Minerva dental and oral science最新文献

{"title":"Exploration of four digital oral examination instruments.","authors":"Jing Kang, Yue Wang","doi":"10.23736/S2724-6329.25.05148-4","DOIUrl":"10.23736/S2724-6329.25.05148-4","url":null,"abstract":"","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"57-58"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145549830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of bone adhesives in bone regeneration: a comprehensive review of clinical applications and outcome.","authors":"Alessio Rosa, Paolo Barnaba, Marco Gargari, Mirko Martelli","doi":"10.23736/S2724-6329.25.05212-X","DOIUrl":"10.23736/S2724-6329.25.05212-X","url":null,"abstract":"<p><p>Bone adhesives have emerged as a promising adjunct in regenerative medicine due to their potential to enhance fixation, improve osteointegration, and reduce operative time. Their application is particularly relevant in scenarios where traditional mechanical fixation is challenging or invasive, such as in cranial, orthopedic, and maxillofacial procedures. This narrative review explores the current landscape of bone adhesives, with a focus on synthetic and bioadhesive composites. A literature search was conducted across PubMed, Scopus, and Web of Science, including both preclinical and clinical studies published in the last two decades. Key parameters analyzed include adhesive composition, mechanical strength, biocompatibility, degradation behavior, and clinical outcomes. The reviewed evidence highlights that bone adhesives exhibit promising properties for use in bone regeneration. Synthetic adhesives, such as cyanoacrylates and polyurethane-based glues, offer high initial bond strength, while bioadhesives - often based on fibrin, collagen, or dopamine-functionalized polymers - demonstrate superior biocompatibility and osteoconductive potential. Clinical studies suggest their utility in bone graft stabilization, cranial defect repair, and minimally invasive maxillofacial surgery. Additionally, adhesives have been shown to reduce the need for hardware fixation, lower infection risks, and promote faster recovery. Bone adhesives represent a valuable complementary tool in regenerative bone procedures. While their integration into clinical practice is still evolving, current data support their safety and efficacy in selected surgical contexts. Further large-scale, long-term trials are warranted to validate their performance and optimize material formulations for specific applications.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"43-50"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145391498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric dental anxiety: a preliminary cognitive survey using the MCDASf scale in two Italian cohorts.","authors":"Matteo Saccucci, Giulia Zumbo, Gabriele DI Carlo, Federica Piscopo, Gaetano Licata, Ida C Corvino, Gaetano Ierardo, Aurora Pasqualini, Valeria Luzzi, Iole Vozza","doi":"10.23736/S2724-6329.25.05240-4","DOIUrl":"10.23736/S2724-6329.25.05240-4","url":null,"abstract":"<p><strong>Background: </strong>The term \"odontophobia\" refers to a phenomenon of extreme fear of dentists and dental treatment in patients, and during dental treatment can make it difficult for dentists to manage their behavior, creating an obstacle to the success of the treatment itself. This study reports a cognitive survey on odontophobia in an Italian pediatric population.</p><p><strong>Methods: </strong>The survey was structured anonymously, the \"Face version of the Modified Child Dental Anxiety Scale\" (MCDASf) questionnaire was used. In the sample analyzed, 140 participants,75 female and 65 male subjects, were included. The subjects were recruited in two different dental pediatric units. Every cohort was composed of 70 subjects.</p><p><strong>Results: </strong>The total mean score on the questionnaire was 22.43 in cohort 1, and 23.46 in cohort 2. Dental extraction emerged as the situation that generated the most concern, with an average score of 4.13 and 3.94. Similarly, local anesthetic injections showed a high degree of anxiety with a mean score of 3.8 and 3.91, respectively.</p><p><strong>Conclusions: </strong>These findings highlight the need for an empathetic and targeted approach to address dental anxiety in all age groups to ensure positive experiences and promote optimal oral health. Ultimately, this research underscores the importance of addressing dental anxiety from an early age in order to provide as much support as possible to patients and promote a positive and comfortable dental environment.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"18-26"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145549777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analgesic efficacy and adverse effects of paracetamol-codeine combination in third molar surgery: a meta-analytic systematic review.","authors":"Alessio Rosa, Michele Miranda, Paolo Barnaba, Patrizio Bollero, Marco Gargari, Mirko Martelli","doi":"10.23736/S2724-6329.25.05216-7","DOIUrl":"10.23736/S2724-6329.25.05216-7","url":null,"abstract":"<p><strong>Introduction: </strong>This systematic review and meta-analysis aimed to assess the analgesic efficacy and adverse event profile of paracetamol combined with codeine for managing postoperative pain following third molar surgery.