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翼状胬肉切除术后继发巨大炎性肉芽肿一例 翼状胬肉切除术后继发巨大炎性肉芽肿一例
Chinese Ophthalmic Research Pub Date : 2010-09-10 DOI: 10.3969/J.ISSN.1003-0808.2010.09.016
吕仲平, 孟丹
{"title":"翼状胬肉切除术后继发巨大炎性肉芽肿一例","authors":"吕仲平, 孟丹","doi":"10.3969/J.ISSN.1003-0808.2010.09.016","DOIUrl":"https://doi.org/10.3969/J.ISSN.1003-0808.2010.09.016","url":null,"abstract":"患者,男,63岁,因左眼翼状胬肉于2010年1月22日在外院行左眼翼状胬肉单纯切除术,术后2周,患者发现左眼内眦部肿块,并进行性增大.眼科检查:手术区可见红色质硬包块,界清,有蒂,无压痛,触之无出血,直径约10 mm(图1).经抗生素、糖皮质激素滴眼液点眼治疗3个月无效后于四川大学华西医院眼科就诊,在局部麻醉下行包块切除术.术中发现肿块蒂约1 mm,在其根部紧贴巩膜处用剪刀将包块完整切除,烧灼止血,手术区见4根黑色缝线松动,线头长约5 mm,暴露于结膜表面,拆除缝线。","PeriodicalId":186994,"journal":{"name":"Chinese Ophthalmic Research","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122517785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of hypoxia-inducible factor-1α,inducible nitric oxide synthase and cyclooxygenase-2 in rat retina with chronic high ocular pressure 慢性高眼压大鼠视网膜缺氧诱导因子-1α、诱导型一氧化氮合酶和环氧合酶-2的表达
Chinese Ophthalmic Research Pub Date : 2010-09-10 DOI: 10.3969/J.ISSN.1003-0808.2010.09.002
归东梅, 杨飏, 李迅, 高殿文
{"title":"Expression of hypoxia-inducible factor-1α,inducible nitric oxide synthase and cyclooxygenase-2 in rat retina with chronic high ocular pressure","authors":"归东梅, 杨飏, 李迅, 高殿文","doi":"10.3969/J.ISSN.1003-0808.2010.09.002","DOIUrl":"https://doi.org/10.3969/J.ISSN.1003-0808.2010.09.002","url":null,"abstract":"目的 探讨缺氧诱导因子-1α(HIF-1α)、诱导型一氧化氮合成酶(iNOS)、环氧合酶-2(COX-2)的表达与高眼压视网膜损伤的关系,为青光眼视网膜缺氧提供证据.方法 用巩膜静脉烧烙法在50只SPF级Wistar大鼠的双眼制作慢性高眼压模型,眼压高于造模前40%以上者为造模成功.按照视网膜取材时间的不同将动物模型眼随机分为高眼压3、7、14、21、28 d组,每组10只大鼠20只眼.另选取10只匹配大鼠作为假手术对照组,仅作球结膜切开.应用逆转录-聚合酶链反应(RT-PCR)法及Western blot法检测各组视网膜组织中HIF-1α、iNOS、COX-2 mRNA及其蛋白在大鼠视网膜中的表达.结果 HIF-1α、iNOS、COX-2 mRNA及蛋白在假手术组大鼠视网膜中呈微弱表达,造模眼HIF-1α、iNOS、COX-2 mRNA及其蛋白在视网膜中的表达水平明显升高,于7 d时达到高峰,随后有所下降,但仍明显高于正常组的表达水平.造模后3、7、14、21、28 d组大鼠视网膜中HIF-1α、iNOS、COX-2 mRNA及其蛋白的表达与假手术组相比,差异均有统计学意义(P＜0.05).结论 HIF-1α、iNOS、COX-2的低氧信号途径是青光眼神经变性发生发展中重要的病理生理机制。","PeriodicalId":186994,"journal":{"name":"Chinese Ophthalmic Research","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122115354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histopathological study on morphology change of optic nerve fibers caused by atherosclerosis of nutrition artery in optic tract 视束营养动脉粥样硬化致视神经纤维形态改变的组织病理学研究
