Mycobiology最新文献_第9页

Didymella acutilobae sp. nov. Causing Leaf Spot and Stem Rot in Angelica acutiloba. 尖叶Didymela acutilobae sp.nov.引起尖叶当归叶斑和茎腐病的研究。

IF 1.9 4区生物学

Mycobiology Pub Date : 2023-10-12 eCollection Date: 2023-01-01 DOI: 10.1080/12298093.2023.2254052

Gyo-Bin Lee, Ki Deok Kim, Weon-Dae Cho, Wan-Gyu Kim

{"title":"Didymella acutilobae sp. nov. Causing Leaf Spot and Stem Rot in Angelica acutiloba.","authors":"Gyo-Bin Lee, Ki Deok Kim, Weon-Dae Cho, Wan-Gyu Kim","doi":"10.1080/12298093.2023.2254052","DOIUrl":"https://doi.org/10.1080/12298093.2023.2254052","url":null,"abstract":"During disease surveys of Angelica acutiloba plants in Korea, leaf spot symptoms were observed in a field in Andong in July 2019, and stem rot symptoms in vinyl greenhouses in Yangpyeong in April 2020. Incidence of leaf spot and stem rot of the plants ranged from 10 to 20% and 5 to 30%, respectively. Morphological and cultural characteristics of fungal isolates from the leaf spot and stem rot symptoms fitted into those of the genus Phoma. Molecular phylogenetic analyses of two single-spore isolates from the symptoms using concatenated sequences of LSU, ITS, TUB2, and RPB2 genes authenticated an independent cluster from other Didymella (anamorph: Phoma) species. Moreover, the isolates showed different morphological and cultural characteristics in comparison to closely related Didymella species. These discoveries confirmed the novelty of the isolates. Pathogenicity of the novel Didymella species isolates was substantiated on leaves and stems of A. acutiloba through artificial inoculation. Thus, this study reveals that Didymella acutilobae sp. nov. causes leaf spot and stem rot in Angelica acutiloba.","PeriodicalId":18825,"journal":{"name":"Mycobiology","volume":"51 5","pages":"313-319"},"PeriodicalIF":1.9,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71483802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re-Identification of Aspergillus Subgenus Circumdati Strains in Korea Led to the Discovery of Three Unrecorded Species. 对韩国环纹曲霉亚属菌株的重新鉴定导致发现了三个未记录的物种。

IF 1.9 4区生物学

Mycobiology Pub Date : 2023-10-09 eCollection Date: 2023-01-01 DOI: 10.1080/12298093.2023.2257997

Anbazhagan Mageswari, Yunhee Choi, Le Dinh Thao, Daseul Lee, Dong-Hyun Kim, Myung Soo Park, Seung-Beom Hong

{"title":"Re-Identification of Aspergillus Subgenus Circumdati Strains in Korea Led to the Discovery of Three Unrecorded Species.","authors":"Anbazhagan Mageswari, Yunhee Choi, Le Dinh Thao, Daseul Lee, Dong-Hyun Kim, Myung Soo Park, Seung-Beom Hong","doi":"10.1080/12298093.2023.2257997","DOIUrl":"https://doi.org/10.1080/12298093.2023.2257997","url":null,"abstract":"Aspergillus is one of the largest and diverse genera of fungi with huge economical, biotechnological, and social significance. Taxonomically, Aspergillus is divided into six subgenera comprising 27 sections. In this study, 235 strains of Aspergillus subgenus Circumdati (section: Candidi, Circumdati, Flavi, Flavipedes, Nigri, and Terrei) preserved at the Korean Agricultural Culture Collection (KACC) were analyzed and re-identified using a combined dataset of partial β-tubulin (BenA), Calmodulin (CaM) gene sequences and morphological data. We confirmed nineteen species to be priorly reported in Korea (A. neotritici, A. terreus, A. floccosus, A. allahabadii, A. steynii, A. westerdijkiae, A. ochraceus, A. ostianus, A. sclerotiorum, A. luchuensis, A. tubingensis, A. niger, A. welwitschiae, A. japonicus, A. nomius, A. tamarii, A. parasiticus, A. flavi, and A. oryzae). Among the studied strains, three species (A. subalbidus, A. iizukae, and A. uvarum), previously unreported or not officially documented, were discovered in Korea, to the best of our knowledge. We have given a detailed description of the characteristic features of the three species, which remain uncharted in Korea.","PeriodicalId":18825,"journal":{"name":"Mycobiology","volume":"51 5","pages":"288-299"},"PeriodicalIF":1.9,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71483809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LAMMER Kinase Modulates Cell Cycle by Phosphorylating the MBF Repressor, Yox1, in Schizosaccharomyces pombe. LAMMER激酶通过磷酸化pombe裂殖酵母中的MBF抑制因子Yox1来调节细胞周期。

