Minerva dental and oral science最新文献

{"title":"A simple method to identify implant sites in totally edentulous arches: a pilot study with thermo-printed templates used with cone beam computed tomography.","authors":"Enzo Cumbo, Giuseppe Gallina, Pietro Messina, Giuseppe A Scardina","doi":"10.23736/S2724-6329.24.04998-2","DOIUrl":"10.23736/S2724-6329.24.04998-2","url":null,"abstract":"<p><strong>Background: </strong>All dental implants must be placed following radiological, clinical and aesthetic indications in compliance with prosthetic principles avoiding iatrogenic damage to patients. In implantology, among the key choices, to obtain predictable results, it is essential to establish (by cone beam computed tomography [CBCT]) the sites where to insert the implants; these sites must be identified, during the surgical phase, in the oral cavity. Surgical guides represent a valid aid especially in complex cases that require multiple implants. For some clinical conditions, expert operators choose the free hand technique during which identifying the chosen implant sites on CBCT in the oral cavity is more difficult.</p><p><strong>Methods: </strong>This experimental study is based on the use of thermo-molded mask as an alternative to surgical guides when the freehand technique is adopted in totally edentulous patients. These innovative masks, containing radiopaque references, are initially worn by patients during the execution of the CBCT, and later during surgery to identify the implant sites in the oral cavity.</p><p><strong>Results: </strong>The procedure described proved to be very useful and able to increase the precision of the freehand technique even if it does not provide information on the inclination of the implants. The metal references help clinical identification of the implant site.</p><p><strong>Conclusions: </strong>Our thermo-molded masks, in particular clinical conditions, could represent a valid and economical alternative to the classic surgical guide. The described procedure does not increase costs for the patient and significantly increases the precision in inserting the implants during free-hand techniques.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"26-34"},"PeriodicalIF":1.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pro-angiogenic VEGF inhibition by cadaverine and hydrocinnamic acid metabolites: impairment of periodontal regeneration due to periodontal inflammation.","authors":"Pradeep K Yadalam, Raghavendra V Anegundi, Ramya Ramadoss, Deepti Shrivastava, Kumar C Srivastava, Rocco Franco, Giuseppe Minervini, Cesare D'Amico","doi":"10.23736/S2724-6329.24.04929-5","DOIUrl":"https://doi.org/10.23736/S2724-6329.24.04929-5","url":null,"abstract":"<p><strong>Background: </strong>Cadaverine and hydrocinnamic acid are frequent metabolites in inflamed periodontal areas. Their role as a metabolite for plant growth inhibition has been established, but their relevance in humans has yet to be determined. Moreover, Vascular endothelial growth factor (VGEF) is a consistent growth factor in neo-angiogenesis in periodontal regeneration. The aim of the study was to utilize an in-silico approach to investigate the potential interaction between Cadaverine and hydrocinnamic acid, metabolites found in inflamed periodontal areas, and vascular endothelial growth factor (VEGF), with a focus on understanding their role in periodontal regeneration.</p><p><strong>Methods: </strong>Desmond MD simulation is an efficient technique for analyzing the dynamics of protein-ligand complexes. The system is minimized and equilibrated after the protein-ligand combination has been solvated in a water box. The system is simulated for a desired time, typically 10-100 nanoseconds. The simulation data is examined to reveal the interactions between proteins and ligands, such as binding affinities, contact maps, and hydrogen bonding patterns. VEGF interactome of metabolites was assessed.</p><p><strong>Results: </strong>Docking interactions between hydrocinnamic acid and VEGF with binding energy -5.0 kcal/mol and docking interactions between Cadaverine and VEGF with -3.6 kcal/mol. Fluctuations in RMSD values remain within 2.0 for the simulation duration, which is perfectly fine. Ligand RMSD values fluctuated within 1.0 Angstrom up to 25 ns, flipped in ligand mode, regained equilibrium at 80 ns, and remained steady for the simulation duration.</p><p><strong>Conclusions: </strong>The current in-silico study suggests that metabolites like Cadaverine and hydrocinnamic acid, which are produced during periodontal inflammation, may have the ability to block pro-angiogenic vascular endothelial growth factors. This interference can have notable effects on the healing and regeneration of tissues by preventing the formation of blood vessels and the expression of VEGF.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basal implants as a treatment alternative for severely resorbed ridges.","authors":"Fadia Awadalkreem, Kusai Baroudi, Giuseppe Minervini, Yazan Zaineh, Ebrahim Al-Mehdhar","doi":"10.23736/S2724-6329.24.05066-6","DOIUrl":"https://doi.org/10.23736/S2724-6329.24.05066-6","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to evaluate the long-term treatment outcomes of basal implants in patients with severely resorbed ridges, including the survival and success rates, patient complaints, satisfaction, and Quality of Life.