numerous diseases. ROS are vital for redox signalling and homeostasis but can damage proteins, lipids and nucleic acids, compromising cellular health and contributing to disease progression. ROS functions are governed by their spatiotemporal distribution within cells and organisms; however, their mechanisms of action remain insufficiently understood, highlighting the compelling need for accurate ROS detection methods. In this context, fluorescence imaging has emerged as a powerful tool for real-time ROS detection. Effective fluorescence probes for ROS feature high specificity and sensitivity, enable imaging within subcellular organelles, support dynamic and reversible imaging and/or allow simultaneous detection of multiple molecules. Despite many advances, ROS imaging remains challenging. This Review provides guidelines for developing reliable fluorescent probes for ROS detection in cells and in vivo, using representative examples of activity-based sensing to aid researchers in improving ROS monitoring to advance research across biology and medicine. Oxidative stress arises from reactive oxygen species that are essential for signalling yet harmful when uncontrolled. Fluorescence imaging enables real-time, sensitive, organelle-level reactive oxygen species detection, and this Review outlines design principles for developing reliable probes to advance biological and medical research. MAO, monoamine oxidase; MPO, myeloperoxidase; NO, nitric oxide; NOS, nitric oxide synthase; SOD, superoxide dismutase.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 7","pages":"493-510"},"PeriodicalIF":51.7,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Listening to the Accessible Audio Periodic Table 收听无障碍音频元素周期表。

IF 51.7 1区化学

Nature reviews. Chemistry Pub Date : 2026-05-27 DOI: 10.1038/s41570-026-00833-8

Cary A. Supalo, Greg J. Williams, Ashley E. Neybert

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Diversifying chemical reactions in solid oxide electrochemical cells 固体氧化物电化学电池中化学反应的多样化。

IF 51.7 1区化学

Nature reviews. Chemistry Pub Date : 2026-05-21 DOI: 10.1038/s41570-026-00830-x

Samuel J. Shin, Min-Chul Kim

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The path to understanding how reactions work and fail 了解反应如何起作用和失败的途径。

IF 51.7 1区化学

Nature reviews. Chemistry Pub Date : 2026-05-17 DOI: 10.1038/s41570-026-00832-9

Guy Lloyd-Jones, Stephanie Greed

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Fluorine-free super-repellency to water and organic liquids 无氟超拒水性和有机液体。

IF 51.7 1区化学

Nature reviews. Chemistry Pub Date : 2026-05-15 DOI: 10.1038/s41570-026-00831-w

Wanshun Deng, Rui Guo, Chaoyi Peng, Frank Caruso, Shuaijun Pan

{"title":"Fluorine-free super-repellency to water and organic liquids","authors":"Wanshun Deng, Rui Guo, Chaoyi Peng, Frank Caruso, Shuaijun Pan","doi":"10.1038/s41570-026-00831-w","DOIUrl":"10.1038/s41570-026-00831-w","url":null,"abstract":"Super-repellent surfaces, characterized by high contact angles and extremely low sliding angles for both water and organic liquids, hold potential for applications in self-cleaning, anti-fouling, anti-icing and oil–water separation. In particular, fluorine-free super-repellent materials have attracted attention owing to their ability to deliver comparable performance to fluorinated systems while minimizing environmental and health risks. Through microscale or nanoscale surface structuring and fluorine-free low-surface-energy chemistries, robust repellency can be achieved across diverse substrates, offering broad material compatibility and enhanced sustainability. The design and fabrication of these surfaces deepen our understanding of surface chemistry, providing perspectives on solid–liquid interactions and informing the development of interfacial theories. This Review explores recent theoretical and technological advances in fluorine-free super-repellency. It also outlines key challenges and discusses future directions, including the development of durable and environmentally friendly fabrication strategies, as well as emerging applications. Fluorine-free super-repellent materials provide sustainable and scalable alternatives to fluorinated counterparts by using re-entrant architectures or pairing non-fluorinated surface chemistries with hierarchical roughness. This Review highlights fundamental design principles, theoretical frameworks, emerging applications and future research opportunities.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 7","pages":"457-470"},"PeriodicalIF":51.7,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147948928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Dialling in the heat 在高温下拨号。

IF 51.7 1区化学

Nature reviews. Chemistry Pub Date : 2026-05-14 DOI: 10.1038/s41570-026-00835-6

Smita Shivraj Dasari

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Light-driven reforming of methane through photothermal catalysis 光热催化下甲烷的光驱动重整。