IF 1.9 4区生物学

Mycobiology Pub Date : 2023-10-09 eCollection Date: 2023-01-01 DOI: 10.1080/12298093.2023.2262806

Kibum Park, Joo-Yeon Lim, Je-Hoon Kim, Jieun Lee, Songju Shin, Hee-Moon Park

{"title":"LAMMER Kinase Modulates Cell Cycle by Phosphorylating the MBF Repressor, Yox1, in Schizosaccharomyces pombe.","authors":"Kibum Park, Joo-Yeon Lim, Je-Hoon Kim, Jieun Lee, Songju Shin, Hee-Moon Park","doi":"10.1080/12298093.2023.2262806","DOIUrl":"https://doi.org/10.1080/12298093.2023.2262806","url":null,"abstract":"Lkh1, a LAMMER kinase homolog in the fission yeast Schizosaccharomyces pombe, acts as a negative regulator of filamentous growth and flocculation. It is also involved in the response to oxidative stress. The lkh1-deletion mutant displays slower cell growth, shorter cell size, and abnormal DNA content compared to the wild type. These phenotypes suggest that Lkh1 controls cell size and cell cycle progression. When we performed microarray analysis using the lkh1-deletion mutant, we found that only four of the up-regulated genes in the lkh1-deletion were associated with the cell cycle. Interestingly, all of these genes are regulated by the Mlu1 cell cycle box binding factor (MBF), which is a transcription complex responsible for regulating the expression of cell cycle genes during the G1/S phase. Transcription analyses of the MBF-dependent cell-cycle genes, including negative feedback regulators, confirmed the up-regulation of these genes by the deletion of lkh1. Pull-down assay confirmed the interaction between Lkh1 and Yox1, which is a negative feedback regulator of MBF. This result supports the involvement of LAMMER kinase in cell cycle regulation by modulating MBF activity. In vitro kinase assay and NetPhosK 2.0 analysis with the Yox1T40,41A mutant allele revealed that T40 and T41 residues are the phosphorylation sites mediated by Lkh1. These sites affect the G1/S cell cycle progression of fission yeast by modulating the activity of the MBF complex.","PeriodicalId":18825,"journal":{"name":"Mycobiology","volume":"51 5","pages":"372-378"},"PeriodicalIF":1.9,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71483805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptome Analysis Reveals the Putative Polyketide Synthase Gene Involved in Hispidin Biosynthesis in Sanghuangporus sanghuang. 转录组分析揭示了桑黄孢Hispidin生物合成的推测性聚酮合成酶基因。

IF 1.9 4区生物学

Mycobiology Pub Date : 2023-09-25 eCollection Date: 2023-01-01 DOI: 10.1080/12298093.2023.2257999

Jiansheng Wei, Liangyan Liu, Xiaolong Yuan, Dong Wang, Xinyue Wang, Wei Bi, Yan Yang, Yi Wang

