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Effects of latrunculin-B on rabbit sclera collagen remodeling 拉曲库林- b对兔巩膜胶原重塑的影响
Chinese Ophthalmic Research Pub Date : 2010-11-10 DOI: 10.3969/J.ISSN.1003-0808.2010.11.011
李卫国, 张磊, 宫月荣, 雷宁玉, 考华婷, 何湘珍
{"title":"Effects of latrunculin-B on rabbit sclera collagen remodeling","authors":"李卫国, 张磊, 宫月荣, 雷宁玉, 考华婷, 何湘珍","doi":"10.3969/J.ISSN.1003-0808.2010.11.011","DOIUrl":"https://doi.org/10.3969/J.ISSN.1003-0808.2010.11.011","url":null,"abstract":"目的 研究latrunculin-B(Lat-B)对兔巩膜通透性的影响,为细胞骨架因子在青光眼治疗中的应用及眼后节疾病的药物传递研究提供新的思路和理论依据.方法 36只家兔随机分为平衡盐液(BSS)组、二甲基亚砜(DMSO)组及Lat-B组,每组12只,分别用BSS、DMSO和Lat-B局部点眼,于用药前1h及用药后1、2、3、4、5、6、24h分别测量眼压,于24h后处死动物并获取部分巩膜组织,自制巩膜滤过装置测试巩膜通透性的变化,部分巩膜组织行免疫组织化学染色以检测前部巩膜组织中基质金属蛋白酶-2(MMP-2)和组织金属蛋白酶-2抑制剂(TIMP-2)的表达.光学显微镜下观察实验兔眼部各组织结构的形态学变化.结果 Lat-B组、BSS组与DMSO组点眼前后各时间点眼压的总体变化差异有统计学意义(F=25.76,P＜0.01),Lat-B点眼后不同时间点与点眼前比较眼压呈下降趋势,差异有统计学意义(Ftime=4.50,P＜0.01),点眼后1h即可引起眼压降低,降眼压作用可持续24h;BSS组与DMSO组点眼前后各时间点眼压变化的差异无统计学意义(P＞0.05);Lat-B点眼后的前部巩膜对BSS的滤过较BSS组和DMSO组明显增加,3组的总体比较差异有统计学意义(F=47.50,P＜0.01);Lat-B组、BSS组和DMSO组MMP-2及TIMP-2表达的吸光度(A)值的总体比较差异均有统计学意义(F=28.70,F=22.30,P＜0.01).MMP-2、TIMP-2的表达Lat-B组与BSS组比较差异有统计学意义(P＜0.01),与DMSO组比较二者的表达均降低,差异均有统计学意义(P＜0.01);BSS组和DMSO组间MMP-2及TIMP-2比较差异均无统计学意义(P＞0.05).结论 Lat-B能够有效降低眼压,明显提高巩膜的房水流出易度,并可通过上调MMP-2、TIMP-2的表达导致巩膜胶原重塑。","PeriodicalId":186994,"journal":{"name":"Chinese Ophthalmic Research","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129997659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
无脉络膜症一家系 无脉络膜症一家系
Chinese Ophthalmic Research Pub Date : 2010-11-10 DOI: 10.3969/J.ISSN.1003-0808.2010.11.007
张京红
{"title":"无脉络膜症一家系","authors":"张京红","doi":"10.3969/J.ISSN.1003-0808.2010.11.007","DOIUrl":"https://doi.org/10.3969/J.ISSN.1003-0808.2010.11.007","url":null,"abstract":"","PeriodicalId":186994,"journal":{"name":"Chinese Ophthalmic Research","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114957880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of hyaluronan synthase messenger ribonucleic acids in orbital tissues of patients with thyroid-associated ophthalmopathy 甲状腺相关性眼病患者眼眶组织中透明质酸合成酶信使核糖核酸的表达
Chinese Ophthalmic Research Pub Date : 2010-10-10 DOI: 10.3969/J.ISSN.1003-0808.2010.10.013
董凯, 何为民, 罗清礼
