Nature reviews. Chemistry最新文献_第6页

The role of biomolecular condensates in protein aggregation 生物分子凝聚体在蛋白质聚集中的作用。

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-08-12 DOI: 10.1038/s41570-024-00635-w

Brent S. Visser, Wojciech P. Lipiński, Evan Spruijt

{"title":"The role of biomolecular condensates in protein aggregation","authors":"Brent S. Visser, Wojciech P. Lipiński, Evan Spruijt","doi":"10.1038/s41570-024-00635-w","DOIUrl":"10.1038/s41570-024-00635-w","url":null,"abstract":"There is an increasing amount of evidence that biomolecular condensates are linked to neurodegenerative diseases associated with protein aggregation, such as Alzheimer’s disease and amyotrophic lateral sclerosis, although the mechanisms underlying this link remain elusive. In this Review, we summarize the possible connections between condensates and protein aggregation. We consider both liquid-to-solid transitions of phase-separated proteins and the partitioning of proteins into host condensates. We distinguish five key factors by which the physical and chemical environment of a condensate can influence protein aggregation, and we discuss their relevance in studies of protein aggregation in the presence of biomolecular condensates: increasing the local concentration of proteins, providing a distinct chemical microenvironment, introducing an interface wherein proteins can localize, changing the energy landscape of aggregation pathways, and the presence of chaperones in condensates. Analysing the role of biomolecular condensates in protein aggregation may be essential for a full understanding of amyloid formation and offers a new perspective that can help in developing new therapeutic strategies for the prevention and treatment of neurodegenerative diseases. Biomolecular condensates help organize cell components under normal conditions but can also be involved in pathological protein aggregation when condensate proteins carry mutations or under stress conditions. This Review discusses the possible mechanisms behind such aggregation processes that potentially lead to neurodegenerative diseases.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"8 9","pages":"686-700"},"PeriodicalIF":38.1,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Stemming the scientific brain drain in Nepal 遏制尼泊尔科学人才外流。

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-08-08 DOI: 10.1038/s41570-024-00638-7

Sushila Maharjan, Stephanie Greed

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Illuminating the deaf experience at STEM conferences 在科学、技术、工程和数学会议上点亮聋人的体验。

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-08-08 DOI: 10.1038/s41570-024-00639-6

Anna M. Kasper, Victoria A. Popov, Sara K. Blick-Nitko, Kameron B. Kinast, Kat Womack, Nikki D. Cherry

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Visible and near-infrared light-induced photoclick reactions 可见光和近红外线诱发的光点击反应。

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-08-07 DOI: 10.1038/s41570-024-00633-y

Youxin Fu, Nadja A. Simeth, Wiktor Szymanski, Ben L. Feringa

{"title":"Visible and near-infrared light-induced photoclick reactions","authors":"Youxin Fu, Nadja A. Simeth, Wiktor Szymanski, Ben L. Feringa","doi":"10.1038/s41570-024-00633-y","DOIUrl":"10.1038/s41570-024-00633-y","url":null,"abstract":"Photoclick reactions combine the advantages offered by light-driven processes, that is, non-invasive and high spatiotemporal control, with classical click chemistry and have found applications ranging from surface functionalization, polymer conjugation, photocrosslinking, protein labelling and bioimaging. Despite these advances, most photoclick reactions typically require near-ultraviolet (UV) and mid-UV light to proceed. UV light can trigger undesirable responses, including cellular apoptosis, and therefore, visible and near-infrared light-induced photoclick reaction systems are highly desirable. Shifting to a longer wavelength can also reduce degradation of the photoclick reagents and products. Several strategies have been used to induce a bathochromic shift in the wavelength of irradiation-initiating photoclick reactions. For instance, the extension of the conjugated π-system, triplet–triplet energy transfer, multi-photon excitation, upconversion technology, photocatalytic and photoinitiation approaches, and designs involving photocages have all been used to achieve this goal. Current design strategies, recent advances and the outlook for long wavelength-driven photoclick reactions are presented. Photoclick reactions have found applications ranging from surface functionalization and polymer crosslinking to protein labelling and bioimaging, but they typically require near-UV and mid-UV light to proceed. This Review presents and discusses strategies and recent advances for long wavelength-driven photoclick reactions.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"8 9","pages":"665-685"},"PeriodicalIF":38.1,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Off to the copper races 铜矿赛跑