</p><p><strong>Evidence acquisition: </strong>An extensive electronic search was conducted on the search engines: PubMed, Web of Science, and Google Scholar using Boolean Operators (AND, OR, NOT) and the key words (basal implants, Corticobasal implants, Strategic Implants, severely resorbed ridge, severely atrophic ridge, treatment outcome, patient satisfaction) within the last 10 years.</p><p><strong>Evidence synthesis: </strong>A total of 21 articles were found, encompassing 9732 basal implants placed in 1219 patients. Thirteen studies had reported a success or survival rate with a range of 90.3-100% for intraoral basal implants and 88.2% and 92.9% for orbital and nasal implants, respectively. Four studies have reported failure rates with a range of 0.3-3.2%, while seven articles documented 0.3-2.4% mobility. The pain was reported in 6 studies (0.3-0.8), marginal bone loss (0.33-7.89 mm), an increase in bone density, and peri-implant bone contact were reported in 3 and 2 studies, respectively.</p><p><strong>Conclusions: </strong>Basal implant-supported prostheses can be a practical treatment modality with high predictable survival or success rates, positive impacts on patient satisfaction, and improved quality of life.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boswellic acid exerts anti-tumor effect in oral squamous cell carcinoma by inhibiting PI3K/AKT1 mediated signaling pathway.","authors":"Sathan Raj Natarajan, Vishnu Priya Veeraraghvan, Selvaraj Jayaraman, Maria Maddalena Marrapodi, Vincenzo Ronsivalle, Marco Cicciù, Giuseppe Minervini","doi":"10.23736/S2724-6329.24.04918-0","DOIUrl":"https://doi.org/10.23736/S2724-6329.24.04918-0","url":null,"abstract":"<p><strong>Background: </strong>Boswellic acid (BA) is a bioactive compound derived from Boswellia trees. This study aims to investigate the anti-cancer properties of BA against KB oral squamous cancer cells and elucidate the underlying mechanisms.</p><p><strong>Methods: </strong>Escalating doses of BA were administered to KB cells, and various analyses were conducted using bioinformatic tools such as GEO, GEO2R, and STITCH database. MTT and trypan blue assays has been validated to measure the cytotoxicity by treating BA in KB Cells. Flow cytometry assessed cell cycle progression, apoptosis induction, and metabolic alterations. Network analysis identified relevant signaling pathways, while RT-PCR validated mRNA expression changes. Docking studies by Autodock evaluated beta-BA's binding affinity with mTOR-mediated pathways.</p><p><strong>Results: </strong>BA effectively hindered KB cell progression, inducing G0/G1 phase cell cycle arrest and apoptosis. It also inhibited aerobic glycolysis, a hallmark of oral cancer cells. Network analysis revealed involvement in apoptosis and mTOR targets. RT-PCR confirmed downregulation of genes associated with aerobic glycolysis and apoptosis. Docking studies indicated strong binding between BA and mTOR pathways.</p><p><strong>Conclusions: </strong>BA shows promise in inhibiting KB oral squamous cancer cell growth. These findings underscore its potential as a treatment for oral cancer. Further research and clinical studies are needed to unlock its full therapeutic potential.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stevioside as a potential therapeutic agent: inhibiting cell growth and regulating epithelial-mesenchymal transitions in oral squamous cell carcinoma.","authors":"Vishnu Priya Veeraraghavan, Selvaraj Jayaraman, Maria Maddalena Marrapodi, Vincenzo Ronsivalle, Marco Cicciù, Giuseppe Minervini","doi":"10.23736/S2724-6329.24.04922-2","DOIUrl":"https://doi.org/10.23736/S2724-6329.24.04922-2","url":null,"abstract":"<p><strong>Background: </strong>Oral cancer is a predominant and aggressive form of head and neck cancer with limited treatment options. Stevioside, a naturally occurring biocompatible compound, has gained attention for its potential therapeutic properties, although its molecular mechanistic role in OSCC merely understood. This study aims to elucidate the impact of stevioside on OSCC cells, focusing on its inhibitory effects on cell proliferation and epithelial-mesenchymal transitions (EMT).</p><p><strong>Methods: </strong>KB cells, representative of OSCC, were subjected to stevioside treatment in a time-dependent manner. The findings obtained from the MTT assay revealed a notable suppression of KB cell growth following 48 hours of treatment with stevioside.</p><p><strong>Results: </strong>The IC<inf>50</inf> values, which represent the concentration at which the inhibitory effect of stevioside is at 50% at 110.54 µM, as determined by this assay, were subsequently utilized further for the analysis of gene expression through RT-PCR. Furthermore, our investigation involved the examination of EMT-related genes (ECADH, SNAIL1, SLUG, and VIM) using molecular docking analysis.