</p><p><strong>Evidence acquisition: </strong>A comprehensive literature search was conducted across PubMed, Scopus, Web of Science, and the Cochrane Library to identify randomized controlled trials comparing paracetamol + codeine with placebo or other analgesics. Data on pain reduction, rescue medication use, and adverse effects were extracted and pooled using a random-effects model. Odds ratios (OR) and numbers needed to treat (NNT) or harm (NNH) were calculated.</p><p><strong>Evidence synthesis: </strong>Six RCTs involving 582 patients met inclusion criteria. The paracetamol-codeine combination significantly reduced postoperative pain and delayed the need for rescue medication (OR=0.45, 95% CI 0.30-0.68). However, adverse events were common, with drowsiness (25%, NNH=7), nausea (18%, NNH=11), and dizziness (12%, NNH=15) being the most frequently reported.</p><p><strong>Conclusions: </strong>Paracetamol + codeine provides effective postoperative analgesia for third molar surgery, especially in patients contraindicated for NSAIDs. Clinicians should consider the increased risk of sedation and gastrointestinal symptoms when prescribing this combination, and educate patients accordingly.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":"75 1","pages":"36-42"},"PeriodicalIF":1.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The pyogenic granuloma: localization, incidence, clinical features.","authors":"Hamid H Enezei, Afrah A Aldelaimi, Thamer Y Humadi, Khalil A Mohammed, Tahrir N Aldelaimi, Maria M Marrapodi, Gabriele Cervino, Giuseppe Minervini","doi":"10.23736/S2724-6329.24.05075-7","DOIUrl":"10.23736/S2724-6329.24.05075-7","url":null,"abstract":"<p><strong>Background: </strong>A pyogenic granuloma (PG) represents a swiftly proliferating benign vascular tumor situated in the skin or subcutaneous tissue, commonly observed as a reactive lesion in the orofacial area. This research intended to scrutinize the clinicopathological characteristics of pyogenic granulomas in the oral and maxillofacial region.</p><p><strong>Methods: </strong>Seventy two participants, comprising 24 men (33%) and 48 women (67%), underwent surgical ablation of pyogenic granuloma in oral and maxillofacial regions utilizing 940nm and 980nm diode lasers. Standard tissue processing procedures were applied to all specimens, with subsequent slicing of paraffin-embedded blocks at a 5µm thickness for H & E staining. A microscopic examination via light microscopy was conducted on all slides to confirm the diagnosis.</p><p><strong>Results: </strong>All cases underwent pyogenic granuloma surgical laser ablation, with 53 individuals (74%) aged 30 years or younger, 19 (26%) aged 30 years or more, 52 (72%) have duration less than six months,, and 20 (28%) have a six months or more.</p><p><strong>Conclusions: </strong>Pyogenic granuloma emerges as a prevalent reactive lesion in the oral and maxillofacial domain. The diode laser demonstrates utility in oral and facial soft tissue surgery owing to its facile application, enhanced coagulation, avoidance of suturing, reduced swelling and pain, and its capacity for esthetically favorable outcomes, encompassing superior de-epithelialization, absence of bleeding, and improved repair. The roles of surgeons and pathologists are pivotal in diagnosing and treating pyogenic granuloma in oral and maxillofacial regions.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"1-7"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental chart validation for an epidemiological oro-functional investigation in a 6-to-14 years-old children population.","authors":"Silvia Fanelli, Arianna Malara, Roberta Lione, Paola Cozza, Giuseppina Laganà","doi":"10.23736/S2724-6329.25.05210-6","DOIUrl":"10.23736/S2724-6329.25.05210-6","url":null,"abstract":"<p><strong>Background: </strong>The aim of this paper was to assess the quality of a dental chart to record the oro-functional conditions in a pediatric population, if a systematic and well-structured questionnaire plays a fundamental role in the correct diagnosis and treatment planning process.</p><p><strong>Methods: </strong>The project was performed by auditing a \"guided\" dental chart formulated for subjects from 6-to-14 years-old, proposed by the International Medical University in Rome \"UniCamillus,\" in the period between March 2022 to June 2024. The subjects included were visited by five dental expert examiners during a project coordinated by the same University. The form was divided into three parts: 1) a questionnaire for the parents regarding remote and current habits; 2) parental consent; 3) a dental chart, filled out by the examiners. At the end of the project each examiners received an anonymous satisfaction questionnaire regarding the dental chart validation.