{"title":"Expression of hyaluronan synthase messenger ribonucleic acids in orbital tissues of patients with thyroid-associated ophthalmopathy","authors":"董凯, 何为民, 罗清礼","doi":"10.3969/J.ISSN.1003-0808.2010.10.013","DOIUrl":"https://doi.org/10.3969/J.ISSN.1003-0808.2010.10.013","url":null,"abstract":"目的 探讨透明质酸合成酶2(HAS2)mRNA在甲状腺相关眼病(TAO)患者球后脂肪组织及眼外肌中的表达.方法 收集四川大学华西医院眼科2000-2005年确诊并行眼眶减压术或斜视矫正术的TAO患者21例为TAO组,获得眼外肌标本18个,脂肪标本17个;Ⅱ期义眼台植入患者、眼袋整形者及共同性斜视患者18例作为对照组,共获得眼外肌组织标本17个,脂肪组织标本11个.所有标本通过原位杂交的方法,测量吸光度(A)值,计算HAS2 mRNA的表达.依据活动期的临床表现对TAO患者进行临床活动性评分(CAS),采用Spearman秩相关分析对HAS2 mRNA在待测眼组织标本中的表达量与TAO患者CAS的相关性进行评估.结果 TAO组患者眼外肌和脂肪间质组织HAS2明显黄染,对照组均呈轻度黄染.TAO组和对照组的眼外肌组织中HAS2 mRNA A值分别为191.133±48.898和133.200±48.933,差异有统计学意义(P=0.001)(95%CI:24.275～91.590);TAO组和对照组眶脂肪组织中HAS2 mRNA A值分别为50.430±26.812和33.048±11.690,差异有统计学意义(t=2.350,P=0.028)(95%CI:2.099～32.664);CAS与TAO脂肪组织中HAS2 mRNA的表达无明显相关性(r=0.044,P=0.868),与肌肉组织中HAS2 mRNA的表达呈弱正相关性(r=0.496,P=0.036).结论 TAO患者HAS2 mRNA的高表达是造成眶后透明质酸堆积的原因之一。","PeriodicalId":186994,"journal":{"name":"Chinese Ophthalmic Research","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128802077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
硅油微小气泡致玻璃体切割联合硅油填充术后早期高眼压一例 硅油微小气泡致玻璃体切割联合硅油填充术后早期高眼压一例
Chinese Ophthalmic Research Pub Date : 2010-10-10 DOI: 10.3969/J.ISSN.1003-0808.2010.10.012
陈放, 季河清, 解正高
{"title":"硅油微小气泡致玻璃体切割联合硅油填充术后早期高眼压一例","authors":"陈放, 季河清, 解正高","doi":"10.3969/J.ISSN.1003-0808.2010.10.012","DOIUrl":"https://doi.org/10.3969/J.ISSN.1003-0808.2010.10.012","url":null,"abstract":"患者,女,53岁,因右眼视物不清3个月来诊.眼部检查:视力右眼0.02,左眼0.80;右眼角膜清,KP(-),前房深度正常,瞳孔圆,晶状体轻度混浊,玻璃体混浊,隐见视网膜色灰;左眼角膜清,前房清,瞳孔圆,晶状体轻度混浊,眼底视盘界清晰、色红,视网膜平伏.非接触眼压计测眼压右眼16mmHg(1mmHg=0.133kPa),左眼18mmHg;B型超声检查示右眼视网膜脱离.患者既往有高血压病史10年,余全身情况无特殊.","PeriodicalId":186994,"journal":{"name":"Chinese Ophthalmic Research","volume":"153 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121392082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in scaffold of tissue engineering corneal epithelium 组织工程角膜上皮支架的研究进展
Chinese Ophthalmic Research Pub Date : 2010-10-10 DOI: 10.3969/J.ISSN.1003-0808.2010.10.025
王雪