</p><p><strong>Conclusions: </strong>In conclusion, this study sheds light on the significant role of stevioside in oral cancer. The observed inhibition of KB cell proliferation and its pronounced impact on EMT-related gene expression indicate the potential of stevioside as a promising therapeutic agent in the context of OSCC. The multifaceted effects of stevioside on OSCC cells present an exciting avenue for advancing our understanding of this devastating disease and the development of innovative therapeutic strategies.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there a correlation between A, B, and O blood group system and dental anxiety in pediatric dental patients? An observational study.","authors":"Vritika Singh, Reema Sharma, Nikhil Marwah, Vipul Sharma, Maria Maddalena Marrapodi, Gabriele Cervino, Giuseppe Minervini","doi":"10.23736/S2724-6329.24.05064-2","DOIUrl":"https://doi.org/10.23736/S2724-6329.24.05064-2","url":null,"abstract":"<p><strong>Background: </strong>Anxiety and fear are significant challenges in pediatric dentistry, often leading to avoidance of dental treatment. Some studies suggest a potential link between the dopamine beta-hydroxylase gene and the ABO gene. As ABO blood group type is determined genetically, it could serve as a bioindicator for assessing the impact of genetics on personality traits. The association between blood types and personality characteristics has long been debated.</p><p><strong>Methods: </strong>Eighty eligible children, meeting the inclusion criteria, were enrolled in the study. Blood group data were obtained from parents/guardians. Dental anxiety assessment was done using the RMS-Picture scale and pulse oximeter.</p><p><strong>Results: </strong>The collected data were analyzed statistically.</p><p><strong>Conclusions: </strong>The study found no correlation between dental anxiety and ABO blood grouping.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home treatment protocol for dentin hypersensitivity with hydroxyapatite-based biodynamic toothpaste and lactoferrin: a pilot study.","authors":"Denise Corridore, Iole Vozza, Gabriele Di Carlo, Fabrizio Guerra, Federica Santucci, Paola Mercuri, Matteo Saccucci","doi":"10.23736/S2724-6329.24.05073-3","DOIUrl":"10.23736/S2724-6329.24.05073-3","url":null,"abstract":"<p><strong>Background: </strong>In recent years, there has been a gradual increase in cases of dentin hypersensitivity, often related to gingival recession, enamel abrasion from brushing, and wear of root cementum. This condition can affect patients of all ages but is more common between 20 and 40 years of age, especially in females and individuals with periodontal disease. The study aimed to evaluate and compare the efficacy over time of a product for at-home treatment of dentin hypersensitivity.</p><p><strong>Methods: </strong>One hundred five patients aged between 28 and 65 years were recruited, each with at least two hypersensitive teeth due to erosions, abrasions, gingival recessions, and/or periodontal diseases. Participants were selected through the Schiff Test and anamnestic evaluations, with compilation of periodontal records. Patients are instructed to use the product three times a day, to be applied with a soft-bristled toothbrush and/or topically as a gel on teeth with strong sensitivity and deep cervical lesions and gingival recessions.</p><p><strong>Results: </strong>There were no statistically significant differences between measurements at baseline and after scaling. However, significant differences were observed in follow-ups from the 1^st to the 8^th week, with a progressive decrease in values. The average trend of product efficacy increases over time according to the Schiff Test, with a significant improvement observed at follow-ups conducted after four and eight weeks.</p><p><strong>Conclusions: </strong>The results indicate that the product enriched with biomimetic hydroxyapatite and lactoferrin is effective in reducing the painful symptoms of dentin hypersensitivity and in counteracting the inflammatory state of the supporting tissues.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"312-318"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medico-legal considerations in immediate loading implantology: risks, responsibilities, and best practices.","authors":"Michele A Karaboue, Eleonora Lo Muzio, Maria E Bizzoca, Karidia Karaboue, Swapnil Saini, Francesco Pettini, Michele Di Cosola, Michele Covelli, Lynn Almasri, Giorgia V Lacasella","doi":"10.23736/S2724-6329.24.05129-5","DOIUrl":"10.23736/S2724-6329.24.05129-5","url":null,"abstract":"<p><p>The field of immediate loading implantology has grown rapidly, offering quicker solutions for prosthetic rehabilitation. However, the complexity of this technique raises significant medico-legal concerns regarding patient safety, treatment planning, and professional liability. These issues are particularly relevant in elective procedures where failure could lead to litigation. A comprehensive review of current literature, including clinical studies, legal rulings, and malpractice claims, was conducted to assess the legal implications of immediate loading implantology. The analysis focused on professional liability, patient consent, and complications during treatment. The evidence indicates that a high standard of care, including detailed preoperative planning, risk assessment, and clear patient communication, is essential in minimizing legal risks. Malpractice claims often arise from inadequate patient information or failure to follow established protocols. Proper documentation of informed consent and adherence to evidence-based dentistry (EBD) guidelines are crucial to protect both patients and practitioners. Immediate loading implantology offers numerous benefits, but it requires meticulous planning and patient management to avoid medico-legal issues. Ensuring comprehensive patient consent and following evidence-based practices are key to reducing professional liability and improving outcomes. Further studies should explore standardized protocols for reducing complications and legal disputes in implantology.