Minerva dental and oral science最新文献_第5页

Biomechanical considerations of chemical structure and biosafety of current ceramic biomaterials for dentistry: review and outlook of the current state of the art. 当前牙科用陶瓷生物材料化学结构和生物安全性的生物力学考虑因素：技术现状回顾与展望。

IF 1.1

Minerva dental and oral science Pub Date : 2024-12-01 Epub Date: 2024-10-08 DOI: 10.23736/S2724-6329.24.05093-9

Gennaro Musella, Andrea Ballini, Michele Di Cosola, Alessandro Motta, Tommaso Dai Prà, Fariba Esperouz, Mario Dioguardi, Lorenzo Lo Muzio, Gaetano Illuzzi, Maria E Bizzoca

{"title":"Biomechanical considerations of chemical structure and biosafety of current ceramic biomaterials for dentistry: review and outlook of the current state of the art.","authors":"Gennaro Musella, Andrea Ballini, Michele Di Cosola, Alessandro Motta, Tommaso Dai Prà, Fariba Esperouz, Mario Dioguardi, Lorenzo Lo Muzio, Gaetano Illuzzi, Maria E Bizzoca","doi":"10.23736/S2724-6329.24.05093-9","DOIUrl":"10.23736/S2724-6329.24.05093-9","url":null,"abstract":"Biomaterial refers to any material, non-pharmaceutical or combination of substances of synthetic or natural origin used for any period independently or as part of a system for the purpose of healing, assisting the growth or replacement of tissues, organs or functions of the body. It is an unsustainable material that interacts with biological systems. Before being produced a biomaterial goes through a sequence of steps, which includes: 1) the definition of the problem that the material will be called to solve (treatment, replacement of the instrument, aesthetic reasons); 2) design of the device, composition and control of materials (mechanical properties, toxicity, biological response, corrosion resistance, interaction with proteins, cells and tissues), manufacture, sterilization and standardization; 3) control of the device (in experimental animals, in vitro) clinical studies, studies; and 4) monitor its long-term use in vivo, in vitro and in patients. Research for ceramic materials is evolving and because they can be porous or glassy, they find applications in medicine and biotechnology, as they can be used as fillers, covering materials and scaffolds. Therefore, ceramic biomaterials are widely used not only in the field of orthopedic and maxillofacial surgery but also in dentistry as for dental prostheses. Materials monitoring technologies allow us to monitor the three-dimensional development in space, as well as imperfections or micro-cracks in the ceramic.","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"352-358"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the effect of aging on the shear bond strength between old composite resin restoration and the repair composite resin: an in-vitro study. 评估老化对旧复合树脂修复体与修复复合树脂之间剪切粘接强度的影响：体外研究。

IF 1.1

Minerva dental and oral science Pub Date : 2024-11-20 DOI: 10.23736/S2724-6329.24.04889-7

Hafiz A Adawi, Saurabh Jain, Ahmed O Shami, Hamood M Mahdali, Ali M Kaabi, Osama B Balki, Marco Cicciù, Giuseppe Minervini

{"title":"Evaluation of the effect of aging on the shear bond strength between old composite resin restoration and the repair composite resin: an in-vitro study.","authors":"Hafiz A Adawi, Saurabh Jain, Ahmed O Shami, Hamood M Mahdali, Ali M Kaabi, Osama B Balki, Marco Cicciù, Giuseppe Minervini","doi":"10.23736/S2724-6329.24.04889-7","DOIUrl":"https://doi.org/10.23736/S2724-6329.24.04889-7","url":null,"abstract":"Background: The current study aimed to evaluate the effect of aging on the repair bond strength between old composite resin and repaired composite resin and to evaluate which type of repair composite material provides better bond strength in different time durations.Methods: Eighty nano-hybrid composite specimens were randomly divided into four groups (N.=20) and exposed to accelerated aging from 0 to 2 years. Each group was further divided into two subgroups, A and B, repaired with packable and flowable composite respectively, after micro-abrasion treatment. Shear bond strength was assessed and statistically analyzed.Results: It was observed that with an increase in aging time, the bond strength of both the composite materials used for repair decreased. The flowable composite's mean bond strength (22.09±0.65, 18.74±2.36, and 17.74±2.38 MPa) was more than the packable composite (21.97±0.84, 17.97±3.85, and 15.97±2.45 MPa) used for repair on aged specimens. In contrast, the bond strength of the packable was more than the flowable composite in control group specimens that were not aged (23.25±0.89 vs. 22.40±1.26).Conclusions: As restored composites age, their bond strength decreases. Flowable composite displays better repair shear strength than packable composite as aging progresses. Micro abrasion followed by flowable composite bonding can repair aged composite restorations effectively.","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AI-based prediction and classification of root caries using radiographic images. 基于人工智能的根龋预测和分类（使用放射影像）。