{"title":"Transcriptome Analysis Reveals the Putative Polyketide Synthase Gene Involved in Hispidin Biosynthesis in Sanghuangporus sanghuang.","authors":"Jiansheng Wei, Liangyan Liu, Xiaolong Yuan, Dong Wang, Xinyue Wang, Wei Bi, Yan Yang, Yi Wang","doi":"10.1080/12298093.2023.2257999","DOIUrl":"https://doi.org/10.1080/12298093.2023.2257999","url":null,"abstract":"Hispidin is an important styrylpyrone produced by Sanghuangporus sanghuang. To analyze hispidin biosynthesis in S. sanghuang, the transcriptomes of hispidin-producing and non-producing S. sanghuang were determined by Illumina sequencing. Five PKSs were identified using genome annotation. Comparative analysis with the reference transcriptome showed that two PKSs (ShPKS3 and ShPKS4) had low expression levels in four types of media. The gene expression pattern of only ShPKS1 was consistent with the yield variation of hispidin. The combined analyses of gene expression with qPCR and hispidin detection by liquid chromatography-mass spectrometry coupled with ion-trap and time-of-flight technologies (LCMS-IT-TOF) showed that ShPKS1 was involved in hispidin biosynthesis in S. sanghuang. ShPKS1 is a partially reducing PKS gene with extra AMP and ACP domains before the KS domain. The domain architecture of ShPKS1 was AMP-ACP-KS-AT-DH-KR-ACP-ACP. Phylogenetic analysis shows that ShPKS1 and other PKS genes from Hymenochaetaceae form a unique monophyletic clade closely related to the clade containing Agaricales hispidin synthase. Taken together, our data indicate that ShPKS1 is a novel PKS of S. sanghuang involved in hispidin biosynthesis.","PeriodicalId":18825,"journal":{"name":"Mycobiology","volume":"51 5","pages":"360-371"},"PeriodicalIF":1.9,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71483810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Nucleolar Protein, MoRRP8 Is Required for Development and Pathogenicity in the Rice Blast Fungus. MoRRP8是稻瘟病菌发育和致病所必需的核蛋白。

IF 1.9 4区生物学

Mycobiology Pub Date : 2023-09-25 eCollection Date: 2023-01-01 DOI: 10.1080/12298093.2023.2257996

Minji Kim, Song Hee Lee, Junhyun Jeon

{"title":"A Nucleolar Protein, MoRRP8 Is Required for Development and Pathogenicity in the Rice Blast Fungus.","authors":"Minji Kim, Song Hee Lee, Junhyun Jeon","doi":"10.1080/12298093.2023.2257996","DOIUrl":"https://doi.org/10.1080/12298093.2023.2257996","url":null,"abstract":"The nucleolus is the largest, membrane-less organelle within the nucleus of eukaryotic cell that plays a critical role in rRNA transcription and assembly of ribosomes. Recently, the nucleolus has been shown to be implicated in an array of processes including the formation of signal recognition particles and response to cellular stress. Such diverse functions of nucleolus are mediated by nucleolar proteins. In this study, we characterized a gene coding a putative protein containing a nucleolar localization sequence (NoLS) in the rice blast fungus, Magnaporthe oryzae. Phylogenetic and domain analysis suggested that the protein is orthologous to Rrp8 in Saccharomyces cerevisiae. MoRRP8-GFP (translational fusion of MoRRP8 with green fluorescence protein) co-localizes with a nucleolar marker protein, MoNOP1 fused to red fluorescence protein (RFP), indicating that MoRRP8 is a nucleolar protein. Deletion of the MoRRP8 gene caused a reduction in vegetative growth and impinged largely on asexual sporulation. Although the asexual spores of ΔMorrp8 were morphologically indistinguishable from those of wild-type, they showed delay in germination and reduction in appressorium formation. Our pathogenicity assay revealed that the MoRRP8 is required for full virulence and growth within host plants. Taken together, these results suggest that nucleolar processes mediated by MoRRP8 is pivotal for fungal development and pathogenesis.","PeriodicalId":18825,"journal":{"name":"Mycobiology","volume":"51 5","pages":"273-280"},"PeriodicalIF":1.9,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71483804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two New Species of the Family Acarosporaceae from South Korea. 标题韩国粉孢科二新种

IF 1.9 4区生物学

Mycobiology Pub Date : 2023-09-07 eCollection Date: 2023-01-01 DOI: 10.1080/12298093.2023.2249693

