Molecules and Cells最新文献_第4页

Dietary salt induces taste desensitization via receptor internalization in Drosophila in a sexually dimorphic manner 饮食盐诱导味觉脱敏通过受体内化在果蝇在两性二态的方式。

IF 3.7 3区生物学

Molecules and Cells Pub Date : 2025-06-18 DOI: 10.1016/j.mocell.2025.100242

Linni Jin , Chul Hoon Kim , Jeong Taeg Seo , Seok Jun Moon

{"title":"Dietary salt induces taste desensitization via receptor internalization in Drosophila in a sexually dimorphic manner","authors":"Linni Jin , Chul Hoon Kim , Jeong Taeg Seo , Seok Jun Moon","doi":"10.1016/j.mocell.2025.100242","DOIUrl":"10.1016/j.mocell.2025.100242","url":null,"abstract":"<div><div>Sodium homeostasis, which is critical for survival, includes mechanisms for regulating salt intake that integrate central neural pathways with the peripheral taste system. Although the central homeostatic mechanisms of salt appetite are well-studied, the mechanisms by which dietary salt modulates peripheral taste responses remain unclear. We found increased dietary salt reduces salt preference in <em>Drosophila</em> by desensitizing sweet gustatory receptor neurons independent of internal sodium levels. We observed a reversible suppression of salt-evoked neural responses following salt exposure accomplished via clathrin-mediated endocytosis in males and both clathrin- and C-terminal binding protein-dependent endocytosis in females. We also found reversing gustatory receptor neuron sexual identity switched the desensitization pattern, indicating cell-autonomous control of this sexual dimorphism. Moreover, C-terminal binding protein-mediated macropinocytosis in females also dampened sweet taste responses, revealing a sex- and modality-specific mechanism underlying sensory adaptation. These findings reveal dietary experience can affect feeding behavior by reprograming peripheral taste responses, clarifying the plasticity of nutrient sensing.</div></div>","PeriodicalId":18795,"journal":{"name":"Molecules and Cells","volume":"48 8","pages":"Article 100242"},"PeriodicalIF":3.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of mitochondrial membrane potential, ROS, and calcium 线粒体膜电位、活性氧和钙的分析。

IF 3.7 3区生物学

Molecules and Cells Pub Date : 2025-06-16 DOI: 10.1016/j.mocell.2025.100238

Hye-Kyung Park, Byoung Heon Kang

引用次数: 0

RNA-associated nuclear condensates: Where the nucleus keeps its RNAs in check rna相关核凝聚物：细胞核控制rna的地方。

IF 3.7 3区生物学

Molecules and Cells Pub Date : 2025-06-15 DOI: 10.1016/j.mocell.2025.100240

Doyeong Ku , Yewon Yang , Yoosik Kim

{"title":"RNA-associated nuclear condensates: Where the nucleus keeps its RNAs in check","authors":"Doyeong Ku , Yewon Yang , Yoosik Kim","doi":"10.1016/j.mocell.2025.100240","DOIUrl":"10.1016/j.mocell.2025.100240","url":null,"abstract":"<div><div>Noncoding RNAs (ncRNAs) are emerging regulators of cellular processes and stress response by controlling chromatin architecture and gene expression. Recent studies have revealed that these ncRNAs functions are closely associated with nuclear condensates, membrane-less compartments formed by liquid-liquid phase separation (LLPS) that provide a specialized subnuclear environment for genome organization as well as transcriptional and post-transcriptional regulation. Disruption of RNA-mediated nuclear condensates is increasingly linked to human diseases, including neurodegenerative disease and cancer, emphasizing their essential role in maintaining cellular homeostasis. Advances in high-resolution microscopy and high-throughput sequencing have elucidated subcompartmental structures and genetic components of nuclear condensates by identifying associated RNA molecules and providing the details of RNA-protein interactions at a single-nucleotide resolution. We now understand that ncRNAs act as scaffolds that recruit RNA-binding proteins with intrinsically disordered domains to trigger the nucleation event for LLPS, resulting in the formation of nuclear condensates. In this review, we summarize how RNAs and RNA-binding proteins contribute to RNA-mediated nuclear condensate formation via LLPS and support their regulatory functions.</div></div>","PeriodicalId":18795,"journal":{"name":"Molecules and Cells","volume":"48 8","pages":"Article 100240"},"PeriodicalIF":3.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pattern recognition receptors and inflammasome: Now and beyond 模式识别受体和炎性体：现在和未来。

IF 3.7 3区生物学

Molecules and Cells Pub Date : 2025-06-15 DOI: 10.1016/j.mocell.2025.100239

SuHyeon Oh , Young Ki Choi , SangJoon Lee

{"title":"Pattern recognition receptors and inflammasome: Now and beyond","authors":"SuHyeon Oh , Young Ki Choi , SangJoon Lee","doi":"10.1016/j.mocell.2025.100239","DOIUrl":"10.1016/j.mocell.2025.100239","url":null,"abstract":"<div><div>Pattern recognition receptors (PRRs) are fundamental to the innate immune system, functioning to detect and eliminate invading pathogens by inhibiting their replication and limiting host tissue damage. Through direct recognition of pathogen-associated molecular patterns and damage-associated molecular patterns, PRRs initiate inflammatory responses, including cytokine production, and modulate the adaptive immune response. Ligand binding activates downstream signaling pathways that promote pathogen clearance and drive inflammasome assembly. Accumulating evidence underscores the critical role of PRRs in sensing cellular damage and preserving homeostasis. Importantly, interactions within PRR networks facilitate the formation of multiple PRR-containing inflammasomes (PANoptosome), enabling coordinated inflammatory cell death under combined pathogen-associated molecular pattern and damage-associated molecular pattern stimulation. A comprehensive understanding of these interconnected signaling networks is essential for elucidating the regulation of innate immunity and its implications for disease pathogenesis, particularly in the context of infection and inflammation. This review provides a detailed overview of PRR-ligand recognition, downstream signaling mechanisms, and inflammasome activation, and discusses emerging insights into PRR regulation that hold promise for novel immunotherapeutic interventions.</div></div>","PeriodicalId":18795,"journal":{"name":"Molecules and Cells","volume":"48 8","pages":"Article 100239"},"PeriodicalIF":3.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover and caption 封面及标题