Chinese Ophthalmic Research Pub Date : 2010-09-10 DOI: 10.3969/J.ISSN.1003-0808.2010.09.017
王凤翔, 刘学军, 张子明
{"title":"Histopathological study on morphology change of optic nerve fibers caused by atherosclerosis of nutrition artery in optic tract","authors":"王凤翔, 刘学军, 张子明","doi":"10.3969/J.ISSN.1003-0808.2010.09.017","DOIUrl":"https://doi.org/10.3969/J.ISSN.1003-0808.2010.09.017","url":null,"abstract":"目的 研究颈内动脉粥样硬化和视神经干小动脉硬化与视神经萎缩的关系.方法 收集猝死于心脑血管疾病的60～83岁老年人的双侧脑组织标本30例(60个),取颈内动脉和相应的视神经切片行苏木精-伊红染色和Wegert染色,进行病理解剖学研究.结果 颈内动脉有粥样硬化改变者55个,占91.7%;视神经内小动脉有硬化改变者45个,占75%.其中纤维增生型15个,占25.0%;纤维斑块型和粥样斑块型28个,占46.6%;钙化斑块型(复合斑块型)17个,占28.4%.视神经束内小动脉有轻度硬化改变者35个,占63.7%;中度改变者14个,占25.3%;重度硬化改变并阻塞小动脉而致视神经萎缩者6个,占11%.结论 颈内动脉硬化可同时伴视神经小动脉硬化,小动脉硬化可致视神经缺血萎缩,是引起老年人视野缺损的原因之一。","PeriodicalId":186994,"journal":{"name":"Chinese Ophthalmic Research","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129314552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of transcorneal permeability of hyaluronic acid-assistant Gd-DTPA using MRI MRI评价透明质酸辅助Gd-DTPA经角膜通透性
Chinese Ophthalmic Research Pub Date : 2010-09-10 DOI: 10.3969/J.ISSN.1003-0808.2010.09.001
王根国, 毛晓春, 李贵刚, 陈辉, 樊建中, 张少维, 杜龙庭
{"title":"Evaluation of transcorneal permeability of hyaluronic acid-assistant Gd-DTPA using MRI","authors":"王根国, 毛晓春, 李贵刚, 陈辉, 樊建中, 张少维, 杜龙庭","doi":"10.3969/J.ISSN.1003-0808.2010.09.001","DOIUrl":"https://doi.org/10.3969/J.ISSN.1003-0808.2010.09.001","url":null,"abstract":"目的 利用磁共振成像(MRI)及其造影剂,探讨加入增黏剂透明质酸钠对钆喷酸葡胺(Gd-DTPA)角膜渗透性的影响.方法 16只新西兰白兔按随机数字表法分为2组,每组8只兔,均取右眼为实验眼,分别点用质量分数23.45%Gd-DTPA滴眼液为Gd-DTPA组、23.45%Gd-DTPA+质量分数0.2%透明质酸钠滴眼液为透明质酸钠组,每 5 min 点眼1次,每次50 μL,共6次.左眼为正常对照眼,不做任何处理.此后进行MRI连续扫描,观察用药前后兔眼结膜囊、前房、后房及玻璃体内示踪剂的信号变化.结果 正常兔眼前房MRI平扫呈均匀低信号.Gd-DTPA组结膜囊信号在用药40 min消失,透明质酸钠组结膜囊内Gd-DTPA信号在用药后60 min消失.与Gd-DTPA组比较,透明质酸钠组结膜囊内和前房示踪剂信号增强明显,60 min时Gd-DTPA组前房信号增强率为19.63%,透明质酸钠组为53.42%.2组兔点眼后后房及玻璃体信号强度均无变化.结论 透明质酸钠可提高与Gd-DTPA性质类似药物的角膜通透性,MRI能够在活体内动态、实时地检测滴眼液的角膜渗透性,是对传统药物代谢检测方法的补充。","PeriodicalId":186994,"journal":{"name":"Chinese Ophthalmic Research","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134363539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in ocular anterior segment imaging 眼前段影像研究进展
Chinese Ophthalmic Research Pub Date : 2010-09-10 DOI: 10.3969/J.ISSN.1003-0808.2010.09.032
Yuyi You, F. Yuan