Jung Shin Park, Young-Nam Kwag, Sang-Kuk Han, Soon-Ok Oh

{"title":"Two New Species of the Family Acarosporaceae from South Korea.","authors":"Jung Shin Park, Young-Nam Kwag, Sang-Kuk Han, Soon-Ok Oh","doi":"10.1080/12298093.2023.2249693","DOIUrl":"10.1080/12298093.2023.2249693","url":null,"abstract":"Acarosporaceae is a crustose lichen and is known as a species that has more than 50 multi-spores, and has hyaline spores. Those taxa are often found in rock and soil in mountain areas or coastal regions in Korea, and very diverse forms and species are known. However, after an overall genetic phylogenetic analysis of carbonized ascomata in 2015, species consisting only of the morphological base are newly divided, and several species of Acarosporaceae in Korea are also being discovered in this situation. As a result of analysis using internal transcribed spacer (ITS) and nuLSU gene analysis, Korean species belonged to Acarospora and Sarcogyne clade, and Acarospora classified as the Acarospora clade was mixed with the Polysporina group and the Sarcogyne clade is mixed with the Acarospora. We identified two new species (Acarospora beangnokdamensis J. S. Park & S. O. Oh, sp. nov., Sarcogyne jejuensis J. S. Park & S. O. Oh, sp. nov.) through morphological, molecular, and secondary metabolite substance and found one new record (Sarcogyne oceanica K. Knudsen & Kocourk). We have made a classification key for Acarospora and Sarcogyne in Korea and reported all information together here.","PeriodicalId":18825,"journal":{"name":"Mycobiology","volume":"51 1","pages":"216-229"},"PeriodicalIF":1.9,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10791086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45449210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正

IF 1.9 4区生物学

Mycobiology Pub Date : 2023-08-03 eCollection Date: 2023-01-01 DOI: 10.1080/12298093.2023.2239652

引用次数: 0

Neocucurbitaria chlamydospora sp. nov.: A Novel Species of the Family Cucurbitariaceae Isolated from a Stink Bug in Korea. Neocucurbitaria chlamydospora sp：从韩国臭虫中分离出的葫芦科新物种。

IF 1.6 4区生物学

Mycobiology Pub Date : 2023-05-12 eCollection Date: 2023-01-01 DOI: 10.1080/12298093.2023.2203973

Soo-Min Hong, Kallol Das, Seong-Keun Lim, Sang Jae Suh, Seung-Yeol Lee, Hee-Young Jung

{"title":"Neocucurbitaria chlamydospora sp. nov.: A Novel Species of the Family Cucurbitariaceae Isolated from a Stink Bug in Korea.","authors":"Soo-Min Hong, Kallol Das, Seong-Keun Lim, Sang Jae Suh, Seung-Yeol Lee, Hee-Young Jung","doi":"10.1080/12298093.2023.2203973","DOIUrl":"10.1080/12298093.2023.2203973","url":null,"abstract":"The fungal strain KNUF-22-18B, belonging to Cucurbitariaceae, was discovered from a stink bug (Hygia lativentris) during the investigation of insect microbiota in Chungnam Province, South Korea. The colonies of the strain KNUF-22-18B were wooly floccose, white to brown in the center on oatmeal agar (OA), and the colonies were buff, margin even, and colorless, reverse white to yellowish toward the center on malt extract agar (MEA). The strain KNUF-22-18B produced pycnidia after 60 days of culturing on potato dextrose agar, but pycnidia were not observed on OA. On the contrary, N. keratinophila CBS 121759T abundantly formed superficial pycnidia on OA and MEA after a few days. The strain KNUF-22-18B produced chlamydospores subglobose to globose, mainly in the chain, with a small diameter of 4.4-8.8 μm. At the same time, N. keratinophila CBS 121759T displayed a globose terminal with a diameter of 8-10 μm. A multilocus phylogeny using the internal transcribed spacer regions, 28S rDNA large subunit, β-tubulin, and RNA polymerase II large subunit genes further validated the uniqueness of the strain. The detailed description and illustration of the proposed species as Neocucurbitaria chlamydospora sp. nov. from Korea was strongly supported by molecular phylogeny.","PeriodicalId":18825,"journal":{"name":"Mycobiology","volume":"51 3","pages":"115-121"},"PeriodicalIF":1.6,"publicationDate":"2023-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ee/6a/TMYB_51_2203973.PMC10288907.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10073191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diversity and community structure of ectomycorrhizal mycorrhizal fungi in roots and rhizosphere soil of Abies koreana and Taxus cuspidata in Mt. Halla. 哈拉山韩国杉和紫杉根系和根瘤土壤中外生菌根真菌的多样性和群落结构。