IF 1.1

Minerva dental and oral science Pub Date : 2024-11-20 DOI: 10.23736/S2724-6329.24.04967-2

Pradeep K Yadalam, Jeevitha Manickavasagam, Trisha Sasikumar, Maria M Marrapodi, Vincenzo Ronsivalle, Marco Cicciù, Giuseppe Minervini

{"title":"AI-based prediction and classification of root caries using radiographic images.","authors":"Pradeep K Yadalam, Jeevitha Manickavasagam, Trisha Sasikumar, Maria M Marrapodi, Vincenzo Ronsivalle, Marco Cicciù, Giuseppe Minervini","doi":"10.23736/S2724-6329.24.04967-2","DOIUrl":"https://doi.org/10.23736/S2724-6329.24.04967-2","url":null,"abstract":"Background: Root surface caries, commonly known as root decay, is a common dental disorder that affects tooth roots. Like enamel-based tooth decay, root caries attack exposed root surfaces caused by gum recession or periodontal disease. Older persons with gum recession, tooth loss, or poor oral hygiene may be more likely to develop this disorder. Dental root caries must be diagnosed early to improve treatment and prevention. This research will examine radiographic image-based AI-based root caries prediction algorithms.Methods: Saveetha Dental College supplied 200 root surface radiographs. An expert dentist and dental radiologist confirmed one hundred teeth with root caries and 100 without. Edited and segmented radiographic images. Orange, a machine learning squeeze net embedding model with Naive Bayes, Logistic Regression, and neural networks, was used to assess prediction accuracy. Training and test data were split 80/20. Cross-validation, confusion matrix, and ROC analysis assessed model performance. This study examined precision and recall.Results: Naïve bayes and logistic regression have 96% and 100% accuracy, but class accuracy is -94% and 100% in image classification of root caries was seen.Conclusions: AI-based root caries prediction utilizing radiographic images would improve dental care by diagnosing and treating early, accurately, and personalized. With appropriate deployment, research, and ethics, AI integration in dentistry could benefit practitioners and patients. Dental professionals and AI experts must work together to maximize this new technology.AI integration in dentistry can significantly improve root caries diagnosis and treatment by predicting root caries using radiographic images. This early detection reduces treatment need and time. Collaboration between dental professionals and AI experts is crucial for maximizing benefits.","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of red blood cell parameters for signs of iron deficiency anemia in patients with oral diseases. 检测口腔疾病患者缺铁性贫血迹象的红细胞参数。

IF 1.1

Minerva dental and oral science Pub Date : 2024-11-20 DOI: 10.23736/S2724-6329.24.04907-6

Kavithaa Rajasekaran, Kaviyarasi Renu, Kavitha Sankaran, Vishnu Priya Veeraraghavan, Gayathri Rengasamy, Vincenzo Ronsivalle, Marco Cicciù, Giuseppe Minervini