IF 51.7 1区化学

Nature reviews. Chemistry Pub Date : 2026-05-12 DOI: 10.1038/s41570-026-00829-4

Jiahao Chen, Jinqiang Zhang, Shuai Yan, Wenhao Zhao, Shaobin Wang, Hongqi Sun

{"title":"Light-driven reforming of methane through photothermal catalysis","authors":"Jiahao Chen, Jinqiang Zhang, Shuai Yan, Wenhao Zhao, Shaobin Wang, Hongqi Sun","doi":"10.1038/s41570-026-00829-4","DOIUrl":"10.1038/s41570-026-00829-4","url":null,"abstract":"Photothermal catalytic methane reforming (PTCMR) demonstrates a transformative strategy for harnessing full-spectrum sunlight to produce clean solar fuels. Despite extensive efforts related to catalyst development, the pathways and mechanistic complexities arising from photothermal coupling remain underexplored. As such, this Review elucidates the interplay between photochemical and photothermal processes that govern PTCMR, illustrating how photogenerated carriers and localized heating cooperatively or competitively influence reactant adsorption, activation, transformation and active-site evolution. Particular attention is devoted to highlighting the gradient fields (such as, temperature, potential and concentration) within the reactor microenvironment inherent to PTCMR, which exert kinetic control while complicating the quantitative differentiation of intertwined photochemical and photothermal contributions. We examine these challenges and propose novel strategies, integrating catalyst design, reactor engineering and system-coupling to regulate charge-heat interactions and mitigate non-uniform energy effects. Finally, we outline future directions for mechanistic studies and the scalable implementation of next-generation solar-driven methane valorization technologies. This Review reframes photothermal catalytic methane reforming as a three-driving-force system, revealing how coupled photocarriers, heat (or phonons) and gradient fields govern reaction pathways, kinetics and selectivity, in addition to creating dynamic microenvironments for efficient solar-driven syngas production exemplified by dry reforming of methane.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 6","pages":"427-444"},"PeriodicalIF":51.7,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147931563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A life researching the path to better polymers 一生都在研究更好的聚合物。

IF 51.7 1区化学

Nature reviews. Chemistry Pub Date : 2026-05-03 DOI: 10.1038/s41570-026-00824-9

Takuzo Aida, Stephanie Greed

引用次数: 0

The chemistry of magnetoelectric multiferroics 磁电多铁性的化学。

IF 51.7 1区化学

Nature reviews. Chemistry Pub Date : 2026-04-30 DOI: 10.1038/s41570-026-00827-6

Nicola A. Spaldin

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Molecular rotor-based probes for protein monitoring in biomedical research 生物医学研究中蛋白质监测的分子转子探针。

IF 51.7 1区化学

Nature reviews. Chemistry Pub Date : 2026-04-29 DOI: 10.1038/s41570-026-00822-x

Xia Wu, Yuxuan Hu, Quan Wang, Wei Zhang, Tao Liu, Fan Xia, Xiaoding Lou, Kanyi Pu

{"title":"Molecular rotor-based probes for protein monitoring in biomedical research","authors":"Xia Wu, Yuxuan Hu, Quan Wang, Wei Zhang, Tao Liu, Fan Xia, Xiaoding Lou, Kanyi Pu","doi":"10.1038/s41570-026-00822-x","DOIUrl":"10.1038/s41570-026-00822-x","url":null,"abstract":"As the fundamental executors of biological function, proteins are frequently dysregulated or differentially expressed in disease states, making them valuable biomarkers and/or therapeutic targets. Conventional approaches to monitoring the presence and activity of these proteins — including enzyme-linked immunosorbent assay, western blotting and mass spectrometry — have limited ability to provide real-time information on living cells. Fluorescence imaging overcomes these limitations by enabling selective, non-invasive and dynamic protein analysis. Molecular rotor fluorophores offer unique advantages owing to their high sensitivity to microenvironmental changes and tunable photophysical properties. Notably, these molecular rotor scaffolds can be functionalized into targeting probes that become highly emissive upon binding to specific proteins via the restriction of intramolecular rotation. Here, we introduce molecular rotor-based probes and outline their design principles and detection mechanisms. We highlight their applications in disease diagnosis and biological research, and we discuss the current challenges and prospects for clinical translation. Fluorescent molecular rotor probes respond to microenvironmental changes in cells, enabling real-time, non-invasive detection of protein biomarkers in living cells, overcoming the limits of conventional approaches. They brighten upon target binding as a result of restricted intramolecular rotation and show promise for both diagnostics and research.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 5","pages":"350-366"},"PeriodicalIF":51.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147776677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0