{"title":"Advances in ocular anterior segment imaging","authors":"Yuyi You, F. Yuan","doi":"10.3969/J.ISSN.1003-0808.2010.09.032","DOIUrl":"https://doi.org/10.3969/J.ISSN.1003-0808.2010.09.032","url":null,"abstract":"以眼前节光学相干断层扫描(OCT)、Scheimpflug技术、高分辨率磁共振成像及裂隙扫描等为代表的眼前节影像技术提供了房角的各种参数,可测量角膜前后表面的曲率和前房内径,计算出角膜的屈光度,在准分子激光角膜原位磨镶术(LASIK)术后能够测量角膜瓣厚度,甚至可用于调节功能及老视的研究,极大地提高了诊疗水平.就几种新型眼前节影像技术的研究进展及其临床应用进行综述。","PeriodicalId":186994,"journal":{"name":"Chinese Ophthalmic Research","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126632668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
贝伐单抗治疗黄斑旁中心凹毛细血管扩张症一例 贝伐单抗治疗黄斑旁中心凹毛细血管扩张症一例
Chinese Ophthalmic Research Pub Date : 2010-09-10 DOI: 10.3969/J.ISSN.1003-0808.2010.09.005
冯超, 陈长征, 杨安怀, 周芸芸
{"title":"贝伐单抗治疗黄斑旁中心凹毛细血管扩张症一例","authors":"冯超, 陈长征, 杨安怀, 周芸芸","doi":"10.3969/J.ISSN.1003-0808.2010.09.005","DOIUrl":"https://doi.org/10.3969/J.ISSN.1003-0808.2010.09.005","url":null,"abstract":"特发性黄斑旁中心凹毛细血管扩张症(idiopathic perifoveal telangiectasia,IPT)是一种较为少见且病因不明的眼科疾病,缺乏有效的治疗方法[1].本研究应用贝伐单抗(avastin)行玻璃体腔注射治疗IPT患者1例,报告如下。","PeriodicalId":186994,"journal":{"name":"Chinese Ophthalmic Research","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124208786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
糖尿病视网膜病变视网膜光凝术后玻璃体积血原因分析及治疗 糖尿病视网膜病变视网膜光凝术后玻璃体积血原因分析及治疗
Chinese Ophthalmic Research Pub Date : 2010-09-10 DOI: 10.3969/J.ISSN.1003-0808.2010.09.033
韩金栋, 颜华
{"title":"糖尿病视网膜病变视网膜光凝术后玻璃体积血原因分析及治疗","authors":"韩金栋, 颜华","doi":"10.3969/J.ISSN.1003-0808.2010.09.033","DOIUrl":"https://doi.org/10.3969/J.ISSN.1003-0808.2010.09.033","url":null,"abstract":"视网膜光凝是防止糖尿病视网膜病变(diabetic retinopathy,DR)进一步发展的有效措施[1],但视网膜光凝术后仍有相当一部分患者因玻璃体积血而引起视力继续下降[2].分析视网膜光凝术后玻璃体积血发生的时间及原因,并给予及时处理,对于防治及恢复患者的视功能具有重要的意义。","PeriodicalId":186994,"journal":{"name":"Chinese Ophthalmic Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127422411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
眼科首诊的黏膜相关淋巴组织淋巴瘤一例 眼科首诊的黏膜相关淋巴组织淋巴瘤一例
Chinese Ophthalmic Research Pub Date : 2010-09-10 DOI: 10.3969/J.ISSN.1003-0808.2010.09.018
高新晓, 王京