{"title":"Determination of red blood cell parameters for signs of iron deficiency anemia in patients with oral diseases.","authors":"Kavithaa Rajasekaran, Kaviyarasi Renu, Kavitha Sankaran, Vishnu Priya Veeraraghavan, Gayathri Rengasamy, Vincenzo Ronsivalle, Marco Cicciù, Giuseppe Minervini","doi":"10.23736/S2724-6329.24.04907-6","DOIUrl":"https://doi.org/10.23736/S2724-6329.24.04907-6","url":null,"abstract":"Background: A lack of healthy red blood cells such as iron deficiency frequently consequences as anemia. In expectant women, iron deficiency increases the risk of developmental delays in the fetus. It is utilized to regenerate red blood cells (RBC), which determines the storage and transport of oxygen in the body. As for oral symptoms and indications, it has an inclusive of atrophic glossitis, oral mucosa atrophy, and oral mucosa tenderness or a sensation with burning in mouth. The objective is to determine RBC parameters for iron deficiency anemia (IDA) symptoms in oral disease patients.Methods: Normal and oral disease patients' blood is collected in a 2-mL EDTA vial for the hematology analyzer. With file number SRB/SDC/UG-2155/22/493, the institutional ethical approval committee approved this study: 10 controls (without anemia) and 10 patients with oral disease (with anemia).Results: In oral disease patients with anemia, a decreased hemoglobin level is observed. In this study, nearly all anemic patients have IDA. In IDA, the RBC count decreases, the MCV decreases, the MCH decreases, and the RDW rises. We have analyzed various iron deficiency anemia indices. Ricercari and Eshani demonstrate a significant change in it.Conclusions: In predicting iron deficiency anemia, our results indicate that oral patients have significant differences in hematological parameters that are individual. It demonstrates that oral disease patients are developing iron deficiency anemia than controls (healthy). Additionally, the discrimination indices reveal that they do not have hemoglobinopathies but rather iron deficiencies. Oral manifestations are more prevalent in Iron deficiency anemia (IDA) patients than in healthy patients, according to our findings.","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The pyogenic granuloma: localization, incidence, clinical features. 化脓性肉芽肿：定位、发病率、临床特征。

IF 1.1

Minerva dental and oral science Pub Date : 2024-11-20 DOI: 10.23736/S2724-6329.24.05075-7

Afrah A Aldelaimi, Hamid H Enezei, Thamer Y Humadi, Khalil A Mohammed, Tahrir N Aldelaimi, Maria M Marrapodi, Gabriele Cervino, Giuseppe Minervini

{"title":"The pyogenic granuloma: localization, incidence, clinical features.","authors":"Afrah A Aldelaimi, Hamid H Enezei, Thamer Y Humadi, Khalil A Mohammed, Tahrir N Aldelaimi, Maria M Marrapodi, Gabriele Cervino, Giuseppe Minervini","doi":"10.23736/S2724-6329.24.05075-7","DOIUrl":"https://doi.org/10.23736/S2724-6329.24.05075-7","url":null,"abstract":"Background: A pyogenic granuloma (PG) represents a swiftly proliferating benign vascular tumor situated in the skin or subcutaneous tissue, commonly observed as a reactive lesion in the orofacial area. This research intended to scrutinize the clinicopathological characteristics of pyogenic granulomas in the oral and maxillofacial region.Methods: Seventy two participants, comprising 24 men (33%) and 48 women (67%), underwent surgical ablation of pyogenic granuloma in oral and maxillofacial regions utilizing 940nm and 980nm diode lasers. Standard tissue processing procedures were applied to all specimens, with subsequent slicing of paraffin-embedded blocks at a 5µm thickness for H & E staining. A microscopic examination via light microscopy was conducted on all slides to confirm the diagnosis.Results: All cases underwent pyogenic granuloma surgical laser ablation, with 53 individuals (74%) aged 30 years or younger, 19 (26%) aged 30 years or more, 52 (72%) have duration less than six months,, and 20 (28%) have a six months or more.Conclusions: Pyogenic granuloma emerges as a prevalent reactive lesion in the oral and maxillofacial domain. The diode laser demonstrates utility in oral and facial soft tissue surgery owing to its facile application, enhanced coagulation, avoidance of suturing, reduced swelling and pain, and its capacity for esthetically favorable outcomes, encompassing superior de-epithelialization, absence of bleeding, and improved repair. The roles of surgeons and pathologists are pivotal in diagnosing and treating pyogenic granuloma in oral and maxillofacial regions.","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-silico immunoinformatic vaccine design for Treponema denticola ergothionase. 针对齿孢子菌麦角硫糖酶的硅内免疫形式疫苗设计。