{"title":"Advances in scaffold of tissue engineering corneal epithelium","authors":"王雪","doi":"10.3969/J.ISSN.1003-0808.2010.10.025","DOIUrl":"https://doi.org/10.3969/J.ISSN.1003-0808.2010.10.025","url":null,"abstract":"体外培养角膜缘干细胞构建组织工程角膜上皮后再行角膜移植是治疗角膜缘干细胞缺乏导致眼表疾病的重要方法,选择理想的支架材料是构建组织工程角膜上皮过程中的一个关键环节.但支架材料的组织相容性、透光度,支架材料的降解与角膜修复的同步化,手术的长期有效性等问题仍有待进一步研究.细胞生物学、分子生物学、组织工程学和材料学的发展为构建组织工程角膜上皮的研究开辟了更广阔的前景.从近年来新发现或研制的支架材料的来源、优缺点及应用等方面,就构建组织工程角膜上皮支架材料的研究进展进行综述。","PeriodicalId":186994,"journal":{"name":"Chinese Ophthalmic Research","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124824035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ca2+ study in retinal pigment epithelial cells of guinea pig with lens induced myopia 晶状体性近视豚鼠视网膜色素上皮细胞Ca2+的研究
Chinese Ophthalmic Research Pub Date : 2010-10-10 DOI: 10.3969/J.ISSN.1003-0808.2010.10.005
仝春梅, 王超英, 王彩荣
{"title":"Ca2+ study in retinal pigment epithelial cells of guinea pig with lens induced myopia","authors":"仝春梅, 王超英, 王彩荣","doi":"10.3969/J.ISSN.1003-0808.2010.10.005","DOIUrl":"https://doi.org/10.3969/J.ISSN.1003-0808.2010.10.005","url":null,"abstract":"目的 激光扫描共焦显微镜(LSCM)检测豚鼠透镜诱导型近视模型视网膜色素上皮(RPE)细胞中Ca2 +,探讨Ca2 +在近视发病中的作用机制.方法 取2周龄豚鼠10只,选取1只眼用-10.00 D凹透镜诱导成近视模型为实验眼,对侧眼为对照眼.实验前后测各组豚鼠屈光度及眼轴长度(AL).原代培养豚鼠眼球赤道前部及后极部RPE细胞,用角蛋白、波形蛋白、结蛋白、S-100抗体进行免疫细胞化学检测对培养细胞进行鉴定.对各组豚鼠眼赤道前部及后极部RPE细胞进行Fluo-3/AM负载,利用LSCM测定细胞中Ca2 +的变化.结果 豚鼠经过45d的透镜诱导,形成(-6.70±1.93)D的相对近视,AL延长了(1.53±0.31)mm,与诱导前的屈光度和AL相比,差异均有统计学意义(F=10.97,P 0.05).结论 在实验性近视形成过程中,RPE细胞中Ca2 +浓度增高。","PeriodicalId":186994,"journal":{"name":"Chinese Ophthalmic Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129720725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
霉菌性蝶窦炎致眼球突出合并视力丧失一例 霉菌性蝶窦炎致眼球突出合并视力丧失一例
Chinese Ophthalmic Research Pub Date : 2010-10-10 DOI: 10.3969/J.ISSN.1003-0808.2010.10.022
韩振强, 高占国
{"title":"霉菌性蝶窦炎致眼球突出合并视力丧失一例","authors":"韩振强, 高占国","doi":"10.3969/J.ISSN.1003-0808.2010.10.022","DOIUrl":"https://doi.org/10.3969/J.ISSN.1003-0808.2010.10.022","url":null,"abstract":"患者,女,69岁,因右侧头痛伴视力下降2个月入院.患者于2个月前无明显诱因出现右侧持续性头部胀痛,伴右眼视力逐渐下降.无鼻塞,右眼球无胀痛,无涕中带血等症状,于眼科就诊查眼底正常,药物治疗无好转,颅脑CT检查未见异常.半个月前发现右眼球突出伴眼球活动受限及视力丧失,眼眶CT检查示:右眼眶尖区可见团块状软组织密度影,形状不规则,边界欠清晰,与内直肌、外直肌及眶内区视神经后段分界不清,相邻骨质结构不规则,有破坏吸收改变,右眼眶筛骨纸板及右侧蝶窦外侧壁部分骨质结构缺损,右侧翼腭窝亦受累。","PeriodicalId":186994,"journal":{"name":"Chinese Ophthalmic Research","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130259997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes of optic disc in rabbit eye following radial optic neurotomy 桡骨视神经切开术后兔眼视盘的变化