</p><p><strong>Results: </strong>A total of 1033 charts were examined. Each chart was edited and validated by each examiner. None of the charts was discarded for inconsistencies/inadequacy. According to the examiner's questionnaire, the results reported that they were partially (60%) aware of the topic covered and that almost everyone (80%) was interested in deepening them; all the examiners (100%) easily filled out the chart and understood the language, supporting the validity of the project.</p><p><strong>Conclusions: </strong>Each expert examiner confirmed the chart validity during the clinical examination, supporting the importance that a complete and standardized method for data collection can be considered essential for a correct diagnosis and therapeutical effective plan, guarantees a proper maintenance of dental records for private/public clinical practice and facilitates data analysis in epidemiological investigations.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"8-17"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145549653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Special needs patients: the University of Milano Bicocca guidelines in management of patients with special needs in pediatric, adult and geriatric age for dentistry. A shift in the conceptualization of patients with special needs in dentistry outlining a new comprehensive and exhaustive management protocol of treatment.","authors":"Gianluca Porcaro, Elisa Cioffi, Augusto Parolini, Alessia Sicignano, Marco Baldoni","doi":"10.23736/S2724-6329.25.05140-X","DOIUrl":"10.23736/S2724-6329.25.05140-X","url":null,"abstract":"<p><p>The strength and innovative challenge of a National Health System is measured, among all parameters, also by its capacity to take care of that portion of the population that presents greater socio-health vulnerabilities. In fact, the direction of national and international socio-political demands, in collective health matters, is precisely that of identifying the volume of the population concerned, not only in epidemiological terms to quantify the necessary services, but above all in terms of definition. The aim of this article is to provide an analysis of the evolution of the definition of vulnerable, fragile and disabled patient, up to the present day, and to present the clinical protocol for the management of the patient with special needs, elaborated and adopted within the IRCCS San Gerardo dei Tintori Dental Clinic in Monza (Italy), in collaboration with the School of Specialization in Oral Surgery of the University of Milan-Bicocca.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"372-385"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145549779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular interactions and gene expression analysis of two equine-derived bone graft materials: an in vitro study.","authors":"Danilo A DI Stefano, Luca Coccoluto, Paola Panina-Bordignon, Elena Brambilla, Francesca Ruffini, Valentina Murtaj, Francesco Orlando, Matteo Colombo, Christian Frigerio, Anna DI Bona, Daniele Recupero, Marco Morroni, Enrico Gherlone","doi":"10.23736/S2724-6329.25.05209-X","DOIUrl":"10.23736/S2724-6329.25.05209-X","url":null,"abstract":"<p><strong>Background: </strong>Bone grafting is a surgical procedure that involves the use of bone tissue or bone substitutes to repair damaged bone. In dentistry and maxillofacial surgery, bone graft substitutes from various sources are commonly used. Given their critical role in clinical outcomes, it is essential to thoroughly investigate the biological and mechanical properties of these materials.</p><p><strong>Methods: </strong>In this in vitro study, we evaluated the biological properties of two equine-derived bone graft substitutes in comparison to β-tricalcium phosphate. The materials included one equine-derived graft containing hydrolyzed type I collagen and another containing preserved type I collagen. To assess their biological performance, we analyzed cell viability, adhesion, osteogenic differentiation, and the expression of genes involved in bone remodeling.</p><p><strong>Results: </strong>All graft substitutes demonstrated similarly good biocompatibility. However, in the β-tricalcium phosphate group, intergranular tissue fibers or extracellular matrix were absent both before and after osteogenic differentiation. In contrast, cells cultured on the equine-derived graft containing hydrolyzed type I collagen exhibited intergranular tissue fibers and matrix, while those on the graft containing preserved type I collagen showed intergranular tissue fibers, individual cells, and matrix. Gene expression analysis suggested that β-tricalcium phosphate may undergo faster resorption kinetics compared to the equine-derived grafts, which were associated with gene expression patterns indicative of enhanced bone formation.