IF 1.1

Minerva dental and oral science Pub Date : 2024-10-29 DOI: 10.23736/S2724-6329.24.04915-5

Jai P Rexlin, Jeevitha Manickavasagam, Pradeep K Yadalam, Deepti Shrivastava, Kumar C Srivastava, Vincenzo Ronsivalle, Marco Cicciù, Giuseppe Minervini

{"title":"In-silico immunoinformatic vaccine design for Treponema denticola ergothionase.","authors":"Jai P Rexlin, Jeevitha Manickavasagam, Pradeep K Yadalam, Deepti Shrivastava, Kumar C Srivastava, Vincenzo Ronsivalle, Marco Cicciù, Giuseppe Minervini","doi":"10.23736/S2724-6329.24.04915-5","DOIUrl":"https://doi.org/10.23736/S2724-6329.24.04915-5","url":null,"abstract":"Background: Treponema denticola, a well-studied oral spirochete, adheres, invades, and damages periodontal tissues - gram-negative, anaerobic Treponema denticola. In previous research, sub-gingival spirochetes have correlated positively with dental plaque score, pocket, and clinical attachment level measurements. Hence, the study aims to design an immunoinformatic vaccine using a reverse vaccinology approach against Treponema denticola ergothionase.Methods: Protein Data Bank provided the FASTA amino acid sequence of Treponema denticola. Antigenicity, toxicity, and stability of discovered T-cell epitopes were evaluated to develop 6S7Q B and A multiepitope vaccination design. The Vaccine's dual major histocompatibility complex (MHC I and II) binding epitopes were also predicted. The designed Vaccine's identified epitope sequence and secondary structure were then predicted and validated. Protein-protein interactions involving ergothionase and human beta-defensins were investigated using molecular docking.Results: The designed Vaccine had high antigenicity, toxicity, and stability. The Vaccine's three-dimensional structure demonstrated a significant association with beta-defensin. Its low binding energy score of -827.6 kcal/mol indicates that the immune system will respond favorably to the antigen.Conclusions: In this research, we employed immunoinformatic techniques to create a reverse vaccination effort to develop an in-silico vaccine.","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene expression analysis of microRNA-1285 in the South Indian oral squamous cell carcinoma population. 南印度口腔鳞状细胞癌人群中 microRNA-1285 的基因表达分析。

IF 1.1

Minerva dental and oral science Pub Date : 2024-10-01 Epub Date: 2023-07-06 DOI: 10.23736/S2724-6329.23.04798-8

Mahathi Neralla, Hiranya S, Sushmaa C Selvakumar, K Auxzilia Preethi, Durairaj Sekar

{"title":"Gene expression analysis of microRNA-1285 in the South Indian oral squamous cell carcinoma population.","authors":"Mahathi Neralla, Hiranya S, Sushmaa C Selvakumar, K Auxzilia Preethi, Durairaj Sekar","doi":"10.23736/S2724-6329.23.04798-8","DOIUrl":"10.23736/S2724-6329.23.04798-8","url":null,"abstract":"Background: Oral squamous cell carcinoma (OSCC) is the most common oral malignant tumor, which has poor prognosis. The traditional investigative modality is invasive biopsy which is the gold standard for diagnosis. In recent years, alternative methods like non-invasive biomarkers have been studied for their potential role in early diagnosis and prognosis. Among them, microRNAs (miRNAs or miRs) are short non-coding RNAs that regulate gene expression in various diseases, including OSCC. Several miRNAs are being researched as non-invasive biomarkers as well as novel therapeutic targets in the treatment of OSCC. MiR expression can be upregulated or downregulated in OSCC. Among the reported miRNAs, miR-1285 is an important miRNA found to be involved in OSCC. The aim of the current study was to quantify the levels of miR-1285 in OSCC samples and to validate their potential role as biomarkers for OSCC detection.Methods: Sixteen samples of cancer tissue and normal tissue were evaluated from a total of 25 patients, in the study, conducted in the Department of Oral and Maxillofacial Surgery. The tissues were processed for H&E staining and gene expression analysis of miR-1285. The samples were collected after proper informed consent from the patients. Total RNA isolated was reverse transcribed into cDNA which was used in the gene expression analysis using qRT-PCR.Results: The histopathological examination confirmed the OSCC cases and the gene expression analysis revealed that miR-1285 was significantly downregulated in OSCC tissues. Since miR-1285 showed significant difference between the OSCC and normal tissues it could be postulated as a potential biomarker and therapeutic target for OSCC.Conclusions: Further in-vitro and in-vivo studies could validate their functional role in OSCC.","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"249-255"},"PeriodicalIF":1.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9812581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MicroRNA-34a-3p and its target tumor necrosis factor-α in the regulation of South Indian oral squamous cell carcinoma population. MicroRNA-34a-3p及其靶肿瘤坏死因子-α在南印度口腔鳞状细胞癌人群中的调控作用