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"359-367"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between the healing rate of post-extraction sites and the quantity of platelets present in the blood: a retrospective observational study.","authors":"Maria E Bizzoca, Fabrizio Bambini, Maria L Garo, Alessio Marani, Roberto Rossi, Francesco Sampalmieri, Lucia Memè","doi":"10.23736/S2724-6329.24.05049-6","DOIUrl":"10.23736/S2724-6329.24.05049-6","url":null,"abstract":"<p><strong>Background: </strong>In daily surgical practice, the dentist deals with various types of oral surgery. At the first visit, the patient fills out a questionnaire about their state of health. If the questionnaire does not reveal any particular hematological problems, no special tests are usually required to determine the platelet count. The aim of this prospective study was to evaluate the healing process of patients and its correlation with platelet levels before surgery.</p><p><strong>Methods: </strong>A total of 50 patients were included in whom blood chemistry tests were performed with special attention to the platelet count and before their mandibular eights were extracted .The type of healing (EHI) and pain on the second day (VAS) were assessed using methods validated in the literature.</p><p><strong>Results: </strong>After the EHI and VAS scores were noted in the medical records, envelopes containing the platelet scores of the previously requested blood samples, which were not read at the time of observation, were opened. An increase in EHI scores and a decrease in VAS scores was observed that were statistically significantly correlated with increasing platelet scores.</p><p><strong>Conclusions: </strong>These results suggest that the dentist should request chemistry tests on preoperative blood, especially if the patient is to undergo a particularly demanding oral surgical procedure, such as implants, guided bone regeneration or complex extractions.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"335-342"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insertion axis in removable prosthesis: a preliminary report.","authors":"Saverio Ceraulo, Paolo Caccianiga, Antonio Barbarisi, Gianluigi Caccianiga, Roberto Biagi","doi":"10.23736/S2724-6329.24.04973-8","DOIUrl":"10.23736/S2724-6329.24.04973-8","url":null,"abstract":"<p><strong>Background: </strong>Removable partial denture (RPD) is still a widely used prosthesis today to solve non-implant cases, despite its aesthetic contraindications. The aim of the following work is to evaluate how much the communication and explanation to the patient of the insertion axis of the removable partial prosthesis in the periodontium and teeth has an impact on his degree of acceptance of the aesthetic limits of this prosthesis.</p><p><strong>Methods: </strong>For this study, 150 patients were examined from 10 dentists, 5 in Lombardy and 5 in Sicily, using inclusion criteria and exclusion criteria. All selected patients required removable partial dentures. The data was obtained by completing 2 questionnaires, at three different times, at prosthesis delivery, at 6 and 12 months.</p><p><strong>Results: </strong>Questionnaires highlighted overlapping data in the two regions and a total absence of communication of the insertion axis by the dental technician laboratories was highlighted with a percentage of 100%. 28% of the patients complained of pain during the insertion of the prosthesis at 12 months and 39.33% of patients had mobility of remaining teeth with clasps at 12 months. All patients experienced no discomfort, and no important data were reported at the first 6-month follow-up.</p><p><strong>Conclusions: </strong>For mobile partial dentures, respecting the insertion axis can improve the predictability of the periodontal tissue and the resistance of the remaining teeth with clasps. The drawing of an arrow in the model shows the insertion axis of the prosthesis. It would be desirable to include information regarding the insertion axis and advice for the management of the removable partial denture in the first days of use in the declaration of conformity given to the doctor and to thepatient, in the indications section. It can be said that correct insertion of the removable partial denture, helped by verbal and written instructions from the doctor, can reduce possible periodontal alterations of the remaining teeth, by eliminating spurious stresses during insertion and removal of the prosthesis.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"328-334"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}