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-07-24 DOI: 10.1038/s41570-024-00636-9

Sapana Jadoun

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Ions go in and new phases appear 离子进入，新的阶段出现。

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-07-24 DOI: 10.1038/s41570-024-00637-8

Ruijie Yang, Zheng Li, Yingying Fan

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The dawn of solar ethylene 太阳能乙烯的曙光

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-07-23 DOI: 10.1038/s41570-024-00632-z

Mohammad Z. Rahman

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Origins of non-ideal behaviour in voltammetric analysis of redox-active monolayers 氧化还原活性单层膜伏安分析非理想行为的起源。

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-07-22 DOI: 10.1038/s41570-024-00629-8

Brittany L. Huffman, Alexandria R. C. Bredar, Jillian L. Dempsey

{"title":"Origins of non-ideal behaviour in voltammetric analysis of redox-active monolayers","authors":"Brittany L. Huffman, Alexandria R. C. Bredar, Jillian L. Dempsey","doi":"10.1038/s41570-024-00629-8","DOIUrl":"10.1038/s41570-024-00629-8","url":null,"abstract":"Disorder in redox-active monolayers convolutes electrochemical characterization. This disorder can come from pinhole defects, loose packing, heterogeneous distribution of redox-active headgroups, and lateral interactions between immobilized redox-active molecules. Identifying the source of non-ideal behaviour in cyclic voltammograms can be challenging as different types of disorder often cause similar non-ideal cyclic voltammetry behaviour such as peak broadening, large peak-to-peak separation, peak asymmetry and multiple peaks for single redox processes. This Review provides an overview of ideal voltammetric behaviour for redox-active monolayers, common manifestations of disorder on voltammetric responses, common experimental parameters that can be varied to interrogate sources of disorder, and finally, examples of different types of disorder and how they impact electrochemical responses. Disorder in redox-active monolayers arising from pinhole defects, loose packing, heterogeneous distribution of redox-active headgroups, and lateral interactions between immobilized redox-active molecules can cause non-ideal cyclic voltammetry behaviour.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"8 8","pages":"628-643"},"PeriodicalIF":38.1,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The astrochemical evolutionary traits of phospholipid membrane homochirality 磷脂膜同色性的天体化学进化特征。

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-07-18 DOI: 10.1038/s41570-024-00627-w

Jana Bocková, Nykola C. Jones, Søren V. Hoffmann, Cornelia Meinert

{"title":"The astrochemical evolutionary traits of phospholipid membrane homochirality","authors":"Jana Bocková, Nykola C. Jones, Søren V. Hoffmann, Cornelia Meinert","doi":"10.1038/s41570-024-00627-w","DOIUrl":"10.1038/s41570-024-00627-w","url":null,"abstract":"Compartmentalization is crucial for the evolution of life. Present-day phospholipid membranes exhibit a high level of complexity and species-dependent homochirality, the so-called lipid divide. It is possible that less stable, yet more dynamic systems, promoting out-of-equilibrium environments, facilitated the evolution of life at its early stages. The composition of the preceding primitive membranes and the evolutionary route towards complexity and homochirality remain unexplained. Organics-rich carbonaceous chondrites are evidence of the ample diversity of interstellar chemistry, which may have enriched the prebiotic milieu on early Earth. This Review evaluates the detections of simple amphiphiles — likely ancestors of membrane phospholipids — in extraterrestrial samples and analogues, along with potential pathways to form primitive compartments on primeval Earth. The chiroptical properties of the chiral backbones of phospholipids provide a guide for future investigations into the origins of phospholipid membrane homochirality. We highlight a plausible common pathway towards homochirality of lipids, amino acids, and sugars starting from enantioenriched monomers. Finally, given their high recalcitrance and resistance to degradation, lipids are among the best candidate biomarkers in exobiology. Compartmentalization is crucial for life’s evolution. Yet, the origin of modern phospholipid membranes and their species-dependent homochirality remains unknown. Amphiphile detection in extraterrestrial samples suggests diverse interstellar chemistry, enriching Earth’s prebiotic chemistry with vital membrane precursors. Moreover, chiroptical properties guide research into membrane homochirality origins.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"8 9","pages":"652-664"},"PeriodicalIF":38.1,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141723986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Monitoring a planetary resource under threat 监测受到威胁的地球资源

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-07-16 DOI: 10.1038/s41570-024-00631-0

Dan E. Angelescu

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