{"title":"眼科首诊的黏膜相关淋巴组织淋巴瘤一例","authors":"高新晓, 王京","doi":"10.3969/J.ISSN.1003-0808.2010.09.018","DOIUrl":"https://doi.org/10.3969/J.ISSN.1003-0808.2010.09.018","url":null,"abstract":"黏膜相关淋巴组织(mucosa associated lymphoid tissue,MALT)淋巴瘤是一种淋巴结外淋巴瘤,常见部位包括胃肠道、肺、甲状腺、涎腺、眼眶等,眼附属器MALT淋巴瘤是眼附属器最常见的淋巴瘤,通常发生于眼眶软组织、结膜、泪腺,但首诊于眼科的MALT淋巴瘤易与眼眶炎性假瘤混淆.现将就诊于眼科的MALT淋巴瘤1例报告如下。","PeriodicalId":186994,"journal":{"name":"Chinese Ophthalmic Research","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130223237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expressions of E-cadherin and β-catenin in pleomorphic adenoma and adenoid cystic carcinoma of lacrimal gland E-cadherin和β-catenin在泪腺多形性腺瘤和腺样囊性癌中的表达
Chinese Ophthalmic Research Pub Date : 2010-09-10 DOI: 10.3969/J.ISSN.1003-0808.2010.09.006
刘辉, 李永平, 张文忻, 林健贤
{"title":"Expressions of E-cadherin and β-catenin in pleomorphic adenoma and adenoid cystic carcinoma of lacrimal gland","authors":"刘辉, 李永平, 张文忻, 林健贤","doi":"10.3969/J.ISSN.1003-0808.2010.09.006","DOIUrl":"https://doi.org/10.3969/J.ISSN.1003-0808.2010.09.006","url":null,"abstract":"目的 研究E-cadherin及β-catenin在泪腺多形性腺瘤和腺样囊性癌中的表达.方法 选取经病理检查确诊为泪腺多形性腺瘤的患者11例11眼和腺样囊性癌的患者6例6眼,分别行E-cadherin和β-catenin免疫组织化学染色.选取泪腺脱垂患者的泪腺组织6例作为正常对照组.结果 正常泪腺组织中E-cadherin呈强阳性表达,主要位于细胞膜;而在泪腺多形性腺瘤中E-cadherin呈弱阳性表达,主要位于细胞质.E-cadherin在腺样囊性癌中未见表达.3组中E-cadherin阳性表达的样本数差异有统计学意义(H=16.492,P=0.000);正常泪腺组E-cadherin阳性表达的样本数明显高于多形性腺瘤组和腺样囊性癌组,差异均有统计学意义(U=-3.561,P=0.000;U=-3.108,P=0.002),多形性腺瘤组中E-cadherin阳性表达的样本数明显高于腺样囊性癌组,差异有统计学意义(U=-2.147,P=0.032).正常泪腺β-catenin细胞膜呈中度或强阳性表达,多形性腺瘤和腺样囊性癌中β-catenin的表达较正常泪腺组织表达阳性程度差异无统计学意义(P＞0.05),腺样囊性癌组中β-catenin细胞核阳性的比例(33.3%,2/6)较多形性腺瘤组(72.7%,7/11)低.结论 E-cadherin表达的下降是参与泪腺上皮性肿瘤发生及癌变的重要因素,而E-cadherin的进一步下降甚至缺失,以及β-catenin的核转位可能是参与泪腺多形性腺瘤恶性转化的因素之一。","PeriodicalId":186994,"journal":{"name":"Chinese Ophthalmic Research","volume":"102 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134094174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
脉络膜骨瘤一例 脉络膜骨瘤一例
Chinese Ophthalmic Research Pub Date : 2010-09-10 DOI: 10.3969/J.ISSN.1003-0808.2010.09.023
王良艳, 王玉, 范传峰, 田洁
{"title":"脉络膜骨瘤一例","authors":"王良艳, 王玉, 范传峰, 田洁","doi":"10.3969/J.ISSN.1003-0808.2010.09.023","DOIUrl":"https://doi.org/10.3969/J.ISSN.1003-0808.2010.09.023","url":null,"abstract":"患者,女,36岁,因左眼视力下降伴视物变形20 d于2010年5月19日就诊.门诊检查:左眼视力0.5,矫正无助.眼前节正常,屈光间质清晰.左眼眼底彩色照相:视盘颞侧视网膜下见-2.5 PD黄白色隆起,呈扁平状,边界不清,表面有色素沉着,累及黄斑区,相应部位视网膜水肿,未见明显出血。","PeriodicalId":186994,"journal":{"name":"Chinese Ophthalmic Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130177696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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