IF 1.1

Minerva dental and oral science Pub Date : 2024-10-01 Epub Date: 2023-10-25 DOI: 10.23736/S2724-6329.23.04835-0

M S Varshan, Sushmaa C Selvakumar, K A Preethi, Karthikeyan Murthykumar, Dhanraj M Ganapathy, Durairaj Sekar

{"title":"MicroRNA-34a-3p and its target tumor necrosis factor-α in the regulation of South Indian oral squamous cell carcinoma population.","authors":"M S Varshan, Sushmaa C Selvakumar, K A Preethi, Karthikeyan Murthykumar, Dhanraj M Ganapathy, Durairaj Sekar","doi":"10.23736/S2724-6329.23.04835-0","DOIUrl":"10.23736/S2724-6329.23.04835-0","url":null,"abstract":"Background: The most frequent head and neck cancer is oral squamous cell carcinoma (OSCC), the common histological cancer of the oral cavity and is one of the most prevalent forms of cancer globally. It has been known that there are several biomarkers and therapeutic targets that have been discovered for OSCC, but none of them were effective against the progression of OSCC. Interestingly, small non-coding RNAs termed microRNAs (miRNAs) regulate cellular activity by targeting numerous signaling pathways or genes that either promote or repress the progression of diseases. Surprisingly, among the differentially expressed miRNAs, miR-34a was identified to be highly sensitive and specific to OSCC and widely studied for its role in various cancers, including OSCC.Methods: The secondary structure of miR-34a-3p was analyzed using bioinformatic analysis and its targets were screened using the TargetScan database. Specimens of 25 OSCC cancer tissues and adjacent normal tissues were collected from the Department of Oral and Maxillofacial Surgery, Saveetha Dental College and Hospitals. The tissues were processed for H&E staining and gene expression analysis of miR-34a-3p and tumor necrosis factor alpha (TNF-α).Results: The minimum free energy for miR-34a-3p was found to be -47.20 kCal which proved the stability of the miRNA. The histopathological examination confirmed the OSCC cases and the gene expression analysis revealed that miR-34a-3p was significantly downregulated in OSCC tissues, whereas TNF-α showed vice versa expression.Conclusions: miR-34a-3p could be postulated as a potential therapeutic target for OSCC.","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"256-263"},"PeriodicalIF":1.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50158338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of oral tissue alterations in patients diagnosed with SARS-CoV-2. SARS-CoV-2确诊患者口腔组织改变的评估

IF 1.1

Minerva dental and oral science Pub Date : 2024-10-01 Epub Date: 2023-10-25 DOI: 10.23736/S2724-6329.23.04870-2

Aida Meto, Arben Ndreu, Emiljano Tragaj, Cesare D'Amico, Agron Meto, Luca Fiorillo