</p><p><strong>Conclusions: </strong>Our results suggest that both hydrolyzed and preserved type I collagen support bone matrix deposition more effectively than β-tricalcium phosphate, with preserved collagen demonstrating superior performance. From a clinical perspective, preserved collagen appears to be the optimal choice for larger or less contained bone defects, as it promotes faster cell repopulation and may lead to more rapid remodeling with the patient's own vital bone. In contrast, hydrolyzed collagen seems to elicit a slower cellular response and may be better suited for smaller, localized defects where immediate biological activity is less critical. Further research is essential to guide clinicians in selecting the most appropriate bone graft substitute based on the specific clinical context.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"355-371"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145378075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basal implants as a treatment alternative for severely resorbed ridges.","authors":"Fadia Awadalkreem, Kusai Baroudi, Giuseppe Minervini, Yazan Zaineh, Ebrahim Al-Mehdhar","doi":"10.23736/S2724-6329.24.05066-6","DOIUrl":"10.23736/S2724-6329.24.05066-6","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to evaluate the long-term treatment outcomes of basal implants in patients with severely resorbed ridges, including the survival and success rates, patient complaints, satisfaction, and Quality of Life.</p><p><strong>Evidence acquisition: </strong>An extensive electronic search was conducted on the search engines: PubMed, Web of Science, and Google Scholar using Boolean Operators (AND, OR, NOT) and the key words (basal implants, Corticobasal implants, Strategic Implants, severely resorbed ridge, severely atrophic ridge, treatment outcome, patient satisfaction) within the last 10 years.</p><p><strong>Evidence synthesis: </strong>A total of 21 articles were found, encompassing 9732 basal implants placed in 1219 patients. Thirteen studies had reported a success or survival rate with a range of 90.3-100% for intraoral basal implants and 88.2% and 92.9% for orbital and nasal implants, respectively. Four studies have reported failure rates with a range of 0.3-3.2%, while seven articles documented 0.3-2.4% mobility. The pain was reported in 6 studies (0.3-0.8), marginal bone loss (0.33-7.89 mm), an increase in bone density, and peri-implant bone contact were reported in 3 and 2 studies, respectively.</p><p><strong>Conclusions: </strong>Basal implant-supported prostheses can be a practical treatment modality with high predictable survival or success rates, positive impacts on patient satisfaction, and improved quality of life.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"393-404"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the influence of nutritional supplements on osseointegration outcomes in dental implantology: a systematic review.","authors":"Muzammil M Ahmed, Maria E Bizzoca, Abdul K Azad, Nubesh K Syed, Syed Shujaulla, Syeda T Tabasum, Raghu S Pavithra, Lorenzo Lo Muzio","doi":"10.23736/S2724-6329.25.05262-3","DOIUrl":"10.23736/S2724-6329.25.05262-3","url":null,"abstract":"<p><strong>Introduction: </strong>This systematic review investigates the role of nutritional supplements in enhancing osseointegration outcomes, a critical factor for the success of dental implants.</p><p><strong>Evidence acquisition: </strong>A comprehensive search was performed across multiple databases (MEDLINE/PubMed, EMBASE, Cochrane Library, Scopus, Web of Science, CINAHL, PsycINFO) to identify relevant studies. Inclusion criteria targeted studies providing quantitative data on osseointegration related to micronutrient supplementation.</p><p><strong>Evidence synthesis: </strong>Analysis of the included studies revealed that adequate Vitamin D levels were consistently associated with improved implant outcomes, enhancing bone density and stability. Vitamin C supplementation was shown to benefit soft tissue healing but did not directly affect bone integration. The review also identified significant interactions between genetic factors (e.g., vitamin D receptor polymorphisms) and implant success, alongside noting that systemic conditions like osteoporosis were associated with poorer prognoses.</p><p><strong>Conclusions: </strong>Nutritional supplementation, particularly vitamin D, plays a significant role in supporting dental implant osseointegration. A holistic patient assessment, considering genetic and systemic health factors, is essential for predicting outcomes. Further research is needed to establish definitive clinical guidelines for nutritional support in implantology.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"413-424"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145549682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}