Chinese Ophthalmic Research Pub Date : 2010-10-10 DOI: 10.3969/J.ISSN.1003-0808.2010.10.011
高永峰, 李素华, 郭希让, 李建新
{"title":"Changes of optic disc in rabbit eye following radial optic neurotomy","authors":"高永峰, 李素华, 郭希让, 李建新","doi":"10.3969/J.ISSN.1003-0808.2010.10.011","DOIUrl":"https://doi.org/10.3969/J.ISSN.1003-0808.2010.10.011","url":null,"abstract":"目的 观察兔眼放射状视神经切开术(RON)后视盘的形态学改变.方法 40只健康成年家兔随机分为正常对照组及术后1、2、4周组,每组10只兔.手术组兔眼行RON后,分别于术后1、2、4周行眼底照相,用IPP5.0软件测量视盘面积、视盘水平径和垂直径,并行常规组织病理学检查.结果 所有RON手术均成功,术中未见严重玻璃体积血和视网膜脱离,仅RON手术部位有少量出血.RON术后1周组的视盘面积和垂直直径较正常组增大(P 0.05),术后4周组与其他组两两比较差异均有统计学意义(P<0.01).组织病理学检查可见,术后1周组RON手术部位可见淋巴细胞和单核细胞浸润,术后2周组和术后4周组手术部位被大量胶原成分填充.结论 兔眼RON术后视盘直径和面积增大,可为RON的作用机制提供实验依据。","PeriodicalId":186994,"journal":{"name":"Chinese Ophthalmic Research","volume":"256 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124213745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
黄斑部局限性脉络膜微小缺损一例 黄斑部局限性脉络膜微小缺损一例
Chinese Ophthalmic Research Pub Date : 2010-10-10 DOI: 10.3969/J.ISSN.1003-0808.2010.10.010
熊小艳, 赵菊莲
{"title":"黄斑部局限性脉络膜微小缺损一例","authors":"熊小艳, 赵菊莲","doi":"10.3969/J.ISSN.1003-0808.2010.10.010","DOIUrl":"https://doi.org/10.3969/J.ISSN.1003-0808.2010.10.010","url":null,"abstract":"患者,男,35岁,因左眼视力下降1年于2010年1月25日就诊,无眼部外伤及手术史,父母非近亲结婚.全身检查正常.眼科检查:视力右眼0.8,左眼0.3;矫正视力右眼-1.50=1.0,左眼-2.50/-1.50×110°=1.0;眼压正常;双眼眼前节正常;左眼底视盘正常,黄斑中心凹偏颞侧色素紊乱,局部色泽较淡,中心凹反光亮点不清(图1),右眼底正常.荧光素眼底血管造影(FFA)检查显示,左眼造影早期可见黄斑拱环外边缘淡荧光,随造影时间的延长而亮度增加,后期荧光减退(图2),右眼FFA正常。","PeriodicalId":186994,"journal":{"name":"Chinese Ophthalmic Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128750855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
放射状角膜切开术术后11年角膜内皮炎行穿透角膜移植一例 放射状角膜切开术术后11年角膜内皮炎行穿透角膜移植一例
Chinese Ophthalmic Research Pub Date : 2010-09-10 DOI: 10.3969/J.ISSN.1003-0808.2010.09.009
余继锋, 杜改萍, 宋静, 葛梅, 宫玉波, 黄一飞
{"title":"放射状角膜切开术术后11年角膜内皮炎行穿透角膜移植一例","authors":"余继锋, 杜改萍, 宋静, 葛梅, 宫玉波, 黄一飞","doi":"10.3969/J.ISSN.1003-0808.2010.09.009","DOIUrl":"https://doi.org/10.3969/J.ISSN.1003-0808.2010.09.009","url":null,"abstract":"","PeriodicalId":186994,"journal":{"name":"Chinese Ophthalmic Research","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115574670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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