{"title":"Assessment of oral tissue alterations in patients diagnosed with SARS-CoV-2.","authors":"Aida Meto, Arben Ndreu, Emiljano Tragaj, Cesare D'Amico, Agron Meto, Luca Fiorillo","doi":"10.23736/S2724-6329.23.04870-2","DOIUrl":"10.23736/S2724-6329.23.04870-2","url":null,"abstract":"Background: The aim of this study was to investigate oral mucosal changes in patients with confirmed moderate-scale severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.Methods: We analyzed 85 COVID-19 patients (50 males, 35 females) with an average age of 53.6 years, treated at the prehospital infectious disease center and Aldent University Clinic in Tirana, Albania, from May 2021 to June 2022.Results: Elevated C-reactive protein levels were observed in 82 patients (±44.20), with 20 patients showing significant fibrinogen increase (mean ± 5.85 g/L), and 22 patients having elevated D-Dimer (mean ± 336.6 mg/mL). Despite the absence of anticoagulant history, 13 patients exhibited bleeding. Xerodermia, xerostomia, and angular cheilitis were noted, with 41 patients displaying angular cheilitis. In 82 patients, oral mucosal and tongue examinations revealed color changes from white to bright yellow, with brown edema. Pigmentation in the fixed gingiva of upper and lower front teeth was observed in 35 patients.Conclusions: Oral mucosal changes during COVID-19 appear more influenced by drug treatment and disease progression than the infection itself, suggesting that secondary factors play a significant role. Despite the oral cavity's potential for viral entry, these changes seem connected to other underlying causes.","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"272-278"},"PeriodicalIF":1.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50158335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive clinical and histological evaluation of bovine hydroxyapatite bone graft with polypropylene membrane versus leukocyte- and platelet-rich fibrin for alveolar preservation after tooth extraction. 聚丙烯膜牛羟基磷灰石骨移植与富含白细胞和血小板的纤维蛋白在拔牙后牙槽骨保存方面的临床和组织学综合评估。

IF 1.1

Minerva dental and oral science Pub Date : 2024-10-01 Epub Date: 2024-06-18 DOI: 10.23736/S2724-6329.24.05016-2

Karine C Lima, Maria E Bizzoca, Michele Covelli, Anderson C DE Oliveira, Fabiano C Zanardo, Ricardo R Vecchiatti, Jocelino L Soares, Nunzio Cirulli, Stefania Cantore, Fábio F Silva

{"title":"Comprehensive clinical and histological evaluation of bovine hydroxyapatite bone graft with polypropylene membrane versus leukocyte- and platelet-rich fibrin for alveolar preservation after tooth extraction.","authors":"Karine C Lima, Maria E Bizzoca, Michele Covelli, Anderson C DE Oliveira, Fabiano C Zanardo, Ricardo R Vecchiatti, Jocelino L Soares, Nunzio Cirulli, Stefania Cantore, Fábio F Silva","doi":"10.23736/S2724-6329.24.05016-2","DOIUrl":"10.23736/S2724-6329.24.05016-2","url":null,"abstract":"Background: Osseointegrated implant placement in the ideal prosthetic position necessitates a sufficient residual alveolar ridge. Tooth extraction and the subsequent healing process often lead to bony deformities, characterized by a reduction in alveolar ridge height and width, resulting in unfavorable ridge architecture for dental implant placement. Several materials, including allografts, alloplastics, xenografts, and autogenous bone, are commonly used to address these concerns. In this context, leucocyte- and platelet-rich fibrin (L-PRF) emerges as a promising solution.Methods: This case report aims to compare the clinical and histological efficacy of bovine hydroxyapatite bone graft covered with polypropylene membrane (BHAG-PM) and leucocyte- and platelet-rich fibrin (L-PRF) in preserving dental alveoli following tooth extraction. Extraction, graft placement in the alveoli, and the anterior border between extracted elements were performed for both treatment groups.Results: Up to 24 months of follow-up revealed satisfactory and comparable clinical and histological outcomes. These results suggest that both BHAG-PM and L-PRF effectively promote alveolar preservation, paving the way for ideal implant placement.Conclusions: In general, bone-substitute materials are effective in reducing alveolar changes after tooth extraction. Xenograft materials should be considered as among the best of the available grafting materials for alveolar preservation after tooth extraction. Both techniques effectively preserve the alveolar bone and facilitate the placement of osseointegrated implants in ideal positions, paving the way for successful oral rehabilitation.","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"279-286"},"PeriodicalIF":1.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141419882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0