IF 1.6 4区生物学

Mycobiology Pub Date : 2023-01-04 eCollection Date: 2022-01-01 DOI: 10.1080/12298093.2022.2161974

Ji-Eun Lee, Ahn-Heum Eom

{"title":"Diversity and community structure of ectomycorrhizal mycorrhizal fungi in roots and rhizosphere soil of Abies koreana and Taxus cuspidata in Mt. Halla.","authors":"Ji-Eun Lee, Ahn-Heum Eom","doi":"10.1080/12298093.2022.2161974","DOIUrl":"10.1080/12298093.2022.2161974","url":null,"abstract":"In this study, the roots and rhizosphere soil of Abies koreana and Taxus cuspidata were collected from sites at two different altitudes on Mt. Halla. Ectomycorrhizal fungi (EMF) were identified by Illumina MiSeq sequencing. The proportion of EMF from the roots was 89% in A. koreana and 69% in T. cuspidata. Among EMF in rhizosphere soils, the genus Russula was the most abundant in roots of A. koreana (p < 0.05). The altitude did not affect the biodiversity of EMF communities but influenced fungal community composition. However, the host plants had the most significant effect on EMF communities. The result of the EMF community analysis showed that even if the EMF were isolated from the same altitudes, the EMF communities differed according to the host plant. The community similarity index of EMF in the roots of A. koreana was higher than that of T. cuspidata (p < 0.05). The results show that both altitude and host plants influenced the structure of EMF communities. Conifers inhabiting harsh sub-alpine environments rely strongly on symbiotic relationships with EMF. A. koreana is an endangered species with a higher host specificity of EMF and climate change vulnerability than T. cuspidata. This study provides insights into the EMF communities, which are symbionts of A. koreana, and our critical findings may be used to restore A. koreana.","PeriodicalId":18825,"journal":{"name":"Mycobiology","volume":"50 6","pages":"448-456"},"PeriodicalIF":1.6,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c7/71/TMYB_50_2161974.PMC9848229.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10601998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Culture Conditions for Mycelial Growth and Anti-Cancer Properties of Termitomyces. 白蚁菌丝生长的培养条件及抗癌特性研究。

IF 1.9 4区生物学

Mycobiology Pub Date : 2023-01-01 DOI: 10.1080/12298093.2023.2187614

Suphachai Tharavecharak, Corina N D'Alessandro-Gabazza, Masaaki Toda, Taro Yasuma, Taku Tsuyama, Ichiro Kamei, Esteban C Gabazza

{"title":"Culture Conditions for Mycelial Growth and Anti-Cancer Properties of Termitomyces.","authors":"Suphachai Tharavecharak, Corina N D'Alessandro-Gabazza, Masaaki Toda, Taro Yasuma, Taku Tsuyama, Ichiro Kamei, Esteban C Gabazza","doi":"10.1080/12298093.2023.2187614","DOIUrl":"https://doi.org/10.1080/12298093.2023.2187614","url":null,"abstract":"Termitomyces sp. that grow in symbiosis with fungus-farming Termites have medicinal properties. However, they are rare in nature, and their artificial culture is challenging. The expression of AXL receptor tyrosine kinase and immune checkpoint molecules favor the growth of cancer cells. The study evaluated the optimal conditions for the artificial culture of Termitomyces and their inhibitory activity on AXL and immune checkpoint molecules in lung adenocarcinoma and melanoma cell lines. The culture of 45 strains of Termitomyces was compared. Five strains with marked growth rates were selected. Four of the selected strains form a single cluster by sequence analysis. The mycelium of 4 selected strains produces more fungal mass in potato dextrose broth than in a mixed media. The bark was the most appropriate solid substrate for Termitomyces mycelia culture. The mycelium of all five selected strains showed a higher growth rate under normal CO2 conditions. The culture broth, methanol, and ethyl acetate of one selected strain (T-120) inhibited the mRNA relative expression of AXL receptor tyrosine kinase and immune checkpoint molecules in cancer cell lines. Overall, these results suggest the potential usefulness of Termitomyces extracts as a co-adjuvant therapy in malignant diseases.","PeriodicalId":18825,"journal":{"name":"Mycobiology","volume":"51 2","pages":"94-108"},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b2/43/TMYB_51_2187614.PMC10142329.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9392601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0