IF 3.7 3区生物学

Molecules and Cells Pub Date : 2025-06-13 DOI: 10.1016/S1016-8478(25)00067-6

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Editorial Board Members/Copyright 编辑委员会成员/版权

IF 3.7 3区生物学

Molecules and Cells Pub Date : 2025-06-13 DOI: 10.1016/S1016-8478(25)00069-X

引用次数: 0

Building blocks for lung regeneration: Stem cells and niches 肺再生的构建模块：干细胞和壁龛。

IF 3.7 3区生物学

Molecules and Cells Pub Date : 2025-06-13 DOI: 10.1016/j.mocell.2025.100241

Hyeyoung Lee , Chae Won Lim , Woo Ram Lee , Ji Eun Park , Da Yeon Yu , Jinwook Choi

{"title":"Building blocks for lung regeneration: Stem cells and niches","authors":"Hyeyoung Lee , Chae Won Lim , Woo Ram Lee , Ji Eun Park , Da Yeon Yu , Jinwook Choi","doi":"10.1016/j.mocell.2025.100241","DOIUrl":"10.1016/j.mocell.2025.100241","url":null,"abstract":"<div><div>The respiratory system is an essential organ that performs gas exchange through the blood circulation in mammals. Unlike other organs, the lungs are directly exposed to the external environment, including particulate matter, cigarette smoke, and various pollutants, and are therefore, highly susceptible to damage. The lungs retain regional-specific stem/progenitor cells that quickly mobilize to replace the damaged epithelium. Accumulating evidences suggest that fate decision of stem cells relies on regulatory programs integrated by niches constituting the microenvironment providing diverse signals that regulate stem cell behavior. Therefore, understanding cellular diversity and precise interaction between stem cells and their respective niches is crucial to understand how tissue recovers homeostasis after injury. Here, in this review, we summarize recent progress in cellular and functional identity of stem cells and distinctive niches in the lungs. We also describe the molecular mechanism of genetic and epigenetic program in the regulation of stem cell behavior during tissue regeneration. Lastly, we introduce the three-dimensional lung organoid platforms that provide valuable insights into the mechanisms of lung pathophysiology in human system.</div></div>","PeriodicalId":18795,"journal":{"name":"Molecules and Cells","volume":"48 8","pages":"Article 100241"},"PeriodicalIF":3.7,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A brief guide to analyzing TurboID-based proximity labeling-mass spectrometry in plants 基于turboid的植物接近标记-质谱分析简介。

IF 3.7 3区生物学

Molecules and Cells Pub Date : 2025-06-03 DOI: 10.1016/j.mocell.2025.100236

Tae-Ki Park , Tae-Wuk Kim

引用次数: 0

Dysregulated RNA-binding proteins and alternative splicing: Emerging roles in autism spectrum disorder 失调的RNA结合蛋白和选择性剪接：在自闭症谱系障碍中的新作用。

IF 3.7 3区生物学

Molecules and Cells Pub Date : 2025-06-03 DOI: 10.1016/j.mocell.2025.100237

Jiwon Jeong , Hee-Jeong Yoo , Joon-Yong An , Sunjoo Jeong

引用次数: 0

READRetro web: A user-friendly platform for predicting plant natural product biosynthesis READRetro Web：一个预测植物天然产物生物合成的用户友好平台。

IF 3.7 3区生物学

Molecules and Cells Pub Date : 2025-06-02 DOI: 10.1016/j.mocell.2025.100235

Yejin Kwak , Taein Kim , Sang-Gyu Kim , Jeongbin Park

{"title":"READRetro web: A user-friendly platform for predicting plant natural product biosynthesis","authors":"Yejin Kwak , Taein Kim , Sang-Gyu Kim , Jeongbin Park","doi":"10.1016/j.mocell.2025.100235","DOIUrl":"10.1016/j.mocell.2025.100235","url":null,"abstract":"<div><div>Natural products (NPs), a fundamental class of bioactive molecules with broad applicability, are valuable sources in pharmaceutical research and drug discovery. Despite their significance, the large-scale production of NPs is often limited by their availability and scalability, requiring alternative approaches such as metabolic engineering or biosynthesis. To identify ideal pathways for the mass production of NPs, deep learning-based retrosynthesis models have been recently developed. Such models accelerate NP discovery; however, these tools are often not easy to use for researchers with a limited computational background, because they require complex environment configurations, command-line interfaces, and substantial computational resources. Here, we introduce READRetro web, a user-friendly web platform that integrates the READRetro machine learning (ML) model for retrosynthesis prediction. Based on modern web technologies, our web platform provides a fast and responsive user experience. READRetro Web bridges the gap between advanced ML-driven retrosynthesis and practical research workflows, making retrosynthesis prediction accessible to a broader range of researchers. Our platform demonstrates high predictive accuracy and computational efficiency, offering well-organized results to facilitate NP retrosynthetic pathway design. READRetro Web is freely accessible via <span><span>https://readretro.net</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":18795,"journal":{"name":"Molecules and Cells","volume":"48 8","pages":"Article 100235"},"PeriodicalIF":3.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0